Glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)

In enzymology, a glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) is an enzyme that catalyzes the chemical reaction


 * D-glyceraldehyde 3-phosphate + phosphate + NADP+ $$\rightleftharpoons$$ 3-phospho-D-glyceroyl phosphate + NADPH + H+

The 3 substrates of this enzyme are D-glyceraldehyde 3-phosphate, phosphate, and NADP+, whereas its 3 products are 3-phospho-D-glyceroyl phosphate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating). Other names in common use include triosephosphate dehydrogenase (NADP+), dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine, dinucleotide phosphate) (phosphorylating), glyceraldehyde phosphate dehydrogenase (nicotinamide adenine, dinucleotide phosphate) (phosphorylating), NADP+-glyceraldehyde-3-phosphate dehydrogenase, NADP+-glyceraldehyde phosphate dehydrogenase, NADP+-dependent glyceraldehyde phosphate dehydrogenase, NADP+-triose phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating), and GAPDH. This enzyme participates in carbon fixation.

Structural studies
As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , and.