SpeF leader

'SpeF is a putative cis acting element identified in several gram negative alpha proteobacteria. Its is proposed to be involved in regulating expression of genes involved in polyamide biosynthesis.

SpeF is one of five putative regulatory elements identified by a computational screen of Agrobacterium tumefaciens and other alpha-proteobacterial genomes for conserved sequence motifs in operon leaders. In the majority of species analysed it is located in the leader of an operon containing the speF gene an ornithine decarboxylase enzyme that catalyses one of the first steps in polyamine biosynthesis. However, the authors did not detect binding of metabolites related to this pathway (L-ornithine, L-lysine, meso-diaminopimelate, putrescine, cadaverine, or spermidine) to the SpeF leader.