Enalapril indications

List of indications
Hypertension Heart Failure Asymptomatic Left Ventricular Dysfunction ---

Hypertension
Enalapril maleate is indicated for the treatment of hypertension.

Enalapril maleate is effective alone or in combination with other antihypertensive agents, especially thiazide-type diuretics. The blood pressure lowering effects of Enalapril maleate and thiazides are approximately additive.

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Heart Failure
Enalapril maleate is indicated for the treatment of symptomatic congestive heart failure, usually in combination with diuretics and digitalis. In these patients Enalapril maleate improves symptoms, increases survival, and decreases the frequency of hospitalization.

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Asymptomatic Left Ventricular Dysfunction
In clinically stable asymptomatic patients with left ventricular dysfunction (ejection fraction <35 percent), Enalapril maleate decreases the rate of development of overt heart failure and decreases the incidence of hospitalization for heart failure.

In using Enalapril maleate consideration should be given to the fact that another angiotensin converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that Enalapril maleate does not have a similar risk.

In considering use of Enalapril maleate, it should be noted that in controlled clinical trials ACE inhibitors have an effect on blood pressure that is less in black patients than in non-blacks. In addition, it should be noted that black patients receiving ACE inhibitors have been reported to have a higher incidence of angioedema compared to non-blacks.

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