Spinal Muscular atrophy Molecular Biology

SMN (survival motor neuron) gene produces SMN protein. This protein is ubiquitously found in all cells (located in both the cytoplasm and in the nucleus).

The main function that is found to be associated with them are-
 * They are components of spliceosome, involved in pre-m-RNA splicing
 * Involved in actin cytoskeletal dynamics (motor axon pathfinding)
 * Appears to be involved in maintaining structural and physiological integrity of neuromuscular junction