2-methyl-branched-chain-enoyl-CoA reductase

In enzymology, a 2-methyl-branched-chain-enoyl-CoA reductase is an enzyme that catalyzes the chemical reaction


 * 2-methylbutanoyl-CoA + NAD+ $$\rightleftharpoons$$ 2-methylcrotonoyl-CoA + NADH + H+

Thus, the two substrates of this enzyme are 2-methylbutanoyl-CoA and NAD+, whereas its 3 products are 2-methylcrotonoyl-CoA, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-methyl-branched-chain-acyl-CoA:NAD+ 2-oxidoreductase. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis. It employs one cofactor, FAD.