Zocor overdose

Overdosage topics
Overdose in clinical trials Overdose in patients Dialyzability of Simvastatin

Overdose in clinical trials
Significant lethality was observed in mice after a single oral dose of 9 g/m2. No evidence of lethality was observed in rats or dogs treated with doses of 30 and 100 g/m2, respectively. No specific diagnostic signs were observed in rodents. At these doses the only signs seen in dogs were emesis and mucoid stools. Return to top

Overdose in patients
A few cases of overdosage with ZOCOR have been reported; the maximum dose taken was 3.6 g. All patients recovered without sequelae. Until further experience is obtained, no specific treatment of overdosage with ZOCOR can be recommended. Return to top

Dialyzability of Simvastatin
The dialyzability of simvastatin and its metabolites in man is not known at present. Return to top