Urea carboxylase

In enzymology, an urea carboxylase is an enzyme that catalyzes the chemical reaction


 * ATP + urea + HCO3- $$\rightleftharpoons$$ ADP + phosphate + urea-1-carboxylate

The 3 substrates of this enzyme are ATP, urea, and HCO3-, whereas its 3 products are ADP, phosphate, and urea-1-carboxylate.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is urea:carbon-dioxide ligase (ADP-forming). Other names in common use include urease (ATP-hydrolysing), urea carboxylase (hydrolysing), ATP-urea amidolyase, urea amidolyase, UALase, and UCA. This enzyme participates in urea cycle and metabolism of amino groups. It employs one cofactor, biotin.