Glutamate synthase (NADH)

In enzymology, a glutamate synthase (NADH) is an enzyme that catalyzes the chemical reaction


 * 2 L-glutamate + NAD+ $$\rightleftharpoons$$ L-glutamine + 2-oxoglutarate + NADH + H+

Thus, the two substrates of this enzyme are L-glutamate and NAD+, whereas its 4 products are L-glutamine, 2-oxoglutarate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-glutamate:NAD+ oxidoreductase (transaminating). Other names in common use include glutamate (reduced nicotinamide adenine dinucleotide) synthase, NADH: GOGAT, L-glutamate synthase (NADH), L-glutamate synthetase, NADH-glutamate synthase, NADH-dependent glutamate synthase, and glutamate synthase (NADH). This enzyme participates in glutamate metabolism and nitrogen metabolism. It employs one cofactor, FMN.