African trypanosomiasis pathophysiology


 * Pilar Almonacid

Pathophysiology & Etiology
Protozoan hemoflagellates belonging to the complex Trypanosoma brucei. Two subspecies that are morphologically indistinguishable cause distinct disease patterns in humans: T. b. gambiense causes West African sleeping sickness and T. b. rhodesiense causes East African sleeping sickness. (A third member of the complex, T. b. brucei, under normal conditions does not infect humans.)

Infection occurs in 3 stages. A trypanosomal chancre can develop on the site of inoculation. This is followed by a hemolymphatic stage with symptoms that include fever, lymphadenopathy, and pruritus. In the meningoencephalitic stage, invasion of the central nervous system can cause headaches, somnolence, abnormal behavior, and lead to loss of consciousness and coma. The course of infection is much more acute with T. b. rhodesiense than T. b. gambiense.

The tsetse fly is large, brown and stealthy. The bite feels like a hot needle being stuck into the flesh. During a blood meal on the mammalian host, an infected tsetse fly (genus Glossina) injects metacyclic trypomastigotes into skin tissue. The parasites enter the lymphatic system and pass into the bloodstream 1. Inside the host, they transform into bloodstream trypomastigotes 2, are carried to other sites throughout the body, reach other blood fluids (e.g., lymph, spinal fluid), and continue the replication by binary fission 3. The entire life cycle of African Trypanosomes is represented by extracellular stages. The tsetse fly becomes infected with bloodstream trypomastigotes when taking a blood meal on an infected mammalian host (4,5). In the fly’s midgut, the parasites transform into procyclic trypomastigotes, multiply by binary fission 6, leave the midgut, and transform into epimastigotes 7. The epimastigotes reach the fly’s salivary glands and continue multiplication by binary fission 8. The cycle in the fly takes approximately 3 weeks. Humans are the main reservoir for Trypanosoma brucei gambiense, but this species can also be found in animals. Wild game animals are the main reservoir of T. b. rhodesiense.



East african trypanosomiasis
The disease is caused by a parasite named Trypanosoma brucei rhodesiense (tri-PAN-o-SO-ma BREW-see-eye rho-DEE-see-ense), carried by the tsetse fly. An individual will get East African trypanosomiasis if they are bitten by a tsetse fly infected with the Trypanosoma brucei rhodesiense parasite. The tsetse fly is common only to Africa.

West african trypanosomiasis
West African trypanosomiasis, also called Gambian sleeping sickness, is caused by a parasite called Trypanosoma brucei gambiense (tri-PAN-o-SO-ma BREW-see-eye GAM-be-ense) carried by the tsetse fly. An individual gets West African trypanosomiasis through the bite of an infected tsetse fly, found only in Africa. On rare occasions, a pregnant woman may pass the infection to her baby, or an individual may become infected through a blood transfusion or organ transplant.