Haloalkane dehalogenase

In enzymology, a haloalkane dehalogenase is an enzyme that catalyzes the chemical reaction


 * 1-haloalkane + H2O $$\rightleftharpoons$$ a primary alcohol + halide

Thus, the two substrates of this enzyme are 1-haloalkane and H2O, whereas its two products are primary alcohol and halide.

This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is 1-haloalkane halidohydrolase. Other names in common use include 1-chlorohexane halidohydrolase, and 1-haloalkane dehalogenase. This enzyme participates in 4 metabolic pathways: gamma-hexachlorocyclohexane degradation, naphthalene and anthracene degradation, 1,2-dichloroethane degradation, and 3-chloroacrylic acid degradation.

Structural studies
As of late 2007, 25 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , , , , , , , , , , , , , , , , and.