Sarcosine dehydrogenase

In enzymology, a sarcosine dehydrogenase is an enzyme that catalyzes the chemical reaction


 * sarcosine + acceptor + H2O $$\rightleftharpoons$$ glycine + formaldehyde + reduced acceptor

The 3 substrates of this enzyme are sarcosine, acceptor, and H2O, whereas its 3 products are glycine, formaldehyde, and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donor with other acceptors. The systematic name of this enzyme class is sarcosine:acceptor oxidoreductase (demethylating). Other names in common use include sarcosine N-demethylase, monomethylglycine dehydrogenase, and sarcosine:(acceptor) oxidoreductase (demethylating). This enzyme participates in glycine, serine and threonine metabolism. It employs one cofactor, FMN.