Grand challenges in global health

The Grand Challenges in Global Health initiative is a partnership dedicated to supporting scientific and technical research to solve critical health problems in the developing world. Currently 14 independent "Grand Challenges" are being supported. The initiative's partners are the Bill & Melinda Gates Foundation, the Canadian Institutes of Health Research, the Foundation for the National Institutes of Health, and the Wellcome Trust.

The Grand Challenges
Grand Challenge #1: Create Effective Single-Dose Vaccines that Can be used Soon After Birth

Grand Challenge #2: Prepare Vaccines that Do Not Require Refrigeration

Grand Challenge #3: Develop Needle-Free Delivery Systems for Vaccines

Grand Challenge #4: Devise Reliable Tests in Model Systems to Evaluate Live-attenuated Vaccines

Grand Challenge #5: Solve How to Design Antigens for Effective, Protective Immunity

Grand Challenge #6: Learn Which Immunological Responses Provide Protective Immunity

Grand Challenge #7: Develop a Genetic Strategy to Deplete or Incapacitate a Disease-transmitting Insect Population

Grand Challenge #8: Develop a Chemical Strategy to Deplete or Incapacitate a Disease-transmitting Insect Population

Grand Challenge #9: Create a Full Range of Optimal, Bioavailable Nutrients in a Single Staple Plant Species

Grand Challenge #10: Discover Drugs and Delivery Systems that Minimize the Likelihood of Drug Resistant Micro-organisms

Grand Challenge #11: Create Therapies that Can Cure Latent Infection

Grand Challenge #12: Create Immunological Methods that Can Cure Latent Infection

Grand Challenge #13: Develop Technologies that Permit Quantitative Assessment of Population Health

Grand Challenge #14: Develop Technologies that Allow Assessment of Individuals for Multiple Conditions or Pathogens at Point of Care