North American smallpox epidemic

Between 1775 and 1782, a smallpox epidemic raged across much of North America, killing more than 130,000 people. Among the places it showed itself:
 * The town of Boston during the British occupation and the American siege of 1775.
 * The American invasion of Quebec, 1775.
 * Smallpox ravaged the populations of escaped slaves who fled to the British lines in the South during the American Revolutionary War.
 * New Orleans, 1778–1779
 * Tens of thousands of people died throughout Mexico beginning in 1779.
 * It swept through the Pueblos of New Mexico beginning in 1780.
 * It probably travelled among the people of the Great Plains.
 * It showed up in the interior trading posts of the Hudson's Bay Company in 1782