Corticosteroid 11-beta-dehydrogenase isozyme 2

Hydroxysteroid (11-beta) dehydrogenase 2, also known as HSD11B2, is a human gene. It encodes an NAD+-dependent enzyme expressed in aldosterone-selective tissues.

In these tissues, HSD11B2 oxidizes cortisol to cortisone and prevents illicit activation of the mineralocorticoid receptor.

Inhibition of this enzyme results in a condition known as pseudohyperaldosteronism