Alpha-enolase

Enolase 1, more commonly known as alpha-enolase, is a glycolytic enzyme expressed in most tissues, one of the isozymes of enolase. It is a homodimer composed of 2 alpha subunits.

Relationship to Myc-binding protein-1
Its gene, the ENO1, also encodes the Myc-binding protein-1(MBP1), which downregulates the activity of c-myc protooncogene. Alpha-enolase is the longer form (48 kDa) localized in both cytoplasm and nuclei, while MBP1 is shorter (37 kDa) and is found mostly in the nuclei.

Clinical significance
Alpha-enolase has been identified as an autoantigen in Hashimoto's encephalopathy. Single studies have also identified it as an autoantigen associated with severe asthma and a putative target antigen of anti-endothelial cell antibody in Behçet's disease. Reduced expression of the enzyme has been found in the corneas of people suffering from keratoconus.