Ureidoglycolate dehydrogenase

In enzymology, an ureidoglycolate dehydrogenase is an enzyme that catalyzes the chemical reaction


 * (S)-ureidoglycolate + NAD(P)+ $$\rightleftharpoons$$ oxalureate + NAD(P)H + H+

The 3 substrates of this enzyme are (S)-ureidoglycolate, NAD+, and NADP+, whereas its 4 products are oxalureate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-ureidoglycolate:NAD(P)+ oxidoreductase. This enzyme participates in purine metabolism.

Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and.