Retinoblastoma natural history, complications, and prognosis

Overview
Retinoblastoma is a cancer of the retina. Development of this tumor is initiated by mutations that inactivate both copies of the RB1 gene, which codes for the retinoblastoma protein.

What to expect (Outlook/Prognosis)?
The prognosis of retinoblastoma depends on the following:
 * Whether or not the tumor can be removed by surgery.
 * The stage of the cancer: the size of the tumor, whether the cancer has spread
 * The child’s general health

Possible complications

 * Local spread of tumor.
 * Development of other tumors.
 * Cataract from radiotherapy.
 * Failure of tooth eruption after radiotherapy.
 * Bony deformities