HLA-DQ6

HLA-DQ6 is an HLA-DQ serotype grouping based on antibody recognition of the HLA DQ beta chain. It is synonymous with the HLA-DQB1*06 allelegroup. This group is composed of many similar beta chains. HLA DQB1*0601 to *0605, and *0609 are the most common. These beta chains are linked to certain alpha chain genes DQA1*01 as a result DQ6 serotyped cells were originally recognized as DQ1 since DQ1 recognizes the DQA1*01 allele group gene products. These gene products are DQA1*0101 to *0106. DQ1 also recognizes cells recognized by DQ5.

=Serology=

=Alleles= DQB1*0601, *0602, *0603, *0604, *0605 and DQB1*0609 are the most common. DQB1*0601 is generally linked to DQA1*0103 as DQ6.1 and is more common in eastern asia. DQB1*0602 is commonly lined to DQA1*0102 as DQ6.2 and is common from central asia into Western Europe, *0602 is also linked to DQA1*0103 in parts of Asia. DQB1*0603 is commonly lined to DQA1*0103 as DQ6.3 and is common from Central asia into Western Europe, *0603 is also linked to DQA1*0102 in parts of Asia. DQB1*0604 is found at higher frequencies in parts of Asia and is linked almost exclusively to DQA1*0102 as DQ6.4. DQB1*0605 and *0609 are elevated in SW europe and Africa and are linked to DQA1*0102 as DQ6.5 and DQ6.9, respectively.

=Haplotypes=

DQ6.1
DQA1*0103:DQB1*0601 (DQ6.1) is found at increased freqeuncies in Asia and is almost absent in Western Europe. It confers protection from Narcolepsy, Type 1 diabetes , Vogt-Koyanagi-Harada (VKH) syndrome , pemphigus vulgaris , Multiple schlerosis , myasthenia gravis.

DQ6.2
DQA1*0102:DQB1*0602 (DQ6.2) is very common in eurasia, particularly central asia and eastern europe.

hypocretin deficiency associated narcolepsy - with DR15

Myasthenia gravis - α34-49 of AChR recognition

Cervical neoplasia - DQA1*0102 - increased risk -

Primary biliary cirrhosis - Protective.

Multiple sclerosis - DQA1*0102 was the most frequent allele in the MS patients and DQB1*0602 increased significantly in the MS patients.

DQ6.3
A1*0103:B1*0603 (DQ6.3) is found in northcentral europe at moderate frequencies, it is a protective against many autoimmune diseases.

DQ6.4
A1*0102:B1*0604 (DQ6.4) is associated with thymoma induced myastenia gravis.

=References=

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