Holo-(acyl-carrier-protein) synthase

In enzymology, a holo-[acyl-carrier-protein] synthase is an enzyme that catalyzes the chemical reaction


 * CoA-[4'-phosphopantetheine] + apo-[acyl-carrier-protein] $$\rightleftharpoons$$ adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein]

Thus, the two substrates of this enzyme are CoA-[4'-phosphopantetheine] and apo-[acyl-carrier-protein], whereas its two products are adenosine 3',5'-bisphosphate and holo-[acyl-carrier-protein].

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CoA-[4'-phosphopantetheine]:apo-[acyl-carrier-protein] 4'-pantetheinephosphotransferase. Other names in common use include acyl carrier protein holoprotein (holo-ACP) synthetase, holo-ACP synthetase, coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine, transferase, holosynthase, acyl carrier protein synthetase, holo-ACP synthase, PPTase, AcpS, ACPS, acyl carrier protein synthase, P-pant transferase, and CoA:apo-[acyl-carrier-protein] pantetheinephosphotransferase. This enzyme participates in pantothenate and coa biosynthesis.

Structural studies
As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , and.