Gadd45

The Growth Arrest and DNA Damage gadd45 genes, including (originally termed gadd45)  (originally termed MyD118), &  (originally termed CR6) are implicated as stress sensors that modulate the response of mammalian cells to genotoxic/physiological stress, and modulate tumor formation. Gadd45 proteins interact with other proteins implicated in stress responses, including PCNA, p21, Cdc2/CyclinB1, MEKK4 & p38 kinase.

History
Gadd45a was discovered & characterized in the laboratory of Dr. Albert Fornace Jr. in 1988.

Gadd45b (MyD118) was discovered & characterized in the laboratories of Drs Dan A.Liebermann & Barbara Hoffman in 1991.

Gadd45g (CR6) was discovered & characterized in the laboratories of Drs Keneneth Smith Dan A.Liebermann & Barbara Hoffman in 1993 & 1999.