Blasticidin-S deaminase

In enzymology, a blasticidin-S deaminase is an enzyme that catalyzes the chemical reaction


 * blasticidin S + H2O $$\rightleftharpoons$$ deaminohydroxyblasticidin S + NH3

Thus, the two substrates of this enzyme are blasticidin S and H2O, whereas its two products are deaminohydroxyblasticidin S and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is blasticidin-S aminohydrolase.

Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and.