Shi epoxidation

The Shi epoxidation is a chemical reaction described as an asymmetric epoxidation of olefins with oxone and a fructose-derived catalyst (1).



This procedure generates epoxides with high enantiomeric excesses from trans-disubstituted alkenes and trisubstituted alkenes. Cis-disubstituted alkenes and styrenes are asymmetrically epoxidized using a similar catalyst.