Histidinol dehydrogenase

In enzymology, a histidinol dehydrogenase is an enzyme that catalyzes the chemical reaction


 * L-histidinol + 2 NAD+ $$\rightleftharpoons$$ L-histidine + 2 NADH + 2 H+

Thus, the two substrates of this enzyme are L-histidinol and NAD+, whereas its 3 products are L-histidine, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-histidinol:NAD+ oxidoreductase. This enzyme is also called L-histidinol dehydrogenase. This enzyme participates in histidine metabolism.

Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes, , , and.