Zenker's degeneration

Zenker's degeneration is a severe glassy or waxy hyaline degeneration or necrosis of skeletal muscles in acute infectious diseases.

The condition was named by Friedrich Albert von Zenker.

it is hyaline degeneration of skeletal muscles as rectus abdominis and diaphragm,occur in sever toxaemia as typhoid fever,,,grossly the muscles appear pale and friable, microscopically the muscle fibres are swollen, loss of cross striations, and show hyaline appearance,, rupture and small hemorrhage may complicate the lesion