Metoprolol overdose

Metoprolol overdose
Acute Toxicity Signs and Symptoms Treatment Elimination of the Drug ---

Acute Toxicity
Several cases of overdosage have been reported, some leading to death. Oral LD50’s (mg/kg): mice, 1158 to 2460; rats, 3090 to 4670.

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Signs and Symptoms
Potential signs and symptoms associated with overdosage with Metoprolol are bradycardia, hypotension, bronchospasm, and cardiac failure.

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Treatment
There is no specific antidote. In general, patients with acute or recent myocardial infarction may be more hemodynamically unstable than other patients and should be treated accordingly.

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Elimination of the Drug
Gastric lavage should be performed. Bradycardia: Atropine should be administered. If there is no response to vagal blockade, isoproterenol should be administered cautiously. Hypotension: A vasopressor should be administered, e.g., levarterenol or dopamine. Bronchospasm: A beta2-stimulating agent and/or a theophylline derivative should be administered. Cardiac Failure: A digitalis glycoside and diuretic should be administered. In shock resulting from inadequate cardiac contractility, administration of dobutamine, isoproterenol, or glucagon may be considered.

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