Zerophilia

Zerophilia is a romantic comedy film with speculative-fiction elements directed by Motion Pictures' Student Academy Award winning director Martin Curland and produced by Microangelo Entertainment. The film was released on October 13, 2006 in North America.

Plot
The film deals with individuals who have the ability to switch gender at will. Luke, a young man insecure about his masculinity, is diagnosed with "zerophilia", a fictional condition where a person has an extra chromosome - the "Z" chromosome. The film states that there are under 1000 "zerophiliacs" in the world. The "Z" chromosome is latent until a zerophiliac has sex (climaxes/orgasms) for the first time. The person then becomes a spontaneous zerophiliac. That means every time a zerophiliac becomes sexually excited, he or she starts to change into the opposite gender. They revert by tranquilizers or removing the source of arousal.

Cast

 * Taylor Handley - Luke (Hidden Palms, The OC, The Texas Chainsaw Massacre: The Beginning)
 * Kyle Schmid - Max (Blood Ties, The Covenant, A History of Violence, The Sisterhood of the Traveling Pants)
 * Alison Folland - Janine (Boys Don't Cry, All Over Me)
 * Gina Bellman - Sydney (BBC's Coupling)
 * Marieh Delfino - Luca (Jeepers Creepers II, National Lampoon's Dorm Daze)
 * Dustin Seavey - Keenan
 * Rebecca Mozo - Michelle
 * Special appearance by Kelly LeBrock (The Woman in Red, Weird Science)

Similar fiction
This film is very similar in plot to Rumiko Takahashi's gender-bending manga (and later animated series) Ranma 1/2, in which the lead character is afflicted with the misfortune of swapping gender on a regular basis.

In Futaba-Kun Change! the transformations are similarly induced by sexual excitement.

The idea of temporary mutability in sex for reproduction was found in Ursula K. LeGuin's fictional Hainish universe, and further explored in a later short story entitled "Coming of Age in Karhide."

Gender-switching is a main plot point of F.M. Busby's science fiction novel The Breeds of Man, as well as a plotline of an episode the X-Files, where a group of aliens living among humans had the capacity to change gender. The female version of the rogue alien was played by Kate Twa.