Folic Acid drug interactions

List of drug interactions
Phenytoin Anticonvulsants Antibiotics

Phenytoin
There is evidence that the anticonvulsant action of phenytoin is antagonized by Folic Acid. A patient whose epilepsy is completely controlled by phenytoin may require increased doses to prevent convulsions if Folic Acid is given. Return to top

Anticonvulsants
Folate deficiency may result from increased loss of folate, as in renal dialysis and/or interference with metabolism (e.g. Folic Acid antagonists such as methotrexate); the administration of anticonvulsants, such as diphenylhydantoin, primidone, and barbiturates; alcohol consumption and, especially alcoholic cirrhosis; and the administration of pyrimethamine and nitrofurantoin. Return to top

Antibiotics
False low serum and red cell folate levels may occur if the patient has been taking antibiotics, such as tetracycline, which suppress the growth of Lactobacillus casei. Return to top