HLA-DR15

HLA-DR15(DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. frequencies. DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.

=Serology=

Serotypes are unknown the following alleles: DRB1*1506, *1508 to *1516, *1518 to *1522. DRB1*1517N is a null.

=Alleles=

=Disease associations=

DR15 is positively asscoiated goodpasture syndrome, early age onset multiple schlerosis , pernicious anaemia, sarcoidosis, and a predisposition for postmenopausal osteoporosis.

DRB1*1501 is positively associated with Goodpasture syndrome, juvenile rheumatoid arthritis , allergic bronchopulmonary aspergillosis , multiple schlerosis , systemic lupus erythematosus , cervical cancer (human papillomavirus infection) , and Sjogren's syndrome associated with systemic lupus erythematosus.

DRB1*1502 is associated with systemic lupus erythematosus, systemic sclerosis (SSc) & anti-topoisomerase antibodies.

DRB1*1503 is associated with Chaga's cardiomyopathy, allergic bronchopulmonary aspergillosis , multiple sclerosis , cervical cancer (human papillomavirus infection).

Extended linkage
DRB1*15:DQA1*0102:DQB1*0602 haplotype us associated with cervical cancer risk in (human papillomavirus infection)

DRB1*1502:DQA1*????:DQB1*0501 haplotype is associated with systemic lupus erythematosus

=Genetic Linkage=

HLA-DR15 is genetically linked to HLA-DR51 and HLA-DQ6 (HLA-DQ1) serotypes.

=References=