Superagonist

A superagonist is a type of agonist that binds permanently to a receptor in such a manner that the receptor is permanently activated. It is distinct from a mere agonist in that the association of an agonist to a recepter is reversible, whereas the binding of an superagonist to a receptor is, at least in theory, irreversible. In practice, the distinction may be more a matter of degree, in which the binding affinity of a superagonist is some orders of magnitude greater than that of an agonist.