Homeostatic model assessment

} The homeostatic model assessment (HOMA) is a method used to quantify insulin resistance and Beta cell function. It was first described under the name HOMA by Matthews et al in 1985.

Derivation
The HOMA authors used data from physiological studies to develop mathematical equations describing glucose regulation as a feedback loop . They published computer software that solves the equations, so that insulin resistance and beta-cell function can be estimated from fasting glucose and insulin levels. They also published an equation (see below) that gave approximately the same answers as an early version of the computer software . However, the computer model has since been improved to better reflect human physiology and recalibrated to modern insulin assays, and the developers have written that they recommend the computer software be used wherever possible .