ADP-ribose diphosphatase

In enzymology, an ADP-ribose diphosphatase is an enzyme that catalyzes the chemical reaction


 * ADP-ribose + H2O $$\rightleftharpoons$$ AMP + D-ribose 5-phosphate

Thus, the two substrates of this enzyme are ADP-ribose and H2O, whereas its two products are AMP and D-ribose 5-phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is ADP-ribose ribophosphohydrolase. Other names in common use include ADPribose pyrophosphatase, adenosine diphosphoribose pyrophosphatase, and ADPR-PPase. This enzyme participates in purine metabolism.

Structural studies
As of late 2007, 26 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , , , , , , , , , , , , , , , , , and.