Vicarious nucleophilic substitution

Vicarious nucleophilic substitution in organic chemistry is a special type of nucleophilic aromatic substitution in which a nucleophile replaces hydrogen and not an aromatic substituent like a halogen that is ordinarily encountered in this reaction type. This reaction type was introduce in 1987 by Mieczyslaw Makosza and Jerzy Winiarski. It is typically encountered with nitroarenes and especially with carbon nucleophiles resulting in new alkylated arenes. Carbon nucleophiles carry a electron-withdrawing group and a nucleofuge:


 * [[Image:VicariousNucleophilicSubstitution.png|400px|Vicarious nucleophilic substitution]]