Naproxen drug interactions

List of drug interactions
ACE-Inhibitors Antacids and Sucralfate Aspirin Cholestyramine Diuretics Lithium Antacids and Sucralfate Methotrexate Warfarin Selective Serotonin Reuptake Inhibitors (SSRIs)

ACE-Inhibitors
Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors. Return to top

Antacids and Sucralfate
Concomitant administration of some antacids (magnesium oxide or aluminum hydroxide) and sucralfate can delay the absorption of Naproxen. Return to top

Aspirin
When Naproxen sodium tablets are administered with aspirin, its protein binding is reduced, although the clearance of free Naproxen is not altered. The clinical significance of this interaction is not known; however, as with other NSAIDs, concomitant administration of Naproxen sodium and aspirin is not generally recommended because of the potential of increased adverse effects. Return to top

Cholestyramine
As with other NSAIDs, concomitant administration of cholestyramine can delay the absorption of Naproxen. Return to top

Diuretics
Clinical studies, as well as postmarketing observations, have shown that Naproxen sodium tablets can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with NSAIDs, the patient should be observed closely for signs of renal failure, as well as to assure diuretic efficacy. Return to top

Lithium
NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance. The mean minimum lithium concentration increased 15% and the renal clearance was decreased by approximately 20%. These effects have been attributed to inhibition of renal prostaglandin synthesis by the NSAID. Thus, when NSAIDs and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity. Return to top

Methotrexate
NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices. Naproxen sodium and other non-steroidal anti-inflammatory drugs have been reported to reduce the tubular secretion of methotrexate in an animal model. This may indicate that they could enhance the toxicity of methotrexate. Caution should be used when NSAIDs are administered concomitantly with methotrexate. Return to top

Warfarin
The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone. No significant interactions have been observed in clinical studies with Naproxen and coumarin-type anticoagulants. However, caution is advised since interactions have been seen with other non-steroidal agents of this class. The free fraction of warfarin may increase substantially in some subjects and Naproxen interferes with platelet function. Return to top

Selective Serotonin Reuptake Inhibitors (SSRIs)
There is an increased risk of gastrointestinal bleeding when selective serotonin reuptake inhibitors (SSRIs) are combined with NSAIDs. Caution should be used when NSAIDs are administered concomitantly with SSRIs. Return to top

Major Interactions

 * adefovir
 * anisindione
 * ardeparin
 * Arixtra
 * Arixtra 10 mg/dose
 * Arixtra 5 mg/dose
 * Arixtra 7.5 mg/dose
 * Bexxar Dosimetric
 * Bexxar I 131 Dosimetric
 * Bexxar I 131 Therapeutic
 * BexxarTherapeutic
 * cidofovir
 * Clexane
 * Clexane Forte
 * Coumadin
 * dalteparin
 * danaparoid
 * dasatinib
 * desirudin
 * dicumarol
 * drotrecogin
 * drotrecogin alfa
 * enoxaparin
 * FK506
 * Folex PFS
 * fondaparinux
 * Fragmin
 * Hepsera
 * ibritumomab
 * In-111 Zevalin
 * Innohep
 * iodine I 131 tositumomab
 * Iprivask
 * Jantoven
 * ketorolac
 * Lovenox
 * Lovenox HP
 * methotrexate
 * Methotrexate Sodium Preservative Free
 * Miradon
 * Normiflo
 * Orgaran
 * Prograf
 * Rapamune
 * Rheumatrex Dose Pack
 * sirolimus
 * sodium biphosphate
 * Sprycel
 * tacrolimus
 * tenofovir
 * tinzaparin
 * Toradol
 * Toradol IM
 * Toradol IV/IM
 * tositumomab
 * Trexall
 * Viread
 * Vistide
 * warfarin
 * Xigris
 * [[Y-90 Zevalin

Moderate Interactions

 * 5-ASA
 * A-Hydrocort
 * A-Methapred
 * Abbokinase
 * Abbokinase Open-Cath
 * abciximab
 * Accupril
 * acebutolol
 * Aceon
 * Acetocot
 * acetohexamide
 * Acetylsalicylic Acid
 * Aciphex
 * Aclasta
 * Acova
 * Activase
 * Acuprin 81
 * Adalat
 * Adalat CC
 * Adbeon
 * Adlone-40
 * Adlone-80
 * Adrenocot
 * Adrenocot L.A.
 * Afeditab CR
 * Aggrastat
 * Agrylin
 * alatrofloxacin
 * alcohol
 * alcohol
 * ethyl
 * Aldactone
 * alendronate
 * alendronate weekly
 * Alimta
 * Altace
 * alteplase
 * Amaryl
 * amikacin
 * Amikin
 * Amikin Pediatric
 * amiloride
 * amlodipine
 * Anafranil
 * anagrelide
 * Ancobon
 * Angiomax
 * anistreplase
 * Anturane
 * aprepitant
 * Apresoline
 * Aquacot
 * Aquatensen
 * Aquazide H
 * Arava
 * Aredia
 * argatroban
 * Aristocort
 * Aristocort For Injection
 * Aristocort Forte
 * Aristopak
 * Aristospan Injection
 * Arthritis Pain
 * ASA
 * Asacol
 * Ascriptin Enteric
 * Aspergum Cherry
 * Aspergum Orginal
 * Aspir-Low
 * aspirin
 * aspirin extended release
 * Aspirin Lite Coat
 * Aspirin Litecoat
 * Aspirin Low Strength
 * Aspirtab
 * Atacand
 * atazanavir
 * atenolol
 * Avapro
 * Avelox
 * Avelox I.V.
 * Axid
 * Axid AR
 * Axid Pulvules
 * Azmacort
 * Azulfidine
 * Azulfidine EN-tabs
 * balsalazide
 * Baraclude
 * Bayer Aspirin
 * Bayer Aspirin Regimen
 * Bayer Aspirin Sugar Free
 * Bayer Aspirin with Calcium
 * Bayer Childrens Aspirin
 * Bayer Low Strength
 * Bayer Plus
 * benazepril
 * bendroflumethiazide
 * Benicar
 * benzthiazide
 * bepridil
 * Beta-Phos/AC
 * betamethasone
 * betamethasone acet-betamethasone na phosphate
 * betamethasone sodium phosphate
 * Betapace
 * Betapace AF
 * Betapace AF(obsolete)
 * betaxolol
 * Bextra
 * bisoprolol
 * bivalirudin
 * Blocadren
 * Bondronat
 * Boniva
 * bosentan
 * Brevibloc
 * Bubbli-Pred
 * budesonide
 * Buffered Aspirin
 * Bufferin
 * Bufferin Arthritis Strength
 * Bufferin Extra Strength
 * Buffex
 * bumetanide
 * Bumex
 * Bystolic
 * Calan
 * Calan SR
 * Canasa
 * Canasa Pac
 * candesartan
 * Capoten
 * captopril
 * Cardene
 * Cardene IV
 * Cardene SR
 * Cardizem
 * Cardizem CD
 * Cardizem LA
 * Cardizem Monovial
 * Cardizem SR
 * Cardoxin
 * Carozide
 * carteolol
 * Cartia XT
 * Cartrol
 * carvedilol
 * carvedilol extended release
 * Cathflo Activase
 * Celebrex
 * celecoxib
 * Celestone
 * Celestone Phosphate
 * Celestone Soluspan
 * Celexa
 * Cell-U-Jec
 * chlorothiazide
 * Chlorpropamide
 * chlorthalidone
 * Cidomycin
 * cilostazol
 * cimetidine
 * Cinobac
 * cinoxacin
 * Cipro
 * Cipro Cystitis Pack
 * Cipro I.V.
 * Cipro XR
 * ciprofloxacin
 * ciprofloxacin extended release
 * citalopram
 * Clinacort
 * Clinalog
 * clofarabine
 * Clolar
 * Clomipramine
 * clopidogrel
 * Colazal
 * Colocort
 * Coreg
 * Coreg CR
 * Corgard
 * Cort-K
 * Cortastat
 * Cortastat 10
 * Cortastat LA
 * Cortef
 * Cortenema
 * Cortifoam
 * cortisone
 * Cortone Acetate
 * Cotolone
 * Covera-HS
 * Cozaar
 * Cubicin
 * Cyclosporine
 * Cymbalta
 * Dalalone
 * Dalalone D.P.
 * Dalalone L.A.
 * daptomycin
 * DDAVP
 * DDAVP Nasal
 * DDAVP Rhinal Tube
 * De-Sone LA
 * Decadron
 * Decadron 5-12 Pak
 * Decadron Phosphate Injectable
 * Decadron-LA
 * Decaject
 * Decaject L.A.
 * Dehydrated Alcohol
 * Deltasone
 * Demadex
 * Demadex I.V.
 * Dep Medalone 80
 * Depmedalone
 * Depo-Medrol
 * Depo-Predate (obsolete)
 * Depoject-80
 * Depopred
 * desmopressin
 * desvenlafaxine
 * Dexacen-4
 * Dexacort Phosphate in Respihaler
 * Dexacort-LA
 * Dexacorten
 * dexamethasone
 * dexamethasone acetate
 * Dexamethasone Intensol
 * dexamethasone sodium phosphate
 * Dexasone
 * Dexasone LA
 * dexfenfluramine
 * Dexone
 * Dexone LA
 * Dexpak Jr. Taperpak
 * Dexpak Taperpak
 * DiaBeta
 * Diabinese
 * Diaqua
 * Diaqua-2
 * Didronel
 * Didronel I.V.
 * Digitek
 * digoxin
 * digoxin capsule
 * Dilacor XR
 * Diltia XT
 * diltiazem
 * diltiazem 24 hour extended release
 * diltiazem extended release
 * Diltiazem Hydrochloride CD
 * Diltiazem Hydrochloride SR
 * Diltiazem Hydrochloride XR
 * Diltiazem Hydrochloride XT
 * Diovan
 * Dipentum
 * dipyridamole
 * Diucardin
 * Diurese
 * Diuril
 * Diuril Sodium
 * drospirenone
 * duloxetine
 * Duralone
 * Dymelor
 * Dynacirc
 * Dynacirc CR
 * Dyrenium
 * Easprin
 * Ecotrin
 * Ecotrin Adult Low Strength
 * Ecotrin Maximum Strength
 * Edecrin
 * Edecrin Sodium
 * Effexor
 * Effexor XR
 * Eloxatin
 * Emend
 * Emend 3-Day
 * Emend for Injection
 * Empirin
 * enalapril
 * enalaprilat
 * Enduron
 * enoxacin
 * Entaprin
 * entecavir
 * Entercote
 * Entocort
 * Entocort EC
 * eplerenone
 * epoprostenol
 * eprosartan
 * eptifibatide
 * escitalopram
 * Esidrix
 * Eskalith
 * Eskalith-CR
 * esmolol
 * esomeprazole
 * ethacrynic acid
 * ethanol
 * Ethyl Alcohol
 * etidronate
 * etravirine
 * Exna
 * Extra Strength Bayer
 * Ezide
 * Factive
 * famotidine
 * Fasprin
 * felodipine
 * felodipine extended release
 * fenfluramine
 * FIV-ASA
 * Flo-Pred
 * Flolan
 * Florinef Acetate
 * Floxin
 * Floxin I.V.
 * flucytosine
 * fludrocortisone
 * fluoxetine
 * fluoxetine extended release
 * fluvoxamine
 * fluvoxamine extended release
 * Fosamax
 * fosaprepitant
 * fosinopril
 * furosemide
 * Garamycin
 * gatifloxacin
 * gemifloxacin
 * Genacote
 * Gengraf
 * Gennin-FC
 * Genprin
 * gentamicin
 * Gleevec
 * glimepiride
 * glipizide
 * glipizide extended release
 * glipizide XL
 * Glucotrol
 * Glucotrol XL
 * glyburide
 * glyburide micronized
 * Glynase PresTab
 * grepafloxacin
 * Halfprin
 * HCTZ
 * Heartburn Relief
 * Hep-Lock
 * Hep-Pak
 * Hep-Pak CVC
 * heparin
 * Heparin Lock Flush
 * Hexadrol
 * Hexadrol Phosphate
 * Hydeltra-T.B.A.
 * Hydeltrasol
 * hydralazine
 * Hydro Par
 * hydrochlorothiazide
 * hydrocortisone
 * hydrocortisone acetate
 * hydrocortisone cypionate
 * hydrocortisone hemisuccinate
 * hydrocortisone sodium phosphate
 * Hydrocortisone Sodium Succinate
 * Hydrocortone
 * Hydrocortone Phosphate
 * hydrodiuril
 * hydroflumethiazide
 * Hygroton
 * ibandronate
 * iloprost
 * imatinib
 * indapamide
 * Inderal
 * Inderal LA
 * InnoPran XL
 * Inspra
 * Integrilin
 * Intelence
 * irbesartan
 * Isoptin
 * Isoptin I.V.
 * Isoptin SR
 * isradipine
 * isradipine extended release
 * Kabikinase
 * kanamycin
 * Kantrex
 * Ken-Jec 40
 * Kenaject-40
 * Kenalog-10
 * Kenalog-40
 * Kerlone
 * Key-Pred
 * Key-Pred SP
 * Kinlytic
 * labetalol
 * Lanoxicaps
 * Lanoxin
 * lansoprazole
 * lapatinib
 * Lasix
 * Leader Acid Reducer
 * leflunomide
 * lepirudin
 * Levaquin
 * Levaquin Leva-Pak
 * Levatol
 * levofloxacin
 * Lexapro
 * Lialda
 * Liquid Pred
 * lisinopril
 * Litecoat Aspirin
 * lithium
 * lithium carbonate
 * lithium carbonate extended release
 * lithium citrate
 * Lithobid
 * Lithonate
 * Lithotabs
 * Lo-Aqua
 * lomefloxacin
 * Lopressor
 * Loqua
 * losartan
 * Lotensin
 * Low Dose ASA
 * Lozol
 * Luvox
 * Luvox CR
 * M-Prednisolone
 * Mavik
 * Maxaquin
 * Med-Jec-40
 * Medicort
 * Medidex
 * Medidex LA
 * Medipred
 * Medralone
 * Medralone 40
 * Medralone 80
 * Medrol
 * Medrol Dosepak
 * Meridia
 * mesalamine
 * mesalamine extended release
 * Mesasal Enteric Coated
 * Metahydrin
 * Methacort 40
 * Methacort 80
 * methyclothiazide
 * Methylcotol
 * Methylcotolone
 * Methylpred DP
 * methylprednisolone
 * methylprednisolone acetate
 * methylprednisolone dose pack
 * methylprednisolone sodium succinate
 * Meticorten
 * metolazone
 * metoprolol
 * metoprolol extended release
 * metoprolol succinate
 * Metoprolol Succinate ER
 * metoprolol tartrate
 * Micardis
 * Micronase
 * Microzide
 * Midamor
 * Millipred
 * Minipress
 * Minirin
 * Minitabs
 * moexipril
 * Monopril
 * moxifloxacin
 * Mykrox
 * Mylanta AR
 * nadolol
 * nalidixic acid
 * Naqua
 * nateglinide
 * Naturetin-10
 * Naturetin-5
 * Nebcin
 * Nebcin Pediatric
 * nebivolol
 * Neggram
 * Neoral
 * netilmicin
 * Netromycin
 * Nexium
 * Nexium I.V.
 * nicardipine
 * nicardipine extended release
 * Nifediac CC
 * Nifedical XL
 * nifedipine
 * nifedipine extended release
 * nimodipine
 * Nimotop
 * nisoldipine
 * nizatidine
 * norfloxacin
 * Normodyne
 * Noroxin
 * Norvasc
 * Norwich Aspirin
 * ofloxacin
 * olmesartan
 * olsalazine
 * omeprazole
 * Oncaspar
 * Orapred
 * Orapred ODT
 * Orasone
 * Oretic
 * Orinase
 * oxaliplatin
 * pamidronate
 * pantoprazole
 * paroxetine
 * paroxetine extended release
 * paroxetine mesylate
 * Paxil
 * Paxil CR
 * Pediapred
 * pegaspargase
 * pemetrexed
 * penbutolol
 * Penetrex
 * Pentasa
 * Pepcid
 * Pepcid AC
 * Pepcid AC Maximum Strength
 * Pepcid RPD
 * perindopril
 * Persantine
 * Persantine IV
 * Pexeva
 * pindolol
 * Plavix
 * Plendil
 * Pletal
 * polythiazide
 * Pondimin
 * Prandin
 * prazosin
 * Pred-Ject-50
 * Predacort 50
 * Predacorten
 * Predaject-50
 * Predalone 50
 * Predate-50
 * Predcor
 * Predicort RP
 * Predicort-50
 * Prednicen-M
 * Prednicot
 * prednisolone
 * prednisolone acetate
 * prednisolone sodium phosphate
 * prednisolone tebutate
 * prednisone
 * Prelone
 * Prevacid
 * Prevacid I.V.
 * Prevacid SoluTab
 * Pri-Cortin 50
 * Priftin
 * Prilosec
 * Prilosec OTC
 * Primethasone
 * Prinivil
 * Pristiq
 * Procardia
 * Procardia XL
 * propranolol
 * propranolol extended release
 * Proquin XR
 * prostacyclin
 * Protonix
 * Protonix IV
 * Prozac
 * Prozac Weekly
 * Pulmicort Flexhaler
 * Pulmicort Nebuamp
 * Pulmicort Respules
 * Pulmicort Turbuhaler
 * quinapril
 * rabeprazole
 * ramipril
 * ranitidine
 * ranitidine bismuth citrate
 * Rapiflux
 * Raxar
 * Reclast
 * Redux
 * Refludan
 * Remodulin
 * Renese
 * Reopro
 * repaglinide
 * Retavase
 * reteplase
 * Reyataz
 * rifapentine
 * rofecoxib
 * Rowasa
 * Salofalk
 * Saluron
 * Sandimmune
 * Sarafem
 * Sectral
 * Selestoject
 * Selfemra
 * Septopal
 * sertraline
 * sibutramine
 * Sloprin
 * Solu-Cortef
 * Solu-Medrol
 * Solurex
 * Solurex LA
 * Sorine
 * sotalol
 * Sotalol Hydrochloride AF
 * Sotalol Hydrochloride AF(obsolete)
 * sparfloxacin
 * spironolactone
 * St. Joseph Aspirin
 * St. Joseph Aspirin Adult Chewable
 * St. Joseph Aspirin Adult EC
 * Stanback Analgesic
 * Starlix
 * Sterapred
 * Sterapred DS
 * Stimate
 * Streptase
 * streptokinase
 * streptomycin
 * Sular
 * sulfasalazine
 * Sulfazine
 * sulfinpyrazone
 * TAC 3
 * Tagamet
 * Tagamet HB
 * Taztia XT
 * telbivudine
 * telmisartan
 * tenecteplase
 * Tenormin
 * Tequin
 * Tequin Teqpaq
 * Teveten
 * Thalitone
 * Therapy Bayer
 * Tiazac
 * Ticlid
 * ticlopidine
 * timolol
 * tirofiban
 * tissue plasminogen activator
 * TNKase
 * Tobi
 * tobramycin
 * Tol-Tab
 * tolazamide
 * tolbutamide
 * Tolinase
 * Toprol-XL
 * torsemide
 * TPA
 * Tracleer
 * Tramacort-D
 * Trandate
 * trandolapril
 * treprostinil
 * Tri-Buffered Aspirin
 * Triam-A
 * Triam-Forte
 * triamcinolone
 * triamcinolone acetonide
 * triamcinolone diacetate
 * triamcinolone hexacetonide
 * triamcinolone ophthalmic
 * Triamcot
 * Triamonide 40
 * triamterene
 * trichlormethiazide
 * Triesence
 * Trilog
 * Trilone
 * Tristoject
 * Tritec
 * trovafloxacin
 * Trovan
 * Tykerb
 * Tyzeka
 * U-Tri-Lone
 * Univasc
 * urokinase
 * valdecoxib
 * valsartan
 * Vascor
 * Vasotec
 * venlafaxine
 * venlafaxine extended release
 * Ventavis
 * verapamil
 * verapamil 24 hour extended release
 * verapamil extended release
 * Verelan
 * Verelan PM
 * verteporfin
 * VFEND
 * Vioxx
 * Visken
 * Visudyne
 * voriconazole
 * YSP Aspirin
 * Zagam
 * Zagam Respipac
 * Zantac
 * Zantac 150
 * Zantac 300
 * Zantac 300 GELdose
 * Zantac 75
 * Zantac EFFERdose
 * Zantac GELdose
 * Zaroxolyn
 * Zebeta
 * Zegerid (Original Formulation)
 * Zero-Order Release
 * Zestril
 * zoledronic acid
 * Zoloft
 * Zometa
 * Zometa Concentrate
 * Zorprin

Minor Interactions

 * Acid Relief
 * Alka-Mints
 * Alkets
 * Alkums
 * Aloh-Gel
 * Alternagel
 * Alu-Cap
 * Alu-Tab
 * aluminum carbonate
 * aluminum hydroxide
 * Amilac
 * Amitone
 * Amphojel
 * Aricept
 * Aricept ODT
 * AZT
 * Basaljel
 * Benemid
 * Cal Oys
 * Cal-Gest
 * Calcarb
 * Calci Mix
 * Calci-Chew
 * Calcitab
 * calcium carbonate
 * Calcium Concentrate
 * Calcium Liquid Softgel
 * Calcium Oyster
 * Calcium Oyster Shell
 * Caltrate
 * Caltro
 * Chooz
 * Concentrated Phillips Milk of Magnesia
 * Cytotec
 * Dewees Carminative
 * Dialume
 * Dicarbosil
 * dihydroxyaluminum sodium carbonate
 * donepezil
 * Equilet
 * Ex-Lax Milk of Magnesia
 * Extra Strength Mylanta Calci Tabs
 * Icar Prenatal Chewable Calcium
 * Losospan
 * Lowsium
 * Maalox Antacid Barrier
 * Maalox Childrens'
 * Maalox Quick Dissolve
 * Maalox Quick Dissolve Extra Strength
 * Maalox Quick Dissolve Maximum Strength
 * Maalox Regular Strength
 * Mag-200
 * Mag-Carb
 * Mag-Ox 400
 * magaldrate
 * MagGel
 * magnesium carbonate
 * magnesium hydroxide
 * magnesium oxide
 * magnesium trisilicate
 * Maoson
 * Mg hydroxide
 * Mg oxide
 * Milk of Magnesia
 * misoprostol
 * Mylanta Child
 * Nephro Calci
 * Neut
 * Norvir
 * Norvir Soft Gelatin
 * Os-Cal
 * Os-Cal 500
 * Oysco 500
 * Oyst Cal
 * Oyst Cal 500
 * Oyster
 * Oyster Cal
 * Oyster Cal 500
 * Oyster Calcium
 * Oyster Shell
 * oyster shell calcium
 * Oyster Shell Calcium 500
 * Pepto Children's
 * Phillips Milk of Magnesia
 * Phillips' Cramp-free
 * probenecid
 * Retrovir
 * Ri-Mag
 * Riopan
 * ritonavir
 * Rolaids Sodium Free
 * Rolaids Soft Chew
 * Ron Acid
 * sodium bicarbonate
 * Super Calcium
 * Surpass
 * Surpass Extra Strength
 * Titralac
 * Tums
 * Tums 500
 * Tums E-X
 * Tums Extra Strength
 * Tums Ultra
 * Ultra Mylanta Calci Tabs
 * Uro-Mag
 * zidovudine