IkappaB kinase

In enzymology, an IkappaB kinase is an enzyme that catalyzes the chemical reaction


 * ATP + [IkappaB protein] $$\rightleftharpoons$$ ADP + [IkappaB phosphoprotein]

Thus, the two substrates of this enzyme are ATP and [IkappaB protein], whereas its two products are ADP and [IkappaB phosphoprotein].

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[IkappaB protein] phosphotransferase. Other names in common use include CHUK, IKBKA, IKBKB, IKK, IKK-1, IKK-2, inhibitor of NFkappaB kinase, inhibitor of NF-kappaB kinase, STK12, TANK-binding kinase 1, and TBK1. This enzyme participates in 15 metabolic pathways: mapk signaling pathway, apoptosis, toll-like receptor signaling pathway, t cell receptor signaling pathway, b cell receptor signaling pathway, insulin signaling pathway, adipocytokine signaling pathway, type ii diabetes mellitus, epithelial cell signaling in helicobacter pylori,, pancreatic cancer, prostate cancer, chronic myeloid leukemia, acute myeloid leukemia, and small cell lung cancer.