Alclometasone

Description
Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent. Alclometasone Dipropionate marketed as medication Aclovate by GlaxoSmithKline.

Pharmacology
Alclometasone inhibits phospholipase A2 by inducing production of lipocortins; inhibits synthesis of arachidonic acid, prostaglandins and leukotrienes acid, reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. histamine).

Indications
Alclometasone cream and onintment are indicated for the relief of corticosteroid-responsive dermatoses, including: atopic dermatitis eczema psoriasis allergic dermatitis contact dermatitis actinic dermatitis kiss-type allergy skin itch Alclometasone may be used on sensetive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.

Contraindications
hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms cutaneous tuberculosis chicken pox perioral dermatitis acne rosacea open wounds trophic ulcers <li>viral infection of skin <li>skin manifestations of syphilis

Side effects
Alclometasone Adverse reactions/Side effects (sometimes, less than 1-2% cases) include: <li>burning <li>itching <li>erythema <li>skin reddening <li>xerodermia <li>skin irritation <li>acne <li>hypopigmentation <li>prickly heat <li>folliculitis <li>white atrophy <li>hypertrichosis <li>reinfection of skin

How supplied
Alclometasone as Aclovate® is supplied in: <li>Cream; Topical; 0.05% <li>Ointment; Topical; 0.05%