Cgk733

CGK733 is a synthetic substance whose molecular structure is shown in the diagram.

It is a complex thiourea derivative which has remarkable properties in reversing cell senescence (aging). Experiments have shown that it can extend the lifetime of cultured cells by approximately 20 divisions, or roughly 25%, specifically in mammalian cells. Current research is investigating its potential uses in wound healing, antiaging cosmetics and tissue engineering.

Tae Kook Kim and several associates at the Korea Advanced Institute of Science & Technology discovered its properties as a result of screening twenty thousand synthetic molecules for their effects on aging cells.

It is an inhibitor of ATM/ATR kinases, which are involved in DNA damage repair.