Richter's transformation

Richter's transformation, or Richter's Syndrome (RS) is a rare complication of B cell chronic lymphocytic leukemia (CLL) or hairy cell leukemia (HCL). With Ricther's, CLL changes into a fast-growing diffuse large B cell lymphoma. It affects perhaps 2% to 8% of CLL patients at some point during their lives.

Symptoms
Symptoms of Richter’s transformation include fever, loss of weight and muscle mass, and enlarged lymph nodes. Richter's can appear suddenly, even in patients who were in remission. The prognosis is generally poor, and aggressive treatment is usually warranted.