NAD(P)+-protein-arginine ADP-ribosyltransferase

In enzymology, a NAD(P)+-protein-arginine ADP-ribosyltransferase is an enzyme that catalyzes the chemical reaction using nicotinamide adenine dinucleotide


 * NAD+ + protein L-arginine $$\rightleftharpoons$$ nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine NADP+ + protein L-arginine $$\rightleftharpoons$$ nicotinamide + Nomega-[(2'-phospho-ADP)-D-ribosyl]-protein-L-arginine

as well as the corresponding reaction using nicotinamide adenine dinucleotide phosphate


 * NADP+ + protein L-arginine $$\rightleftharpoons$$ nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine NADP+ + protein L-arginine $$\rightleftharpoons$$ nicotinamide + Nomega-[(2'-phospho-ADP)-D-ribosyl]-protein-L-arginine

Thus, the two substrates of this enzyme are NAD+ (or NADP+) and protein L-arginine, whereas its two products are nicotinamide and Nomega-(ADP-D-ribosyl)-protein-L-arginine (or Nomega-[(2'-phospho-ADP)-D-ribosyl]-protein-L-arginine, respectively).

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase. Other names in common use include ADP-ribosyltransferase, mono(ADP-ribosyl)transferase, NAD+:L-arginine ADP-D-ribosyltransferase, NAD(P)+-arginine ADP-ribosyltransferase, NAD(P)+-arginine ADP-ribosyltransferase, and NAD(P)+:L-arginine ADP-D-ribosyltransferase.

Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes, , , , , and.