Granulomatous amoebic encephalitis causes

Overview
Granulomatous amoebic encephalitis is a central nervous system disease caused by certain species of amoeba, especially Balamuthia mandrillaris.

Causes
Balamuthia mandrillaris has only recently been isolated from the environment and has also been isolated from autopsy specimens of infected humans and animals. B. mandrillaris has only two stages, cysts and trophozoites, in its life cycle. No flagellated stage exists as part of the life  cycle. The trophozoites replicate by mitosis (nuclear membrane does not remain intact). The trophozoites are the infective forms, although both cysts and  trophozoites gain entry into the body  through various means. Entry can occur through the nasal passages to  the lower respiratory tract, or ulcerated or broken skin. When B. mandrillaris enters the respiratory system or  through the skin, it can invade the central nervous system by hematogenous   dissemination causing granulomatous amebic encephalitis (GAE)  or disseminated disease, or skin lesions  in individuals who are immune competent as well as those with   compromised immune systems. B. mandrillaris cysts and trophozoites are  found in tissue.