TetR

Tetracyclin (tc) is a broad family of antibiotics to which bacteria have evolved resistance. The expression of tc resistance genes is regulated by Tet Repressor Protein, called TetR.

TetR is used in artificially engineered Gene regulatory network is due to its capacity for fine regulation : in the absence of tc, its basal level is maintained at very low levels, but raises sharply upon detection of minute quantity of tc by positively feedbacking on itself.

See also Tetracycline controlled transcriptional activation