12-oxophytodienoate reductase

In enzymology, a 12-oxophytodienoate reductase is an enzyme that catalyzes the chemical reaction


 * 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate + NADP+ $$\rightleftharpoons$$ (15Z)-12-oxophyto-10,15-dienoate + NADPH + H+

Thus, the two substrates of this enzyme are 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate and NADP+, whereas its 3 products are (15Z)-12-oxophyto-10,15-dienoate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate:NADP+ 4-oxidoreductase. This enzyme is also called 12-oxo-phytodienoic acid reductase.

Structural studies
As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , and.