Topotecan Hydrochloride (patient information)

IMPORTANT WARNING:
Topotecan can cause a decrease in the number of blood cells in your bone marrow. Your doctor will order tests before, during, and after your treatment to see if your blood cells are affected by this drug.

About your treatment
Your doctor has ordered the drug topotecan to help treat your illness. The drug is given by injection into your vein.

This medication is used to treat:


 * ovarian cancer

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Topotecan is in a class of drugs known as topoisomerase inhibitors; it slows or stops the growth of cancer cells. The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer you have.

Precautions
Before taking topotecan


 * tell your doctor and pharmacist if you are allergic to topotecan or any other drugs.
 * tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially aspirin and vitamins.
 * tell your doctor if you have or have ever had kidney disease.
 * you should know that topotecan may interfere with the normal menstrual cycle (period) in women and may stop sperm production in men. However, you should not assume that you cannot get pregnant or that you cannot get someone else pregnant. Women who are pregnant or breast-feeding should tell their doctors before they begin taking this drug. You should not plan to have children while receiving chemotherapy or for a while after treatments. (Talk to your doctor for further details.) Use a reliable method of birth control to prevent pregnancy. Topotecan may harm the fetus.
 * do not have any vaccinations (e.g., measles or flu shots) without talking to your doctor.

Minor Side Effects
Side effects from topotecan are common and include:


 * headache
 * loss of appetite
 * thinned or brittle hair
 * diarrhea
 * constipation
 * nausea
 * abdominal pain

Tell your doctor if either of these symptoms is severe or lasts for several hours:


 * mouth blistering
 * fatigue

Severe Side Effects
If you experience any of the following symptoms, call your doctor immediately:


 * unusual bruising or bleeding
 * red, itchy rash
 * fever
 * chills
 * cough
 * sore throat
 * difficulty swallowing
 * change in normal bowel habits for more than 2 days
 * severe vomiting
 * dizziness
 * shortness of breath

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/report.htm] or by phone [1-800-332-1088].

In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Brand names

 * Hycamtin®