Tunica externa (vessels)

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Overview
The tunica externa, also known as the tunica adventitia, is the outermost layer of a blood vessel, surrounding the tunica media. It is mainly composed of collagen. The collagen serves to anchor the blood vessel to nearby organs, giving it stability.

Pathology
A common pathological disorder concerning the tunica externa is scurvy, also known as vitamin C deficiency. Scurvy occurs because vitamin C is essential for the synthesis of collagen, and without it, the faulty collagen cannot maintain the vein walls, and they rupture, leading to a wide multitude of problems.