4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase

In enzymology, a 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase is an enzyme that catalyzes the chemical reaction


 * ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol $$\rightleftharpoons$$ ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

Thus, the two substrates of this enzyme are ATP and 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol, whereas its two products are ADP and 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase. This enzyme is also called CDP-ME kinase. This enzyme participates in biosynthesis of steroids.

Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , and.