Formate-tetrahydrofolate ligase

In enzymology, a formate-tetrahydrofolate ligase is an enzyme that catalyzes the chemical reaction


 * ATP + formate + tetrahydrofolate $$\rightleftharpoons$$ ADP + phosphate + 10-formyltetrahydrofolate

The 3 substrates of this enzyme are ATP, formate, and tetrahydrofolate, whereas its 3 products are ADP, phosphate, and 10-formyltetrahydrofolate.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is formate:tetrahydrofolate ligase (ADP-forming). Other names in common use include formyltetrahydrofolate synthetase, 10-formyltetrahydrofolate synthetase, tetrahydrofolic formylase, and tetrahydrofolate formylase. This enzyme participates in glyoxylate and dicarboxylate metabolism and one carbon pool by folate.

Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes, , and.