Amine oxidase (copper-containing)

In enzymology, an amine oxidase (copper-containing) is an enzyme that catalyzes the chemical reaction


 * RCH2NH2 + H2O + O2 $$\rightleftharpoons$$ RCHO + NH3 + H2O2

The 3 substrates of this enzyme are RCH2NH2, H2O, and O2, whereas its 3 products are RCHO, NH3, and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with oxygen as acceptor. The systematic name of this enzyme class is amine:oxygen oxidoreductase (deaminating) (copper-containing). Other names in common use include diamine oxidase, diamino oxhydrase, histaminase, amine oxidase, monoamine oxidase, amine oxidase (pyridoxal containing), benzylamine oxidase, histamine deaminase, histamine oxidase, Cu-amine oxidase, amine oxygen oxidoreductase, diamine:O2 oxidoreductase (deaminating), semicarbazide-sensitive amine oxidase, and SSAO. This enzyme participates in 8 metabolic pathways: urea cycle and metabolism of amino groups, glycine, serine and threonine metabolism, histidine metabolism, tyrosine metabolism, phenylalanine metabolism, tryptophan metabolism, beta-alanine metabolism, and alkaloid biosynthesis ii. It has 2 cofactors: copper, and PQQ.

Structural studies
As of late 2007, 51 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , and.