Presumed ocular histoplasmosis syndrome

Presumed ocular histoplasmosis syndrome (POHS) is a disease syndrome affecting the eye that is characterized by peripheral atrophic chorioretinal scars, atrophy or scarring adjacent to the optic disc and maculopathy. It is thought to be caused by Histoplasma capsulatum, but the fungus has rarely been isolated from cases with POHS. The loss of vision in POHS is caused by choroidal neovascularisation. Fluorescein angiography is required for diagnosis and follow-up of patients with POHS. Treatment requires careful consideration of FA findings and few cases may respond to corticosteroids and laser photocoagulation. A vitreo-retinal specialist should be consulted for proper management of the case.