6'-deoxychalcone synthase

In enzymology, a 6'-deoxychalcone synthase is an enzyme that catalyzes the chemical reaction


 * 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ $$\rightleftharpoons$$ 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O

The 4 substrates of this enzyme are malonyl-CoA, 4-coumaroyl-CoA, NADPH, and H+, whereas its 5 products are CoA, isoliquiritigenin, CO2, NADP+, and H2O.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing).