Glucocorticoid resistance

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Overview
Patients can be both resistant and hypersensitive to glucocorticoids.

In glucocorticoid resistance, the target tissue is unable to respond to glucocorticoids. The lack of responsiveness can be
 * 1) Generalized or tissue-specific
 * 2) Transient or permanent
 * 3) Partial or complete
 * 4) Compensated or noncompensated.

The presence of complete glucocorticoid resistance is fatal. Absence of functional glucocorticoid receptors (GRs) in GR -/- knockout mice is associated with death within hours.

Related Key Words and Synonyms: cortisol resistance, glucocorticoid insensitivity, steroid hormone resistance, glucocorticoid receptor, steroid hormone insensitivity, overexpression of human glucocorticoid receptor beta, generalized partial end-organ insensitivity to physiologic glucocorticoid concentrations, elevations in circulating cortisol, mineralocorticoid excess, androgen excess

Acknowledgements
The content on this page was first contributed by: C. Michael Gibson, M.S., M.D.

Initial content for this page in some instances came from Wikipedia

List of contributors: