Mannose-1-phosphate guanylyltransferase (GDP)

In enzymology, a mannose-1-phosphate guanylyltransferase (GDP) is an enzyme that catalyzes the chemical reaction


 * GDP + alpha-D-mannose 1-phosphate $$\rightleftharpoons$$ phosphate + GDP-mannose

Thus, the two substrates of this enzyme are GDP and alpha-D-mannose 1-phosphate, whereas its two products are phosphate and GDP-mannose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GDP:alpha-D-mannose-1-phosphate guanylyltransferase. Other names in common use include GDP mannose phosphorylase, mannose 1-phosphate (guanosine diphosphate) guanylyltransferase, GDP mannose phosphorylase, GDP-mannose 1-phosphate guanylyltransferase, guanosine diphosphate-mannose 1-phosphate guanylyltransferase, guanosine diphosphomannose phosphorylase, mannose 1-phosphate guanylyltransferase, and GDP:D-mannose-1-phosphate guanylyltransferase. This enzyme participates in fructose and mannose metabolism.