Allylprodine

Allylprodine is an opioid analgesic that is an analogue of prodine. It was developed in the 1970s during research into the related drug pethidine.

Allylprodine is more potent as an analgesic than other similar drugs such as α-prodine, due to the allyl group binding to an additional amino acid target in the binding site on the μ-opioid receptor. It is also stereoselective, with one isomer being much more active. Allylprodine produces similar effects to other opioids, such as analgesia and sedation, along with side effects such as nausea, itching, vomiting and respiratory depression which may be harmful or fatal.