UDP-N-acetylmuramate dehydrogenase

In enzymology, an UDP-N-acetylmuramate dehydrogenase is an enzyme that catalyzes the chemical reaction


 * UDP-N-acetylmuramate + NADP+ $$\rightleftharpoons$$ UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+

Thus, the two substrates of this enzyme are UDP-N-acetylmuramate and NADP+, whereas its 3 products are UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is UDP-N-acetylmuramate:NADP+ oxidoreductase. Other names in common use include MurB reductase, UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylglucosamine-enoylpyruvate reductase, UDP-GlcNAc-enoylpyruvate reductase, uridine diphosphoacetylpyruvoylglucosamine reductase, uridine diphospho-N-acetylglucosamine-enolpyruvate reductase, uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-, and lactylglucose:NADP-oxidoreductase. This enzyme participates in aminosugars metabolism. It employs one cofactor, FAD.

Structural studies
As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , and.