Diaminopimelate dehydrogenase

In enzymology, a diaminopimelate dehydrogenase is an enzyme that catalyzes the chemical reaction


 * meso-2,6-diaminoheptanedioate + H2O + NADP+ $$\rightleftharpoons$$ L-2-amino-6-oxoheptanedioate + NH3 + NADPH + H+

The 3 substrates of this enzyme are meso-2,6-diaminoheptanedioate, H2O, and NADP+, whereas its 4 products are L-2-amino-6-oxoheptanedioate, NH3, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating). Other names in common use include meso-alpha,epsilon-diaminopimelate dehydrogenase, and meso-diaminopimelate dehydrogenase. This enzyme participates in lysine biosynthesis.

Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes, , , and.