Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase

In enzymology, a guanosine-3',5'-bis(diphosphate) 3'-diphosphatase is an enzyme that catalyzes the chemical reaction


 * guanosine 3',5'-bis(diphosphate) + H2O $$\rightleftharpoons$$ guanosine 5'-diphosphate + diphosphate

Thus, the two substrates of this enzyme are guanosine 3',5'-bis(diphosphate) and H2O, whereas its two products are guanosine 5'-diphosphate and diphosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on diphosphoric monoester bonds. The systematic name of this enzyme class is guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase. Other names in common use include guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase, PpGpp-3'-pyrophosphohydrolase, and PpGpp phosphohydrolase. This enzyme participates in purine metabolism.

Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code.