Proglumide

Proglumide (Milid) is a drug which inhibits gastrointestinal motility and reduces gastric secretions.

Proglumide acts as a cholecystokinin antagonist. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application.

An interesting side effect of proglumide is that it enhances the analgesia produced by opioid drugs, and can prevent or even reverse the development of tolerance to opioid drugs. This can make it a useful adjuvant treatment to use alongside opioid drugs in the treatment of chronic pain conditions such as cancer, where opioid analgesics may be required for long periods and development of tolerance reduces clinical efficacy of these drugs.