Tetrahydroxynaphthalene reductase

In enzymology, a tetrahydroxynaphthalene reductase is an enzyme that catalyzes the chemical reaction


 * scytalone + NADP+ $$\rightleftharpoons$$ 1,3,6,8-tetrahydroxynaphthalene + NADPH + H+

Thus, the two substrates of this enzyme are scytalone and NADP+, whereas its 3 products are 1,3,6,8-tetrahydroxynaphthalene, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is scytalone:NADP+ Delta5-oxidoreductase.

Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes, , and.