CIAS1

CIAS1, or cold autoinflammatory syndrome 1, is a gene that encodes a protein called "cryopyrin" that has important roles in controlling inflammation; the gene product is also known under the names CATERPILLER-like receptor 1.1 (CLR1.1), NALP3, and NOD-like receptor family, pryin domain containing 3 (NLRP3).

CIAS1 is located on the long arm of chromosome 1.

Pathology
Mutations in the gene for CIAS1 have been linked to autoinflammatory diseases such as Muckle-Wells syndrome and familial cold urticaria syndrome, two dominantly inherited disorders with some similarities to neonatal onset multisystem inflammatory disease (NOMID) or chronic infantile neurologic cutaneous articular syndrome (CINCA).