Rosiglitazone drug interactions

List of drug interactions
Drugs that Inhibit, Induce, or are Metabolized by Cytochrome P450 Gemfibrozil Drug/lab test interactions Rifampin Glyburide Glimepiride Metformin Digoxin Ethanol Ranitidine

Drugs that Inhibit, Induce, or are Metabolized by Cytochrome P450
In vitro drug metabolism studies suggest that rosiglitazone does not inhibit any of the major P450 enzymes at clinically relevant concentrations. In vitro data demonstrate that rosiglitazone is predominantly metabolized by CYP2C8, and to a lesser extent, 2C9. Return to top

Gemfibrozil
Concomitant administration of gemfibrozil (600 mg twice daily), an inhibitor of CYP2C8, and rosiglitazone (4 mg once daily) for 7 days increased rosiglitazone AUC by 127%, compared to the administration of rosiglitazone (4 mg once daily) alone. Given the potential for dose-related adverse events with rosiglitazone, a decrease in the dose of rosiglitazone may be needed when gemfibrozil is introduced. 'Return to top''

Rifampin
Rifampin administration (600 mg once a day), an inducer of CYP2C8, for 6 days is reported to decrease rosiglitazone AUC by 66%, compared to the administration of rosiglitazone (8 mg) alone (see PRECAUTIONS).1 AVANDIA (4 mg twice daily) was shown to have no clinically relevant effect on the pharmacokinetics of nifedipine and oral contraceptives (ethinyl estradiol and norethindrone), which are predominantly metabolized by CYP3A4. 'Return to top''

Glyburide
AVANDIA (2 mg twice daily) taken concomitantly with glyburide (3.75 to 10 mg/day) for 7 days did not alter the mean steady-state 24-hour plasma glucose concentrations in diabetic patients stabilized on glyburide therapy. Repeat doses of AVANDIA (8 mg once daily) for 8 days in healthy adult Caucasian subjects caused a decrease in glyburide AUC and Cmax of approximately 30%. In Japanese subjects, glyburide AUC and Cmax slightly increased following coadministration of AVANDIA. 'Return to top''

Glimepiride
Single oral doses of glimepiride in 14 healthy adult subjects had no clinically significant effect on the steady-state pharmacokinetics of AVANDIA. No clinically significant reductions in glimepiride AUC and Cmax were observed after repeat doses of AVANDIA (8 mg once daily) for 8 days in healthy adult subjects. 'Return to top''

Metformin
Concurrent administration of AVANDIA (2 mg twice daily) and metformin (500 mg twice daily) in healthy volunteers for 4 days had no effect on the steady-state pharmacokinetics of either metformin or rosiglitazone. Acarbose: Coadministration of acarbose (100 mg three times daily) for 7 days in healthy volunteers had no clinically relevant effect on the pharmacokinetics of a single oral dose of AVANDIA. 'Return to top''

Digoxin
Repeat oral dosing of AVANDIA (8 mg once daily) for 14 days did not alter the steady-state pharmacokinetics of digoxin (0.375 mg once daily) in healthy volunteers. Warfarin: Repeat dosing with AVANDIA had no clinically relevant effect on the steady-state pharmacokinetics of warfarin enantiomers. 'Return to top''

Ethanol
A single administration of a moderate amount of alcohol did not increase the risk of acute hypoglycemia in type 2 diabetes mellitus patients treated with AVANDIA. 'Return to top''

Ranitidine
Pretreatment with ranitidine (150 mg twice daily for 4 days) did not alter the pharmacokinetics of either single oral or intravenous doses of rosiglitazone in healthy volunteers. These results suggest that the absorption of oral rosiglitazone is not altered in conditions accompanied by increases in gastrointestinal pH. 'Return to top''

Major Interactions

 * gatifloxacin
 * Tequin
 * Tequin Teqpaq

Moderate Interactions

 * Accolate
 * alatrofloxacin
 * Apidra
 * Apidra OptiClik Cartridge
 * Arava
 * Avelox
 * Avelox I.V.
 * Avonex
 * Avonex Prefilled Syringe
 * Betaseron
 * bortezomib
 * Chroma-Pak
 * chromic chloride
 * chromic chloride hexahydrate
 * Chromium GTF
 * chromium picolinate
 * Cinobac
 * cinoxacin
 * Cipro
 * Cipro Cystitis Pack
 * Cipro I.V.
 * Cipro XR
 * ciprofloxacin
 * ciprofloxacin extended release
 * clofarabine
 * Clolar
 * clotrimazole
 * Cr-GTF
 * CRM
 * Diflucan
 * echinacea
 * enoxacin
 * Eskalith
 * Eskalith-CR
 * EXUBERA
 * EXUBERA Combination Pack 12
 * EXUBERA Combination Pack 15
 * EXUBERA Kit
 * Factive
 * Floxin
 * Floxin I.V.
 * fluconazole
 * Folex PFS
 * gemfibrozil
 * gemifloxacin
 * grepafloxacin
 * Humalog
 * Humalog Cartridge
 * Humalog KwikPen
 * Humalog Pen
 * Humulin L
 * Humulin N
 * Humulin N Pen
 * Humulin R
 * Humulin R (Concentrated)
 * Humulin U
 * Iletin II Lente Pork
 * Iletin II NPH Pork
 * Iletin II Regular Pork
 * Iletin Lente
 * Iletin NPH
 * Iletin Regular
 * insulin
 * insulin analog
 * insulin aspart
 * insulin aspart protamine
 * insulin detemir
 * insulin glargine
 * insulin glulisine
 * insulin inhalation rapid acting
 * insulin isophane
 * Insulin Lente Pork
 * insulin lispro
 * insulin lispro protamine
 * Insulin Purified NPH Pork
 * Insulin Purified Regular Pork
 * insulin regular
 * insulin zinc
 * insulin zinc extended
 * insulin lente
 * insulin NPH
 * insulin ultralente
 * interferon beta-1a
 * interferon beta-1b
 * itraconazole
 * ketoconazole
 * Lantus
 * Lantus OptiClik Cartridge
 * Lantus Solostar Pen
 * lapatinib
 * leflunomide
 * Lente insulin
 * Levaquin
 * Levaquin Leva-Pak
 * Levemir
 * Levemir FlexPen
 * Levemir InnoLet
 * Levemir PenFill
 * levofloxacin
 * lithium
 * lithium carbonate
 * lithium carbonate extended release
 * lithium citrate
 * Lithobid
 * Lithonate
 * Lithotabs
 * lomefloxacin
 * Lopid
 * Lyrica
 * Maxaquin
 * methotrexate
 * Methotrexate Sodium Preservative Free
 * miconazole
 * Monistat I.V.
 * montelukast
 * moxifloxacin
 * Mycelex Troche
 * nalidixic acid
 * naltrexone
 * Nebupent
 * Neggram
 * Nexavar
 * Nizoral
 * norfloxacin
 * Noroxin
 * Novolin L
 * Novolin N
 * Novolin N Innolet
 * Novolin N PenFill
 * Novolin R
 * Novolin R Innolet
 * Novolin R PenFill
 * NovoLog
 * NovoLog FlexPen
 * NovoLog PenFill
 * NPH insulin
 * ofloxacin
 * pegvisomant
 * Penetrex
 * Pentam 300
 * pentamidine
 * pregabalin
 * Priftin
 * Primsol
 * Proloprim
 * Proquin XR
 * protamine zinc insulin
 * Raxar
 * Rebif
 * regular insulin
 * ReliOn/Novolin N
 * ReliOn/Novolin R
 * ReVia
 * Rheumatrex Dose Pack
 * Rifadin
 * Rifadin IV
 * rifampin
 * rifapentine
 * Rimactane
 * Singulair
 * Somavert
 * sorafenib
 * sparfloxacin
 * Sporanox
 * thioguanine
 * TMP
 * Trexall
 * trimethoprim
 * Trimpex
 * trovafloxacin
 * Trovan
 * Tykerb
 * Ultralente insulin
 * Velcade
 * Velosulin BR
 * VFEND
 * Vivitrol
 * voriconazole
 * zafirlukast
 * Zagam
 * Zagam Respipac

Minor Interactions

 * Aclovate
 * Acticort 100
 * Aeroseb-HC
 * Ala-Cort
 * Ala-Scalp HP
 * alclometasone topical
 * Aloe Cort
 * Alpha Lipoic Acid
 * alpha-lipoic acid
 * Alphatrex
 * amcinonide topical
 * aminoglutethimide
 * Anucort-HC
 * Anumed-HC
 * Anuprep-HC
 * Anurx-HC
 * Anusert HC-1
 * Anusol HC-1
 * Anusol-HC
 * Anutone-HC
 * Anuzone HC
 * ApexiCon
 * ApexiCon E
 * Aquanil HC
 * Aricin
 * Aristocort A
 * Aristocort R
 * Aristocort Topical
 * Beta HC
 * Beta-Val
 * Betaderm
 * betamethasone benzoate topical
 * betamethasone dipropionate topical
 * betamethasone dipropionate augmented topical
 * betamethasone topical
 * betamethasone valerate topical
 * Betanate
 * Betatrex
 * Caldecort
 * Capex
 * Cetacort
 * Cinalog
 * Cinolar
 * clobetasol topical
 * Clobevate
 * Clobex
 * clocortolone topical
 * Cloderm
 * Cordran
 * Cordran SP
 * Cordran Tape
 * Cormax
 * Cort-Dome
 * Cort-Dome High Potency
 * Cortaid
 * Cortaid Intensive Therapy
 * Cortaid Maximum Strength
 * Cortaid with Aloe
 * Cortane
 * Corticaine
 * Corticreme
 * Cortizone for Kids
 * Cortizone-10
 * Cortizone-10 Anal Itch Cream
 * Cortizone-10 Intensive Healing Formula
 * Cortizone-10 Plus
 * Cortizone-5
 * Cotacort
 * Cutivate
 * Cyclocort
 * Cytadren
 * Del-Beta
 * Delcort
 * Delonide
 * Delta-Tritex
 * Derma-Smoothe/FS
 * Dermacin
 * Dermacort
 * Dermarest Dricort
 * Dermarest Eczema Medicated
 * Dermarest Plus Anti-Itch
 * Dermatop
 * Dermol HC
 * Dermolate
 * Dermotic
 * Dermtex HC
 * Desonate
 * desonide topical
 * DesOwen
 * DesOwen 2 oz
 * DesOwen 4 oz
 * desoximetasone topical
 * dexamethasone topical
 * diflorasone topical
 * Diprolene
 * Diprolene AF
 * Diprosone
 * Elocon
 * Embeline
 * Embeline E
 * Encort
 * Florone
 * Florone E
 * Fluex
 * fluocinolone topical
 * fluocinonide topical
 * Fluocinonide-E
 * Fluonid
 * flurandrenolide topical
 * Flurosyn
 * Flutex
 * fluticasone topical
 * FS Shampoo
 * garlic
 * Garlic Oil
 * Genasone/Aloe
 * Gly-Cort
 * Gynecort Maximum Strength
 * halcinonide topical
 * halobetasol topical
 * Halog
 * Halog-E
 * Hemorrhoidal HC
 * Hemril-30
 * Hemril-HC Uniserts
 * Hi-Cor
 * Hycort
 * Hydrocort cream
 * Hydrocortisone 1% In Absorbase
 * Hydrocortisone AC
 * hydrocortisone butyrate topical
 * hydrocortisone probutate topical
 * hydrocortisone topical
 * hydrocortisone valerate topical
 * Hydrocortisone with Aloe
 * Hydrocortisone-Aloe
 * Hytone
 * Instacort
 * Instacort 10
 * Itch-X Lotion
 * Ivocort
 * Kenalog
 * Kenalog in Orabase
 * Lacticare-HC
 * Licon
 * Lidex
 * Lidex-E
 * Locoid
 * Locoid Lipocream
 * LoKara
 * Luxiq
 * Massengill Medicated Soft Cloth
 * Maxiflor
 * Maxivate
 * MD Hydrocortisone
 * methylprednisolone topical
 * mometasone topical
 * Neutrogena T-Scalp
 * Nogenic HC
 * Nupercainal HC 1%
 * Nutracort
 * NuZon
 * Olux
 * Olux-E
 * Olux/Olux-E Kit
 * Orabase HCA
 * Oralone
 * Pandel
 * Penecort
 * prednicarbate topical
 * Preparation H Hydrocortisone
 * Procort
 * Procto-Kit 1%
 * Procto-Kit 2.5%
 * Procto-Pak 1%
 * Proctocort
 * Proctocream-HC
 * Proctosert HC
 * Proctosol-HC
 * Proctozone HC
 * Proctozone-H
 * Psorcon
 * Psorcon E
 * Recort Plus
 * Rectasol-HC
 * Rederm
 * Rx Triamcinolone
 * Sarnol-HC
 * Scalp-Aid
 * Scalp-Cort
 * Synalar
 * Synalar-HP
 * Synemol
 * Teladar
 * Temovate
 * Temovate E
 * Texacort
 * thioctic acid
 * Topicort
 * Topicort LP
 * Triacet
 * triamcinolone topical
 * Triderm
 * Tridesilon
 * Tucks HC
 * U-Cort
 * Ultravate
 * Uticort
 * Valisone
 * Vanos
 * Verdeso
 * Westcort