Desformylflustrabromine

Desformylflustrabromine is an active metabolite of marine bryozoan Flustra foliacea. Desformylflustrabromine has been identified a novel positive allosteric modulator of neuronal nicotinic acetylcholine receptor with sub-type specificity for hetromeric receptor with no effect on homomeric sub-type. A recent study has been published which describes the synthesis of water-soluble salts of Desformylflustrabromine and its action has been confirmed as selective potentiator of alpha4 beta2 receptor responses by using two-electrode voltage clamp whole cell recordings.