Promethazine side effects

List of side effects
Central nervous system Cardiovascular Dermatologic Hematologic Gastrointestinal Respiratory Other Paradoxical reactions

Central nervous system
Drowsiness is the most prominent CNS effect of this drug. Sedation, somnolence, blurred vision, dizziness, confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. Hallucinations have also been reported. Return to top

Cardiovascular
Increased or decreased blood pressure, tachycardia, bradycardia, faintness. Return to top

Dermatologic
Dermatitis, photosensitivity, urticaria. Return to top

Hematologic
Leukopenia, thrombocytopenia, thrombocytopenic purpura, agranulocytosis. Return to top

Gastrointestinal
Dry mouth, nausea, vomiting, jaundice. Return to top

Respiratory
Asthma, nasal stuffiness, respiratory depression (potentially fatal) and apnea (potentially fatal). Return to top

Other
Angioneurotic edema. Neuroleptic malignant syndrome (potentially fatal) has also been reported. Return to top

Paradoxical reactions
Hyperexcitability and abnormal movements have been reported in patients following a single administration of Promethazine HCl. Consideration should be given to the discontinuation of Promethazine HCl and to the use of other drugs if these reactions occur. Respiratory depression, nightmares, delirium, and agitated behavior have also been reported in some of these patients. Return to top