Trimeperidine

Trimeperidine (Promedol) is an opioid analgesic that is an analogue of prodine. It was developed in the 1950s during research into the related drug pethidine.

Trimeperidine has four structural isomers, of which two are active, the γ isomer trimeperidine, and the β isomer isopromedol. It is around half the potency of morphine as an analgesic, and has been widely used for the treatment of pain. Trimeperidine produces similar effects to other opioids, such as analgesia and sedation, along with side effects such as nausea, itching, vomiting and respiratory depression which may be harmful or fatal.