DISC1

Disrupted in Schizophrenia 1 or DISC1 is a protein with a wide array of interactions. It participates in cell growth, movement, axonal growth and transport, neural positioning. Among its known partners are LIS1 and NUDEL proteins and PDE4B enzyme. Disruptions in DISC1 structure play an important role at least in some cases of schizophrenia, as confirmed by experimental and genetic data, which points at DISC1 gene as a major schizophrenia susceptibility gene candidate.