Lorazepam drug interactions

List of drug interactions
CNS depressants Clozapine Valproate Probenecid Theophylline and aminophylline

CNS depressants
The benzodiazepines, including Lorazepam, produce CNS-depressant effects when administered with other CNS depressants such as alcohol, barbiturates, antipsychotics, sedative/hypnotics, anxiolytics, antidepressants, narcotic analgesics, sedative antihistamines, anticonvulsants, and anesthetics. Return to top

Clozapine
Concomitant use of clozapine and Lorazepam may produce marked sedation, excessive salivation, hypotension, ataxia, delirium, and respiratory arrest. Return to top

Valproate
Concurrent administration of Lorazepam with valproate results in increased plasma concentrations and reduced clearance of Lorazepam. Lorazepam dosage should be reduced to approximately 50% when coadministered with valproate. Return to top

Probenecid
Concurrent administration of Lorazepam with probenecid may result in a more rapid onset or prolonged effect of Lorazepam due to increased half-life and decreased total clearance. Lorazepam dosage needs to be reduced by approximately 50% when coadministered with probenecid. Return to top

Theophylline and aminophylline
Administration of theophylline or aminophylline may reduce the sedative effects of benzodiazepines, including Lorazepam. Return to top