AIDS landmark trials

Ujjwal Rastogi, MBBS [mailto:urastogi@perfuse.org]

Overview
Clinical trials are a set of procedures in medical research and drug development that are conducted to allow safety (or more specifically, information about adverse drug reactions and adverse effects of other treatments) and efficacy data to be collected for health interventions (e.g., drugs, diagnostics, devices, therapy protocols). Several trials have been conducted till date that have immense contribution.

Clinical trials of Non-nucleoside reverse transcriptase inhibitors
1. Efavirenz and nevirapine (2NN study) (2004)
 * Purpose : It was a randomised comparison of the non-nucleoside reverse-transcriptase inhibitors (NNRTI) nevirapine and efavirenz.
 * Study Design: Randomised trial

2. Rilpivirine versus efavirenz with tenofovir and emtricitabine in treatment-naive adults infected with HIV-1 (ECHO) (2011)
 * Purpose :  Interventional
 * Study Design: Randomised, double-blind, double-dummy, active-controlled trial.