2-oxoglutarate carboxylase

In enzymology, a 2-oxoglutarate carboxylase is an enzyme that catalyzes the chemical reaction


 * ATP + 2-oxoglutarate + HCO3- $$\rightleftharpoons$$ ADP + phosphate + oxalosuccinate

The 3 substrates of this enzyme are ATP, 2-oxoglutarate, and HCO3-, whereas its 3 products are ADP, phosphate, and oxalosuccinate.

This enzyme belongs to the family of ligases, specifically those forming carbon-carbon bonds. The systematic name of this enzyme class is . Other names in common use include oxalosuccinate synthetase, carboxylating factor for ICDH (incorrect), CFI, and OGC.