Coenzyme M

Coenzyme M is a coenzyme required for methyl-transfer reactions in the metabolism of methanogens. The coenzyme is an anion with the formula HSCH2CH2SO3-. It is named 2-mercaptoethanesulfonate and abbreviated HS-CoM. The cation is unimportant, but the sodium salt is most available. Mercaptoethanesulfonate contains both a thiol, which is the main site of reactivity, and a sulfonate group, which confers solubility in aqueous media.

Biochemical role
The coenzyme is the C1 carrier in methanogenesis. It is converted to methyl coenzyme M, the thioether CH3SCH2CH2SO3-, in the penultimate step to methane formation. Coenzyme M reacts with coenzyme B, 7-thioheptanoylthreoninephosphate, to give a heterodisulfide, releasing methane:
 * CH3-S-CoM + HS-CoB &rarr;  CH4  +  CoB-S-S-CoM

This conversion is catalyzed by the enzyme methyl coenzyme M reductase, which contains cofactor F430 as the prosthetic group.