Pelger-Huet abnormality

Overview
Pelger-Huet abnormality or Pelger-Huët anomaly (PHA) is a benign dominantly inherited defect of terminal neutrophil differentiation secondary to mutations in the lamin B receptor (LBR) gene.

Laboratory findings
Characteristics observed on blood smears include leukocytes with dumbbell-shaped bilobed nuclei; a reduced number of nuclear segments; and coarse clumping of the nuclear chromatin in neutrophils, lymphocytes, and monocytes.

Differential Diagnosis

 * Enteroviral infections
 * Malaria
 * Myelodysplasia
 * Myelodysplastic syndrome
 * Panhypopituitarism