Aquacobalamin reductase (NADPH)

In enzymology, an aquacobalamin reductase (NADPH) is an enzyme that catalyzes the chemical reaction


 * 2 cob(II)alamin + NADP+ $$\rightleftharpoons$$ 2 aquacob(III)alamin + NADPH + H+

Thus, the two substrates of this enzyme are cob(II)alamin and NADP+, whereas its 3 products are aquacob(III)alamin, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cob(II)alamin:NADP+ oxidoreductase. Other names in common use include aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate), reductase, NADPH-linked aquacobalamin reductase, and NADPH2:aquacob(III)alamin oxidoreductase. This enzyme participates in porphyrin and chlorophyll metabolism. It employs one cofactor, FAD.