Ferroportin

Ferroportin is a transmembrane protein that transports iron from the inside of a cell to the outside of it. It is found on the surface of cells that store or transport iron, including:


 * Enterocytes in the duodenum
 * Hepatocytes
 * Macrophages of the reticuloendothelial system.

Recent research suggests that ferroportin is the key molecule regulated by hepcidin, the apparent "master regulator" of human iron metabolism.

Clinical significance
Ferroportin can be associated with African iron overload.