Glucose 1-dehydrogenase

In enzymology, a glucose 1-dehydrogenase is an enzyme that catalyzes the chemical reaction


 * beta-D-glucose + NAD(P)+ $$\rightleftharpoons$$ D-glucono-1,5-lactone + NAD(P)H + H+

The 3 substrates of this enzyme are beta-D-glucose, NAD+, and NADP+, whereas its 4 products are D-glucono-1,5-lactone, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is beta-D-glucose:NAD(P)+ 1-oxidoreductase. Other names in common use include D-glucose dehydrogenase (NAD(P)+), and hexose phosphate dehydrogenase. This enzyme participates in pentose phosphate pathway.

Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , and.