Protriptyline

Protriptyline (Vivactil®) is a tricyclic antidepressant (TCA), specifically a secondary amine, indicated for depression and ADHD. Unique among the tricyclics, protriptyline tends to be energizing instead of sedating, and it is sometimes used in narcolepsy to achieve a wakefulness-promoting effect. (The other TCAs tend to be sedating and therefore are often taken in the evening.)

Tricyclics including protriptyline are also used to reduce the incidence of recurring headaches such as migraine, and for other types of chronic pain.