Anabasine

Anabasine is a pyridine alkaloid found in the stem of the (Nicotiana glauca) plant, a close relative of (Nicotiana tabacum) the common tobacco plant.

Effects
Anabasine is present in trace amounts in tobacco smoke. In larger amounts it is thought to be teratogenic in swine. 

Pharmacology
Pharmacodynamics:

Anabasine is a nicotinic receptor agonist toxin and cholinesterase inhibitor which acts upon the nicotinic acetylcholine receptors. 

Anabasine is a minor tobacco alkaloid which can be used as an indicator of a person's exposure to tobacco smoke.

In high doses, anabasine will cause a depolarizing block of the nicotinic acetylcholine receptor, which can cause death by asystolia and toxicity.

As such, its principal industrial use is as an insecticide.

Anabasine was also extensively investigated by the US Navy as part of Project CHATTER as a potential truth drug. 

Toxicology
As anabasine lacks the imine double bond of anabaseine, which significantly more toxic in mouse bioassay than S-anabasine (27-fold) and R-anabasine (18-fold). The relative agonistic potencies of the three alkaloids on human fetal nicotinic neuromuscular receptors were of the same rank order: anabaseine >> S-anabasine > R-anabasine.  A mouse bioassay was used to determine the relative lethalities of S- and R-enriched anabasine enantiomers. The intravenous LD50 of the (+)-R-anabasine rich fraction was 11±1.0 mg/kg and that of the (-)-S-anabasine-rich fraction was 16±1.0 mg/kg. The LD50 of anabaseine was 0.58±0.05 mg/kg. Anabaseine was significantly more toxic in the mouse bioassay than S-anabasine (27-fold) and R-anabasine (18-fold). The relative agonistic potencies of the three alkaloids on human fetal nicotinic neuromuscular receptors were of the same rank order: anabaseine >> S-anabasine > R-anabasine.