Carbon-monoxide dehydrogenase (acceptor)

In enzymology, a carbon-monoxide dehydrogenase (acceptor) is an enzyme that catalyzes the chemical reaction


 * CO + H2O + A $$\rightleftharpoons$$ CO2 + AH2

The 3 substrates of this enzyme are CO, H2O, and A, whereas its two products are CO2 and AH2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with other acceptors. The systematic name of this enzyme class is carbon-monoxide:acceptor oxidoreductase. Other names in common use include anaerobic carbon monoxide dehydrogenase, carbon monoxide oxygenase, carbon-monoxide dehydrogenase, and carbon-monoxide:(acceptor) oxidoreductase. This enzyme participates in methane metabolism. It has 4 cofactors: iron, Zinc, Nickel, and Iron-sulfur.

Structural studies
As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , , , , and.