Bis(5'-adenosyl)-triphosphatase

In enzymology, a bis(5'-adenosyl)-triphosphatase is an enzyme that catalyzes the chemical reaction


 * P1,P3-bis(5'-adenosyl) triphosphate + H2O $$\rightleftharpoons$$ ADP + AMP

Thus, the two substrates of this enzyme are P1,P3-bis(5'-adenosyl) triphosphate and H2O, whereas its two products are ADP and AMP.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase. Other names in common use include dinucleosidetriphosphatase, diadenosine 5,5-P1,P3-triphosphatase, and 1-P,3-P-bis(5'-adenosyl)-triphosphate adenylohydrolase. This enzyme participates metabolic pathways involved in purine metabolism, and may have a role in the development of small cell lung cancer, and non-small cell lung cancer.

Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes, , , , and.