N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase

In enzymology, a N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase is an enzyme that catalyzes the chemical reaction


 * UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl- proteoglycan $$\rightleftharpoons$$ UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)- beta-D-glucuronosyl-proteoglycan

The 3 substrates of this enzyme are UDP-alpha-D-glucuronate, N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-, and proteoglycan, whereas its 3 products are UDP, beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-, and beta-D-glucuronosyl-proteoglycan.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glu curonosyl-proteoglycan 3-beta-glucuronosyltransferase. This enzyme is also called chondroitin glucuronyltransferase II. This enzyme participates in chondroitin sulfate biosynthesis and glycan structures - biosynthesis 1.