List of EC numbers (EC 4)

This list contains a list of EC numbers for the fourth group, EC 4, lyases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.

EC 4.1.1: Carboxy-Lyases

 * : pyruvate decarboxylase
 * : oxalate decarboxylase
 * : oxaloacetate decarboxylase
 * : acetoacetate decarboxylase
 * : acetolactate decarboxylase
 * : aconitate decarboxylase
 * : benzoylformate decarboxylase
 * : oxalyl-CoA decarboxylase
 * : malonyl-CoA decarboxylase
 * : deleted, included in EC 4.1.1.12
 * : aspartate 1-decarboxylase
 * : aspartate 4-decarboxylase
 * : deleted
 * : valine decarboxylase
 * : glutamate decarboxylase
 * : hydroxyglutamate decarboxylase
 * : ornithine decarboxylase
 * : lysine decarboxylase
 * : arginine decarboxylase
 * : diaminopimelate decarboxylase
 * : phosphoribosylaminoimidazole carboxylase
 * : histidine decarboxylase
 * : orotidine-5'-phosphate decarboxylase
 * : aminobenzoate decarboxylase
 * : tyrosine decarboxylase
 * : deleted, included in EC 4.1.1.28
 * : deleted, included in EC 4.1.1.28
 * : aromatic-L-amino-acid decarboxylase
 * : sulfoalanine decarboxylase
 * : pantothenoylcysteine decarboxylase
 * : phosphoenolpyruvate carboxylase
 * : phosphoenolpyruvate carboxykinase (GTP)
 * : diphosphomevalonate decarboxylase
 * : dehydro-L-gulonate decarboxylase
 * : UDP-glucuronate decarboxylase
 * : phosphopantothenoylcysteine decarboxylase
 * : uroporphyrinogen decarboxylase
 * : phosphoenolpyruvate carboxykinase (diphosphate)
 * : ribulose-bisphosphate carboxylase
 * : hydroxypyruvate decarboxylase
 * : methylmalonyl-CoA decarboxylase
 * : carnitine decarboxylase
 * : phenylpyruvate decarboxylase
 * : 4-carboxymuconolactone decarboxylase
 * : aminocarboxymuconate-semialdehyde decarboxylase
 * : o-pyrocatechuate decarboxylase
 * : tartronate-semialdehyde synthase
 * : indole-3-glycerol-phosphate synthase
 * : phosphoenolpyruvate carboxykinase (ATP)
 * : adenosylmethionine decarboxylase
 * : 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase
 * : 6-methylsalicylate decarboxylase
 * : phenylalanine decarboxylase
 * : dihydroxyfumarate decarboxylase
 * : 4,5-dihydroxyphthalate decarboxylase
 * : 3-oxolaurate decarboxylase
 * : methionine decarboxylase
 * : orsellinate decarboxylase
 * : gallate decarboxylase
 * : stipitatonate decarboxylase
 * : 4-hydroxybenzoate decarboxylase
 * : gentisate decarboxylase
 * : protocatechuate decarboxylase
 * : 2,2-dialkylglycine decarboxylase (pyruvate)
 * : phosphatidylserine decarboxylase
 * : uracil-5-carboxylate decarboxylase
 * : UDP-galacturonate decarboxylase
 * : 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase
 * : 3,4-dihydroxyphthalate decarboxylase
 * : glutaconyl-CoA decarboxylase
 * : 2-oxoglutarate decarboxylase
 * : branched-chain-2-oxoacid decarboxylase
 * : tartrate decarboxylase
 * : indolepyruvate decarboxylase
 * : 5-guanidino-2-oxopentanoate decarboxylase
 * : arylmalonate decarboxylase
 * : 4-oxalocrotonate decarboxylase
 * : acetylenedicarboxylate decarboxylase
 * : sulfopyruvate decarboxylase
 * : 4-hydroxyphenylpyruvate decarboxylase
 * : threonine-phosphate decarboxylase
 * : phosphonopyruvate decarboxylase
 * : 4-hydroxyphenylacetate decarboxylase
 * : D-dopachrome decarboxylase
 * : 3-dehydro-L-gulonate-6-phosphate decarboxylase

EC 4.1.2: Aldehyde-Lyases

 * : deleted, included in EC 4.1.3.16
 * : ketotetrose-phosphate aldolase
 * : deleted
 * : deoxyribose-phosphate aldolase
 * : threonine aldolase
 * : deleted
 * : deleted, included in EC 4.1.2.13
 * : deleted
 * : phosphoketolase
 * : mandelonitrile lyase
 * : hydroxymandelonitrile lyase
 * : 2-dehydropantoate aldolase
 * : fructose-bisphosphate aldolase
 * : 2-dehydro-3-deoxy-phosphogluconate aldolase
 * : now EC 2.5.1.54
 * : now EC 2.5.1.55
 * : L-fuculose-phosphate aldolase
 * : 2-dehydro-3-deoxy-L-pentonate aldolase
 * : rhamnulose-1-phosphate aldolase
 * : 2-dehydro-3-deoxyglucarate aldolase
 * : 2-dehydro-3-deoxy-6-phosphogalactonate aldolase
 * : fructose-6-phosphate phosphoketolase
 * : 3-deoxy-D-manno-octulosonate aldolase
 * : dimethylaniline-N-oxide aldolase
 * : dihydroneopterin aldolase
 * : phenylserine aldolase
 * : sphinganine-1-phosphate aldolase
 * : 2-dehydro-3-deoxy-D-pentonate aldolase
 * : 5-dehydro-2-deoxyphosphogluconate aldolase
 * : 17a-hydroxyprogesterone aldolase
 * : deleted, included in EC 4.1.3.16
 * : trimethylamine-oxide aldolase
 * : fucosterol-epoxide lyase
 * : 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase
 * : propioin synthase
 * : lactate aldolase
 * : hydroxynitrilase
 * : benzoin aldolase
 * : Deleted, same as EC 4.1.2.37
 * : tagatose-bisphosphate aldolase
 * : vanillin synthase

EC 4.1.3: Oxo-Acid-Lyases

 * : isocitrate lyase
 * : now EC 2.3.3.9
 * : N-acetylneuraminate lyase
 * : hydroxymethylglutaryl-CoA lyase
 * : now EC 2.3.3.10
 * : citrate (pro-3S)-lyase
 * : now EC 2.3.3.1
 * : now EC 2.3.3.8
 * : now EC 2.3.3.11
 * : now EC 2.3.3.7
 * : now EC 2.3.3.12
 * : now EC 2.3.3.13
 * : oxalomalate lyase
 * : 3-hydroxyaspartate aldolase
 * : now EC 2.2.1.5
 * : 4-hydroxy-2-oxoglutarate aldolase
 * : 4-hydroxy-4-methyl-2-oxoglutarate aldolase
 * : now EC 2.2.1.6
 * : now EC 2.5.1.56
 * : now EC 2.5.1.57
 * : now EC 2.3.3.14
 * : citramalate lyase
 * : now EC 2.3.3.2
 * : malyl-CoA lyase
 * : citramalyl-CoA lyase
 * : 3-hydroxy-3-isohexenylglutaryl-CoA lyase
 * : anthranilate synthase
 * : now EC 2.3.3.3
 * : now EC 2.3.3.4
 * : methylisocitrate lyase
 * : now EC 2.3.3.5
 * : 2,3-dimethylmalate lyase
 * : now EC 2.3.3.6
 * : citryl-CoA lyase
 * : (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase
 * : naphthoate synthase
 * : now EC 2.2.1.7
 * : aminodeoxychorismate lyase

EC 4.1.99: Other Carbon-Carbon Lyases

 * : tryptophanase
 * : tyrosine phenol-lyase
 * : deoxyribodipyrimidine photo-lyase
 * : now EC 3.5.99.7
 * : octadecanal decarbonylase
 * : now EC 4.2.3.6
 * : now EC 4.2.3.9
 * : now EC 4.2.3.14
 * : now EC 4.2.3.15
 * : now EC 4.2.3.16
 * : benzylsuccinate synthase

EC 4.2.1: Hydro-Lyases

 * : carbonate dehydratase
 * : fumarate hydratase
 * : aconitate hydratase
 * : citrate dehydratase
 * : arabinonate dehydratase
 * : galactonate dehydratase
 * : altronate dehydratase
 * : mannonate dehydratase
 * : dihydroxy-acid dehydratase
 * : 3-dehydroquinate dehydratase
 * : phosphopyruvate hydratase
 * : phosphogluconate dehydratase
 * : now EC 4.3.1.17
 * : now EC 4.3.1.18
 * : now EC 4.4.1.1
 * : now EC 4.3.1.19
 * : enoyl-CoA hydratase
 * : methylglutaconyl-CoA hydratase
 * : imidazoleglycerol-phosphate dehydratase
 * : tryptophan synthase
 * : now EC 4.2.1.22
 * : cystathionine b-synthase
 * : deleted
 * : porphobilinogen synthase
 * : L-arabinonate dehydratase
 * : now EC 4.3.1.21
 * : acetylenecarboxylate hydratase
 * : propanediol dehydratase
 * : now EC 4.99.1.6
 * : glycerol dehydratase
 * : maleate hydratase
 * : L(+)-tartrate dehydratase
 * : 3-isopropylmalate dehydratase
 * : (S)-2-methylmalate dehydratase
 * : (R)-2-methylmalate dehydratase
 * : homoaconitate hydratase
 * : now EC 3.3.2.4
 * : now EC 4.3.1.20
 * : gluconate dehydratase
 * : glucarate dehydratase
 * : 5-dehydro-4-deoxyglucarate dehydratase
 * : galactarate dehydratase
 * : 2-dehydro-3-deoxy-L-arabinonate dehydratase
 * : myo-inosose-2 dehydratase
 * : CDP-glucose 4,6-dehydratase
 * : dTDP-glucose 4,6-dehydratase
 * : GDP-mannose 4,6-dehydratase
 * : D-glutamate cyclase
 * : urocanate hydratase
 * : pyrazolylalanine synthase
 * : prephenate dehydratase
 * : dihydrodipicolinate synthase
 * : oleate hydratase
 * : lactoyl-CoA dehydratase
 * : 3-hydroxybutyryl-CoA dehydratase
 * : itaconyl-CoA hydratase
 * : isohexenylglutaconyl-CoA hydratase
 * : crotonoyl-(acyl-carrier-protein) hydratase
 * : 3-hydroxyoctanoyl-(acyl-carrier-protein) dehydratase
 * : 3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase
 * : 3-hydroxypalmitoyl-(acyl-carrier-protein) dehydratase
 * : 5a-hydroxysteroid dehydratase
 * : now EC 3.3.2.3
 * : now EC 3.3.2.3
 * : 3-cyanoalanine hydratase
 * : cyanide hydratase
 * : D-fuconate dehydratase
 * : L-fuconate dehydratase
 * : cyanamide hydratase
 * : pseudouridylate synthase
 * : identical to EC 4.2.1.27
 * : now EC 4.1.1.78
 * : protoaphin-aglucone dehydratase (cyclizing)
 * : long-chain-enoyl-CoA hydratase
 * : uroporphyrinogen-III synthase
 * : UDP-glucose 4,6-dehydratase
 * : trans-L-3-hydroxyproline dehydratase
 * : (S)-norcoclaurine synthase
 * : 2-methylcitrate dehydratase
 * : 2-oxopent-4-enoate hydratase
 * : D(-)-tartrate dehydratase
 * : xylonate dehydratase
 * : 4-oxalmesaconate hydratase
 * : nitrile hydratase
 * : dimethylmaleate hydratase
 * : deleted identical to EC 4.2.1.98
 * : octopamine dehydratase
 * : synephrine dehydratase
 * : carnitine dehydratase
 * : L-rhamnonate dehydratase
 * : arogenate dehydratase
 * : hydroperoxide dehydratase
 * : ATP-dependent NAD(P)H-hydrate dehydratase
 * : scytalone dehydratase
 * : kievitone hydratase
 * : 4a-hydroxytetrahydrobiopterin dehydratase
 * : phaseollidin hydratase
 * : 16a-hydroxyprogesterone dehydratase
 * : 2-methylisocitrate dehydratase
 * : cyclohexa-1,5-dienecarbonyl-CoA hydratase
 * : trans-feruloyl-CoA hydratase
 * : now EC 4.2.1.100
 * : cyclohexyl-isocyanide hydratase
 * : cyanate hydratase
 * : 2-hydroxyisoflavanone dehydratase
 * : bile-acid 7a-dehydratase
 * : 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA dehydratase

EC 4.2.2: Acting on Polysaccharides

 * : hyaluronate lyase
 * : pectate lyase
 * : poly(b-D-mannuronate) lyase
 * : chondroitin ABC lyase
 * : chondroitin AC lyase
 * : oligogalacturonide lyase
 * : heparin lyase
 * : heparin-sulfate lyase
 * : pectate disaccharide-lyase
 * : pectin lyase
 * : poly(a-L-guluronate) lyase
 * : xanthan lyase
 * : exo-(1(arrow to right)4)-a-D-glucan lyase
 * : glucuronan lyase
 * : anhydrosialidase
 * : levan fructotransferase (DFA-IV-forming)
 * : inulin fructotransferase (DFA-I-forming)
 * : inulin fructotransferase (DFA-III-forming)
 * : chondroitin B lyase

EC 4.2.3: Acting on phosphates

 * : threonine synthase
 * : ethanolamine-phosphate phospho-lyase
 * : methylglyoxal synthase
 * : 3-dehydroquinate synthase
 * : chorismate synthase
 * : trichodiene synthase
 * : pentalenene synthase
 * : casbene synthase
 * : aristolochene synthase
 * : (-)-endo-fenchol synthase
 * : sabinene-hydrate synthase
 * : 6-pyruvoyltetrahydropterin synthase
 * : (+)-d-cadinene synthase
 * : pinene synthase
 * : myrcene synthase
 * : (4S)-limonene synthase
 * : taxadiene synthase
 * : abietadiene synthase
 * : ent-kaurene synthase
 * : (R)-limonene synthase
 * : vetispiradiene synthase

EC 4.2.99: Other Carbon-Oxygen Lyases

 * : now EC 4.2.2.2
 * : now EC 4.2.3.1
 * : now EC 4.2.2.2
 * : now EC 4.2.2.3
 * : deleted
 * : deleted, included in EC 4.2.2.4 and EC 4.2.2.5
 * : now EC 4.2.3.2
 * : now EC 2.5.1.47
 * : now EC 2.5.1.48
 * : now EC 2.5.1.49
 * : now EC 4.2.3.3
 * : carboxymethyloxysuccinate lyase
 * : now EC 2.5.1.50
 * : now EC 2.5.1.51
 * : now EC 2.5.1.52
 * : now EC 2.5.1.53
 * : now EC 4.2.99.14
 * : DNA-(apurinic or apyrimidinic site) lyase
 * : transferred entry, now EC 4.4.1.23

EC 4.3.1: Ammonia-Lyases

 * : aspartate ammonia-lyase
 * : methylaspartate ammonia-lyase
 * : histidine ammonia-lyase
 * : formiminotetrahydrofolate cyclodeaminase
 * : phenylalanine ammonia-lyase
 * : b-alanyl-CoA ammonia-lyase
 * : ethanolamine ammonia-lyase
 * : now EC 2.5.1.61
 * : glucosaminate ammonia-lyase
 * : serine-sulfate ammonia-lyase
 * : dihydroxyphenylalanine ammonia-lyase
 * : ornithine cyclodeaminase
 * : carbamoyl-serine ammonia-lyase
 * : 3-aminobutyryl-CoA ammonia-lyase
 * : diaminopropionate ammonia-lyase
 * : threo-3-hydroxyaspartate ammonia-lyase
 * : L-serine ammonia-lyase
 * : D-serine ammonia-lyase
 * : threonine ammonia-lyase
 * : erythro-3-hydroxyaspartate ammonia-lyase
 * : Identical to EC 4.3.1.9

EC 4.3.2: Amidine-Lyases

 * : argininosuccinate lyase
 * : adenylosuccinate lyase
 * : ureidoglycolate lyase
 * : purine imidazole-ring cyclase
 * : peptidylamidoglycolate lyase

EC 4.3.3: Amine-Lyases

 * : 3-ketovalidoxylamine C-N-lyase
 * : strictosidine synthase
 * : deacetylisoipecoside synthase
 * : deacetylipecoside synthase

EC 4.3.99: Other Carbon-Nitrogen Lyases

 * : now EC 4.2.1.104

EC 4.4: Carbon-Sulfur Lyases

 * : cystathionine g-lyase
 * : homocysteine desulfhydrase
 * : dimethylpropiothetin dethiomethylase
 * : alliin lyase
 * : lactoylglutathione lyase
 * : S-alkylcysteine lyase
 * : deleted, included in EC 2.5.1.18
 * : cystathionine b-lyase
 * : L-3-cyanoalanine synthase
 * : cysteine lyase
 * : methionine g-lyase
 * : deleted
 * : cysteine-S-conjugate b-lyase
 * : 1-aminocyclopropane-1-carboxylate synthase
 * : D-cysteine desulfhydrase
 * : selenocysteine lyase
 * : holocytochrome-c synthase
 * : now EC 1.8.3.5
 * : phosphosulfolactate synthase
 * : leukotriene-C4 synthase
 * : S-ribosylhomocysteine lyase
 * : S-(hydroxymethyl)glutathione synthase
 * : 2-hydroxypropyl-CoM lyase

EC 4.5: Carbon-Halide Lyases

 * : DDT-dehydrochlorinase
 * : 3-chloro-D-alanine dehydrochlorinase
 * : dichloromethane dehalogenase
 * : L-2-amino-4-chloropent-4-enoate dehydrochlorinase
 * : S-carboxymethylcysteine synthase

EC 4.6: Phosphorus-Oxygen Lyases

 * : adenylate cyclase
 * : guanylate cyclase
 * : now EC 4.2.3.4
 * : now EC 4.2.3.5
 * : now EC 4.2.3.7
 * : cytidylate cyclase
 * : now EC 4.2.3.8
 * : now EC 4.2.3.10
 * : now EC 4.2.3.11
 * : now EC 4.2.3.12
 * : now EC 4.2.3.13
 * : 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
 * : phosphatidylinositol diacylglycerol-lyase
 * : glycosylphosphatidylinositol diacylglycerol-lyase
 * : FAD-AMP lyase (cyclizing)

EC 4.99: Other Lyases

 * : ferrochelatase
 * : alkylmercury lyase
 * : sirohydrochlorin cobaltochelatase
 * : sirohydrochlorin ferrochelatase
 * : aliphatic aldoxime dehydratase
 * : indoleacetaldoxime dehydratase
 * : phenylacetaldoxime dehydratase