4-hydroxybenzoyl-CoA reductase

In enzymology, a 4-hydroxybenzoyl-CoA reductase is an enzyme that catalyzes the chemical reaction


 * benzoyl-CoA + acceptor + H2O $$\rightleftharpoons$$ 4-hydroxybenzoyl-CoA + reduced acceptor

The 3 substrates of this enzyme are benzoyl-CoA, acceptor, and H2O, whereas its two products are 4-hydroxybenzoyl-CoA and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is benzoyl-CoA:acceptor oxidoreductase. Other names in common use include 4-hydroxybenzoyl-CoA reductase (dehydroxylating), and 4-hydroxybenzoyl-CoA:(acceptor) oxidoreductase. This enzyme participates in benzoate degradation via coa ligation.

Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and.