Granulocyte colony-stimulating factor receptor

The granulocyte colony-stimulating factor receptor, abbreviated G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.

The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction.

Th G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. Mutations in the intracellular part of this receptor are associated with certain types of leukemia.

GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2.

Isoforms
The class IV isoform defective for both internalization and differentiation signaling.