Dopamine receptor D3

Dopamine receptor D3, also known as DRD3, is a human gene.

This gene encodes the D3 subtype of the dopamine receptor. The D3 subtype inhibits adenylyl cyclase through inhibitory G-proteins. This receptor is expressed in phylogenetically older regions of the brain, suggesting that this receptor plays a role in cognitive and emotional functions. It is a target for drugs which treat schizophrenia, drug addiction, and Parkinson disease. Alternative splicing of this gene results in multiple transcript variants that would encode different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).

Ligands
Numerous non-selective prescription drugs also bind to D3, but lack the strong receptor type and subtype selectivity that some of the following research compounds afford:
 * (R)-3-(4-propylmorpholin-2-yl)phenol, an arylmorpholine, agonist, >1000-fold functional (efficiacy) selectivity over D2
 * 3-(4-chlorophenyl)-N-(4-(4-(2-fluorophenyl)piperazin-1-yl)butyl)acryl amide, full agonist, significant binding selectivity over D2
 * trans-N-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]cyclohexyl}-3-methoxybenzamide, full agonist, > 200-fold binding selectivity over D4, D2, 5-HT1A, and α1-receptors
 * (-)-7-{[2-(4-Phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol
 * FAUC 346, partial agonist, subtype selective
 * FAUC 365, silent antagonist, subtype selective