Ranitidine drug interactions

List of drug interactions
Drugs Affecting Hepatic Metabolism Enzymes Alcohol Diazepam

Drugs Affecting Hepatic Metabolism
The metabolism and pharmacokinetics of Ranitidine may be affected by the induction or inhibition of drug-metabolizing enzymes. Return to top

Enzymes
Many drugs are metabolized by and/or inhibit various cytochrome P450 enzymes, e.g., 2D6, 1A2, 3A4, etc. In vitro studies have shown that mirtazapine is a substrate for several of these enzymes, including 2D6, 1A2, and 3A4. While in vitro studies have shown that mirtazapine is not a potent inhibitor of any of these enzymes, an indication that mirtazapine is not likely to have a clinically significant inhibitory effect on the metabolism of other drugs that are substrates for these cytochrome P450 enzymes, the concomitant use of Ranitidine with most other drugs metabolized by these enzymes has not been formally studied. Consequently, it is not possible to make any definitive statements about the risks of coadministration of Ranitidine with such drugs. Return to top

Alcohol
Concomitant administration of alcohol (equivalent to 60 g) had a minimal effect on plasma levels of mirtazapine (15 mg) in 6 healthy male subjects. However, the impairment of cognitive and motor skills produced by Ranitidine were shown to be additive with those produced by alcohol. Accordingly, patients should be advised to avoid alcohol while taking Ranitidine. Return to top

Diazepam
Concomitant administration of diazepam (15 mg) had a minimal effect on plasma levels of mirtazapine (15 mg) in 12 healthy subjects. However, the impairment of motor skills produced by Ranitidine has been shown to be additive with those caused by diazepam. Accordingly, patients should be advised to avoid diazepam and other similar drugs while taking Ranitidine. Return to top