Myd88

Myeloid differentiation primary response gene (88) (MYD88) is a universal adapter protein as it is used by all TLRs (except TLR 3) to activate transcription factor Nfkappa B. Mal is necessary to recruit Myd88 to TLR 2 and TLR 4. TLRs can use Myd88 dependent and independent pathways. MYD88 is also its human gene.



History
MyD88 was originally discovered and cloned by Drs Dan A Liebermann& Barbara Hoffman as "Myeloid Differentiation primary response gene 88".

MAL was found by Katherine Fitzgerald et al.