Laughter-induced syncope

Seinfeld syncope is laughter-induced syncope (fainting). It is an unusual but recognized form of situational syncope likely to have a similar pathophysiological origin to tussive syncope.

There are few case reports of this syndrome in the literature. Patients, as in this case, might present initially to the ED, and laughter should be considered among the numerous differentials for syncope.

To date there have been few cases of Seinfeld Syncope documented in medical literature.