2-dehydropantolactone reductase (A-specific)

In enzymology, a 2-dehydropantolactone reductase (A-specific) is an enzyme that catalyzes the chemical reaction


 * (R)-pantolactone + NADP+ $$\rightleftharpoons$$ 2-dehydropantolactone + NADPH + H+

Thus, the two substrates of this enzyme are (R)-pantolactone and NADP+, whereas its 3 products are 2-dehydropantolactone, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-pantolactone:NADP+ oxidoreductase (A-specific). Other names in common use include 2-oxopantoyl lactone reductase, ketopantoyl lactone reductase, 2-ketopantoyl lactone reductase, and 2-dehydropantoyl-lactone reductase (A-specific).