Fukuyama indole synthesis

Overview
The Fukuyama indole synthesis is the chemical reaction of alkenylthioanilides to give 2,3-disubstituted indoles. Most commonly tributyltin hydride is utilized as the reducing agent, with azobisisobutyronitrile (AIBN) as a radical initiator.



Being one of the simplest methods for synthesizing poly-substituted indoles, this procedure has been utilized in numerous natural product syntheses, including aspidophytine, vinblastine , and strychnine.