Type I cytokine receptor

Type I cytokine receptors are proteins expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction.

Families
The signal transducing chains are often shared between different receptors within this receptor family.


 * The IL-2 receptor common gamma chain (also known as CD132) is shared between IL-2, IL-4, IL-7, IL-9, IL-13 and IL-15 receptors


 * The common beta chain (CD131 or CDw131) is shared between GM-CSF, IL-3 and IL-5.

Examples
Type I cytokine receptors include:


 * Interleukin-2 receptor
 * Interleukin-3 receptor
 * Interleukin-4 receptor
 * Interleukin-5 receptor
 * Interleukin-6 receptor
 * Interleukin-7 receptor
 * Interleukin-9 receptor
 * Interleukin-11 receptor
 * Interleukin-12 receptor
 * Interleukin-13 receptor
 * Interleukin-15 receptor
 * Erythropoietin receptor
 * GM-CSF receptor
 * G-CSF receptor
 * growth hormone receptor
 * prolactin receptor