MAS1 oncogene

The MAS1 oncogene is a G protein-coupled receptor which binds the angiotensin-II metabolite angiotensin-(1-7). The MAS1 receptor when activated by binding angiotensin-(1-7) opposes many of the effects of angiotensin-II activated angiotensin receptor. Hence MAS1 receptor agonists have similar therapeutic effects as angiotensin-II receptor antagonists including lowering blood pressure.