Thiamine pyrophosphate

Thiamine pyrophosphate (TPP) or thiamine diphosphate (ThDP) is a thiamine derivative which is cleaved by thiamine pyrophosphatase. Thiamine phyrophosphate is the active form of thiamine (vitamin B1).

ThDP is a prosthetic group in many enzymes, such as:


 * Pyruvate dehydrogenase complex
 * Alpha-ketoglutarate dehydrogenase complex
 * Branched-chain amino acid dehydrogenase complex
 * 2-hydroxyphytanoyl-CoA lyase
 * Transketolase

Thiaminpyrophosphat Thiamine pyrophosphate