NADH peroxidase

In enzymology, a NADH peroxidase is an enzyme that catalyzes the chemical reaction


 * NADH + H+ + H2O2 $$\rightleftharpoons$$ NAD+ + 2 H2O

The 3 substrates of this enzyme are NADH, H+, and H2O2, whereas its two products are NAD+ and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a peroxide as acceptor (peroxidases). The systematic name of this enzyme class is NADH:hydrogen-peroxide oxidoreductase. Other names in common use include DPNH peroxidase, NAD peroxidase, diphosphopyridine nucleotide peroxidase, NADH-peroxidase, nicotinamide adenine dinucleotide peroxidase, and NADH2 peroxidase. It employs one cofactor, FAD.

Structural studies
As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , and.