Succinate-semialdehyde dehydrogenase

In enzymology, a succinate-semialdehyde dehydrogenase is an enzyme that catalyzes the chemical reaction


 * succinate semialdehyde + NAD+ + H2O $$\rightleftharpoons$$ succinate + NADH + 2 H+

The 3 substrates of this enzyme are succinate semialdehyde, NAD+, and H2O, whereas its 3 products are succinate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is succinate-semialdehyde:NAD+ oxidoreductase. Other names in common use include succinate semialdehyde dehydrogenase, succinic semialdehyde dehydrogenase, succinyl semialdehyde dehydrogenase, and succinate semialdehyde:NAD+ oxidoreductase. This enzyme participates in glutamate and butanoate metabolism.