Alteplase contraindications

List of contraindications

 * Active internal bleeding;
 * history of cerebrovascular accident;
 * intracranial hemorrhage;
 * recent (within 3 mo) intracranial or intraspinal surgery or trauma;
 * recent previous stroke; seizure at the onset of stroke
 * intracranial neoplasm;
 * arteriovenous malformation or aneurysm;
 * bleeding diathesis;
 * severe uncontrolled hypertension;
 * evidence of intracranial hemorrhage on pretreatment evaluation;
 * suspicion of subarachnoid hemorrhage;
 * uncontrolled hypertension at time of treatment;
 * current use of oral anticoagulants;
 * prothrombin time longer than 15 sec,
 * administration of heparin within 48 h preceding stroke onset with an elevated activated partial thromboplastin time at presentation;


 * platelet count below 100,000/mm 3.