Risperidone

Synonyms / Brand Names: Risperidona, Risperidonum, Risperdal, Risperdal Consta, Risperdal M-Tab, Risperidal M-Tab, Risperin, Rispolept, Rispolin, Sequinan

Dosing and Administration
Schizophrenia Bipolar mania
 * Usual initial dose: Risperidone can be administered on either a BID or a QD schedule. In early clinical trials, Risperidone was generally administered at 1 mg BID initially, with increases in increments of 1 mg BID on the second and third day, as tolerated, to a target dose of 3 mg BID by the third day. Subsequent controlled trials have indicated that total daily Risperidone doses of up to 8 mg on a QD regimen are also safe and effective. However, regardless of which regimen is employed, in some patients a slower titration may be medically appropriate. Further dosage adjustments, if indicated, should generally occur at intervals of not less than 1 week, since steady state for the active metabolite would not be achieved for approximately 1 week in the typical patient. When dosage adjustments are necessary, small dose increments/decrements of 1–2 mg are recommended.
 * Usual dose: Risperidone should be administered on a once daily schedule, starting with 2 mg to 3 mg per day. Dosage adjustments, if indicated, should occur at intervals of not less than 24 hours and in dosage increments/decrements of 1 mg per day, as studied in the short-term, placebo-controlled trials. In these trials, short-term (3 week) anti-manic efficacy was demonstrated in a flexible dosage range of 1–6 mg per day. Risperidone doses higher than 6 mg per day were not studied.

FDA Package Insert Resources Indications, Contraindications, Side Effects, Drug Interactions, etc. Calculate Creatine Clearance On line calculator of your patients Cr Cl by a variety of formulas. Convert pounds to Kilograms On line calculator of your patients weight in pounds to Kg for dosing estimates. Publication Resources Recent articles, WikiDoc State of the Art Review, Textbook Information Trial Resources Ongoing Trials, Trial Results Guidelines & Evidence Based Medicine Resources US National Guidelines, Cochrane Collaboration, etc. Media Resources Slides, Video, Images, MP3, Podcasts, etc. Patient Resources Discussion Groups, Handouts, Blogs, News, etc. International Resources en Español

FDA Package Insert Resources
Indications Contraindications Side Effects Drug Interactions Precautions Overdose Instructions for Administration How Supplied Pharmacokinetics and Molecular Data FDA label FDA on Return to top

Publication Resources
Most Recent Articles on Review Articles on Articles on in N Eng J Med, Lancet, BMJ WikiDoc State of the Art Review Textbook Information on Return to top

Trial Resources
Ongoing Trials with at Clinical Trials.gov Trial Results with Return to top

Guidelines & Evidence Based Medicine Resources
US National Guidelines Clearinghouse on Cochrane Collaboration on Cost Effectiveness of Return to top

Media Resources
Powerpoint Slides on Images of Podcasts & MP3s on Videos on Return to top

Patient Resources
Patient Information from National Library of Medicine Patient Resources on Discussion Groups on Patient Handouts on Blogs on in the News in the Marketplace Return to top

International Resources
en Español Return to top