Amiodarone overdose

There have been cases, some fatal, of Amiodarone overdose.

In addition to general supportive measures, the patient's cardiac rhythm and blood pressure should be monitored, and if bradycardia ensues, a β-adrenergic agonist or a pacemaker may be used. Hypotension with inadequate tissue perfusion should be treated with positive inotropic and/or vasopressor agents. Neither Amiodarone nor its metabolite is dialyzable.

The acute oral LD50 of Amiodarone HCl in mice and rats is greater than 3,000 mg/kg.