PICALM

Phosphatidylinositol binding clathrin assembly protein, also known as PICALM, is a human gene.

PICALM has been shown to be associated with Alzheimer's Disease in recent publications of genome-wide association studies.

Interactions
PICALM has been shown to interact with CLTC.

Clinical significance
In humans, certain alleles of this gene have been statistically associated with an increased risk of developing late-onset Alzheimer's disease. The association has been independently replicated, however estimates of attributable risk are low