HBB

Beta globin (HBB, β-globin) is a protein that, along with alpha globin (HBA), makes up the most common form of hemoglobin in adult humans. The gene is located in the β-globin locus. Mutant beta globin is responsible for the sickling of red blood cells seen in sickle cell anemia. Expression of beta globin and the neighboring globins in the β-globin locus is controlled by single locus control region (LCR).