Steroid sulfotransferase

In enzymology, a steroid sulfotransferase is an enzyme that catalyzes the chemical reaction


 * 3'-phosphoadenylyl sulfate + a phenolic steroid $$\rightleftharpoons$$ adenosine 3',5'-bisphosphate + steroid O-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and phenolic steroid, whereas its two products are adenosine 3',5'-bisphosphate and steroid O-sulfate.

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferase. This enzyme is also called steroid alcohol sulfotransferase. This enzyme participates in androgen and estrogen metabolism.