TRNA (adenine-N1-)-methyltransferase

In enzymology, a tRNA (adenine-N1-)-methyltransferase is an enzyme that catalyzes the chemical reaction


 * S-adenosyl-L-methionine + tRNA $$\rightleftharpoons$$ S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine

Thus, the two substrates of this enzyme are S-adenosyl methionine and tRNA, whereas its two products are S-adenosylhomocysteine and tRNA containing N1-methyladenine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA (adenine-N1-)-methyltransferase. Other names in common use include transfer ribonucleate adenine 1-methyltransferase, transfer RNA (adenine-1) methyltransferase, 1-methyladenine transfer RNA methyltransferase, adenine-1-methylase, and S-adenosyl-L-methionine:tRNA (adenine-1-N-)-methyltransferase.