Testosterone 17beta-dehydrogenase

In enzymology, a testosterone 17beta-dehydrogenase is an enzyme that catalyzes the chemical reaction


 * testosterone + NAD+ $$\rightleftharpoons$$ androst-4-ene-3,17-dione + NADH + H+

Thus, the two substrates of this enzyme are testosterone and NAD+, whereas its 3 products are androst-4-ene-3,17-dione, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 17beta-hydroxysteroid:NAD+ 17-oxidoreductase. Other names in common use include 17-ketoreductase, and 17beta-HSD. This enzyme participates in androgen and estrogen metabolism.