Aminoacyl-tRNA hydrolase

In enzymology, an aminoacyl-tRNA hydrolase is an enzyme that catalyzes the chemical reaction


 * N-Substituted aminoacyl-tRNA + H2O $$\rightleftharpoons$$ N-substituted amino acid + tRNA

Thus, the two substrates of this enzyme are N-Substituted aminoacyl-tRNA and H2O, whereas its two products are N-substituted amino acid and tRNA.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is aminoacyl-tRNA aminoacylhydrolase. Other names in common use include aminoacyl-transfer ribonucleate hydrolase, N-substituted aminoacyl transfer RNA hydrolase, and peptidyl-tRNA hydrolase.

Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , and.