4-hydroxybenzoyl-CoA thioesterase

In enzymology, a 4-hydroxybenzoyl-CoA thioesterase is an enzyme that catalyzes the chemical reaction


 * 4-hydroxybenzoyl-CoA + H2O $$\rightleftharpoons$$ 4-hydroxybenzoate + CoA

Thus, the two substrates of this enzyme are 4-hydroxybenzoyl-CoA and H2O, whereas its two products are 4-hydroxybenzoate and CoA.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is 4-hydroxybenzoyl-CoA hydrolase. This enzyme participates in 2,4-dichlorobenzoate degradation.

Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , and.