2'-phosphotransferase

In enzymology, a 2'-phosphotransferase is an enzyme that catalyzes the chemical reaction


 * 2'-phospho-[ligated tRNA] + NAD+ $$\rightleftharpoons$$ mature tRNA + ADP-ribose 1,2-phosphate + nicotinamide + H2O

Thus, the two substrates of this enzyme are 2'-phospho-[ligated tRNA] and NAD+, whereas its 4 products are mature tRNA, ADP-ribose 1,2-phosphate, nicotinamide, and H2O.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is 2'-phospho-[ligated tRNA]:NAD+ phosphotransferase. Other names in common use include yeast 2'-phosphotransferase, Tpt1, Tpt1p, and 2'-phospho-tRNA:NAD+ phosphotransferase.