MIAMI Trial


 * MIAMI
 * In the Metoprolol In Acute Myocardial Infarction (MIAMI) trial, STEMI patients were randomized to receive either metoprolol (up to 15 mg IV in 3 divided doses followed by 50 mg orally every six hours for 48 hours and then 100 mg twice per day thereafter) or placebo (n=5,700 patients). There was a favorable trend in mortality at 15 days (4.3% vs 4.9%) which was sustained over time. The benefits of metroprolol were greater in high risk patients.