Lysine dehydrogenase

In enzymology, a lysine dehydrogenase is an enzyme that catalyzes the chemical reaction


 * L-lysine + NAD+ $$\rightleftharpoons$$ 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH + H+

Thus, the two substrates of this enzyme are L-lysine and NAD+, whereas its 4 products are 1,2-didehydropiperidine-2-carboxylate, NH3, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-lysine:NAD+ oxidoreductase (deaminating, cyclizing).