Primary sclerosing cholangitis causes

Overview
The cause(s) for PSC are unknown. It is often considered to be an autoimmune disorder. PSC is associated withulcerative colitis. It is assumed that these diseases share a common cause.

Ulcerative colitis is a systemic disease that affects many areas of the body. PSC is often listed as a manifestation of ulcerative colitis outside the colon. PSC differs from these manifestations in that, unlike most other manifestations, PSC continues in spite of surgical removal of the colon. This suggests that, while the cause of ulcerative colitis, and most of its manifestations, is in the colon, the cause of PSC is located outside the colon.