Mir-29 microRNA precursor

mir-29 microRNA precursor is a small non-coding RNA that is involved in regulating gene expression. This microRNA (miRNA) has been predicted or confirmed in a wide range of species (MIPF0000009). Animal miRNAs are transcribed as an approximately 70 nucleotide precursor and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 3' arm of the precursor RNA. The products are thought to have regulatory roles through complementarity to mRNA.

Targets of mir-29
It has been shown that miR-29 regulates the level of the Mcl-1 protein. Mcl-1 is an anti-apoptotic member of the Bcl-2 family of proteins.

It has been shown that miR-29 regulates the level of Tcl1 protein. The Tcl1 (T-cell leukemia/lymphoma 1) oncogene found to be disrupted in many T-cell leukemias.

It has been shown that miR-29 directly target both DNMT3A and DNMT-3B which DNA methyltransferase proteins frequently upregulated in lung cancer.