Doxazosin drug interactions

Most (98%) of plasma Doxazosin is protein bound. In vitro data in human plasma indicate that Doxazosin mesylate has no effect on protein binding of digoxin, warfarin, phenytoin or indomethacin. There is no information on the effect of other highly plasma protein bound drugs on Doxazosin binding. Doxazosin mesylate has been administered without any evidence of an adverse drug interaction to patients receiving thiazide diuretics, beta-blocking agents, and nonsteroidal anti-inflammatory drugs. In a placebo-controlled trial in normal volunteers, the administration of a single 1 mg dose of Doxazosin on day 1 of a four-day regimen of oral cimetidine (400 mg twice daily) resulted in a 10% increase in mean AUC of Doxazosin (p = 0.006), and a slight but not statistically significant increase in mean Cmax and mean half-life of Doxazosin. The clinical significance of this increase in Doxazosin AUC is unknown.

In clinical trials, Doxazosin mesylate tablets have been administered to patients on a variety of concomitant medications; while no formal interaction studies have been conducted, no interactions were observed. Doxazosin mesylate tablets have been used with the following drugs or drug classes: 1) analgesic/anti-inflammatory (e.g., acetaminophen, aspirin, codeine and codeine combinations, ibuprofen, indomethacin); 2) antibiotics (e.g., erythromycin, trimethoprim and sulfamethoxazole, amoxicillin); 3) antihistamines (e.g., chlorpheniramine); 4) cardiovascular agents (e.g., atenolol, hydrochlorothiazide, propranolol); 5) corticosteroids; 6) gastrointestinal agents (e.g., antacids); 7) hypoglycemics and endocrine drugs; 8) sedatives and tranquilizers (e.g., diazepam); 9) cold and flu remedies.

Cardiac Toxicity in Animals: An increased incidence of myocardial necrosis or fibrosis was displayed by Sprague-Dawley rats after 6 months of dietary administration at concentrations calculated to provide 80 mg Doxazosin/kg/day and after 12 months of dietary administration at concentrations calculated to provide 40 mg Doxazosin/kg/day (AUC exposure in rats 8 times the human AUC exposure with a 12 mg/day therapeutic dose). Myocardial fibrosis was observed in both rats and mice treated in the same manner with 40 mg Doxazosin/kg/day for 18 months (exposure 8 times human AUC exposure in rats and somewhat equivalent to human Cmax exposure in mice). No cardiotoxicity was observed at lower doses (up to 10 or 20 mg/kg/day, depending on the study) in either species. These lesions were not observed after 12 months of oral dosing in dogs at maximum doses of 20 mg/kg/day [maximum plasma concentrations (Cmax) in dogs 14 times the Cmax exposure in humans receiving a 12 mg/day therapeutic dose] and in Wistar rats at doses of 100 mg/kg/day (Cmax exposures 15 times human Cmax exposure with a 12 mg/day therapeutic dose). There is no evidence that similar lesions occur in humans.

Major Interactions

 * GHB
 * sodium oxybate
 * tizanidine
 * Xyrem
 * Zanaflex

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0-9

 * 40 Winks

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A

 * A-Hydrocort
 * A-Methapred
 * Abilify
 * Abilify Discmelt
 * Accupril
 * acebutolol
 * Aceon
 * Acetocot
 * acetylcarbromal
 * ACTH
 * ACTH Gel
 * ACTH-40 HP
 * ACTH-80
 * Acthar
 * Acthar Gel H.P.
 * Acthrel
 * Actiq
 * Adalat
 * Adalat CC
 * Adapin
 * Adbeon
 * Adgan
 * Adlone-40
 * Adlone-80
 * Adrenocot
 * Adrenocot L.A.
 * Afeditab CR
 * Akbeta
 * alcohol
 * alcohol ethyl
 * aldesleukin
 * Aler-Dryl
 * Aler-Tab
 * Alfenta
 * alfentanil
 * alfuzosin
 * alfuzosin extended release
 * All Day Allergy
 * Allergia-C
 * Allermax
 * Altace
 * Altaryl
 * Ambien
 * Ambien CR
 * amifostine
 * amitriptyline
 * amoxapine
 * Anafranil
 * Anergan 50
 * Antiflex
 * Antinaus 50
 * APO-Go
 * APO-Go Pen
 * Apokyn
 * apomorphine
 * Aquachloral Supprettes
 * Aquacot
 * Aquatensen
 * Aquazide H
 * aripiprazole
 * Aristocort
 * Aristocort For Injection
 * Aristocort Forte
 * Aristopak
 * Aristospan Injection
 * Asendin
 * Astramorph PF
 * Atarax
 * atenolol
 * Ativan
 * Aventyl HCl
 * Avinza
 * Azmacort

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B

 * baclofen
 * Banaril
 * Banflex
 * Banophen
 * Beldin
 * Belix
 * Ben-Tann
 * Benadryl
 * Benadryl Allergy
 * Benadryl Child Dye Free
 * Benadryl Childrens Allergy Fastmelt
 * Benadryl DF
 * Benadryl Dye Free Allergy
 * Benadryl Ultratab
 * Benahist-10
 * Benahist-50
 * benazepril
 * bendroflumethiazide
 * Benoject-50
 * benzthiazide
 * Beta-Phos/AC
 * Betagan
 * Betagan C-Cap
 * betamethasone
 * betamethasone acet-betamethasone na phosphate
 * betamethasone sodium phosphate
 * Betapace
 * Betapace AF
 * Betapace AF (obsolete)
 * betaxolol
 * betaxolol ophthalmic
 * Betimol
 * Betoptic
 * Betoptic S
 * bisoprolol
 * Blocadren
 * Brevibloc
 * Bubbli-Pred
 * Budeprion SR
 * Budeprion XL
 * budesonide
 * Buprenex
 * buprenorphine
 * bupropion
 * bupropion 24 hour extended release
 * bupropion extended release
 * Busodium
 * BuSpar
 * BuSpar Dividose
 * buspirone
 * butabarbital
 * butalbital
 * Butisol Sodium
 * butorphanol
 * butorphanol nasal
 * Bydramine
 * Bystolic

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C

 * cabergoline
 * Calan
 * Calan SR
 * Calm-Aid
 * Capoten
 * captopril
 * Carbacot
 * carisoprodol
 * Carozide
 * carteolol
 * carteolol ophthalmic
 * Cartrol
 * carvedilol
 * carvedilol extended release
 * Catapres
 * Catapres-TTS-1
 * Catapres-TTS-2
 * Catapres-TTS-3
 * Celestone
 * Celestone Phosphate
 * Celestone Soluspan
 * Celexa
 * Cell-U-Jec
 * cetirizine
 * chloral hydrate
 * chlordiazepoxide
 * chlormezanone
 * chlorothiazide
 * chlorpromazine
 * chlorpromazine extended release
 * chlorthalidone
 * chlorzoxazone
 * Cialis
 * citalopram
 * Clinacort
 * Clinalog
 * clomipramine
 * clonidine
 * clonidine topical
 * Clopine
 * clorazepate
 * clorazepate extended release
 * clozapine
 * Clozapine Synthon
 * Clozaril
 * codeine
 * codeine phosphate
 * codeine sulfate
 * Colocort
 * Compazine
 * Compazine Spansule
 * Compoz Nighttime Sleep Aid
 * Compro
 * Coreg
 * Coreg CR
 * Corgard
 * Corlopam
 * Cort-K
 * Cortastat
 * Cortastat 10
 * Cortastat LA
 * Cortef
 * Cortenema
 * corticorelin
 * corticotropin
 * Cortifoam
 * cortisone
 * Cortone Acetate
 * Cortrosyn
 * cosyntropin
 * Cotolone
 * Covera-HS

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D

 * Dalalone
 * Dalalone D.P.
 * Dalalone L.A.
 * Dalgan
 * Dalmane
 * Dazidox
 * De-Sone LA
 * Decadron
 * Decadron 5-12 Pak
 * Decadron Phosphate Injectable
 * Decadron-LA
 * Decaject
 * Decaject L.A.
 * Dehydrated Alcohol
 * Deltasone
 * Demerol HCl
 * Denzapine
 * Dep Medalone 80
 * Depmedalone
 * Depo-Medrol
 * Depo-Predate (obsolete)
 * Depoject-80
 * Depopred
 * Desyrel
 * Desyrel Dividose
 * Dexacen-4
 * Dexacort Phosphate in Respihaler
 * Dexacort-LA
 * Dexacorten
 * dexamethasone
 * dexamethasone acetate
 * Dexamethasone Intensol
 * dexamethasone sodium phosphate
 * Dexasone
 * Dexasone LA
 * Dexone
 * Dexone LA
 * Dexpak Jr. Taperpak
 * Dexpak Taperpak
 * dezocine
 * Diaqua
 * Diastat
 * Diastat AcuDial
 * Diastat Pediatric
 * diazepam
 * dichloralphenazone
 * dihydrocodeine
 * Dilaudid
 * Dilaudid-5
 * Dilaudid-HP
 * Diphedryl
 * Diphen
 * Diphen AF
 * Diphen Cough
 * Diphenadryl
 * Diphendryl
 * Diphenhist
 * diphenhydramine
 * diphenhydramine citrate
 * diphenhydramine tannate
 * Diphenmax
 * Diphenydramine Quick Melt
 * Diphenyl
 * Diphenylin Diskets
 * Diucardin
 * Diurese
 * Diuril
 * Diuril Sodium
 * Dizac
 * Dolophine
 * Doloral
 * Doloral Sirop
 * Dopar
 * Doral
 * Dostinex
 * doxepin
 * doxepin topical
 * DPH
 * Duraclon
 * Duragesic
 * Duragesic-100
 * Duragesic-12
 * Duragesic-25
 * Duragesic-50
 * Duragesic-75
 * Duralone
 * Duramorph PF
 * Dytan
 * Dytuss

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E

 * Effexor
 * Effexor XR
 * Elavil
 * enalapril
 * enalaprilat
 * Endep
 * Endocodone
 * Enduron
 * Entocort
 * Entocort EC
 * epoprostenol
 * Equanil
 * escitalopram
 * Esidrix
 * Eskalith
 * Eskalith-CR
 * esmolol
 * estazolam
 * ETH-Oxydose
 * ethanol
 * Ethyl Alcohol
 * Ethyol
 * Exna
 * Eze D.S.
 * Ezide

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F

 * FazaClo
 * fenoldopam
 * fentanyl
 * fentanyl topical
 * Fentora
 * Flexoject
 * Flexon
 * Flo-Pred
 * Flolan
 * Florinef Acetate
 * fludrocortisone
 * fluoxetine
 * fluoxetine extended release
 * fluphenazine
 * fluphenazine decanoate
 * fluphenazine enanthate
 * fluphenazine hydrochloride
 * flurazepam
 * fluvoxamine
 * fluvoxamine extended release
 * fosinopril

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G

 * Genahist
 * Geodon

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H

 * halazepam
 * Halcion
 * HCTZ
 * Hexadrol
 * Hexadrol Phosphate
 * Hydeltra-T.B.A.
 * Hydeltrasol
 * Hydramine
 * Hydramine Compound
 * Hydramine Cough Syrup
 * Hydro Par
 * hydrochlorothiazide
 * hydrocodone
 * hydrocortisone
 * hydrocortisone acetate
 * hydrocortisone cypionate
 * hydrocortisone hemisuccinate
 * hydrocortisone sodium phosphate
 * Hydrocortisone Sodium Succinate
 * Hydrocortone
 * Hydrocortone Phosphate
 * Hydrodiuril
 * hydroflumethiazide
 * Hydromorph Contin
 * hydromorphone
 * hydromorphone extended release
 * Hydrostat IR
 * hydroxyzine
 * hydroxyzine hydrochloride
 * hydroxyzine pamoate
 * Hygroton
 * Hyrexin
 * Hyzine

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I

 * iloprost
 * imipramine
 * imipramine pamoate
 * indapamide
 * Inderal
 * Inderal LA
 * Infumorph
 * InnoPran XL
 * Invega
 * Ionsys
 * Isoptin
 * Isoptin I.V.
 * Isoptin SR
 * Istalol

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K

 * Kadian
 * Ken-Jec 40
 * Kenaject-40
 * Kenalog-10
 * Kenalog-40
 * Kerlone
 * Key-Pred
 * Key-Pred SP

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L

 * labetalol
 * Largon
 * Larodopa
 * Levatol
 * Levitra
 * Levo-Dromoran
 * levobetaxolol ophthalmic
 * Levobunolol
 * levobunolol ophthalmic
 * levocetirizine
 * levodopa
 * levorphanol
 * Levrix
 * Lexapro
 * Librium
 * Lioresal
 * Lioresal Intrathecal
 * Liquid Pred
 * lisinopril
 * lithium
 * lithium carbonate
 * lithium carbonate extended release
 * lithium citrate
 * Lithobid
 * Lithonate
 * Lithotabs
 * Lopressor
 * Loqua
 * lorazepam
 * Lotensin
 * Lozol
 * Ludiomil
 * Luminal
 * Luvox
 * Luvox CR

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M

 * M-Eslon
 * M-Oxy
 * M-prednisolone
 * M. O. S.
 * maprotiline
 * maraviroc
 * Mavik
 * MB-TAB
 * Mebaral
 * Med-Jec-40
 * Medicort
 * Medidex
 * Medidex LA
 * Medipred
 * Medralone
 * Medralone 40
 * Medralone 80
 * Medrol
 * Medrol Dosepak
 * Mellaril
 * Mellaril-S
 * meperidine
 * mephobarbital
 * meprobamate
 * mesoridazine
 * Metahydrin
 * metaxalone
 * Methacort 40
 * Methacort 80
 * methadone
 * Methadose
 * methocarbamol
 * methyclothiazide
 * Methylcotol
 * Methylcotolone
 * Methylpred DP
 * methylprednisolone
 * methylprednisolone acetate
 * Methylprednisolone Dose Pack
 * methylprednisolone sodium succinate
 * Meticorten
 * metipranolol ophthalmic
 * metolazone
 * metoprolol
 * metoprolol extended release
 * metoprolol succinate
 * Metoprolol Succinate ER
 * metoprolol tartrate
 * Microzide
 * midazolam
 * midodrine
 * Miltown
 * minoxidil topical
 * Mio-Rel
 * mirtazapine
 * Mitran
 * Moban
 * moexipril
 * molindone
 * Monopril
 * morphine
 * morphine 24 hour extended release
 * morphine extended release
 * Morphine IR
 * Morphine LP Epidural
 * morphine preservative-free
 * Morphine Rapi-Ject
 * Morphitec
 * MS
 * MS Contin
 * MS/S
 * MSIR
 * Mykrox
 * Myolin

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N

 * Nadolol
 * Nalbuphine
 * Naqua
 * Naturetin-10
 * Naturetin-5
 * Navane
 * Nebivolol
 * Nefazodone
 * Nembutal
 * Nembutal Sodium
 * Nervine
 * Nifediac CC
 * Nifedical XL
 * Nifedipine
 * Nifedipine extended release
 * Nightime Sleepaid
 * Norflex
 * Norflex Injectable
 * Normodyne
 * Nortriptyline
 * Nu-Med
 * Nubain
 * Numorphan HCl
 * Nytol Caplet

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O

 * Ocupress
 * olanzapine
 * OMS
 * Opana
 * Opana ER
 * opium
 * Opium Deodorized
 * OptiPranolol
 * Oramorph SR
 * Orapred
 * Orapred ODT
 * Orasone
 * Oretic
 * Orfro
 * Ormazine
 * orphenadrine
 * orphenadrine extended release
 * Orphenate
 * Orvaten
 * oxazepam
 * oxycodone
 * oxycodone extended release
 * OxyContin
 * Oxyfast
 * OxyIR
 * oxymorphone
 * oxymorphone extended release

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P

 * paliperidone
 * Palladone
 * Palladone SR
 * Pamelor
 * Paraflex
 * Parafon Forte DSC
 * Paral
 * paraldehyde
 * Pardryl
 * Paregoric
 * paroxetine
 * paroxetine extended release
 * paroxetine mesylate
 * Paxarel
 * Paxil
 * Paxil CR
 * Pediapred
 * penbutolol
 * Pentazine
 * pentazocine
 * pentobarbital
 * Percolone
 * perindopril
 * Permitil
 * perphenazine
 * Pexeva
 * Phenadoz
 * Phenazine 50
 * Phenergan
 * Phenergan Fortis
 * phenobarbital
 * Phenoject-50
 * pindolol
 * polythiazide
 * Pred-Ject-50
 * Predacort 50
 * Predacorten
 * Predaject-50
 * Predalone 50
 * Predate-50
 * Predcor
 * Predicort RP
 * Predicort-50
 * Prednicen-M
 * Prednicot
 * prednisolone
 * prednisoloneacetate
 * prednisolonesodium phosphate
 * prednisolonetebutate
 * prednisone
 * Prelone
 * Pri-Cortin 50
 * Primethasone
 * Prinivil
 * Pro-Med
 * ProAmatine
 * Procardia
 * Procardia XL
 * prochlorperazine
 * prochlorperazine extended release
 * Procot
 * Proleukin
 * Prolixin
 * Prolixin Decanoate
 * Prolixin Enanthate
 * Promacot
 * promazine
 * promethazine
 * Promethegan
 * propiomazine
 * propranolol
 * propranolol extended release
 * Prorex
 * Prosom
 * prostacyclin
 * protriptyline
 * Prozac
 * Prozac Weekly
 * Prudoxin
 * Pulmicort Flexhaler
 * Pulmicort Nebuamp
 * Pulmicort Respules
 * Pulmicort Turbuhaler

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Q

 * Q-Dryl
 * Q-Dryl A/F
 * quazepam
 * Quenalin
 * quetiapine
 * quetiapine extended release
 * quinapril

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R

 * ramipril
 * Rapiflux
 * Relaxazone
 * Remeron
 * Remeron SolTab
 * remifentanil
 * Remodulin
 * Remular
 * Remular-S
 * Renese
 * Rescudose
 * Restoril
 * Revatio
 * Rezine
 * Risperdal
 * Risperdal Consta
 * Risperdal M-Tab
 * risperidone
 * RMS
 * Robaxin
 * Robaxin-750
 * Rogaine
 * Rogaine Extra Strength
 * Ronoxidil
 * Roxanol
 * Roxanol 100
 * Roxanol-T
 * Roxicodone
 * Roxicodone Intensol

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S

 * Saluron
 * Sarafem
 * Scot-Tussin Allergy Relief Formula
 * secobarbital
 * Seconal Sodium
 * Sectral
 * Selestoject
 * Selzentry
 * Serax
 * Serentil
 * Seroquel
 * Seroquel XR
 * sertraline
 * Serzone
 * Siladryl
 * Siladryl DAS
 * Siladyl SA
 * sildenafil
 * Silphen Cough
 * Simply Sleep
 * Sinequan
 * Skelaxin
 * Skelex
 * Sleep Tab II
 * Sleep Tabs
 * Sleep-ettes
 * Sleep-Eze-3
 * Sleepinal
 * Solfoton
 * Solu-Cortef
 * Solu-Medrol
 * Solurex
 * Solurex LA
 * Soma
 * Sominex
 * Sominex Maximum Strength Caplet
 * Somnicaps
 * Somnote
 * Sonata
 * Sorine
 * sotalol
 * Sotalol Hydrochloride AF
 * Sotalol Hydrochloride AF(obsolete)
 * Sparine
 * Stadol
 * Stadol NS
 * Statex
 * Stelazine
 * Sterapred
 * Sterapred DS
 * Strifon Fort
 * Sublimaze
 * Subutex
 * Sufenta
 * sufentanil
 * Surmontil

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T

 * TAC 3
 * tadalafil
 * Talwin Lactate
 * temazepam
 * Tenormin
 * Thalitone
 * Theraflu Thin Strips Multi Symptom
 * thioridazine
 * thiothixene
 * Thorazine
 * timolol
 * timolol hemihydrate ophthalmic
 * timolol ophthalmic
 * timolol ophthalmic long-acting
 * Timoptic Ocudose
 * Timoptic Ocumeter
 * Timoptic Ocumeter Plus
 * Timoptic-XE
 * Tofranil
 * Tofranil-PM
 * Toprol-XL
 * Total Allergy
 * Tramacort-D
 * Trancopal
 * Trandate
 * trandolapril
 * Tranxene SD
 * Tranxene T-Tab
 * trazodone
 * treprostinil
 * Triam-A
 * Triam-Forte
 * triamcinolone
 * triamcinolone acetonide
 * triamcinolone diacetate
 * triamcinolone hexacetonide
 * Triamcot
 * Triaminic Thin Strips Cough & Runny Nose
 * Triamonide 40
 * triazolam
 * trichlormethiazide
 * trifluoperazine
 * triflupromazine
 * Trilafon
 * Trilog
 * Trilone
 * trimipramine
 * Tristoject
 * Trux-adryl
 * Tusstat
 * Twilite

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U

 * U-Tri-Lone
 * Ultiva
 * Uni-Tann
 * Unisom Sleepgels Maximum Strength
 * Univasc
 * Uprima
 * Uroxatral

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V

 * V-Gan-25
 * V-Gan-50
 * Valium
 * Valrelease
 * Valu-Dryl
 * Vanadom
 * Vanatrip
 * vardenafil
 * Vasotec
 * venlafaxine
 * venlafaxine extended release
 * Ventavis
 * verapamil
 * verapamil 24 hour extended release
 * verapamil extended release
 * Verelan
 * Verelan PM
 * Versed
 * verteporfin
 * Viagra
 * Visken
 * Vistacon
 * Vistacot
 * Vistaject-50
 * Vistaril
 * Vistaril IM
 * Vistazine
 * Vistazine 50
 * Visudyne
 * Vivactil

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W

 * Wellbutrin
 * Wellbutrin SR
 * Wellbutrin XL

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X

 * Xyzal
 * XYZALL

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Z

 * zaleplon
 * Zaponex
 * Zaroxolyn
 * Zebeta
 * Zestril
 * Zetran
 * ziprasidone
 * Zoloft
 * zolpidem
 * zolpidem extended release
 * Zonalon
 * Zyban
 * Zyban Advantage Pack
 * Zyprexa
 * Zyprexa Zydis
 * Zyrtec
 * Zyrtec Hives

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Minor Interactions

 * Alphagan
 * Alphagan P
 * apraclonidine ophthalmic
 * Atapryl
 * Azilect
 * brimonidine ophthalmic
 * Carbex
 * Eldepryl
 * Emsam
 * furazolidone
 * Furoxone
 * Iopidine
 * isocarboxazid
 * Jumex
 * linezolid
 * Marplan
 * Matulane
 * Nardil
 * Parnate
 * phenelzine
 * procarbazine
 * rasagiline
 * selegiline
 * Selgene
 * tranylcypromine
 * Zelapar
 * Zyvox

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