Nuclear receptor related 1 protein

The Nuclear receptor related 1 (NURR1) protein is a member of the nuclear receptor family of intracellular transcription factors and is encoded by the gene (nuclear receptor subfamily 4, group A, member 2).

NURR1 plays a key role in the maintenance of the dopaminergic system of the brain. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full length nature has not been determined.