GlmS glucosamine-6-phosphate activated ribozyme

Glucosamine-6-phosphate activated ribozyme is found in the mRNA for GlmS. GlmS is an enzyme that uses fructose-6-phosphate and glutamine to generate glucosamine-6-phosphate. The ribozyme catalyses self cleavage of the glmS mRNA thereby regulating GlmS activity. The GlmS element is only catalytic when bound to glucosamine-6-phosphate. The glucosamine-6-phosphate is a cofactor for the catalytic reaction, directly participating in the chemistry. This is the only known case of a ribozyme using a small-molecule cofactor at present.

Structure
The structure of the GlmS ribozyme has been determined by X-ray crystallography.