Metabotropic glutamate receptor 2

Glutamate receptor, metabotropic 2, GluR2, also known as GRM2, is a human gene.

Subtype-selective potentiators
Although a number of group-II-selective (GluR2/3) ligands are known, ligands displaying high selectivity, including subtype-selectivity over GluR3, are currently rare (2008). Examples of subtype-selective ligands are the following allosteric potentiators. GluR2 potentiation is a new approach for the treatment of schizophrenia.
 * BINA: potent potentiator; modest direct agonist; robust in-vivo activity [→formula]
 * LY487379:  devoid of orthosteric activity; along with related 3-pyridylmethylsulfonamides  the first subtype-2-selective potentiator published (2003).