Bivalirudin mechanism of action

Mechanism of action
1) Specific and reversible direct thrombin inhibitor

2) Binds to the catalytic and anionic sites of both circulating and clot-bound thrombin.

3) Catalytic binding site occupation functionally inhibits coagulant effects by preventing thrombin-mediated cleavage of fibrinogen to fibrin monomers, and activation of factors V, VIII, and XIII.