Chromosome 10 (human)



Chromosome 10 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 10 spans about 135 million base pairs (the building material of DNA) and represents between 4 and 4.5 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 10 likely contains between 800 and 1,200 genes.

Genes
The following are some of the genes located on chromosome 10:
 * CDH23: cadherin-like 23
 * CXCL12: chemokine (C-X-C motif) ligand 12, SDF-1, scyb12
 * EGR2: early growth response 2 (Krox-20 homolog, Drosophila)
 * ERCC6: excision repair cross-complementing rodent repair deficiency, complementation group 6
 * FGFR2: fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome)
 * PCBD1: 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)
 * PCDH15: protocadherin 15
 * PTEN: phosphatase and tensin homolog (mutated in multiple advanced cancers 1)
 * RET: ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
 * UROS: uroporphyrinogen III synthase (congenital erythropoietic porphyria)

Diseases & disorders
The following diseases are some of those related to genes on chromosome 10:
 * Apert syndrome
 * Beare-Stevenson cutis gyrata syndrome
 * Charcot-Marie-Tooth disease
 * Charcot-Marie-Tooth disease, type 1
 * Charcot-Marie-Tooth disease, type 4
 * Cockayne syndrome
 * congenital erythropoietic porphyria
 * Cowden syndrome
 * Crouzon syndrome
 * Jackson-Weiss syndrome
 * multiple endocrine neoplasia type 2
 * nonsyndromic deafness
 * nonsyndromic deafness, autosomal recessive
 * Pfeiffer syndrome
 * porphyria
 * tetrahydrobiopterin deficiency
 * Usher syndrome
 * Usher syndrome type I
 * Wolman syndrome