Ink4

INK4 is a tumour suppressor protein. It is associated with several genes, including p16INK4a and p14ARF, and with several other proteins, like HRAS. Lack of this protein has been associated with several types of cancer, including bladder and melanoma. The 'INK4' label is given to three proteins: INK4A and INK4B. These proteins act to inhibit cdk4 and cdk6 upon binding, causing the arrest of the cell cycle in G1.