Estrogen receptor beta

Estrogen receptor beta (ER-beta), also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2), is a nuclear receptor which is activated by the sex hormone estrogen. ER-beta is encoded by the human gene (EStrogen Receptor 2).

Tissue Distribution
ER-β is expressed by many tissues including blood monocytes and tissue macrophages, colonic and pulmonary epithelial cells and in prostatic epithelium and in malignant counterparts of these tissues.

Function
ER-β may have anti-proliferative effects and therefore oppose the actions of ER-α in reproductive tissue. ER-β may also have an important role in adpative function of the lung during pregnancy.