Mastocytosis history and symptoms

History
Scientists first described urticaria pigmentosa in 1869. Systemic mastocytosis was first reported by scientists in 1936.

Symptoms
In some rare cases chemicals released by mast cells cause changes in the immune system leading to typical allergy symptoms such as:
 * Itching; pruritis, may also have flushing.
 * Abdominal cramping; diarrhea, multiple peptic ulcerations.
 * Anaphylaxis (shock from allergic or immune causes); manifest with wheezing and dyspnea.

When too many mast cells exist in a person's body, the additional chemicals can cause:
 * Skin lesions
 * Abdominal discomfort
 * Episodes of very low blood pressure (including shock) and faintness
 * Bone or muscle pain; may also have evidence of myelofibrosis and osteosclerosis.
 * Nausea and vomiting
 * Paroxysmal hypertension.