Petasis reaction

The Petasis reaction is the chemical reaction of an amine, aldehyde, and vinyl- or aryl-boronic acid to form substituted amines.



The Petasis reaction can be viewed as a boronic acid equivalent of the Mannich reaction, and is often used as an alternative to the reductive amination reaction.

In one application the Petasis reaction is used for quick access to a multifunctional scaffold for divergent synthesis: