Matrix extracellular phosphoglycoprotein

Matrix, extracellular phosphoglycoprotein with ASARM motif (bone), also known as MEPE, is a human gene.

Phosphatonins have a role in phosphate homeostasis and the relationship between phosphate handling by the kidney and gastrointestinal tract. Matrix extracellular phosphoglycoprotein (MEPE), one of several candidate phosphatonins, promotes phosphaturia. Short-term infusion of MEPE inhibits phosphate absorption in the jejunum but not the duodenum. The phosphaturic action of MEPE may correlate with a significant reduction in renal sodium-phosphate co-transporter NaPi-IIa in the proximal convoluted tubules of the outer renal cortex. This short-term inhibitory effect of MEPE on renal and intestinal phosphate handling occurs without changes in the circulating levels of parathyroid hormone (PTH), 1,25-dihydroxyvitamin D(3), or fibroblast growth factor 23 (FGF23). MEPE may be involved in phosphate homeostasis, acting in both the kidney and the gastrointestinal tract.