Formaldehyde dehydrogenase

In enzymology, a formaldehyde dehydrogenase is an enzyme that catalyzes the chemical reaction


 * formaldehyde + NAD+ + H2O $$\rightleftharpoons$$ formate + NADH + 2 H+

The 3 substrates of this enzyme are formaldehyde, NAD+, and H2O, whereas its 3 products are formate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is formaldehyde:NAD+ oxidoreductase. Other names in common use include NAD+-linked formaldehyde dehydrogenase, and NAD+-dependent formaldehyde dehydrogenase. This enzyme participates in methane metabolism.

Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code.