Enzyme-thiol transhydrogenase (glutathione-disulfide)

In enzymology, an enzyme-thiol transhydrogenase (glutathione-disulfide) is an enzyme that catalyzes the chemical reaction


 * [xanthine dehydrogenase] + glutathione disulfide $$\rightleftharpoons$$ [xanthine oxidase] + 2 glutathione

Thus, the two substrates of this enzyme are [xanthine dehydrogenase] and glutathione disulfide, whereas its two products are [xanthine oxidase] and glutathione.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with a disulfide as acceptor. The systematic name of this enzyme class is [xanthine-dehydrogenase]:glutathione-disulfide S-oxidoreductase. Other names in common use include [xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase, enzyme-thiol transhydrogenase (oxidized-glutathione), glutathione-dependent thiol:disulfide oxidoreductase, and thiol:disulphide oxidoreductase. This enzyme participates in glutathione metabolism.