Nicotinate-nucleotide adenylyltransferase

In enzymology, a nicotinate-nucleotide adenylyltransferase is an enzyme that catalyzes the chemical reaction


 * ATP + nicotinate ribonucleotide $$\rightleftharpoons$$ diphosphate + deamido-NAD+

Thus, the two substrates of this enzyme are ATP and nicotinate ribonucleotide, whereas its two products are diphosphate and deamido-NAD+.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:nicotinate-ribonucleotide adenylyltransferase. Other names in common use include deamido-NAD+ pyrophosphorylase, nicotinate mononucleotide adenylyltransferase, deamidonicotinamide adenine dinucleotide pyrophosphorylase, NaMN-ATase, and nicotinic acid mononucleotide adenylyltransferase. This enzyme participates in nicotinate and nicotinamide metabolism.

Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , and.