Epoxyeicosatrienoic acid

The Epoxyeicosatrienoic acids or EETs are signaling molecules formed by the action of Cytochrome P450 epoxygenase on 20-carbon essential fatty acids, such as arachidonic acid. These nonclassic eicosanoids act as short-range hormones, (i.e. they are autocrine and paracrine mediators) of the cardiovascular system and kidney. They produce vasorelaxation as well as anti-inflammatory and pro-fibrinolytic effects.

Biological effects
EETs are cardioprotective after ischemic heart attack and reperfusion. They act in the corpus cavernosum to maintain penile erection. Specific epoxidation of EET sites produces endogenous PPARα agonists.