Aphidicolin

Aphidicolin is defined as a tetracyclic diterpene antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. It blocks the cell cycle at early S-phase. It is a specific inhibitor of DNA polymerase A,D in eukaryotic cells and in some viruses and an Apoptosis inducer in HeLa cells.