Diphenyl prolinol

Diphenyl prolinol, or (R,S)(+,-)-diphenyl-2-pyrrolidinyl-methanol, is a relatively mild dopamine and norepinephrine reuptake inhibitor. The dextrorotary (R,+) enantiomer is the most pharmacologically active. Anecdotally, the dextrorotary enantiomer is orally active in the 25-100mg range, with a duration of 5-8 hours. The effects are said to be similar to other NDRIs, producing mild stimulation (at least in relation to substances like methamphetamine or cocaine) which is productive for working or studying, but with relatively little euphoria. Similar drugs to diphenylprolinol include pipradrol, desoxypipradrol, and to a lesser extent methylphenidate.

There have been some recent indications (e.g. detailed reports posted on forums dedicated to researching this compound) that diphenyl prolinol may not be as benign as its mild effects seem to suggest. At higher doses and with more frequent administration, its effects on dopamine appear to become significant enough that binging and addiction can enter the picture. Several large overdoses requiring hospitalization have been reported, possibly related to addiction issues. It seems prudent to exercise caution when administering this compound, even for occasional work/study applications, as most dopamine reuptake inhibitors are addictive. Precautions to take might include limiting access and watching closely for symptoms of addiction, such as loss of control over dosage or difficulty stopping use once it has started.

CAS numbers: 22348-32-9 or  112068-01-6