3-dehydrosphinganine reductase

In enzymology, a 3-dehydrosphinganine reductase is an enzyme that catalyzes the chemical reaction


 * sphinganine + NADP+ $$\rightleftharpoons$$ 3-dehydrosphinganine + NADPH + H+

Thus, the two substrates of this enzyme are sphinganine and NADP+, whereas its 3 products are 3-dehydrosphinganine, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase. Other names in common use include D-3-dehydrosphinganine reductase, D-3-oxosphinganine reductase, DSR, 3-oxosphinganine reductase, 3-oxosphinganine:NADPH oxidoreductase, and D-3-oxosphinganine:B-NADPH oxidoreductase. This enzyme participates in sphingolipid metabolism.