Glutathione reductase

Glutathione reductase is an enzyme which reduces glutathione disulphide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant.

For every mole of GSSG one mole of NADPH is required.

In cells exposed to high levels of oxidative stress, like red blood cells, up to 10% of the glucose consumption may be used for production of the NADPH needed for this reaction.