Aryldialkylphosphatase

In enzymology, an aryldialkylphosphatase is an enzyme that catalyzes the chemical reaction


 * an aryl dialkyl phosphate + H2O $$\rightleftharpoons$$ dialkyl phosphate + an aryl alcohol

Thus, the two substrates of this enzyme are aryl dialkyl phosphate and H2O, whereas its two products are dialkyl phosphate and aryl alcohol.

This enzyme belongs to the family of hydrolases, specifically those acting on ester bonds phosphoric-triester hydrolases. The systematic name of this enzyme class is aryltriphosphate dialkylphosphohydrolase. Other names in common use include organophosphate hydrolase, paraoxonase, A-esterase, aryltriphosphatase, organophosphate esterase, esterase B1, esterase E4, paraoxon esterase, pirimiphos-methyloxon esterase, OPA anhydrase, organophosphorus hydrolase, phosphotriesterase, paraoxon hydrolase, OPH, and organophosphorus acid anhydrase. This enzyme participates in gamma-hexachlorocyclohexane degradation. It employs one cofactor, divalent cation. At least one compound, Chelating agent is known to inhibit this enzyme.

Structural studies
As of late 2007, 15 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , , , , , , and.