Nitrofurantoin contraindications

List of contraindications
Anuria, oliguria, or significant impairment of renal function Pregnant patients Neonates under one month of age Nitrofurantoin hypersensitivity

Anuria, oliguria, or significant impairment of renal function
Anuria, oliguria, or significant impairment of renal function (creatinine clearance under 60 mL per minute or clinically significant elevated serum creatinine) are contraindications. Treatment of this type of patient carries an increased risk of toxicity because of impaired excretion of the drug. Return to top

Pregnant patients
Because of the possibility of hemolytic anemia due to immature erythrocyte enzyme systems (glutathione instability), the drug is contraindicated in pregnant patients at term (38 to 42 weeks gestation), during labor and delivery, or when the onset of labor is imminent. Return to top

Neonates under one month of age
Nitrofurantoin is contraindicated in neonates under one month of age. Return to top

Nitrofurantoin hypersensitivity
Nitrofurantoin monohydrate/macrocrystals capsules are also contraindicated in those patients with known hypersensitivity to Nitrofurantoin. Return to top