Surface epithelial-stromal tumor

Overview
Surface epithelial-stromal tumors are a class of ovarian neoplasms that may be benign or malignant. Neoplasms in this group are thought to be derived from the ovarian surface epithelium (modified peritoneum) or from ectopic endometrial tissue. This group of tumors accounts for the majority of all ovarian tumors. Serum CA-125 is often elevated but is only 50% accurate so it is not a useful tumour marker to assess the progress of treatment.

Classification
Epithelial-stromal tumors are classified on the basis of the epithelial cell type, the relative amounts of epithelium and stroma, the presence of papillary processes, and the location of the epithelial elements. Microscopic pathological features determine whether a surface epithelial-stromal tumor is benign, borderline, or malignant (evidence of malignancy and stromal invasion). Borderline tumors are of uncertain malignant potential.

This group consists of serous, mucinous, endometrioid, clear cell, and brenner (transitional cell) tumors, though there are a few mixed, undifferentiated and unclassified types.



Serous tumors

 * These tumors vary in size from small and nearly imperceptible to large, filling the abdominal cavity.
 * Benign, borderline, and malignant types of serous tumors account for about 30% of all ovarian tumors.
 * 75% are benign or of borderline malignancy, and 25% are malignant
 * The malignant form of this tumor, serous cystadenocarcinoma, accounts for approximately 40% of all carcinomas of the ovary and are the most common malignant ovarian tumors.
 * Benign and borderline tumors are most common between the ages of 20 and 50 years.
 * Malignant serous tumors occur later in life on average, although somewhat earlier in familial cases.
 * 20% of benign, 30% of borderline, and 66% of malignant tumors are bilateral (affect both ovaries).

Components can include:
 * 1) cystic areas
 * 2) cystic and fibrous areas
 * 3) predominantly fibrous areas

The chance of malignancy of the tumor increases with the amount of solid areas present, including both papillary structures and any necrotic tissue present.

Pathology

 * lined by tall, columnar, ciliated epithelial cells
 * filled with clear serous fluid
 * the term serous which originated as a description of the cyst fluid has come to be describe the particular type of epithelial cell seen in these tumors
 * may involve the surface of the ovary
 * the division between benign, borderline, and malignant is ascertained by assessing:
 * cellular atypia (whether or not individual cells look abnormal)
 * invasion of surrounding ovarian stroma (whether or not cells are infiltrating surrounding tissue)
 * borderline tumors my have cellular atypia but do NOT have evidence of invasion
 * the presence of psammoma bodies are a characteristic microscopic finding of cystadenocarcinomas

Prognosis
The prognosis of a serous tumor, like most neoplasms, depends on
 * degree of diffentiation
 * this is how closely the tumor cells resemble benign cells
 * a well-differentiated tumor closely resembles benign tumors
 * a poorly differentiated tumor may not resemble the cell type of origin at all
 * a moderately differentiated tumor usually resembles the cell type of origin, but appears frankly malignant
 * extension of tumor to other structures
 * in particular with serous malignancies, the presence of malignant spread to the peritoneum is important with regard to prognosis.

The five year survival rate of borderline and malignant tumors confined to the ovaries are 100% and 70% respectively. If the peritoneum is involved, these rates become 90% and 25%.

While the 5-year survival rates of borderline tumors are excellent, this should not be seen as evidence of cure, as recurrences can occur many years later.

Mucinous tumors
Mucinous tumors:
 * Closely resemble their serous counterparts
 * Somewhat less common, accounting for about 25% of all ovarian neoplasms
 * Occur principally in middle adult life and are rare before puberty and after menopause
 * 80% are benign or borderline and about 15% are malignant
 * Mucinous cystadenocarcinomas (the malignant form of this tumor) are relatively uncommon and account for only 10% of all ovarian cancers
 * Mucinous tumors are characterized by more cysts of variable size and a rarity of surface involvement as compared to serous tumors
 * Also in comparison to serous tumors, mucinous tumorsare less frequently bilateral, approximately 5% of primary mucinous tumors are bilateral.
 * May form very large cystic masses, with recorded weights exceeding 25kg
 * Appear as multiloculated tumors filled with sticky, gelatinous fluid

Pathology
Benign mucinous tumors are characterized by a lining of tall columnar epithelial cells with apical mucin and the absence of cilia, similar in appearance with benign cervical or intestinal epithelia. Cystadenocarcinomas (malignant tumors) contain a more solid growth pattern with the hallmarks of malignancy: cellular atypia and stratification, loss of the normal architecture of the tissu, and necrosis. The appearance can look similar to colonic cancer. Clear stromal invasion is used to differentiate borderline tumors from malignant tumors.

Prognosis
10-year survival rates for borderline tumors contained within the ovary, malignant tumors without invasion, and invasive malignant tumors are greater than 95%, 90%, and 66%, respectively. One rare but noteworthy condition associated with mucinous ovarian neoplasms is pseudomyxoma peritonei. As primary ovarian mucinous tumors are usually unilateral (in one ovary), the presentation of bilateral mucinous tumors requires exclusion of a non-ovarian origin.

Endometrioid tumors
Endometrioid tumors account for approximately 20% of all ovarian cancers and are mostly malignant (endometroid carcinomas). They are made of tubular glands bearing a close resemblance to benign or malignant endometrium. 15-30% of endometrioid carcinomas occur in individuals with carcinoma of the endometrium, and these patients have a better prognosis. They appear similar to other surface epithelial-stromal tumors, with solid and cystic areas. 40% of these tumors are bilateral, when bilateral, metastases is often present.

Pathology

 * Glands bearing a strong resemblance to endometrial-type glands
 * Benign tumors have mature-appearing glands in a fibrous stroma
 * Borderline tumors have a complex branching pattern without stromal invasion
 * Carcinomas (malignant tumors) have invasive glands with crowded, atypical cells, frequent mitoses. With poorer differentiation, the tumor becomes more solid.

Prognosis
Prognosis again is dependent on the spread of the tumor, as well as how differentiated the tumor appears. The overall prognosis is somewhat worse than for serous or mucinous tumors, and the 5-year survival rate for patients with tumors confined to the ovary is approximately 75%.

Clear cell tumors
Clear cell tumors are characterized by large epithelial cells with abundant clear cytoplasm	and may be seen in association with endometriosis or endometrioid carcinoma of the ovary, bearing a resemblance to clear cell carcinoma of the endometrium. They may be predominantly solid or cystic. If solid, the clear cells tend to be arranged in sheets or tubules. In the cystic variety, the neoplastic cells make up the cyst lining.

Prognosis
These tumors tend to be aggressive, the five year survival rate for tumors confined to the ovaries in approximately 65%. If the tumor has spread beyond the ovary at diagnosis, the prognosis is poor

Brenner tumor
Brenner tumors are uncommon surface-epithelial stromal cell tumors in which the epithelial cell (which defines these tumors) is a transitional cell. These are similar in appearance to bladder epithelia. The tumors may be very small to very large, and may be solid or cystic. Histologically, the tumor consists of nests of the aforementioned transitional cells within surrounding tissue that resembles normal ovary. Brenner tumors may be benign or malignant, depending on whether or not the tumor cells invade the surrounding tissue.

Treatment of ovarian cancer
Surgical treatment may be sufficient for malignant tumors that are well-differentiated and confined to the ovary. Addition of chemotherapy may be required for more aggressive tumors that are confined to the ovary. For patients with advanced disease a combination of surgical reduction with a combination chemotherapy regimen is standard. Borderline tumors, even following spread outside of the ovary, are managed well with surgery, and chemotherapy is not seen as useful.