Paraneoplastic cerebellar degeneration

Overview
Paraneoplastic cerebellar degeneration is a paraneoplastic phenomenon associated with lung, ovarian, breast, and other cancers.

It is believed to be due to an autoimmune reaction targeted against components of the central nervous system (specifically Purkinje cells and large brain stem nuclei).

It typically presents as a subacute progressive cerebellar ataxia, both truncal and appendicular.