Irbesartan drug interactions

Drug interactions
No significant drug-drug pharmacokinetic (or pharmacodynamic) interactions have been found in interaction studies with hydrochlorothiazide, digoxin, warfarin, and nifedipine. In vitro studies show significant inhibition of the formation of oxidized irbesartan metabolites with the known cytochrome CYP 2C9 substrates/inhibitors sulphenazole, tolbutamide and nifedipine. However, in clinical studies the consequences of concomitant irbesartan on the pharmacodynamics of warfarin were negligible. Based on in vitro data, no interaction would be expected with drugs whose metabolism is dependent upon cytochrome P450 isoenzymes 1A1, 1A2, 2A6, 2B6, 2D6, 2E1, or 3A4. In separate studies of patients receiving maintenance doses of warfarin, hydrochlorothiazide, or digoxin, irbesartan administration for 7 days had no effect on the pharmacodynamics of warfarin (prothrombin time) or pharmacokinetics of digoxin. The pharmacokinetics of irbesartan were not affected by coadministration of nifedipine or hydrochlorothiazide.

Major Interactions

 * Aldactone
 * Amiloride
 * Dyrenium
 * Midamor
 * Sodium biphosphate
 * Spironolactone
 * Tizanidine
 * Triamterene
 * Zanaflex

Moderate Interactions

 * 40 Winks
 * A-Hydrocort
 * A-Methapred
 * Abilify
 * Abilify Discmelt
 * Acetocot
 * Acetylsalicylic Acid
 * ACTH
 * ACTH Gel
 * ACTH-40 HP
 * ACTH-80
 * Acthar
 * Acthar Gel H.P.
 * Acthrel
 * Actiq
 * Actron
 * Acuprin 81
 * Adapin
 * Adbeon
 * Adgan
 * Adlone-40
 * Adlone-80
 * Adrenocot
 * Adrenocot L.A.
 * Advil
 * Advil Childrens
 * Advil Junior Strength
 * Advil Liquigel
 * Advil Migraine
 * Advil Pediatric
 * Aflaxen
 * aldesleukin
 * Aler-Dryl
 * Aler-Tab
 * Aleve
 * Aleve Caplet
 * Aleve Easy Open Arthritis
 * Aleve Gelcap
 * Alfenta
 * alfentanil
 * All Day Allergy
 * Allergia-C
 * Allermax
 * alprazolam
 * alprazolam extended release
 * Altaryl
 * Ambien
 * Ambien CR
 * amifostine
 * Amigesic
 * Aminosyn II 3.5%-Dextrose 25% Electrolytes Ca
 * Aminosyn II 4.25%-Dextrose 20% Electrolyte Ca
 * Aminosyn II 4.25%-Dextrose 25% Electrolyte Ca
 * Aminosyn II with Electrolytes
 * Aminosyn II with Electrolytes Sulfite-Free
 * Aminosyn with Electrolytes
 * Aminosyn with Electrolytes Sulfite-Free
 * amitriptyline
 * amoxapine
 * Anaflex
 * Anafranil
 * Anaprox
 * Anaprox-DS
 * Anergan 50
 * Ansaid
 * Antiflex
 * Antinaus 50
 * APO-Go
 * APO-Go Pen
 * Apokyn
 * apomorphine
 * aprepitant
 * Aquachloral Supprettes
 * Argesic-SA
 * aripiprazole
 * Aristocort
 * Aristocort For Injection
 * Aristocort Forte
 * Aristopak
 * Aristospan Injection
 * Arthritis Pain
 * Arthropan
 * ASA
 * Ascriptin Enteric
 * Asendin
 * Aspergum Cherry
 * Aspergum Orginal
 * Aspir-Low
 * aspirin
 * aspirin extended release
 * Aspirin Lite Coat
 * Aspirin Litecoat
 * Aspirin Low Strength
 * Aspirtab
 * Astramorph PF
 * Atarax
 * Ativan
 * Aventyl HCl
 * Avinza
 * Azmacort
 * baclofen
 * Banaril
 * Banflex
 * Banophen
 * Bayer Aspirin
 * Bayer Aspirin Regimen
 * Bayer Aspirin Sugar Free
 * Bayer Aspirin with Calcium
 * Bayer Childrens Aspirin
 * Bayer Low Strength
 * Bayer Plus
 * Bayer Select Backache Pain Formula
 * Beldin
 * Belix
 * Ben-Tann
 * Benadryl
 * Benadryl Allergy
 * Benadryl Child Dye Free
 * Benadryl Childrens Allergy Fastmelt
 * Benadryl DF
 * Benadryl Dye Free Allergy
 * Benadryl Ultratab
 * Benahist-10
 * Benahist-50
 * Benoject-50
 * Beta-Phos/AC
 * betamethasone
 * betamethasone acet-betamethasone na phosphate
 * betamethasone sodium phosphate
 * Bextra
 * bosentan
 * bromfenac
 * Bubbli-Pred
 * Budeprion SR
 * Budeprion XL
 * budesonide
 * Buffered Aspirin
 * Bufferin
 * Bufferin Arthritis Strength
 * Bufferin Extra Strength
 * Buffex
 * Buprenex
 * buprenorphine
 * bupropion
 * bupropion 24 hour extended release
 * bupropion extended release
 * busodium
 * BuSpar
 * BuSpar Dividose
 * busPIRone
 * butabarbital
 * Butisol Sodium
 * Bydramine
 * cabergoline
 * Calm-Aid
 * Carbacot
 * carisoprodol
 * Cataflam
 * Celebrex
 * celecoxib
 * Celestone
 * Celestone Phosphate
 * Celestone Soluspan
 * Celexa
 * Cell-U-Jec
 * Cena K
 * cetirizine
 * Childrens Ibuprofen Berry
 * chloral hydrate
 * chlordiazepoxide
 * chlorpromazine
 * chlorpromazine extended release
 * choline salicylate
 * citalopram
 * Clinacort
 * Clinalog
 * Clinimix E Sulfite Free
 * Clinoril
 * clomipramine
 * clonazepam
 * Clopine
 * clorazepate
 * clorazepate extended release
 * clozapine
 * Clozapine Synthon
 * Clozaril
 * codeine
 * codeine phosphate
 * codeine sulfate
 * Colocort
 * Compazine
 * Compazine Spansule
 * Compoz Nighttime Sleep Aid
 * Compro
 * Corlopam
 * Cort-K
 * Cortastat
 * Cortastat 10
 * Cortastat LA
 * Cortef
 * Cortenema
 * corticorelin
 * corticotropin
 * Cortifoam
 * cortisone
 * Cortone Acetate
 * Cortrosyn
 * cosyntropin
 * Cotolone
 * cyclosporine
 * Dalalone
 * Dalalone D.P.
 * Dalalone L.A.
 * Dalmane
 * Darvon
 * Darvon-N
 * Daypro
 * Dazidox
 * De-Sone LA
 * Decadron
 * Decadron 5-12 Pak
 * Decadron Phosphate Injectable
 * Decadron-LA
 * Decaject
 * Decaject L.A.
 * Deltasone
 * Demerol HCl
 * Denzapine
 * Dep Medalone 80
 * Depmedalone
 * Depo-Medrol
 * Depo-Predate (obsolete)
 * Depoject-80
 * Depopred
 * Desyrel
 * Desyrel Dividose
 * Dexacen-4
 * Dexacort Phosphate in Respihaler
 * Dexacort-LA
 * Dexacorten
 * dexamethasone
 * dexamethasone acetate
 * Dexamethasone Intensol
 * dexamethasone sodium phosphate
 * Dexasone
 * Dexasone LA
 * Dexone
 * Dexone LA
 * Dexpak Jr. Taperpak
 * Dexpak Taperpak
 * Dextrose 10% and Electrolyte No. 48
 * Diastat
 * Diastat AcuDial
 * Diastat Pediatric
 * diazepam
 * diclofenac
 * diclofenac potassium
 * diclofenac sodium
 * diclofenac sodium extended release
 * diflunisal
 * dihydrocodeine
 * Dilaudid
 * Dilaudid-5
 * Dilaudid-HP
 * Diphedryl
 * Diphen
 * Diphen AF
 * Diphen Cough
 * Diphenadryl
 * Diphendryl
 * diphenhist
 * diphenhydramine
 * diphenhydramine citrate
 * diphenhydramine tannate
 * Diphenmax
 * Diphenydramine Quick Melt
 * Diphenyl
 * Diphenylin
 * Disalcid
 * Diskets
 * Dizac
 * Doans Pills
 * Doans Pills Extra Strength
 * Dolobid
 * Dolophine
 * Doloral
 * Doloral Sirop
 * Dopar
 * Doral
 * Dostinex
 * doxepin
 * doxepin topical
 * DPH
 * drospirenone
 * DurAct
 * Duragesic
 * Duragesic-100
 * Duragesic-12
 * Duragesic-25
 * Duragesic-50
 * Duragesic-75
 * Duralone
 * Duramorph PF
 * Dytan
 * Dytuss
 * Easprin
 * EC-Naprosyn
 * Ecotrin
 * Ecotrin Adult Low Strength
 * Ecotrin Maximum Strength
 * Ed K+10
 * Effervescent Potassium
 * Effexor
 * Effexor XR
 * Elavil
 * Emend
 * Emend 3-Day
 * Emend for Injection
 * Empirin
 * Endep
 * Endocodone
 * Entaprin
 * Entercote
 * Entocort
 * Entocort EC
 * eplerenone
 * Equanil
 * escitalopram
 * Eskalith
 * Eskalith-CR
 * ETH-Oxydose
 * Ethyol
 * etodolac
 * etodolac extended release
 * etravirine
 * Extra Strength Bayer
 * Fasprin
 * FazaClo
 * Feldene
 * fenoldopam
 * fenoprofen
 * fentanyl
 * Fentora
 * Flexoject
 * Flexon
 * Flo-Pred
 * Florinef Acetate
 * fludrocortisone
 * fluoxetine
 * fluoxetine extended release
 * fluphenazine
 * fluphenazine decanoate
 * fluphenazine enanthate
 * fluphenazine hydrochloride
 * flurazepam
 * flurbiprofen
 * fluvoxamine
 * fluvoxamine extended release
 * fosaprepitant
 * Freamine III with Electrolytes
 * Genacote
 * Genahist
 * Gengraf
 * Gennin-FC
 * Genpril
 * Genprin
 * Geodon
 * Glu-K
 * Halfprin
 * Haltran
 * Hexadrol
 * Hexadrol Phosphate
 * Hydeltra-T.B.A.
 * Hydeltrasol
 * Hydramine
 * Hydramine Compound
 * Hydramine Cough Syrup
 * hydrocortisone
 * hydrocortisone acetate
 * hydrocortisone cypionate
 * hydrocortisone hemisuccinate
 * hydrocortisone sodium phosphate
 * Hydrocortisone Sodium Succinate
 * Hydrocortone
 * Hydrocortone Phosphate
 * Hydromorph Contin
 * hydromorphone
 * hydromorphone extended release
 * Hydrostat IR
 * Hydroxyzine
 * Hydroxyzine Hydrochloride
 * Hydroxyzine Pamoate
 * Hyrexin
 * Hyzine
 * Ibu
 * IBU-200
 * Ibu-4
 * Ibu-6
 * Ibu-8
 * Ibu-Tab
 * ibuprofen
 * Ibuprofen PMR
 * iloprost
 * imipramine
 * imipramine pamoate
 * Indocin
 * Indocin SR
 * indomethacin
 * indomethacin extended release
 * Infumorph
 * Inspra
 * Intelence
 * Invega
 * Ionosol B and 5% Dextrose
 * Ionosol MB and 5% Dextrose
 * Ionosol T and 5% Dextrose
 * Ionsys
 * Isolyte E
 * Isolyte H and 5 % Dextrose
 * Isolyte M and 5% Dextrose
 * Isolyte P and 5% Dextrose
 * Isolyte R and 5% Dextrose
 * K + Potassium
 * K+Care ET
 * K-10
 * K-8
 * K-Dur 10
 * K-Dur 20
 * K-Effervescent
 * K-Lor
 * K-Norm
 * K-Phos Original
 * K-Sol
 * K-Tab
 * K-vescent
 * K-Vescent (obsolete)
 * K-Vescent (Potassium Chloride)
 * Kadian
 * Kaochlor
 * Kaochlor S-F
 * Kaon
 * Kaon-CI
 * Kaon-CL 10
 * Kaon-CL 20%
 * Kato
 * Kay Ciel
 * KCl
 * KCl-20
 * Ken-Jec 40
 * Kenaject-40
 * Kenalog-10
 * Kenalog-40
 * ketoprofen
 * ketoprofen extended release
 * ketorolac
 * Key-Pred
 * Key-Pred SP
 * Klonopin
 * Klonopin Wafer
 * Klor-Con
 * Klor-Con 10
 * Klor-Con 8
 * Klor-Con M10
 * Klor-Con M15
 * Klor-Con M20
 * Klor-Con/25
 * Klotrix
 * Larodopa
 * Leader Naproxen Sodium
 * levocetirizine
 * levodopa
 * Levrix
 * Lexapro
 * Librium
 * Lioresal
 * Lioresal Intrathecal
 * Liquid Pred
 * Litecoat Aspirin
 * lithium
 * lithium carbonate
 * lithium carbonate extended release
 * lithium citrate
 * Lithobid
 * Lithonate
 * Lithotabs
 * Lodine
 * Lodine XL
 * lorazepam
 * Low Dose ASA
 * Ludiomil
 * Luminal
 * Luvox
 * Luvox CR
 * LVP solution with potassium
 * M-Eslon
 * M-Oxy
 * M-Prednisolone
 * M. O. S.
 * Magan
 * magnesium salicylate
 * maprotiline
 * maraviroc
 * Marthritic
 * MB-TAB
 * meclofenamate
 * Meclomen
 * Med-Jec-40
 * Medicort
 * Medidex
 * Medidex LA
 * Medipred
 * Medralone
 * Medralone 40
 * Medralone 80
 * Medrol
 * Medrol Dosepak
 * mefenamic acid
 * Mellaril
 * Mellaril-S
 * meloxicam
 * Menadol
 * meperidine
 * meprobamate
 * Methacort 40
 * Methacort 80
 * methadone
 * Methadose
 * methdilazine
 * methocarbamol
 * Methylcotol
 * Methylcotolone
 * Methylpred DP
 * methylprednisolone
 * methylprednisolone acetate
 * methylprednisolone dose pack
 * methylprednisolone sodium succinate
 * Meticorten
 * Micro-K
 * Micro-K 10
 * Midol Extended Relief
 * Midol IB
 * Midol Maximum Strength Cramp Formula
 * Millipred
 * Miltown
 * Minitabs
 * Mio-Rel
 * mirtazapine
 * Mitran
 * Mobic
 * Mobidin
 * Mono-Gesic
 * morphine
 * morphine 24 hour extended release
 * morphine extended release
 * Morphine IR
 * Morphine LP Epidural
 * morphine preservative-free
 * Morphine Rapi-Ject
 * Morphitec
 * Motrin
 * Motrin Childrens
 * Motrin IB
 * Motrin Infant Drops
 * Motrin Junior Strength
 * Motrin Migraine Pain
 * MS
 * MS Contin
 * MS/S
 * MSIR
 * MST
 * Myolin
 * nabumetone
 * nalbuphine
 * Nalfon
 * Naprelan '375'
 * Naprelan '500'
 * Naprosyn
 * naproxen
 * naproxen sodium
 * Naproxen Sodium DS
 * naproxen sodium extended release
 * nefazodone
 * NeoProfen
 * Neoral
 * Nervine
 * Neutra-Phos-K
 * Nightime Sleepaid
 * Niravam
 * Norflex
 * Norflex Injectable
 * Normosol-M and 5% Dextrose
 * nortriptyline
 * Norwich Aspirin
 * Nu-Med
 * Nubain
 * Nuprin
 * Nuprin Backache Caplet
 * Nytol Caplet
 * olanzapine
 * OMS
 * opium
 * Opium Deodorized
 * Oramorph SR
 * Orapred
 * Orapred ODT
 * Orasone
 * Orfro
 * Ormazine
 * orphenadrine
 * orphenadrine extended release
 * Orphenate
 * Orudis
 * Orudis KT
 * Oruvail
 * oxaprozin
 * oxazepam
 * oxycodone
 * oxycodone extended release
 * OxyContin
 * Oxyfast
 * OxyIR
 * paliperidone
 * Palladone
 * Palladone SR
 * Pamelor
 * Paral
 * paraldehyde
 * Pardryl
 * Paregoric
 * parenteral nutrition solution w/electrolytes
 * paroxetine
 * paroxetine extended release
 * paroxetine mesylate
 * Paxil
 * Paxil CR
 * PC-10
 * Pediacare Fever
 * Pediapred
 * Pentazine
 * pentazocine
 * Perchloracap
 * Percolone
 * Permitil
 * perphenazine
 * Pexeva
 * Phenadoz
 * Phenazine 50
 * Phenergan
 * Phenergan Fortis
 * phenobarbital
 * Phenoject-50
 * phenyl salicylate
 * phenylbutazone
 * Pima
 * piroxicam
 * Plasma-Lyte 56
 * Plasma-Lyte and 5% Dextrose
 * Ponstel
 * Potaba
 * potassium acid phosphate
 * potassium aminobenzoate
 * potassium bicarbonate
 * potassium chloride
 * potassium chloride extended release
 * potassium citrate
 * potassium gluconate
 * potassium guaiacolsulfonate
 * potassium iodide
 * potassium perchlorate
 * potassium phosphate
 * PP-Cap
 * Pred-Ject-50
 * Predacort 50
 * Predacorten
 * Predaject-50
 * Predalone 50
 * Predate-50
 * Predcor
 * Predicort RP
 * Predicort-50
 * Prednicen-M
 * Prednicot
 * prednisolone
 * prednisolone acetate
 * prednisolone sodium phosphate
 * prednisolone tebutate
 * prednisone
 * Prelone
 * Pri-Cortin 50
 * Priftin
 * Primethasone
 * Primsol
 * Pro-Med
 * Procalamine
 * prochlorperazine
 * prochlorperazine extended release
 * Procot
 * Proleukin
 * Prolixin
 * Prolixin Decanoate
 * Prolixin Enanthate
 * Proloprim
 * Promacot
 * promazine
 * promethazine
 * Promethegan
 * propoxyphene
 * propoxyphene hydrochloride
 * propoxyphene napsylate
 * Prorex
 * Prozac
 * Prozac Weekly
 * Prudoxin
 * Pulmicort Flexhaler
 * Pulmicort Nebuamp
 * Pulmicort Respules
 * Pulmicort Turbuhaler
 * Q-Dryl
 * Q-Dryl A/F
 * Q-Profen
 * quazepam
 * Quenalin
 * quetiapine
 * quetiapine extended release
 * Rapamune
 * Rapiflux
 * Relafen
 * Remeron
 * Remeron SolTab
 * Rescudose
 * Restoril
 * Rexolate
 * Rezine
 * rifapentine
 * Risperdal
 * Risperdal Consta
 * Risperdal M-Tab
 * risperidone
 * RMS
 * Robaxin
 * Robaxin-750
 * rofecoxib
 * Roxanol
 * Roxanol 100
 * Roxanol-T
 * Roxicodone
 * Roxicodone Intensol
 * Rufen
 * Rum-K
 * Saleto-200
 * Saleto-400
 * Saleto-600
 * Saleto-800
 * Salflex
 * salicylamide
 * salsalate
 * Salsitab
 * Sandimmune
 * Sarafem
 * Scot-Tussin Allergy Relief Formula
 * secobarbital
 * Seconal Sodium
 * Selestoject
 * Selfemra
 * Selzentry
 * Serax
 * Seroquel
 * Seroquel XR
 * sertraline
 * Serzone
 * Siladryl
 * Siladryl DAS
 * Siladyl SA
 * Silphen Cough
 * Simply Sleep
 * Sinequan
 * sirolimus
 * Skelex
 * Sleep Tab II
 * Sleep Tabs
 * Sleep-ettes
 * Sleep-Eze-3
 * Sleepinal
 * Sloprin
 * Slow-K
 * sodium salicylate
 * sodium thiosalicylate
 * Solfoton
 * Solu-Cortef
 * Solu-Medrol
 * Solurex
 * Solurex LA
 * Soma
 * Sominex
 * Sominex Maximum Strength Caplet
 * Somnicaps
 * Somnote
 * Sonata
 * Sparine
 * SSKI
 * St. Joseph Aspirin
 * St. Joseph Aspirin Adult Chewable
 * St. Joseph Aspirin Adult EC
 * Stanback Analgesic
 * Statex
 * Stelazine
 * Sterapred
 * Sterapred DS
 * Sublimaze
 * Subutex
 * sulindac
 * Surmontil
 * TAC 3
 * Tacaryl
 * Talwin Lactate
 * temazepam
 * temsirolimus
 * Ten-K
 * Theraflu Thin Strips Multi Symptom
 * Therapy Bayer
 * thioridazine
 * Thorazine
 * ThyroShield
 * TMP
 * Tofranil
 * Tofranil-PM
 * Tolectin
 * Tolectin 600
 * Tolectin DS
 * tolmetin
 * Toradol
 * Toradol IM
 * Toradol IV/IM
 * Torisel
 * Total Allergy
 * Tracleer
 * Tramacort-D
 * Tranxene SD
 * Tranxene T-Tab
 * Travasol with Electrolytes
 * Travasol with Electrolytes Dual Chamber
 * Travert 10% and Electrolyte No.2
 * Travert 5% and Electrolyte No.2
 * trazodone
 * Tri-Buffered Aspirin
 * Triam-A
 * Triam-Forte
 * triamcinolone
 * triamcinolone acetonide
 * triamcinolone diacetate
 * triamcinolone hexacetonide
 * Triamcot
 * Triaminic Thin Strips Cough & Runny Nose
 * Triamonide 40
 * trifluoperazine
 * Trilafon
 * Trilog
 * Trilone
 * trimethoprim
 * trimipramine
 * Trimpex
 * Tristoject
 * Trux-adryl
 * Tusal
 * Tusstat
 * Twilite
 * Twin-K
 * U-Tri-Lone
 * Uni-Tann
 * Unisom Sleepgels Maximum Strength
 * Uprima
 * Urocit-K
 * V-Gan-25
 * V-Gan-50
 * valdecoxib
 * Valium
 * Valrelease
 * Valu-Dryl
 * Vanadom
 * Vanatrip
 * venlafaxine
 * venlafaxine extended release
 * Ventavis
 * vfend
 * Vioxx
 * Vistacon
 * Vistacot
 * Vistaject-50
 * Vistaril
 * Vistaril IM
 * Vistazine
 * Vistazine 50
 * Voltaren
 * Voltaren-XR
 * voriconazole
 * Wellbutrin
 * Wellbutrin SR
 * Wellbutrin XL
 * Xanax
 * Xanax XR
 * Xyzal
 * Xyzall
 * YSP Aspirin
 * zaleplon
 * Zaponex
 * Zero-Order Release
 * Zetran
 * ziprasidone
 * Zoloft
 * zolpidem
 * zolpidem extended release
 * Zonalon
 * Zorprin
 * Zyban
 * Zyban Advantage Pack
 * Zyprexa
 * Zyprexa Zydis
 * Zyrtec
 * Zyrtec Hives

Minor Interactions

 * Adalat
 * Adalat CC
 * Afeditab CR
 * aliskiren
 * apraclonidine ophthalmic
 * Atapryl
 * Azilect
 * Carbex
 * Cialis
 * Diflucan
 * Eldepryl
 * Emsam
 * fluconazole
 * furazolidone
 * Furoxone
 * Iopidine
 * isocarboxazid
 * Jumex
 * linezolid
 * Marplan
 * Matulane
 * Nardil
 * Nifediac CC
 * Nifedical XL
 * Nifedipine
 * Nifedipine extended release
 * Norvir
 * Norvir Soft Gelatin
 * Orinase
 * Parnate
 * phenelzine
 * procarbazine
 * Procardia
 * Procardia XL
 * rasagiline
 * ritonavir
 * selegiline
 * Selgene
 * tadalafil
 * Tekturna
 * Tol-Tab
 * Tolbutamide
 * tranylcypromine
 * Zelapar
 * Zyvox