Aromatic-L-amino-acid decarboxylase

Aromatic L-amino acid decarboxylase (, synonyms: DOPA decarboxylase, tryptophan decarboxylase, 5-hydroxytryptophan decarboxylase, AAAD) is a lyase enzyme.

Reactions
It catalyzes several different decarboxylation reactions:
 * L-DOPA to dopamine - a neurotransmitter
 * 5-HTP to serotonin (5-HT) - also a neurotransmitter
 * tryptophan to tryptamine - a precursor to many alkaloids found in plants and animals

The enzyme uses pyridoxal phosphate as a cofactor.

As a rate limiting step
In normal dopamine and serotonin (5-HT) neurotransmitter synthesis, AAAD is not the rate-limiting step of in either reaction. However, AAAD becomes the rate-limiting step of dopamine synthesis in patients treated with L-DOPA (such as in Parkinson's Disease), and the rate-limiting step of serotonin synthesis in people treated with 5-HTP (such as in mild depression or dysthymia).

AAAD is the rate-limiting enzyme in the formation of biogenic trace amines.