(methionine synthase) reductase

In enzymology, a [methionine synthase] reductase is an enzyme that catalyzes the chemical reaction


 * 2 [methionine synthase]-methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP+ $$\rightleftharpoons$$ 2 [methionine synthase]-cob(I)alamin + NADPH + H+ + 2 S-adenosyl-L-methionine

The 3 substrates of this enzyme are [methionine synthase]-methylcob(I)alamin, S-adenosylhomocysteine, and NADP+, whereas its 4 products are [methionine synthase]-cob(I)alamin, NADPH, H+, and S-adenosyl-L-methionine.

This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is [methionine synthase]-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase. Other names in common use include methionine synthase cob(II)alamin reductase (methylating), methionine synthase reductase, [methionine synthase]-cobalamin methyltransferase (cob(II)alamin, and reducing). It employs one cofactor, flavoprotein.