Pyruvate, water dikinase

In enzymology, a pyruvate, water dikinase is an enzyme that catalyzes the chemical reaction


 * ATP + pyruvate + H2O $$\rightleftharpoons$$ AMP + phosphoenolpyruvate + phosphate

The 3 substrates of this enzyme are ATP, pyruvate, and H2O, whereas its 3 products are AMP, phosphoenolpyruvate, and phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with paired acceptors. The systematic name of this enzyme class is ATP:pyruvate, water phosphotransferase. Other names in common use include phosphoenolpyruvate synthase, pyruvate-water dikinase (phosphorylating), PEP synthetase, phosphoenolpyruvate synthase, phoephoenolpyruvate synthetase, phosphoenolpyruvic synthase, and phosphopyruvate synthetase. This enzyme participates in pyruvate metabolism and reductive carboxylate cycle (co2 fixation). It employs one cofactor, manganese.

Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code.