Pyruvate dehydrogenase kinase

Pyruvate dehydrogenase kinase (PDC kinase, PDK) is a kinase enzyme which acts to phosphorylate pyruvate dehydrogenase using ATP.

Pyruvate dehydrogenase kinase participates in the regulation of the pyruvate dehydrogenase complex. When phosphorylated, pyruvate dehydrogenase is inactivated. Dephosphorylation and activation of pyruvate dehydrogenase is catalyzed by a phosphoprotein phosphatase called pyruvate dehydrogenase phosphatase.

Genes
It has four isozymes:
 * PDK1
 * PDK2
 * PDK3
 * PDK4

Regulation
Pyruvate dehydrogenase kinase is stimulated by ATP, NADH and acetyl-CoA.

It is inhibited by ADP, NAD+, CoA-SH and pyruvate.