4-hydroxyphenylacetaldehyde dehydrogenase

In enzymology, a 4-hydroxyphenylacetaldehyde dehydrogenase is an enzyme that catalyzes the chemical reaction


 * 4-hydroxyphenylacetaldehyde + NAD+ + H2O $$\rightleftharpoons$$ 4-hydroxyphenylacetate + NADH + 2 H+

The 3 substrates of this enzyme are 4-hydroxyphenylacetaldehyde, NAD+, and H2O, whereas its 3 products are 4-hydroxyphenylacetate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase. This enzyme is also called 4-HPAL dehydrogenase. This enzyme participates in tyrosine metabolism.