The Living Guidelines: Oral Antiplatelet Therapy Suggest Revisions to the CLASS IIa Guidelines

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Class IIa Guidelines

 * 1) If clopidogrel is given at the time of procedure, supplementation with GP IIb/IIIa receptor antagonists can be beneficial. (Class IIa Level of Evidence: B)
 * 2) For patients with an absolute contraindication to aspirin, it is reasonable to give a 300-mg to 600-mg loading dose of clopidogrel, administered at least 6 hours before PCI, and / or GP IIb/IIIa antagonists, administered at the time of PCI. (Class IIa Level of Evidence: C)
 * 3) In patients for whom the physician is concerned about risk of bleeding, a lower dose of 75 mg to 162 mg of aspirin is reasonable during the initial period after stent implantation. (Class IIa Level of Evidence: C)