TRNA cytidylyltransferase

In enzymology, a tRNA cytidylyltransferase is an enzyme that catalyzes the chemical reaction


 * CTP + tRNAn $$\rightleftharpoons$$ diphosphate + tRNAn+1

Thus, the two substrates of this enzyme are CTP and tRNA(n), whereas its two products are diphosphate and tRNA(n+1).

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:tRNA cytidylyltransferase. Other names in common use include tRNA CCA-pyrophosphorylase, tRNA-nucleotidyltransferase, transfer-RNA nucleotidyltransferase, transfer ribonucleic acid nucleotidyl transferase, CTP(ATP):tRNA nucleotidyltransferase, transfer ribonucleate adenylyltransferase, transfer RNA adenylyltransferase, transfer ribonucleate nucleotidyltransferase, ATP (CTP):tRNA nucleotidyltransferase, ribonucleic cytidylic cytidylic adenylic pyrophosphorylase, transfer ribonucleate nucleotidyltransferase, transfer ribonucleic adenylyl (cytidylyl) transferase, transfer ribonucleic-terminal trinucleotide nucleotidyltransferase, transfer ribonucleate cytidylyltransferase, ribonucleic cytidylyltransferase, -C-C-A pyrophosphorylase, ATP(CTP)-tRNA nucleotidyltransferase, tRNA adenylyl(cytidylyl)transferase, ATP(CTP):tRNA nucleotidyltransferase, tRNA adenylyltransferase, and ATP:tRNA adenylyltransferase.

Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , and.