Gq protein

Gq protein is a heterotrimeric G protein subunit that activates phospholipase C (PLC). PLC in turn hydrolizes phosphatidylinositol (PIP2) to diacyl glycerol (DAG) and inositol triphosphate (IP3) signal transduction pathway. DAG acts as a second messenger that activates the Protein Kinase C (PKC) and IP3 helps in phosphorylation of some proteins.

From modulatory neurotransmitter receptors (amine receptors belonging to rhodopsin family), Gq is usually coupled to


 * Alpha 1 adrenergic receptors
 * 5-HT receptor type 2
 * Muscarinic receptors 1, 3 and 5
 * Histamine receptor type 1