Marchiafava-Bignami disease

Overview
Marchiafava-Bignami disease is a progressive neurological disease characterized by corpus callosum demyelination and necrosis and subsequent atrophy. It was first described in 1903 by the Italian pathologists Amico Bignami and Ettore Marchiafava in an Italian Chianti drinker. It is classically associated with chronic alcoholics who abuse cheap Italian red wine.