Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)

there are 5 articles for malate dehydrogenase. i wish i knew how to fix this.

In enzymology, a malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) is an enzyme that catalyzes the chemical reaction


 * (S)-malate + NADP+ $$\rightleftharpoons$$ pyruvate + CO2 + NADPH

Thus, the two substrates of this enzyme are (S)-malate and NADP+, whereas its 3 products are pyruvate, CO2, and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating). Other names in common use include 'malic' enzyme, pyruvic-malic carboxylase, malate dehydrogenase (decarboxylating, NADP+), NADP+-linked decarboxylating malic enzyme, NADP+-malic enzyme, NADP+-specific malic enzyme, NADP+-specific malate dehydrogenase, malate dehydrogenase (NADP+, decarboxylating), L-malate:NADP+ oxidoreductase, and malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+). This enzyme participates in pyruvate metabolism and carbon fixation.

Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes, , and.