3-hydroxy-2-methylbutyryl-CoA dehydrogenase

In enzymology, a 3-hydroxy-2-methylbutyryl-CoA dehydrogenase is an enzyme that catalyzes the chemical reaction


 * (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+ $$\rightleftharpoons$$ 2-methylacetoacetyl-CoA + NADH + H+

Thus, the two substrates of this enzyme are (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA and NAD+, whereas its 3 products are 2-methylacetoacetyl-CoA, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase. Other names in common use include 2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase, 2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase, and 2-methyl-3-hydroxy-butyryl CoA dehydrogenase. This enzyme participates in valine, leucine and isoleucine degradation.

Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code.