SLC34A3

Solute carrier family 34 (sodium phosphate), member 3, also known as SLC34A3, is a human gene.

Both NPT2a and SLC34A3 (NPT2c) are regulated in a similar fashion by parathyroid hormone (PTH), FGF23, and dietary phosphate. Phosphate deprivation increases NPT2a and NPT2c expression. The relative expression of NPT2a is an order of magnitude higher than that of NPT2c in kidneys of organisms maintained on a normal phosphate diet. Normal animals exhibit a more robust increase in NPT2c than in NPT2a in response to phosphate deprivation. NPT2c is regulated by FGF23 and probably downregulated by PTH. As such SLC34A3 is involved in phosphate homeostasis.