Histidine kinase

In enzymology, a histidine kinase is an enzyme that catalyzes the chemical reaction


 * ATP + protein L-histidine $$\rightleftharpoons$$ ADP + protein N-phospho-L-histidine

Thus, the two substrates of this enzyme are ATP and protein L-histidine, whereas its two products are ADP and protein N-phospho-L-histidine.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain of histidine residues in proteins (protein-histidine kinases). The systematic name of this enzyme class is ATP:protein-L-histidine N-phosphotransferase. Other names in common use include EnvZ, histidine kinase (ambiguous), histidine protein kinase (ambiguous), protein histidine kinase (ambiguous), protein kinase (histidine) (ambiguous), HK1, HP165, and Sln1p. This enzyme participates in 4 metabolic pathways: two-component system - general, bacterial chemotaxis - general, bacterial chemotaxis - organism-specific, and type ii secretion system.

Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , and.