Dodecenoyl-CoA isomerase

In enzymology, a dodecenoyl-CoA isomerase is an enzyme that catalyzes the chemical reaction


 * (3Z)-dodec-3-enoyl-CoA $$\rightleftharpoons$$ (2E)-dodec-2-enoyl-CoA

Hence, this enzyme has one substrate, (3Z)-dodec-3-enoyl-CoA, and one product, (2E)-dodec-2-enoyl-CoA.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is dodecenoyl-CoA (3Z)-(2E)-isomerase. Other names in common use include dodecenoyl-CoA Delta-isomerase, Delta3-cis-Delta2-trans-enoyl-CoA isomerase, acetylene-allene isomerase, dodecenoyl-CoA Delta-isomerase, and dodecenoyl-CoA Delta3-cis-Delta2-trans-isomerase. This enzyme participates in fatty acid metabolism.

Structural studies
As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , , , and.