NADH dehydrogenase (quinone)

In enzymology, a NADH dehydrogenase (quinone) is an enzyme that catalyzes the chemical reaction


 * NADH + H+ + acceptor $$\rightleftharpoons$$ NAD+ + reduced acceptor

The 3 substrates of this enzyme are NADH, H+, and acceptor, whereas its two products are NAD+ and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with other acceptors. The systematic name of this enzyme class is NADH:(quinone-acceptor) oxidoreductase. Other names in common use include reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase, NADH-quinone oxidoreductase, DPNH-menadione reductase, D-diaphorase, and NADH2 dehydrogenase (quinone). This enzyme participates in oxidative phosphorylation. Several compounds are known to inhibit this enzyme, including AMP, and 2,4-Dinitrophenol.

Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code.