Giovanni Battista Morgagni

Giovanni Battista Morgagni (February 25, 1682 – December 6, 1771), Italian anatomist, was born on at Forlì and he is celebrated as the father of the modern anatomical pathology.

Education
His parents were in comfortable circumstances, but not of the nobility; it appears from his letters to G. M. Lancisi that Morgagni was ambitious of gaining admission into that rank, and it may be inferred that he succeeded from the fact that he is described on a memorial tablet at Padua as nobilis forolensis. At the age of sixteen he went to Bologna to study philosophy and medicine, and he graduated with much éclat as doctor in both faculties three years later, in 1701. He acted as prosector to Antonio Maria Valsalva (one of the distinguished pupils of Malpighi), who held the office of demonstrator anatomicus in the Bologna school, and whom he assisted more particularly in preparing his celebrated work on the Anatomy and Diseases of the Ear, published in 1704.

Early career
Many years after, in 1740, Morgagni edited a collected edition of Valsalva's writings, with important additions to the treatise on the ear, and with a memoir of the author. When Valsalva was transferred to Parma Morgagni succeeded to his anatomical demonstratorship. At this period he enjoyed a high repute in Bologna; he was made president of the Academia Enquietorum when in his twenty-fourth year, and he is said to have signalized his tenure of the presidential chair by discouraging abstract speculations, and by setting the fashion towards exact anatomical observation and reasoning.

He published the substance of his communications to the Academy in 1706 under the title of Adversaria anatomica, the first of a series by which he became favorably known throughout Europe as an accurate anatomist; the book included Observations of the Larynx, the Lachrymal Apparatus, and the Pelvic Organs in the Female. After a time he gave up his post at Bologna, and occupied himself for the next two or three years at Padua, where he had a friend in Domenico Guglielmini (1655-1710), professor of medicine, but better-known as a writer on physics and mathematics, whose works he afterwards edited (1719) with a biography. Guglielmini desired to see him settled as a teacher at Padua, and the unexpected death of Guglielmini himself made the project feasible, Antonio Vallisneri (1661-1730) being transferred to the vacant chair, and Morgagni succeeding to the chair of theoretical medicine. He came to Padua in the spring of 1712, being then in his thirty-first year, and he taught medicine there with the most brilliant success until his death on the 6th of December 1771.

Middle career
When he had been three years in Padua an opportunity occurred for his promotion (by the Venetian senate) to the chair of anatomy, in which he became, the successor of an illustrious line of scholars, including Vesalius, Gabriele Falloppio, Geronimo Fabrizio, Gasserius, and Adrianus Spigelius, and in which he enjoyed a stipend that was increased from time to time by vote of the senate until it reached twelve hundred gold ducats. Shortly after coming to Padua he married a lady of Forlì, of noble parentage, who bore him three sons and twelve daughters.

Morgagni enjoyed an unequalled popularity among all classes. He was of tall and dignified figure, with blonde hair and lilac eyes, and with a frank and happy expression; his manners were polished, and he was noted for the elegance of his Latin style. He lived in harmony with his colleagues, who are said not even to have envied him his unprecedentedly large stipend; his house and lecture-theatre were frequented tanquam officina sapientiae by students of all ages, attracted from all parts of Europe; he enjoyed the friendship and favor of distinguished Venetian senators and of cardinals; and successive popes conferred honours upon him.

Before he had been long in Padua the students of the German nation, of all the faculties there, elected him their patron, and he advised and assisted them in the purchase of a house to be a German library and club, for all time. He was elected into the imperial Caesareo-Leopoldina Academy in 1708 (originally located at Schweinfurth), and to a higher grade in 1732, into the Royal Society in 1724, into the Paris Academy of Sciences in 1731, the St. Petersburg Academy in 1735, and the Berlin Academy in 1754. Among his more celebrated pupils were Antonio Scarpa (who died in 1832, connecting the school of Morgagni with the modern era), Domenico Cotugno (1736-1822), and Caldani (1725-1813), the author of the magnificent atlas of anatomical plates published in 2 volumes at Venice in 1801-1814.

In his earlier years at Padua, Morgagni brought out (1717-1719) five more series of the Adversaria anatomica, these his strictly medical publications were few and casual (on gallstones, varices of the Venae cavae, cases of stone, and several memoranda on medico-legal points, drawn up at the request of the curia). Classical scholarship in those years occupied his pen more than anatomical observation.

Late career
It was not until 1761, when he was in his eightieth year, that he brought out the great work which, once for all, made pathological anatomy a science, and diverted the course of medicine into new channels of exactness or precision--the De Sedibus et causis morborum per anatomem indagatis, which during the succeeding ten years, notwithstanding its bulk, was reprinted several times (thrice in four years) in its original Latin, and was translated into French (1765), English (1769), and German (1771). Some account of this remarkable work remains now to be given.

The only special treatise on pathological anatomy previous to that of Morgagni was the work of Théophile Bonet of Neuchâtel, Sepulchretum: sive anatomia practica ex cadaveribus morbo denalis, first published (Geneva, 2 vols. folio) in 1679, three years before Morgagni was born; it was republished at Geneva (3 vols., folio) in 1700, and again at Leiden in 1709. Although the normal anatomy of the body had been comprehensively, and in some parts exhaustively, written by Vesalius and Fallopius, it had not occurred to any one to examine and describe systematically the anatomy of diseased organs and parts. Harvey, a century after Vesalius, poignantly remarks that there is more to be learned from the dissection of one person who had died of tuberculosis or other chronic malady than from the bodies of ten persons who had been hanged.

Francis Glisson indeed (1597-1677) shows in a passage quoted by Bonet in the preface to the Sepulchretum, that he was familiar with the idea, at least, of systematically comparing the state of the organs in a series of bodies, and of noting those conditions which invariably accompanied a given set of symptoms. The work of Bonet was, however, the first attempt at a system of morbid anatomy, and, although it dwelt mostly upon curiosities and monstrosities, it enjoyed much repute in its day; Haller speaks of it as an immortal work, which may in itself serve for a pathological library.

Morgagni, in the preface to his own work, discusses the defects and merits of the Sepulchrelum: it was largely a compilation of other men's cases, well and ill authenticated; it was prolix, often inaccurate and misleading from ignorance of the normal anatomy, and it was wanting in what would now be called objective impartiality a quality which was introduced as decisively into morbid anatomy by Morgagni as it had been introduced two centuries earlier into normal human anatomy by Vesalius.

Morgagni has narrated the circumstances under which the De Sedibus took origin. Having finished his edition of Valsalva in 1740, he was taking a holiday in the country, spending much of his time in the company, of a young friend who was curious in many branches of knowledge. The conversation turned upon the Sepulchretum of Bonet, and it was suggested to Morgagni by his dilettante friend that he should put on record his own observations. It was agreed that letters on the anatomy of diseased, organs and parts should be written for the perusal of this favoured youth (whose name is not mentioned); and they were continued from time to time until they numbered seventy. Those seventy letters constitute the De sedibus et causis morborum, which was given to the world as a systematic treatise in 2 vols., folio (Venice, 1761), twenty years after the task of epistolary instruction was begun.

The letters are arranged in five books, treating of the morbid conditions of the body a capite ad calcem, and together containing the records of some 646 dissections. Some of these are given at great length, and with a precision of statement and exhaustiveness of detail hardly surpassed in the so-called protocols of the German pathological institutes of the present time; others, again, are fragments brought in to elucidate some question that had arisen. The symptoms during the course of the malady and other antecedent circumstances are always prefixed with more or less fullness, and discussed from the point of view of the conditions found after death. Subjects in all ranks of life, including several cardinals, figure in this remarkable gallery of the dead. Many of the cases are taken from Morgagni's early experiences at Bologna, and from the records of his teachers Valsalva and HF Albertini not elsewhere published. They are selected and arranged with method and purpose, and they are often (and somewhat casually) made the occasion of a long excursus on general pathology and medicine.

Legacy
The range of Morgagni's scholarship, as evidenced by his references to early and contemporary literature, is astonishing. It has been contended that he was himself not free from prolixity, the besetting sin of the learned; and certainly the form and arrangement of his treatise are such as to make it difficult to use in the present day, notwithstanding that it is well indexed in the original edition, in that of Tissot (3 vols., 4to, Yverdun, 1779), and in more recent editions. It differs from modern treatises in so far as the symptoms determine the order and manner of presenting the anatomical facts.

Although Morgagni was the first to understand and to demonstrate the absolute necessity of basing diagnosis, prognosis, and treatment on an exact and comprehensive knowledge of anatomical conditions, he made no attempt (like that of the Vienna school sixty years later) to exalt pathological anatomy into a science disconnected from clinical medicine and remote from practical experience with the scalpel, his precision, his exhaustiveness, and his freedom from bias are his essentially modern or scientific qualities; his scholarship and high consideration for classical and foreign work, his sense of practical ends (or his common sense), and the breadth of his intellectual horizon prove him to have lived before medical science had become largely technical or mechanical.

His treatise was the commencement of the era of steady, or cumulative progress in pathology and in practical medicine. Symptoms from that, time ceased to be made up into more or less conventional groups, each of which was a disease; on the other hand, they began to be viewed as the cry of the suffering organs, and it became possible to develop Thomas Sydenham's grand conception of a natural history of disease in a catholic or scientific spirit.

Eponymous structures

 * Hydatid of Morgagni
 * Foramina of Morgagni
 * Aortic sinus ("sinus of Morgagni")
 * Morgagni's hernia

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