Trans-2-enoyl-CoA reductase (NADPH)

In enzymology, a trans-2-enoyl-CoA reductase (NADPH) is an enzyme that catalyzes the chemical reaction


 * acyl-CoA + NADP+ $$\rightleftharpoons$$ trans-2,3-dehydroacyl-CoA + NADPH + H+

Thus, the two substrates of this enzyme are acyl-CoA and NADP+, whereas its 3 products are trans-2,3-dehydroacyl-CoA, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is acyl-CoA:NADP+ trans-2-oxidoreductase. Other names in common use include NADPH-dependent trans-2-enoyl-CoA reductase, reductase, trans-enoyl coenzyme A, and trans-2-enoyl-CoA reductase (NADPH). This enzyme participates in fatty acid elongation in mitochondria and polyunsaturated fatty acid biosynthesis.

Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code.