Sodium-hydrogen exchange regulatory cofactor 2

Sodium-hydrogen exchange regulatory cofactor 2 (gene name SLC9A3R2; also known as NHERF-2 and Tyrosine kinase activator protein 1) is a human scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. It is necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus.