JWH-200

JWH-200 is an analgesic drug from the aminoalkylindole family, which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is 42nM, around the same as that of THC, but interestingly its analgesic potency in vivo was higher than that of other analogues which had stronger CB1 binding affinity in vitro, around 3x that of THC but with less sedative effect, most likely reflecting favourable pharmacokinetic characteristics.