HLA-DR2



HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups.

=Serology=

=Disease associations= DR2 serotypes are associated with Goodpasture syndrome, multiple sclerosis, and narcolepsy, tuberculoid leprosy (multi-drug resistent tuberculosis or leprosy), Hashimoto's thyroiditis , ulcerative colitis(Japanese) , primary biliary cirrhosis and autoimmune hepatitis. DR2 is also found in all patients that test positive for anti-anti-Asn-RNA-synthetaes and chronic interstitial lung disease.

=Genetic linkage= DR2 is linked to the HLA-DR53.

=References=