Plakoglobin

Plakoglobin (gamma-catenin, was originally identified as a component of desmosomes where it can bind to the cadherin family member desmoglein I.

Plakoglobin also associates with classical cadherins such as E-cadherin and in that context it was called gamma-catenin.

Plakoglobin is O-glycosylated near its N-terminal destruction box.