HLA-A24

HLA-A24 (A24) is an HLA-A serotype. The serotype identifies the more common HLA-A*24 gene products. A24 is a split antigen that is also recognized by the A9 broad antigen type. This broad antigen also recognizes the similar A23 types. A24 is common in Austronesia. A*2402 has one of the highest A allele frequencies for a number of peoples, including Papua New Guineans, Indigeonous Taiwanese (Eastern Tribals), Yupik and Greenland Eskimos. It is common over much of Southeastern Asia. In eurasia it is least common in Ireland, and it is relatively uncommon in Africa except North Africa and Kenya.

Serotype
There are over 90 known A*24 alleles, 69 code for different isoforms and 7 are nulls.

By serotype
A24 has a secondary risk factor for myasthenia gravis,, Buerger's disease

By allele
A*2402 is a secondary risk factor, alters type 1 diabetes risk, and allele associated with thyomoma induced myasthenia gravis.

A24-B Haplotypes
A24-Cw7-B39 A24-Cw10-B60 A24-Cw10-B61 A24-B48

A24-Cw4-B35
This particular haplotype is common across a fairly wide region, possibly the most widely spread A-Cw-B haplotype in humans. Cw4-B35 has a node within the region once referred to as Thracia/Dacia.