Brimonidine drug interactions

List of drug interactions
CNS depressants/beta-blockers Tricyclic antidepressants

CNS depressants/beta-blockers
Although specific drug interaction studies have not been conducted with Brimonidine tartrate ophthalmic solution 0.2%, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, or anesthetics) should be considered. Alpha-agonists, as a class, may reduce pulse and blood pressure. Caution in using concomitant drugs such as beta-blockers (ophthalmic and systemic), antihypertensives and/or cardiac glycosides is advised. Return to top

Tricyclic antidepressants
Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine. It is not known whether the concurrent use of these agents with Brimonidine tartrate ophthalmic solution 0.2% in humans can lead to resulting interference with the IOP lowering effect. No data on the level of circulating catecholamines after Brimonidine tartrate ophthalmic solution 0.2% are available. Caution, however, is advised in patients taking tricyclic antidepressants which can affect the metabolism and uptake of circulating amines. Return to top

Major Interactions

 * Atapryl
 * Azilect
 * Carbex
 * Eldepryl
 * Emsam
 * furazolidone
 * Furoxone
 * isocarboxazid
 * Jumex
 * linezolid
 * Marplan
 * Matulane
 * Nardil
 * Parnate
 * phenelzine
 * procarbazine
 * rasagiline
 * selegiline
 * Selgene
 * tranylcypromine
 * Zelapar
 * Zyvox

Moderate Interactions

 * 40 Winks
 * Abilify
 * Abilify Discmelt
 * acetylcarbromal
 * Actiq
 * Adapin
 * Adgan
 * AHist
 * Akineton HCl
 * alcohol
 * alcohol
 * ethyl
 * Aler-Dryl
 * Aler-Tab
 * Alfenta
 * alfentanil
 * All Day Allergy
 * Aller-Chlor
 * Allergia-C
 * Allerhist-1
 * Allermax
 * alprazolam
 * alprazolam extended release
 * Altaryl
 * Ambien
 * Ambien CR
 * amitriptyline
 * amobarbital
 * amoxapine
 * Amrix
 * Amytal Sodium
 * Anafranil
 * Anergan 50
 * Antiflex
 * Antinaus 50
 * Antivert
 * Aquachloral Supprettes
 * aripiprazole
 * Artane
 * Asendin
 * Astelin
 * Astramorph PF
 * Atarax
 * Ativan
 * Aventyl HCl
 * Avinza
 * azatadine
 * azelastine nasal
 * B-Vex
 * baclofen
 * Banaril
 * Banflex
 * Banophen
 * Beldin
 * Belix
 * Ben-Tann
 * Benadryl
 * Benadryl Allergy
 * Benadryl Child Dye Free
 * Benadryl Childrens Allergy Fastmelt
 * Benadryl DF
 * Benadryl Dye Free Allergy
 * Benadryl Ultratab
 * Benahist-10
 * Benahist-50
 * Benoject-50
 * Benzacot
 * benztropine
 * Bidhist
 * biperiden
 * Bonine
 * Bromaphen
 * bromocriptine
 * bromodiphenhydramine
 * brompheniramine
 * brompheniramine extended release
 * BroveX
 * BroveX CT
 * Buprenex
 * buprenorphine
 * Busodium
 * Buspar
 * Buspar Dividose
 * Buspirone
 * butabarbital
 * butalbital
 * Butisol Sodium
 * butorphanol
 * butorphanol nasal
 * Bydramine
 * C.P.M.
 * Calm-Aid
 * cannabis (Schedule I substance)
 * Carbacot
 * carbamazepine
 * carbamazepine extended release
 * Carbatrol
 * carbetapentane
 * carbinoxamine
 * carbinoxamine extended release
 * Carbinoxamine PD
 * Carboxine
 * carisoprodol
 * Celexa
 * Celontin
 * Cerebyx
 * Cesamet
 * cetirizine
 * Chem Mart Tramadol
 * Chlo-Amine
 * Chlor-Al Rel
 * Chlor-Mal
 * Chlor-Phen
 * Chlor-Phenit
 * Chlor-Trimeton
 * Chlor-Trimeton Allergy SR
 * chloral hydrate
 * chlordiazepoxide
 * chlormezanone
 * Chlorphen
 * chlorphenesin
 * chlorpheniramine
 * Chlorpheniramine (Allergy)
 * chlorpheniramine 24 hour extended release
 * chlorpheniramine extended release
 * chlorpromazine
 * chlorpromazine extended release
 * ChlorTan
 * chlorzoxazone
 * citalopram
 * clemastine
 * Clomipramine
 * clonazepam
 * Clopine
 * clorazepate
 * clorazepate extended release
 * clozapine
 * Clozapine Synthon
 * Clozaril
 * codeine
 * codeine phosphate
 * codeine sulfate
 * Codimal A
 * Cogentin
 * Compazine
 * Compazine Spansule
 * Compoz Nighttime Sleep Aid
 * Compro
 * Comtan
 * Contac 12 Hour Allergy
 * Cophene B
 * Cordron NR
 * cyclizine
 * cyclobenzaprine
 * cyclobenzaprine extended release
 * Cymbalta
 * cyproheptadine
 * D-Vert
 * Dailyhist-1
 * Dalgan
 * Dalmane
 * Dantrium
 * Dantrium Intravenous
 * dantrolene
 * Darvon
 * Darvon-N
 * Dazidox
 * Dehydrated Alcohol
 * Demerol HCl
 * Denzapine
 * Depacon
 * Depakene
 * Depakote
 * Depakote ER
 * Depakote Sprinkles
 * DepoDur
 * desipramine
 * desvenlafaxine
 * Desyrel
 * Desyrel Dividose
 * dexbrompheniramine
 * dexchlorpheniramine
 * dexchlorpheniramine extended release
 * dexmedetomidine
 * dezocine
 * Di-Phen
 * Diamode
 * Diar-Aid
 * Diastat
 * Diastat AcuDial
 * Diastat Pediatric
 * diazepam
 * dichloralphenazone
 * difenoxin
 * dihydrocodeine
 * Dilantin
 * Dilantin Infatabs
 * Dilantin Kapseals
 * Dilantin-125
 * Dilaudid
 * Dilaudid-5
 * Dilaudid-HP
 * dimenhydrinate
 * Dimetane
 * Dimetane Extentab
 * Dimetapp Allergy
 * Dimetapp Allergy Liquigel
 * Diphedryl
 * Diphen
 * Diphen AF
 * Diphen Cough
 * Diphenadryl
 * Diphendryl
 * Diphenhist
 * diphenhydramine
 * diphenhydramine citrate
 * diphenhydramine tannate
 * Diphenmax
 * diphenoxylate
 * Diphenydramine Quick Melt
 * Diphenyl
 * Diphenylin
 * Diprivan
 * Diskets
 * divalproex sodium
 * divalproex sodium extended release
 * Dizac
 * DMH
 * Dolophine
 * Doloral
 * Doloral Sirop
 * Doral
 * doxepin
 * doxepin topical
 * doxylamine
 * DPH
 * Dramamine
 * Dramamine II
 * Dramoject
 * Driminate
 * Driminate II
 * Dromadol SR
 * Dromadol XL
 * dronabinol
 * droperidol
 * duloxetine
 * Duragesic
 * Duragesic-100
 * Duragesic-12
 * Duragesic-25
 * Duragesic-50
 * Duragesic-75
 * Duramorph PF
 * Dymenate
 * Dytan
 * Dytuss
 * Ed Chlor-Tan
 * Ed ChlorPed
 * Effexor
 * Effexor XR
 * Efidac-24 Chlorpheniramine
 * Elavil
 * Endep
 * Endocodone
 * entacapone
 * Epitol
 * Equanil
 * Equetro
 * escitalopram
 * Eskalith
 * Eskalith-CR
 * estazolam
 * eszopiclone
 * ETH-Oxydose
 * ethanol
 * ethchlorvynol
 * ethosuximide
 * ethotoin
 * Ethyl Alcohol
 * Eze D.S.
 * FazaClo
 * felbamate
 * Felbatol
 * fentanyl
 * fentanyl topical
 * Fentora
 * Fexmid
 * flavoxate
 * Flexeril
 * Flexoject
 * Flexon
 * fluoxetine
 * fluoxetine extended release
 * fluphenazine
 * fluphenazine decanoate
 * fluphenazine enanthate
 * fluphenazine hydrochloride
 * flurazepam
 * fluvoxamine
 * fluvoxamine extended release
 * fosphenytoin
 * gabapentin
 * Gabarone
 * Gabitril
 * Genahist
 * GenRx Tramadol
 * Geodon
 * halazepam
 * Halcion
 * Haldol
 * Haldol Decanoate
 * haloperidol
 * haloperidol decanoate
 * hashish
 * hashish (Schedule I substance)
 * heroin (Schedule I substance)
 * Histaject
 * Histex CT
 * Histex I/E
 * Histex PD
 * Histex Pd 12
 * Hydramine
 * Hydramine Compound
 * Hydramine Cough Syrup
 * Hydrate
 * hydrocodone
 * Hydromorph Contin
 * hydromorphone
 * hydromorphone extended release
 * Hydrostat IR
 * hydroxyzine
 * hydroxyzine hydrochloride
 * hydroxyzine pamoate
 * hypericum perforatum
 * Hyrexin
 * Hyzine
 * imipramine
 * imipramine pamoate
 * Imodium
 * Imodium A-D
 * Imodium A-D EZ Chews
 * Imodium A-D New Formula
 * Imotil
 * Inapsine
 * Infumorph
 * Invega
 * Ionsys
 * J-Tan
 * J-Tan PD
 * Kadian
 * Kao-Paverin
 * Kaopectate Caplet
 * Kemadrin
 * Keppra
 * Ketalar
 * ketamine
 * Klonopin
 * Klonopin Wafer
 * Lamictal
 * Lamictal Blue
 * Lamictal CD
 * Lamictal Green
 * Lamictal Orange
 * lamotrigine
 * Larapam SR
 * Largon
 * levetiracetam
 * Levo-Dromoran
 * levocetirizine
 * levomethadyl acetate
 * Levoprome
 * levorphanol
 * Levrix
 * Lexapro
 * Librium
 * Lioresal
 * Lioresal Intrathecal
 * lithium
 * lithium carbonate
 * lithium carbonate extended release
 * lithium citrate
 * Lithobid
 * Lithonate
 * Lithotabs
 * Lodrane 12 Hour
 * Lodrane 24
 * Lodrane XR
 * loperamide
 * lorazepam
 * loxapine
 * Loxitane
 * Loxitane C
 * Loxitane IM
 * Ludiomil
 * Luminal
 * Lunesta
 * Luvox
 * Luvox CR
 * Lyrica
 * M-Eslon
 * M-Oxy
 * M. O. S.
 * Maalox Anti-Diarrheal
 * Maolate
 * maprotiline
 * Marezine
 * marijuana (Do Not Order)
 * marijuana (Schedule I substance)
 * Marinol
 * MB-TAB
 * Mebaral
 * Meclicot
 * meclizine
 * Medivert
 * Mellaril
 * Mellaril-S
 * Meni-D
 * meperidine
 * mephenytoin
 * mephobarbital
 * meprobamate
 * Meridia
 * Mesantoin
 * mesoridazine
 * metaxalone
 * methadone
 * Methadose
 * methdilazine
 * methocarbamol
 * methotrimeprazine
 * methsuximide
 * metoclopramide
 * midazolam
 * Milontin
 * Miltown
 * Mio-Rel
 * Mirapex
 * mirtazapine
 * Mitran
 * Moban
 * molindone
 * morphine
 * morphine 24 hour extended release
 * morphine extended release
 * Morphine IR
 * morphine liposomal
 * Morphine LP Epidural
 * morphine preservative-free
 * Morphine Rapi-Ject
 * Morphitec
 * MS
 * MS Contin
 * MS/S
 * MSIR
 * Myolin
 * Mysoline
 * nabilone
 * nalbuphine
 * Nasahist B
 * Navane
 * ND-Stat
 * nefazodone
 * Nembutal
 * Nembutal Sodium
 * Nervine
 * Neupro
 * Neurontin
 * Nightime Sleepaid
 * Niravam
 * Nolahist
 * Norflex
 * Norflex Injectable
 * Norpramin
 * nortriptyline
 * Nu-Med
 * Nubain
 * Numorphan HCl
 * Nytol Caplet
 * Nytol Maximum Strength
 * olanzapine
 * OMS
 * Opana
 * Opana ER
 * opium
 * Opium Deodorized
 * Optimine
 * Oramorph SR
 * Orap
 * Orfro
 * Orlaam
 * Ormazine
 * orphenadrine
 * orphenadrine extended release
 * Orphenate
 * oxazepam
 * oxcarbazepine
 * oxycodone
 * oxycodone extended release
 * OxyContin
 * Oxyfast
 * OxyIR
 * oxymorphone
 * oxymorphone extended release
 * P-Tann
 * P-Tex
 * Palgic
 * paliperidone
 * Palladone
 * Palladone SR
 * Pamelor
 * Paradione
 * Paraflex
 * Parafon Forte DSC
 * Paral
 * paraldehyde
 * paramethadione
 * Pardryl
 * Paregoric
 * Parlodel
 * paroxetine
 * paroxetine extended release
 * paroxetine mesylate
 * Paxarel
 * Paxil
 * Paxil CR
 * PBZ
 * PBZ-SR
 * PCP (Do Not Order)
 * PCP (Schedule I substance)
 * PediaTan
 * Pediatex
 * Pediatex 12
 * Pediox
 * Pediox-S
 * Peganone
 * Pentazine
 * pentazocine
 * pentobarbital
 * Pentothal
 * Pepto Diarrhea Control
 * Percolone
 * pergolide
 * Periactin
 * Permax
 * Permitil
 * perphenazine
 * Pexeva
 * phenacemide
 * Phenadoz
 * Phenazine 50
 * phencyclidine (Schedule I substance)
 * Phenergan
 * Phenergan Fortis
 * phenindamine
 * pheniramine
 * phenobarbital
 * Phenoject-50
 * phensuximide
 * Phenurone
 * phenyltoloxamine
 * Phenytek
 * phenytoin
 * phenytoin extended release
 * Phenytoin Sodium
 * Prompt
 * pimozide
 * Placidyl
 * Polaramine
 * Polaramine Repetabs
 * PP-Cap
 * pramipexole
 * Precedex
 * pregabalin
 * Prialt
 * primidone
 * Pristiq
 * Pro-Med
 * prochlorperazine
 * prochlorperazine extended release
 * Procot
 * procyclidine
 * Prolixin
 * Prolixin Decanoate
 * Prolixin Enanthate
 * Promacot
 * promazine
 * promethazine
 * Promethegan
 * Prop-A-Tane
 * propiomazine
 * propofol
 * propoxyphene
 * propoxyphene hydrochloride
 * propoxyphene napsylate
 * Prorex
 * Prosom
 * protriptyline
 * Prozac
 * Prozac Weekly
 * Prudoxin
 * pyrilamine
 * pyrilamine extended release
 * Pyrlex
 * Q-Dryl
 * Q-Dryl A/F
 * Qdall AR
 * quazepam
 * Quenalin
 * quetiapine
 * quetiapine extended release
 * Rapiflux
 * Reglan
 * Relaxazone
 * Remeron
 * Remeron SolTab
 * remifentanil
 * Remular
 * Remular-S
 * Repreve
 * Requip
 * ReQuip Follow on Pack
 * Requip Starter Kit
 * ReQuip Starter Pack
 * Rescudose
 * Restoril
 * Rezine
 * Ridramin
 * Risperdal
 * Risperdal Consta
 * Risperdal M-Tab
 * risperidone
 * RMS
 * Robaxin
 * Robaxin-750
 * Rohist
 * ropinirole
 * rotigotine
 * Roxanol
 * Roxanol 100
 * Roxanol-T
 * Roxicodone
 * Roxicodone Intensol
 * Ru-Vert-M
 * Sarafem
 * Scot-Tussin Allergy Relief Formula
 * secobarbital
 * Seconal Sodium
 * Selfemra
 * Serax
 * Serentil
 * Seroquel
 * Seroquel XR
 * sertraline
 * Serzone
 * sibutramine
 * Siladryl
 * Siladryl DAS
 * Siladyl SA
 * Silphen Cough
 * Siltane
 * Simply Sleep
 * Sinequan
 * Skelaxin
 * Skelex
 * Sleep Tab II
 * Sleep Tabs
 * Sleep-ettes
 * Sleep-Eze-3
 * Sleepinal
 * sodium valproate
 * Solfoton
 * solotuss
 * Soma
 * Sominex
 * Sominex Maximum Strength Caplet
 * Somnicaps
 * Somnote
 * Sonata
 * Sparine
 * St. John's wort
 * Stadol
 * Stadol NS
 * Statex
 * Stelazine
 * Strifon Fort
 * Sublimaze
 * Subutex
 * Sufenta
 * sufentanil
 * Surmontil
 * Tacaryl
 * Talwin Lactate
 * Tanacof-XR
 * TanaHist-PD
 * Tasmar
 * Tavist
 * Tavist Allergy
 * Tavist-1
 * Tegretol
 * Tegretol XR
 * Temaril
 * temazepam
 * Terry White Chemists Tramadol
 * thalidomide
 * Thalomid
 * Theraflu Thin Strips Multi Symptom
 * thiethylperazine
 * thiopental
 * thioridazine
 * thiothixene
 * Thorazine
 * tiagabine
 * Ticon
 * Tigan
 * tizanidine
 * Tofranil
 * Tofranil-PM
 * tolcapone
 * Topamax
 * Topamax Sprinkle
 * topiramate
 * Torecan
 * Total Allergy
 * Tramadol
 * traMADOL extended release
 * Tramahexal
 * Tramahexal SR
 * Tramake
 * Tramake Insts
 * Tramal
 * Tramal SR
 * Tramedo
 * Trancopal
 * Tranxene SD
 * Tranxene T-Tab
 * Trazodone
 * Triaminic Allergy
 * Triaminic Thin Strips Cough & Runny Nose
 * triazolam
 * Tridione
 * trifluoperazine
 * triflupromazine
 * Trihexane
 * trihexyphenidyl
 * Trilafon
 * Trileptal
 * trimeprazine
 * trimethadione
 * trimethobenzamide
 * trimipramine
 * tripelennamine
 * Tripohist
 * triprolidine
 * triprolidine extended release
 * Triptone
 * Trux-adryl
 * Tusstat
 * Twilite
 * Ultiva
 * Ultram
 * Ultram ER
 * Uni-Tann
 * Unisom
 * Unisom Sleepgels Maximum Strength
 * Urispas
 * V-Gan-25
 * V-Gan-50
 * Valium
 * valproic acid
 * Valrelease
 * Valu-Dryl
 * Vanadom
 * Vanatrip
 * VaZol
 * venlafaxine
 * venlafaxine extended release
 * Versed
 * Vistacon
 * Vistacot
 * Vistaject-50
 * Vistaril
 * Vistaril IM
 * Vistazine
 * Vistazine 50
 * Vivactil
 * Wal-finate
 * Xanax
 * Xanax XR
 * Xyzal
 * Xyzall
 * zaleplon
 * Zamadol
 * Zamadol 24hr
 * Zamadol Melt
 * Zamadol SR
 * Zanaflex
 * Zaponex
 * Zarontin
 * Zetran
 * ziconotide
 * ziprasidone
 * Zoloft
 * zolpidem
 * zolpidem extended release
 * Zonalon
 * Zonegran
 * zonisamide
 * Zydol
 * Zydol SR
 * Zydol XL
 * Zymine
 * Zymine XR
 * Zyprexa
 * Zyprexa Zydis
 * Zyrtec
 * Zyrtec Hives

Minor Interactions

 * Accupril
 * acebutolol
 * Aceon
 * Adalat
 * Adalat CC
 * Afeditab CR
 * Akbeta
 * Aldomet
 * alfuzosin
 * alfuzosin extended release
 * Altace
 * amlodipine
 * atenolol
 * benazepril
 * bepridil
 * Betagan
 * Betagan C-Cap
 * Betapace
 * Betapace AF
 * Betapace AF(obsolete)
 * betaxolol
 * betaxolol ophthalmic
 * Betimol
 * Betoptic
 * Betoptic S
 * bisoprolol
 * Blocadren
 * Brevibloc
 * Calan
 * Calan SR
 * Capoten
 * captopril
 * Cardene
 * Cardene IV
 * Cardene SR
 * Cardizem
 * Cardizem CD
 * Cardizem LA
 * Cardizem Monovial
 * Cardizem SR
 * Cardoxin
 * Cardura
 * Cardura XL
 * Carduran
 * carteolol
 * carteolol ophthalmic
 * Cartia XT
 * Cartrol
 * carvedilol
 * carvedilol extended release
 * Cascor
 * Catapres
 * Catapres-TTS-1
 * Catapres-TTS-2
 * Catapres-TTS-3
 * clonidine
 * clonidine topical
 * Coreg
 * Coreg CR
 * Corgard
 * Covera-HS
 * deserpidine
 * diazoxide
 * Digitek
 * digitoxin
 * digoxin
 * digoxin capsule
 * Dilacor XR
 * Diltia XT
 * diltiazem
 * diltiazem 24 hour extended release
 * diltiazem extended release
 * Diltiazem Hydrochloride CD
 * Diltiazem Hydrochloride SR
 * Diltiazem Hydrochloride XR
 * Diltiazem Hydrochloride XT
 * Doxadura
 * doxazosin
 * doxazosin extended release
 * Duraclon
 * Dynacirc
 * Dynacirc CR
 * enalapril
 * enalaprilat
 * esmolol
 * felodipine
 * felodipine extended release
 * guanabenz
 * guanadrel
 * guanethidine
 * guanfacine
 * Harmonyl
 * Hylorel
 * Hyperstat
 * Hytrin
 * Inderal
 * Inderal LA
 * InnoPran XL
 * Ismelin
 * Isoptin
 * Isoptin I.V.
 * Isoptin SR
 * isradipine
 * isradipine extended release
 * Istalol
 * Kerlone
 * labetalol
 * Lanoxicaps
 * Lanoxin
 * Levatol
 * levobetaxolol ophthalmic
 * Levobunolol
 * levobunolol ophthalmic
 * lisinopril
 * Lopressor
 * Lotensin
 * methyldopa
 * metipranolol ophthalmic
 * metoprolol
 * metoprolol extended release
 * metoprolol succinate
 * Metoprolol Succinate ER
 * metoprolol tartrate
 * Minipress
 * moexipril
 * nadolol
 * nicardipine
 * nicardipine extended release
 * Nifediac CC
 * Nifedical XL
 * Nifedipine
 * Nifedipine extended release
 * nimodipine
 * Nimotop
 * nisoldipine
 * Nitropress
 * nitroprusside
 * Normodyne
 * Norvasc
 * Ocupress
 * OptiPranolol
 * penbutolol
 * perindopril
 * pindolol
 * Plendil
 * prazosin
 * Prinivil
 * Procardia
 * Procardia XL
 * Proglycem
 * propranolol
 * propranolol extended release
 * quinapril
 * ramipril
 * Rauwolfemms
 * Rauwolfia 1X
 * rauwolfia serpentina
 * reserpine
 * Sectral
 * sodium nitroprusside
 * Sorine
 * sotalol
 * Sotalol Hydrochloride AF
 * Sotalol Hydrochloride AF(obsolete)
 * Sular
 * Taztia XT
 * Tenex
 * Tenormin
 * terazosin
 * Tiazac
 * timolol
 * timolol hemihydrate ophthalmic
 * timolol ophthalmic
 * timolol ophthalmic long-acting
 * Timoptic Ocudose
 * Timoptic Ocumeter
 * Timoptic Ocumeter Plus
 * Timoptic-XE
 * Toprol-XL
 * Trandate
 * Univasc
 * Uroxatral
 * Vascor
 * Vasotec
 * verapamil
 * verapamil 24 hour extended release
 * verapamil extended release
 * Verelan
 * Verelan PM
 * Visken
 * Wytensin
 * Zebeta
 * Zestril