Dextro-transposition of the great arteries natural history, Complications & Prognosis


 * Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [mailto:psingh@perfuse.org]; ; Keri Shafer, M.D. [mailto:kshafer@bidmc.harvard.edu]; Assistant Editor(s)-In-Chief: Kristin Feeney, B.S. [mailto:kfeeney@perfuse.org]

Overview
The prognosis on simple dextro-TGA depends mainly on the presence of cardiac shunts such as fossa ovalis, atrial septal defect, ventricular septal defect, and ductus arteriosus. With complex d-TGA, the infant will fail to thrive and is unlikely to survive longer than a year if corrective surgery is not performed.

Prognosis
Simple d-TGA
 * The prognosis on simple d-TGA depends mainly on the presence of cardiac shunts such as fossa ovalis, atrial septal defect, ventricular septal defect, and ductus arteriosus.
 * If one or more of these defects are present, blood will be mixed, allowing a small amount of oxygen to be delivered to the body, giving an opportunity to the newborn to survive long enough to receive corrective surgery.
 * With simple d-TGA, if the foramen ovale and ductus arteriosus are allowed to close naturally, the newborn will likely not survive long enough to receive corrective surgery.
 * While the foramen ovale and ductus arteriosus are open after birth, some mixing of red and blue blood occurs allowing a small amount of oxygen to be delivered to the body; if ASD, VSD, PFO, and/or PDA are present, this will allow a higher amount of the red and blue blood to be mixed, therefore delivering more oxygen to the body, but can complicate and lengthen the corrective surgery and/or be symptomatic.

Complex

 * With complex d-TGA, the infant will fail to thrive and is unlikely to survive longer than a year if corrective surgery is not performed.
 * Generally, if the defect (dextro-TGA) is not corrected during the first year of life, the patient's condition will deteriorate to the point of inoperability.
 * Modern repair procedures within the ideal time-frame and without additional complications have a very high success rate.

Acknowledgements and Initial Contributors to Page
Leida Perez, M.D.