Lefetamine

Lefetamine (Santenol) is a psychoactive drug which is both a stimulant and an analgesic with effects comparable to both morphine and methylphenidate.

Lefetamine was invented in the 1940s and was widely abused in Japan during the 1950s. It has been researched for medicinal use but showed little advantage over other analgesics, although it did seem promising for treating opiate withdrawal it was not as good as buprenorphine for this purpose. More recently it has been abused in Europe, but it remains an obscure drug on the illicit market.

Due to its chemical structure, it binds to opioid receptors while simultaneously inhibiting reuptake of dopamine and norepinephrine. Lefetamine has the necessary tertiary amine functional group required for opioid receptor recognition, as well as a phenethylamine skeleton (which is responsible for its amphetamine-like effects). It is also reported to have some NMDA antagonist effects and to have neurotoxic properties.

Boiling Point: 142-147° C

Optical Rotation: [α]D20 -124.2° (ethanol).

CAS number of hydrochloride: 14148-99-3