Mediastinal germ cell tumor pathophysiology

Pathophysiology
Some investigators suggest that this distribution arises as a consequence of abnormal migration of germ cells during embryogenesis. Others hypothesize a widespread distribution of germ cells to multiple sites during normal embryogenesis, with these cells conveying genetic information or providing regulatory functions at somatic sites.

Associated Syndromes
 * Klinefelter's syndrome
 * Hematologic Neoplasia