PLATO bleeding criteria

Overview
PLATO bleeding classification

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1. Major life-threatening:

 * Fatal
 * Intracranial
 * Intrapericardial with cardiac tamponade
 * Resulting in hypovolemic shock or severe hypotension that requires pressors or surgery
 * Clinically overt or apparent bleeding associated with decrease in hemoglobin >5 g/dL
 * Requiring transfusion of ≥4 U whole blood or PRBCs

Other major

 * Significantly disabling (eg, intraocular with permanent vision loss)
 * Associated drop in hemoglobin of 3 to 5 g/dL
 * Requiring transfusion of 2 to 3 U whole blood or PRBCs

Any major

 * Any one of the above criteria

2. Minor

 * Requiring medical intervention to stop or treat bleeding (e.g., epistaxis requiring visit to medical facility for packing)

3. Minimal

 * All others (e.g., bruising, bleeding gums, oozing from injection sites) not requiring intervention or treatment}}