Thiocyanate hydrolase

In enzymology, a thiocyanate hydrolase is an enzyme that catalyzes the chemical reaction


 * thiocyanate + 2 H2O $$\rightleftharpoons$$ carbonyl sulfide + NH3 + HO-

Thus, the two substrates of this enzyme are thiocyanate and H2O, whereas its 3 products are carbonyl sulfide, NH3, and HO-.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in nitriles. The systematic name of this enzyme class is thiocyanate aminohydrolase.

Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes, , , and.