Sertoli-Leydig cell tumor

Overview
Sertoli-Leydig cell tumour is a member of the sex cord-stromal tumour group of ovarian and testicular cancers. The tumour is rare, comprising less than 1% of ovarian tumours and 25% are malignant.

The tumour is subdivided into many different subtypes. The most typical is composed of tubules lined by Sertoli cells and interstitial clusters of Leydig cells.

Epidemiology
The average age of patients with Sertoli-Leydig tumours is 25

Signs
One-third of female patients present with masculinization. Masculinization is preceded by oligomenorrhea, amenorrhea and defeminization