Irbesartan instructions for administration

Instructions for administration
Overview Hypertension Nephropathy in type 2 diabetic patients Volume/salt-depleted patients

Overview
Avapro may be administered with other antihypertensive agents and with or without food. Return to top

Hypertension
The recommended initial dose of Avapro (irbesartan) is 150 mg once daily. Patients requiring further reduction in blood pressure should be titrated to 300 mg once daily. A low dose of a diuretic may be added, if blood pressure is not controlled by Avapro alone. Hydrochlorothiazide has been shown to have an additive effect. Patients not adequately treated by the maximum dose of 300 mg once daily are unlikely to derive additional benefit from a higher dose or twice-daily dosing. No dosage adjustment is necessary in elderly patients, or in patients with hepatic impairment or mild to severe renal impairment. Return to top

Nephropathy in type 2 diabetic patients
The recommended target maintenance dose is 300 mg once daily. There are no data on the clinical effects of lower doses of Avapro on diabetic nephropathy. Return to top

Volume/salt-depleted patients
A lower initial dose of Avapro (75 mg) is recommended in patients with depletion of intravascular volume or salt (eg, patients treated vigorously with diuretics or on hemodialysis). Return to top