Amlodipine/benazepril

'Synonyms / Brand Names: Amlodipine Benzenesulfonate, Amlodipine Besilate, Amlodipine Free Base, Amlodipino, Amlodipinum,Amlocard, Amlodis, Amvaz, Coroval, Lipinox, Lotrel, benazepril, Benazepril HCl, Benazepril Hydrochloride, Benazeprilum, Briem, Cibacen, Cibacene

'

Dosing and Administration
Treatment of hypertension Amlodipine is an effective treatment of hypertension in once-daily doses of 2.5-10 mg while benazepril is effective in doses of 10-80 mg. In clinical trials of amlodipine/benazepril combination therapy using amlodipine doses of 2.5-10 mg and benazepril doses of 10-20 mg, the antihypertensive effects increased with increasing dose of amlodipine in all patient groups, and the effects increased with increasing dose of benazepril in nonblack groups. All patient groups benefited from the reduction in amlodipine-induced edema Dose Titration Guided by Clinical Effect A patient whose blood pressure is not adequately controlled with amlodipine (or another dihydropyridine) alone or with benazepril (or another ACE inhibitor) alone may be switched to combination therapy with Lotrel. The addition of benazepril to a regimen of amlodipine should not be expected to provide additional antihypertensive effect in African-Americans. However, all patient groups benefit from the reduction in amlodipine-induced edema. Dosage must be guided by clinical response; steady-state levels of benazepril and amlodipine will be reached after approximately 2 and 7 days of dosing, respectively.

FDA Package Insert Resources Indications, Contraindications, Side Effects, Drug Interactions, etc. Calculate Creatine Clearance On line calculator of your patients Cr Cl by a variety of formulas. Convert pounds to Kilograms On line calculator of your patients weight in pounds to Kg for dosing estimates. Publication Resources Recent articles, WikiDoc State of the Art Review, Textbook Information Trial Resources Ongoing Trials, Trial Results Guidelines & Evidence Based Medicine Resources US National Guidelines, Cochrane Collaboration, etc. Media Resources Slides, Video, Images, MP3, Podcasts, etc. Patient Resources Discussion Groups, Handouts, Blogs, News, etc. International Resources en Español

FDA Package Insert Resources
Indications Contraindications Side Effects Drug Interactions Precautions Overdose Instructions for Administration How Supplied Pharmacokinetics and Molecular Data FDA label FDA on Return to top

Publication Resources
Most Recent Articles on Review Articles on Articles on in N Eng J Med, Lancet, BMJ WikiDoc State of the Art Review Textbook Information on Return to top

Trial Resources
Ongoing Trials with at Clinical Trials.gov Trial Results with Return to top

Guidelines & Evidence Based Medicine Resources
US National Guidelines Clearinghouse on Cochrane Collaboration on Cost Effectiveness of Return to top

Media Resources
Powerpoint Slides on Images of Podcasts & MP3s on Videos on Return to top

Patient Resources
Patient Resources on Discussion Groups on Patient Handouts on Blogs on in the News in the Marketplace Return to top

International Resources
en Español Return to top