(acyl-carrier-protein) phosphodiesterase

In enzymology, a [acyl-carrier-protein] phosphodiesterase is an enzyme that catalyzes the chemical reaction


 * holo-[acyl-carrier-protein] + H2O $$\rightleftharpoons$$ 4'-phosphopantetheine + apo-[acyl-carrier-protein]

Thus, the two substrates of this enzyme are holo-[acyl-carrier-protein] and H2O, whereas its two products are 4'-phosphopantetheine and apo-[acyl-carrier-protein].

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is holo-[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase. Other names in common use include ACP hydrolyase, ACP phosphodiesterase, AcpH, and [acyl-carrier-protein] 4'-pantetheine-phosphohydrolase. This enzyme participates in pantothenate and coa biosynthesis.

Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and.