Lansoprazole overdose

Overdose Topics
Manifestations Panic disorder Lansoprazole overdose

Manifestations
Significant naproxen overdosage may be characterized by drowsiness, heartburn, indigestion, nausea or vomiting. In the event that ANAPROX/ANAPROX-DS, ALEVE, or naproxen sodium is taken with Lansoprazole, earlier and higher blood levels may be anticipated due to the rapid absorption of naproxen sodium. A few patients have experienced seizures, but it is not clear whether or not these were drug-related. It is not known what dose of the drug would be lifethreatening. Return to top

Oral LD50
The oral LD50 of the drug is 543 mg/kg in rats, 1234 mg/kg in mice, 4110 mg/kg in hamsters, and greater than 1000 mg/kg in dogs. Should a patient ingest a large number of tablets, accidentally or purposefully, the stomach may be emptied and usual supportive measures employed. In animals 0.5 g/kg of activated charcoal was effective in reducing plasma levels of naproxen. Hemodialysis does not decrease the plasma concentration of naproxen because of the high degree of its protein binding. Return to top

Lansoprazole overdose
Oral doses up to 5000 mg/kg in rats (approximately 1300 times the 30 mg human dose based on body surface area) and mice (about 675.7 times the 30 mg human dose based on body surface area) did not produce deaths or any clinical signs. LANSOPRAZOLE IS NOT REMOVED FROM THE CIRCULATION BY HEMODIALYSIS. IN ONE REPORTED CASE OF OVERDOSE, THE PATIENT CONSUMED 600 MG OF LANSOPRAZOLE WITH NO ADVERSE REACTION. Return to top