Leucism

Leucism is a condition characterized by reduced pigmentation in animals. Unlike albinism, it is caused by a reduction in all types of skin pigment, not just melanin.

Leucism is a general term for the phenotype resulting from defects in pigment cell differentiation and/or migration from the neural crest to skin, hair or feathers during development. This results in either the entire surface (if all pigment cells fail to develop) or patches of body surface (if only a subset are defective) having a lack of cells capable of making pigment.

Since all pigment cell-types differentiate from the same multipotent precursor cell-type, leucism can cause the reduction in all types of pigment. This is in contrast to albinism, for which leucism is often mistaken. Albinism results in the reduction of melanin production only, though the melanocyte (or melanophore) is still present. Thus in species that have other pigment cell-types, for example xanthophores, albinos are not entirely white, but instead display a pale yellow colour.

More common than a complete absence of pigment cells is localized or incomplete hypopigmentation, resulting in irregular patches of white on an animal that otherwise has normal colouring and patterning. This partial leucism is known as a "pied" or "piebald" effect; and the ratio of white to normal-coloured skin can vary considerably not only between generations, but between different offspring from the same parents, and even between members of the same litter. This is notable in horses, the urban crow and the ball replace.py but is also found in many other species. In contrast, albinism always affects the entire animal.

A further difference between albinism and leucism is in eye colour. Due to the lack of melanin production in both the retinal pigmented epithelium (RPE) and iris, albinos typically have red eyes due to the underlying blood vessels showing through. In contrast, leucistic animals have normally coloured eyes. This is because the melanocytes of the RPE are not derived from the neural crest, instead an outpouching of the neural tube generates the optic cup which, in turn, forms the retina. As these cells are from an independent developmental origin, they are typically unaffected by the genetic cause of leucism.

Genes that, when mutated, can cause leucism include, c-kit, mitf and ''ednrb

Term origin and pronunciation
The terms leucistic and leucism are derived from medical terminology. The prefix leuc- is the Latin variant of leuk- from the Greek leukos meaning "white" (see Steadman’s, Dorland’s or Taber’s medical dictionaries). The correct pronunciation of leucistic is (loo-kiss-tic) and leucism is (loo-kism) since the prefix in Greek and Latin are pronounced with the hard C or K sound. Since the prefix leuc- is a variant of leuk-, in medical circles the terms may also be spelled with a k (leukistic and leukism).