Digoxin

Synonyms / Brand Names:

Dosing and Administration
Because the pharmacokinetics of Digoxin are complex, and because toxic levels of Digoxin are only slightly higher than therapeutic levels, Digoxin dosing can be difficult. The recommended approach is to: Estimated daily maintenance dose These doses will, in uncomplicated patients, tend to produce steady-state post-absorptive levels of 1 to 2 ng/mL, but the confidence limits around this range are wide.
 * estimate the patient’s daily maintenance dose;
 * adjust the estimate to account for patient-specific factors;
 * choose a dosing regimen;
 * monitor the patient for toxicity and for therapeutic effect, if possible; and
 * adjust the dose.
 * Children > 2 years old - daily oral dose 10 mcg/kg/day
 * Prepubertal children - daily oral dose 10 mcg/kg/day
 * Adults - daily oral dose 3 mcg/kg/day

FDA Package Insert Resources Indications, Contraindications, Side Effects, Drug Interactions, etc. Calculate Creatine Clearance On line calculator of your patients Cr Cl by a variety of formulas. Convert pounds to Kilograms On line calculator of your patients weight in pounds to Kg for dosing estimates. Publication Resources Recent articles, WikiDoc State of the Art Review, Textbook Information Trial Resources Ongoing Trials, Trial Results Guidelines & Evidence Based Medicine Resources US National Guidelines, Cochrane Collaboration, etc. Media Resources Slides, Video, Images, MP3, Podcasts, etc. Patient Resources Discussion Groups, Handouts, Blogs, News, etc. International Resources en Español

FDA Package Insert Resources
Indications Contraindications Side Effects Drug Interactions Precautions Overdose Instructions for Administration How Supplied Pharmacokinetics and Molecular Data FDA label FDA on Return to top

Publication Resources
Most Recent Articles on Review Articles on Articles on in N Eng J Med, Lancet, BMJ WikiDoc State of the Art Review Textbook Information on Return to top

Trial Resources
Ongoing Trials with at Clinical Trials.gov Trial Results with Return to top

Guidelines & Evidence Based Medicine Resources
US National Guidelines Clearinghouse on Cochrane Collaboration on Cost Effectiveness of Return to top

Media Resources
Powerpoint Slides on Images of Podcasts & MP3s on Videos on Return to top

Patient Resources
Patient Information from National Library of Medicine Patient Resources on Discussion Groups on Patient Handouts on Blogs on in the News in the Marketplace Return to top

International Resources
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