Myoneurogenic gastrointestinal encephalopathy

Myoneurogenic gastrointestinal encephalopathy or MNGIE is a rare mitochondrial disease typically appearing between the second and fifth decades of life.

Presentation
MNGIE is a multisystem disorder causing ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, thin body habitus, peripheral neuropathy, and myopathy.