Male contraceptive

The only forms of male contraceptives currently available to men are condoms, the withdrawal method, and vasectomy. Other forms of male contraception are in various stages of research and development.

Methods in development

 * Reversible inhibition of sperm under guidance (RISUG) consists of injecting styrene maleic anhydride in dimethyl sulfoxide into the vas deferens and leads to long lasting sterility. A second injection washes out the substance and restores fertility.  As of 2007, RISUG is in Phase III of human testing.


 * Vas-occlusive contraception consists of partially or completely blocking the vas deferens, the tubes connecting the epididymis to the urethra. While a vasectomy removes a piece of each vas deferens, the intra vas device (IVD) and other injectable plugs only block the tubes until the devices are removed.


 * Heat-based contraception involves heating the testicles to a high temperature for a short period of time to prevent the formation of sperm.


 * Adjudin, a non-toxic analog of lonidamine which, in tests on rats, has been shown to cause reversible infertility. The drug disrupts the junctions between nurse cells (Sertoli cells) in the testes and forming spermatids. The sperm are released prematurely and never become functional gametes. A new targeted delivery mechanism has made Adjudin much more effective.


 * A male hormonal contraceptive combination protocol has been developed, involving injections of Depo-Provera to prevent spermatogenesis, combined with the topical application of testosterone gel to provide hormonal support.


 * Research has been performed on interference with the maturation of sperm in the epididymis.

Abandoned research

 * Gossypol, derived from cotton seeds, was used in trials by the Chinese government for about fifteen years. While it was found to be a reliable contraceptive, it has serious health effects, and ten to twenty percent of users become permanently sterile.  Research on it as a temporary contraceptive has been abandoned.
 * Zavesca (aka Miglustat or NB-DNJ) is a drug approved for treatment of several rare lipid storage disorder diseases. In mice, it provided effective and fully reversible contraception.  But it seems this effect was only true for several genetically related strains of laboratory mice.  Zavesca showed no contraceptive effect in other mammals.