Familial amyloid neuropathy

The familial amyloid neuropathies (or familial amyloidotic neuropathies, neuropathic heredofamilial amyloidosis, familial amyloid polyneuropathy) are a rare group of autosomal dominant neuropathies of autonomic and peripheral nerves.

Classification
The precursor proteins are: transthyretin (ATTR, the most commonly implicated protein), apolipoprotein A1, and gelsolin.

Due to the rareness of the other types, it is sometimes associated with transthyretin alone.

"FAP-I" and "FAP-II" are associated with transthyretin. (Senile systemic amyloidosis is also associated with transthyretin.)

"FAP-III" is also known as "Iowa-type", and involves apolipoprotein A1.

"FAP-IV" is also known as "Finnish-type", and involves gelsolin.

Fibrinogen, apolipoprotein A1, and lysozyme are associated with a closely related condition, familial visceral amyloidosis.

Treatment
Liver transplantation has demonstrated moderate improvement in ATTR familial amyloidosis.