Arachidonate 15-lipoxygenase

In enzymology, an arachidonate 15-lipoxygenase is an enzyme that catalyzes the chemical reaction


 * arachidonate + O2 $$\rightleftharpoons$$ (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate

Thus, the two substrates of this enzyme are arachidonate and O2, whereas its product is (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is arachidonate:oxygen 15-oxidoreductase. Other names in common use include 15-lipoxygenase, linoleic acid omega6-lipoxygenase, and omega6 lipoxygenase. This enzyme participates in arachidonic acid metabolism and linoleic acid metabolism.

Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code.