Histidine-tRNA ligase

In enzymology, a histidine-tRNA ligase is an enzyme that catalyzes the chemical reaction


 * ATP + L-histidine + tRNAHis $$\rightleftharpoons$$ AMP + diphosphate + L-histidyl-tRNAHis

The 3 substrates of this enzyme are ATP, L-histidine, and tRNA(His), whereas its 3 products are AMP, diphosphate, and L-histidyl-tRNA(His).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-histidine:tRNAHis ligase (AMP-forming). Other names in common use include histidyl-tRNA synthetase, histidyl-transfer ribonucleate synthetase, and histidine translase. This enzyme participates in histidine metabolism and aminoacyl-trna biosynthesis.

Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , and.