Reissert reaction

The Reissert reaction is a series of chemical reactions that transforms quinoline to quinaldic acid. Quinolines will react with acid chlorides and potassium cyanide to give 1-acyl-2-cyano-1,2-dihydroquinolines, also known as Reissert compounds. Hydrolysis gives the desired quinaldic acid.



The Reissert reaction is also successful with isoquinolines and most pyridines.

Several reviews have been published.