Monodehydroascorbate reductase (NADH)

In enzymology, a monodehydroascorbate reductase (NADH) is an enzyme that catalyzes the chemical reaction


 * NADH + H+ + 2 monodehydroascorbate $$\rightleftharpoons$$ NAD+ + 2 ascorbate

The 3 substrates of this enzyme are NADH, H+, and monodehydroascorbate, whereas its two products are NAD+ and ascorbate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with a quinone or similar compound as acceptor. The systematic name of this enzyme class is NADH:monodehydroascorbate oxidoreductase. Other names in common use include NADH:semidehydroascorbic acid oxidoreductase, MDHA, semidehydroascorbate reductase, AFR, AFR-reductase, ascorbic free radical reductase, ascorbate free radical reductase, SOR, MDAsA reductase (NADPH), SDA reductase, NADH:ascorbate radical oxidoreductase, NADH-semidehydroascorbate oxidoreductase, ascorbate free-radical reductase, NADH:AFR oxidoreductase, and monodehydroascorbate reductase (NADH2). This enzyme participates in ascorbate and aldarate metabolism.