Parathyroid hormone receptor 1

Parathyroid hormone receptor 1 is a parathyroid hormone receptor It is encoded by the gene PTHR1. It is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH).

Function
It is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.

Mechanism
It is a member of the secretin family of G protein-coupled receptors. The activity of this receptor is mediated by Gs G proteins which activate adenylyl cyclase. Besides, they also activate phosphatidylinositol-calcium second messenger system.

Pathology
Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis.