Palmar plantar erythrodysesthesia historical perspective

Overview
Palmar plantar erythrodysesthesia (PPE) is a swelling and numbness of the hands and feet that occurs with chemotherapy, usually with fluorouracil, capecitabine, cytarabine, and doxorubicin.

Historical perspective
First reported in association with chemotherapy by Zuehlke in 1974 (Zuehlke, 1974).