Glycolaldehyde dehydrogenase

In enzymology, a glycolaldehyde dehydrogenase is an enzyme that catalyzes the chemical reaction


 * glycolaldehyde + NAD+ + H2O $$\rightleftharpoons$$ glycolate + NADH + 2 H+

The 3 substrates of this enzyme are glycolaldehyde, NAD+, and H2O, whereas its 3 products are glycolate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glycolaldehyde:NAD+ oxidoreductase. This enzyme is also called glycol aldehyde dehydrogenase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes, , and.