Dimethylacetamide

Dimethylacetamide (DMA or DMAc), also known as acetic acid-dimethylamide, N,N-dimethylacetamide or acetyldimethylamine, is a colorless, water miscible, high boiling, polar and hygroscopic liquid commonly used as a solvent in organic synthesis. DMA can be mixed with other solvents, such as alcohols, ethers, ketones, chlorinated and aromatic solvents. However it is very poorly miscible with aliphatic hydrocarbons.

The chemical reactions of dimethylacetamide are typical of disubstituted amides, therefore will hydrolize in the presence of acids and will undergo saponification when reacted with strong bases such as sodium hydroxide:


 * CH3CON(CH3)2 + H2O + HCl → CH3COOH + (CH3)2NH·HCl
 * CH3CON(CH3)2 + NaOH → CH3COONa + (CH3)2NH

Dimethylacetamide is commonly used as a solvent for fibers or in the adhesive industry. It is also employed in the production of pharmaceuticals and plasticizers as a reaction medium.

DMA is a harmful liquid, particularly if exposure takes place by means of inhalation or contact with skin. It is considered to be a carcinogen, teratogen and a possible reproductive hazard.