Torsade de pointes


 * Associate Editor(s)-In-Chief:

Overview
Torsade de pointes in French means "Twisting of the Points". It is characterized by a polymorphic ventricular tachycardia and can occur in the congenital long QT syndromes, electrolyte abnormalities (hypomagnesemia, hypokalemia), usage of certain drugs like antiarrhythmic (quinidine), nonsedating antihistamines (terfenadine); antibiotics (erythromycin) and neuroleptics (thioridazine). Torsade de pointes is characterized by constantly changing rhythm amplitude. The changing rhythm amplitudes comes from the ventricular depolarizing waves constantly shifting its axis. The underlying mechanism is thought to be triggered activity arising as a consequence of early after-depolarizations. Torsade de pointes is typically initiated by a short-long-short interval. A ventricle extrasystole (first beat: short) is followed by a compensatory pause. The following beat (second beat: long) has a longer QT interval. If the next beat follows shortly thereafter, there is a good chance that this third beat falls within the QT interval, resulting in the R on T phenomenon and subsequent Torsade de pointes. During Torsade de pointes the ventricles depolarize in a circular fashion resulting in QRS complexes with a continuously turning heart axis around the baseline (hence the name Torsade de Pointes). An understanding of the patho-physiology has led to development of treatment modalities like pacing, isoproterenol and drugs like magnesium and beta blockers. Although Torsades de Pointes (TdP) is a rare ventricular arrhythmia, it can degenerate into ventricular fibrillation, leading to death without rapid medical intervention. TdP is associated with long QT syndrome, a condition whereby prolonged QT intervals are visible on the ECG. Also, a more rare form of short coupled Torsade de pointes has been observed.

Historical Perspective

 * It was first described by Dessertenne in 1966 and refers to a specific variety of ventricular tachycardia that exhibits distinct characteristics on the electrocardiogram (ECG).


 * The French term is largely due to the fact that the phenomenon was originally described in a French medical journal by Dessertenne in 1966, when he observed this rhythm disorder in an 80-year-old female patient with complete intermittent atrioventricular block.


 * There has been much debate in the Circulation journal among French and American scientist whether one should write Torsades de Pointes or Torsade de Pointes.


 * As for now Torsade is prefered (unless one sees rotations around more than one axis in one episode), but both forms are used in similar frequency.

History and symptoms
Torsades is a rapid, polymorphic ventricular tachycardia with a characteristic twist of the QRS complex around the isoelectric baseline. It is also associated with a fall in arterial blood pressure, which gives rise to the syncopal symptoms experienced by patients. Although torsade de pointes is a rare ventricular arrhythmia, it can degenerate into ventricular fibrillation, which will lead to sudden death in the absence of medical intervention.

History
It is important to gather the following information from the patient:
 * History of congenital long QT syndrome
 * Family history of sudden cardiac death
 * Family history of sudden infant death syndrome
 * Family history of congenital deafness (Jervell and Lange-Nielsen syndrome presenting with congenital sensorineural deafness and cardiac abnormalities)
 * Family history of congenital long QT syndrome with normal hearing i.e. Romano-Ward syndrome
 * Medication history to rule out acquired causes of Torsade de pointes

Symptoms

 * Nausea, vomiting
 * Shortness of breath
 * Chest pain
 * Recurrent palpitations
 * Dizziness
 * Syncope
 * Sudden cardiac death

Physical examination
Physical examination findings depends on the rate and duration of the episode and the effect on cerebral perfusion during the episode. The physical finding may include:


 * Pallor and diaphoresis
 * Bradycardia followed by tachycardia
 * Loss of consciousness

Causes
Long QT syndrome can either be inherited as congenital mutations of ion channels carrying the cardiac impulse/action potential or acquired as a result of drugs that block these cardiac ion currents.

Common causes for torsades de pointes include hypomagnesemia and hypokalemia. It is commonly seen in malnourished individuals and chronic alcoholics. Drug interactions such as erythromycin or Avelox, taken concomitantly with inhibitors like nitroimidazole, Diarrhea, dietary supplements, and various medications like methadone, Lithium, tricyclic antidepressants or phenothiazines may also contribute.

Factors that are associated with an increased tendency toward torsades de pointes include:
 * Familial long QT syndrome
 * Class IA antiarrhythmics
 * Hypomagnesemia
 * Hypokalemia
 * Hypoxia
 * Acidosis
 * Heart failure
 * Left ventricular hypertrophy
 * Slow heart rate
 * Female gender
 * Baseline electrocardiographic abnormalities
 * Renal or liver failure

The List of Drugs that Causing Torsades de pointes
Drugs that are generally accepted to have a risk of causing torsades de pointes


 * Amiodarone
 * Arsenic trioxide
 * Astemizole
 * Bepridil
 * Chloroquine
 * Chlorpromazine
 * Cisapride
 * Clarithromycin
 * Disopyramide
 * Dofetilide
 * Domperidone
 * Droperidol
 * Erythromycin
 * Halofantrine
 * Haloperidol
 * Ibutilide
 * Levomethadyl
 * Mesoridazine
 * Methadone
 * Pentamidine
 * Pimozide
 * Probucol
 * Procainamide
 * Quinidine
 * Sotalol
 * Sparfloxacin
 * Terfenadine
 * Thioridazine

The List of Drugs that Possible Causing Torsades de pointes
Drugs that in some reports have been associated with torsades de pointes and/or QT prolongation but at this time lack substantial evidence for causing torsades de pointes.


 * Alfuzosin
 * Amantadine
 * Atazanavir
 * Azithromycin
 * Chloral hydrate
 * Clozapine
 * Dolasetron
 * Felbamate
 * Flecainide
 * Foscarnet
 * Fosphenytoin
 * Gatifloxacin
 * Gemifloxacin
 * Granisetron
 * Indapamide
 * Isradipine
 * Levofloxacin
 * Lithium
 * Moexipril / HCTZ
 * Moxifloxacin
 * Nicardipine
 * Octreotide
 * Ofloxacin
 * Ondansetron
 * Oxytocin
 * Paliperidone
 * Perflutren
 * Quetiapine
 * Ranolazine
 * Risperidone
 * Roxithromycin
 * Sunitinib
 * Tacrolimus
 * Tamoxifen
 * Telithromycin
 * Tizanidine
 * Vardenafil
 * Venlafaxine
 * Voriconazole
 * Ziprasidone

The List of Drugs that Causing Torsades de pointes in Certain Conditions
Drugs that, in some reports, have been weakly associated with torsades de pointes and/or QT prolongation but that are unlikely to be a risk for torsades de pointes when used in usual recommended dosages and in patients without other risk factors (e.g., concomitant QT prolonging drugs, bradycardia, electrolyte disturbances, congenital long QT syndrome, concomitant drugs that inhibit metabolism)


 * Amitriptyline
 * Amoxapine
 * Ciprofloxacin
 * Citalopram
 * Clomipramine
 * Desipramine
 * Doxepin
 * Fluconazole
 * Fluoxetine
 * Galantamine
 * Imipramine
 * Itraconazole
 * Ketoconazole
 * Mexiletine
 * Nortriptyline
 * Paroxetine
 * Protriptyline
 * Sertraline
 * Solifenacin
 * Trimethoprim-Sulfamethoxazole
 * Trimipramine

Differential diagnosis

 * Ventricular Tachycardia (polymorphic, monomorphic)
 * Supraventricular tachycardia
 * Ventricular Fibrillation
 * Sudden Cardiac Death
 * Syncope
 * Renal Failure
 * Dialysis complication
 * Drug toxicity like antiarrhythmic, Antihistaminics

Electrocardiography
EKG is the main diagnostic tool in patients with Torsade de pointes. EKG findings that can be seen are:


 * Progressive change in polarity of QRS about the isoelectric line occurs
 * Prolonged QT interval (QT ≥ 0.60 s or QTc ≥ 0.45 s)
 * Pathological U
 * Rotation of the heart's electrical axis by at least 180º
 * Preceded by short long and short RR-intervals
 * Triggered by an early premature ventricular contraction(R-on-T PVC)
 * Paroxysms of 5-20 beats at a rate ≥ 200 bpm
 * Patients may revert spontaneously to a nonpolymorphic ventricular tachycardia or ventricular fibrillation

Video: Torsade de pointes




'''Torsade de pointes is characterized by constantly changing rhythm amplitude. 'Torsade de pointes' in French means "Twisting of the Points". The changing rhythm amplitudes comes from the ventricular depolarizing waves constantly shifting its axis. It is usually caused by hypomagnesemia, hypokalemia, and malnourished alcoholics. Although Torsades de Pointes (TdP) is a rare ventricular arrhythmia, it can degenerate into ventricular fibrillation, leading to death without rapid medical intervention. TdP is associated with long QT syndrome, a condition whereby prolonged QT intervals are visible on the ECG.'''

Other lab studies

 * Electrolytes levels to rule out hypokalemia, hypomagnesemia, and hypocalcemia.
 * Cardiac enzymes
 * Echocardiography to rule out structural heart disease

Acute Treatment
If the episode of does not terminate on its own and degenerates into ventricular fibrillation, cardioversion is required.



Once the patient is back in normal sinus rhythm, a vigorous search for and correction of conditions that predispose to torsades de pointes which include hypokalemia, hypomagnesemia, and bradycardia should be made. Magnesium sulfate (1-2 g IV over 30-60 seconds) reduces the influx of calcium thereby lowering the amplitude of early after depolarizations and should also be infused even if the magnesium is normal. Administration of lidocaine is generally not effective, but mexiletene may be helpful in suppressing the recurrence of torsade de pointes.

Additional Information

 * Torsade de Pointes and Polymorphic VT

Examples
EKG's shown below are courtesy of C. Michael Gibson MS MD, and copylefted