SCF-complex

Skp, Cullin, F-box containing complex (or SCF complex) is a multi-protein complex catalyzing the ubiquitylation of proteins destined for proteasomal degradation.

Protein substrates are recognized by an F-box protein and delivered to the E3 ligase through the bridging protein, Skp. Cullen is the major scaffold of the SCF, as dogma indicates its binding of Skp, the ring-finger catalytic protein (eg ROC1), and recruitment of E2.