Mastocytosis other diagnostic studies

Biopsy
Can be diagnose urticaria pigmentosa (cutaneous mastocytosis, see below) by seeing the characteristic lesions that are dark-brown and fixed. A small skin sample (biopsy) may help confirm the diagnosis.

By taking a biopsy from a different organ, such as the bone marrow, the doctor can diagnose systemic mastocytosis. Using special techniques on a bone marrow sample, the doctor looks for an increase in mast cells. The bone marrow may show disordered bone formation and bizzare mast cells.