Plasminogen activator inhibitor-2

Overview
Plasminogen activator inhibitor-2 (placental PAI) is a coagulation factor which inactivates tPA & urokinase. It is present in most cells, especially monocytes/macrophages. PAI-2 exists in two forms, a 60 kDa extracellular glycosylated form and a 43 kDa intracellular form.



It is only present at detectable quantities in blood during pregnancy, as it is produced by the placenta, and may explain partially the increased rate of thrombosis during pregnancy. The majority of expressed PAI-2 remains unsecreted due to the presence of an inefficient internal signal peptide.