Nifedipine side effects

List of side effects
Occurrence in > 3% of patients Occurrence in < 3% of patients Occurrence in < 1% of patients Post-marketing experience

Occurrence in > 3% of patients
The most common side effect reported with Nifedipine extended-release was edema which was dose related and ranged in frequency from approximately 10% to about 30% at the highest dose studied (180 mg). Other common adverse experiences reported in placebo-controlled trials include: headache, fatigue, dizziness, constipation, and nausea. Of these, only edema and headache were more common in Nifedipine extended-release patients than placebo patients. Return to top

Occurrence in < 3% of patients
The following adverse reactions occurred with an incidence of less than 3.0%. With the exception of leg cramps, the incidence of these side effects was similar to that of placebo alone. Return to top
 * Body as a Whole/Systemic: asthenia, flushing, pain
 * Cardiovascular: palpitations
 * Central Nervous System: insomnia, nervousness, paresthesia, somnolence
 * Dermatologic: pruritus, rash
 * Gastrointestinal: abdominal pain, diarrhea, dry mouth, dyspepsia, flatulence
 * Musculoskeletal: arthralgia, leg cramps
 * Respiratory: chest pain (nonspecific), dyspnea
 * Urogenital: impotence, polyuria

Occurrence in < 1% of patients
Other adverse reactions were reported sporadically with an incidence of 1.0% or less. These include: Return to top
 * Body as a Whole/Systemic: face edema, fever, hot flashes, malaise, periorbital edema, rigors
 * Cardiovascular: arrhythmia, hypotension, increased angina, tachycardia, syncope
 * Central Nervous System: anxiety, ataxia, decreased libido, depression, hypertonia, hypoesthesia, migraine, paroniria, tremor, vertigo
 * Dermatologic: alopecia, increased sweating, urticaria, purpura
 * Gastrointestinal: eructation, gastroesophageal reflux, gum hyperplasia, melena, vomiting, weight increase
 * Musculoskeletal: back pain, gout, myalgias
 * Respiratory: coughing, epistaxis, upper respiratory tract infection, respiratory disorder, sinusitis
 * Special Senses: abnormal lacrimation, abnormal vision, taste perversion, tinnitus
 * Urogenital/Reproductive: breast pain, dysuria, hematuria, nocturia

Post-marketing experience
In post-marketing experience, there have been rare reports of exfoliative dermatitis caused by Nifedipine. There have been rare reports of exfoliative or bullous skin adverse events (such as erythema multiforme, Stevens-Johnson Syndrome, and toxic epidermal necrolysis) and photosensitivity reactions. Return to top