Synaptojanin

Synaptojanin is a protein involved in vesicle uncoating in neurons. This is an important regulatory lipid phosphatase. It dephosphorylates the D-5 position phosphate from Phosphatidylinositol (3,4,5)-trisphosphate and Phosphatidylinositol (4,5)-bisphosphate. It belongs to family of 5-phosphatases, which are structurally unrelated to D-3 inositol phosphatases like PTEN.