Phosphonoacetate hydrolase

In enzymology, a phosphonoacetate hydrolase is an enzyme that catalyzes the chemical reaction


 * phosphonoacetate + H2O $$\rightleftharpoons$$ acetate + phosphate

Thus, the two substrates of this enzyme are phosphonoacetate and H2O, whereas its two products are acetate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-phosphorus bonds. The systematic name of this enzyme class is phosphonoacetate phosphonohydrolase. This enzyme participates in aminophosphonate metabolism. It employs one cofactor, zinc.

Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code.