Monosialoganglioside sialyltransferase

In enzymology, a monosialoganglioside sialyltransferase is an enzyme that catalyzes the chemical reaction


 * CMP-N-acetylneuraminate + D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D- galactosyl-D-glucosylceramide $$\rightleftharpoons$$ CMP + N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N- acetylneuraminyl)-D-galactosyl-D-glucosylceramide

The 3 substrates of this enzyme are CMP-N-acetylneuraminate, D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-, and galactosyl-D-glucosylceramide, whereas its 3 products are CMP, N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-, and acetylneuraminyl)-D-galactosyl-D-glucosylceramide.

This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-ac etylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetylneuraminyltransferase.