GRB7

Growth factor receptor-bound protein 7, also known as GRB7, is a human gene.

GRB7 is an SH2-domain adaptor protein that binds to Receptor-tyrosine kinases and provides the intra-cellular direct link to the Ras proto-oncogene. Human GRB7 is located on the long arm of chromosome 17, next to the ERBB2 (alias her2/neu) proto-oncogene.

These two genes are commonly co-amplified (present in excess copies) in breast cancers. GRB7, thought to be involved in migration, is well known to be over-expressed in testicular germ cell tumors, esophagous cancers, and gastric cancers.