Gemfibrozil pharmacokinetics and molecular data

Pharmacokinetics
Peak plasma concentrations Rate of Absorption AUC

Peak plasma concentrations
Gemfibrozil is completely absorbed after oral administration of LOPID tablets, reaching peak plasma concentrations 1 to 2 hours after dosing. Return to top

Rate of Absorption
Gemfibrozil pharmacokinetics are affected by the timing of meals relative to time of dosing. In one study, both the rate and extent of absorption of the drug were significantly increased when administered 0.5 hour before meals. Return to top

AUC
Average AUC was reduced by 14-44% when LOPID was administered after meals compared to 0.5 hour before meals. In a subsequent study (ref. 4), rate of absorption of LOPID was maximum when administered 0.5 hour before meals with the Cmax 50-60% greater than when given either with meals or fasting. In this study, there were no significant effects on AUC of timing of dose relative to meals. Return to top