Ganglioneuroma (patient information)

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 * Associate Editor-In-Chief: Lakshmi Gopalakrishnan, M.B.B.S.

Overview
Ganglioneuroma is a tumor of the peripheral nervous system.

What are the symptoms of Ganglioneuroma?

 * A ganglioneuroma usually causes no symptoms, and is only discovered when being examined or treated for another condition.


 * Symptoms depend on the location of the tumor and the type of chemicals released.


 * If the tumor is in the chest area (mediastinum), symptoms may include:
 * Breathing difficulty
 * Chest pain
 * Compression of the windpipe (trachea)


 * If the tumor is lower down in the abdomen in the area called the retroperitoneal space, symptoms may include:
 * Abdominal pain
 * Bloating


 * If the tumor is near the spinal cord, it may cause:
 * Compression of the spinal cord, which leads to pain and loss of strength or :*Feeling in the legs, the arms, or both
 * Spine deformity


 * These tumors may produce certain hormones, which can cause the following symptoms:
 * Diarrhea
 * Enlarged clitoris (women)
 * High blood pressure
 * Increased body hair
 * Sweating

What causes Ganglioneuroma?

 * Ganglioneuromas are rare tumors that most frequently start in the autonomic nerve cells, which may be in any part of the body. The tumor are usually noncancerous (benign).


 * Ganglioneuromas usually occur in people ages 10 to 40. They grow slowly, and may release certain chemicals or hormones.

Who is at highest risk?
There are no known risk factors. However, the tumors may be associated with some genetic problems, such as neurofibromatosis type 1.

When to seek urgent medical care?
Call your health care provider if you or your child has symptoms that may be caused by this type of tumor.

Diagnosis

 * The best tools to identify a ganglioneuroma are:
 * CT scan of the chest, abdomen, and pelvis
 * MRI scan of the chest and abdomen


 * Blood and urine tests may be done to determine if the tumor is producing hormones or other chemicals.


 * A biopsy or complete removal of the tumor may be needed to confirm the diagnosis.

Treatment options
Treatment involves surgery to remove the tumor (if it is causing symptoms).

Where to find medical care for Ganglioneuroma?
Directions to Hospitals Treating Ganglioneuroma

What to expect (Outlook/Prognosis)?
Most ganglioneuromas are noncancerous. The expected outcome is usually good. A ganglioneuroma may, however, become cancerous and spread to other areas, or it may come back after removal.

Possible complications

 * If the tumor has been present for a long time and has pressed on the spinal cord or caused other symptoms, surgery to remove the tumor may not necessarily reverse the damage.


 * Compression of the spinal cord may result in loss of movement (paralysis), especially if the cause is not detected promptly.


 * Surgery to remove the tumor may also lead to complications in some cases. However, rare, persistant problems due to compression may occur even after the tumor is removed.