Leukocyte alkaline phosphatase

Overview

 * Alkaline phosphatase is an enyzme present throughout the body
 * Alkaline phosphatase functions optimally at pH 8.6
 * Leukocyte alkaline phosphatase is a test that tests the level of enzyme within the white blood cells
 * Sometimes referred to as LAP

Differential Diagnosis
In alphabetical order.

Decreased

 * Anemia
 * Chronic Myelogenous Leukemia
 * Hemolysis
 * Iron deficiency anemia
 * Sideroachrestic anemia (SA)

Increased

 * Acute leukemia
 * Aplastic Anemia
 * Malignant lymphomas
 * Megaloblastic anemia
 * Multiple Myeloma
 * Osteomyelofibrosis
 * Polycythemia Vera
 * Solid tumors
 * Tissue necrosis