CCL22

Chemokine (C-C motif) ligand 22 (CCL22) is a small cytokine belonging to the CC chemokine family that is also known under several other names, including macrophage-derived chemokine (MDC) and stimulated T cell chemotactic protein (STCP-1). It is a chemoattractant for activated T cells, monocytes, monocyte-derived dendritic cells, and natural killer cells. CCL22 is secreted by dendritic cells and macrophages, and elicits its effects on its target cells by interacting with cell surface chemokine receptors such as CCR4. The gene for CCL22 is located in human chromosome 16 in a cluster with other chemokines called CX3CL1 and CCL17.