Zonulin

Overview
Zonulin is a protein that participates in tight junctions between cells of the wall of the digestive tract. Initially discovered in 2000 as the target of zonula occludens toxin, secreted by cholera pathogen Vibrio cholerae, it has been implicated in the pathogenesis of coeliac disease and diabetes mellitus type 1. It is being studied as a target for vaccine adjuvants. ALBA Therapeutics is developing a zonulin receptor agonist, AT-1001, that is currently in phase 2 clinical trials.