Citramalate lyase

In enzymology, a citramalate lyase is an enzyme that catalyzes the chemical reaction


 * (2S)-2-hydroxy-2-methylbutanedioate $$\rightleftharpoons$$ acetate + pyruvate

Hence, this enzyme has one substrate, (2S)-2-hydroxy-2-methylbutanedioate, and two products, acetate and pyruvate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase (acetate-forming). Other names in common use include citramalate pyruvate-lyase, citramalate synthase, citramalic-condensing enzyme, citramalate synthetase, citramalic synthase, (S)-citramalate lyase, (+)-citramalate pyruvate-lyase, citramalate pyruvate lyase, (3S)-citramalate pyruvate-lyase, and (2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase. This enzyme participates in c5-branched dibasic acid metabolism.