The Living Guidelines: STEMI Antiplatelet Agents / Anticoagulants Therapy: Warfarin Suggest Revisions to the CLASS I Guidelines

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Class I Guidelines

 * 1) Managing warfarin to an INR equal to 2.0 to 3.0 for paroxysmal or chronic atrial fibrillation or atrial flutter is recommended, and in post MI patients when clinically indicated (e.g., atrial fibrillation, left ventricular thrombus). Class I (Level of Evidence: A)
 * 2) Use of warfarin in conjunction with aspirin and/or clopidogrel is associated with an increased risk of bleeding and should be monitored closely. Class I (Level of Evidence: B)
 * 3) In patients requiring warfarin, clopidogrel, and aspirin therapy, an INR of 2.0 to 2.5 is recommended with low dose aspirin (75 mg to 81 mg) and a 75 mg dose of clopidogrel. Class I (Level of Evidence: C)