Nuclear receptor co-repressor 1

The nuclear receptor co-repressor 1 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR1 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the down regulation of DNA expression.

NCOR1 is also sometimes referred to as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1).