Proline-tRNA ligase

In enzymology, a proline-tRNA ligase is an enzyme that catalyzes the chemical reaction


 * ATP + L-proline + tRNAPro $$\rightleftharpoons$$ AMP + diphosphate + L-prolyl-tRNAPro

The 3 substrates of this enzyme are ATP, L-proline, and tRNA(Pro), whereas its 3 products are AMP, diphosphate, and L-prolyl-tRNA(Pro).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-proline:tRNAPro ligase (AMP-forming). Other names in common use include prolyl-tRNA synthetase, prolyl-transferRNA synthetase, prolyl-transfer ribonucleate synthetase, proline translase, prolyl-transfer ribonucleic acid synthetase, prolyl-s-RNA synthetase, and prolinyl-tRNA ligase. This enzyme participates in arginine and proline metabolism and aminoacyl-trna biosynthesis.

Structural studies
As of late 2007, 15 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , , , , , , and.