Hemolytic-uremic syndrome (patient information)

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Overview
Hemolytic-uremic syndrome (HUS) is a disorder that usually occurs when an infection in the digestive system produces toxic substances that destroy red blood cells, causing kidney injury.

What are the symptoms of Hemolytic-uremic syndrome?

 * HUS often begins with vomiting and diarrhea, which may be bloody. Within a week, the person may become weak and irritable. Persons with this condition may urinate less than normal. Urine output may almost stop.


 * Red blood cell destruction leads to symptoms of anemia.


 * Early symptoms:
 * Blood in the stools
 * Irritability
 * Fever
 * Lethargy
 * Vomiting and diarrhea
 * Weakness


 * Later symptoms:
 * Bruising
 * Decreased consciousness
 * Low urine output
 * No urine output
 * Pallor
 * Seizures -- rare
 * Skin rash that looks like fine red spots (petechiae)
 * Yellow skin (jaundice)

What causes Hemolytic-uremic syndrome?

 * Hemolytic-uremic syndrome (HUS) often occurs after a gastrointestinal infection with E. coli bacteria (Escherichia coli O157:H7). However, the condition has also been linked to other gastrointestinal infections, including shigella and salmonella, as well as nongastrointestinal infections.

Who is at highest risk?

 * HUS is most common in children. It is the most common cause of acute kidney failure in children. Several large outbreaks in 1992 and 1993 were linked to undercooked hamburger meat contaminated with E. coli.


 * Other risk factors for HUS are unknown, although some cases are due to a familial form of the disease. HUS may occur with a variety of other diseases and infections, and after taking certain medications such as mitomycin C or ticlopidine.


 * HUS is more complicated in adults. It is similar to another disease called thrombotic thrombocytopenic purpura (TTP).

When to seek urgent medical care?

 * Call your health care provider if you develop symptoms of HUS. Emergency symptoms include:
 * Blood in the stool
 * No urination
 * Reduced alertness (consciousness)


 * Call your health care provider if you have had an episode of HUS and your urine output decreases, or you develop other new symptoms.

Diagnosis

 * The health care provider will perform a physical exam. This may show:
 * Liver or spleen swelling
 * Nervous system changes


 * Laboratory tests will show signs of hemolytic anemia and acute renal failure. Laboratory tests may include:
 * Blood clotting tests (PT and PTT)
 * Comprehensive metabolic panel may show increased levels of BUN and creatinine
 * Complete blood count (CBC) may show increased white blood cell count and decreased red blood cell count
 * Platelet count is usually reduced
 * Urinalysis may reveal blood and protein in the urine
 * Urine protein test can be used to show the amount of protein in the urine


 * Other tests:
 * Kidney biopsy
 * Stool culture may be positive for a certain type of E. coli bacteria or other bacteria

Treatment options
You can prevent the known cause, E. coli, by cooking hamburger and meats well and avoiding contact with unclean water.


 * Treatment may involve:
 * Dialysis
 * Medications such as corticosteroids
 * Transfusions of packed red blood cells and platelets


 * Some people may have the liquid portion of their blood (plasma) removed and replaced with fresh (donated) plasma, or the plasma is filtered to remove antibodies from the blood.

Where to find medical care for Hemolytic-uremic syndrome?
Directions to Hospitals Treating Hemolytic-uremic syndrome

What to expect (Outlook/Prognosis)?
This is a serious illness in both children and adults, and it can cause death. With proper treatment, more than half of patients will recover. The outcome is better in children than adults.

Possible complications

 * Blood clotting problems
 * Hemolytic anemia
 * Kidney failure
 * Nervous system problems
 * Too few platelets (thrombocytopenia)
 * Uremia

Source
http://www.nlm.nih.gov/medlineplus/ency/article/000510.htm