Valproate semisodium drug interactions

List of drug interactions
Topiramate Glucuronosyltransferase elevators Cytochrome P450 isozyme inhibitors Aspirin Felbamate Rifampin Antacids Chlorpromazine Haloperidol Cimetidine and Ranitidine Amitriptyline/Nortriptyline Carbamazepine/carbamazepine-10,11-Epoxide Clonazepam Diazepam Ethosuximide Lamotrigine Phenobarbital Primidone Phenytoin Tolbutamide Warfarin Zidovudine Drugs with no interaction found Complete list of drug interactions

Topiramate
Concomitant administration of valproic acid and topiramate has been associated with hyperammonemia with and without encephalopathy. Concomitant administration of topiramate with valproic acid has also been associated with hypothermia in patients who have tolerated either drug alone. It may be prudent to examine blood ammonia levels in patients in whom the onset of hypothermia has been reported Return to top

Glucuronosyltransferase elevators
Drugs that affect the level of expression of hepatic enzymes, particularly those that elevate levels of glucuronosyltransferases, may increase the clearance of valproate. For example, phenytoin, carbamazepine, and phenobarbital (or primidone) can double the clearance of valproate. Thus, patients on monotherapy will generally have longer half-lives and higher concentrations than patients receiving polytherapy with antiepilepsy drugs. Return to top

Cytochrome P450 isozyme inhibitors
Drugs that are inhibitors of cytochrome P450 isozymes, e.g., antidepressants, may be expected to have little effect on valproate clearance because cytochrome P450 microsomal mediated oxidation is a relatively minor secondary metabolic pathway compared to glucuronidation and beta-oxidation. Return to top

Aspirin
A study involving the co-administration of aspirin at antipyretic doses (11 to 16 mg/kg) with valproate to pediatric patients (n=6) revealed a decrease in protein binding and an inhibition of metabolism of valproate. Valproate free fraction was increased 4-fold in the presence of aspirin compared to valproate alone. The -oxidation pathway consisting of 2-E-valproic acid, 3-OH-valproic acid, and 3-keto valproic acid was decreased from 25% of total metabolites excreted on valproate alone to 8.3% in the presence of aspirin. Caution should be observed if valproate and aspirin are to be co-administered. Return to top

Felbamate
A study involving the co-administration of 1200 mg/day of felbamate with valproate to patients with epilepsy (n=10) revealed an increase in mean valproate peak concentration by 35% (from 86 to 115 μg/mL) compared to valproate alone. Increasing the felbamate dose to 2400 mg/day increased the mean valproate peak concentration to 133 μg/mL (another 16% increase). A decrease in valproate dosage may be necessary when felbamate therapy is initiated. Return to top

Rifampin
A study involving the administration of a single dose of valproate (7 mg/kg) 36 hours after 5 nights of daily dosing with rifampin (600 mg) revealed a 40% increase in the oral clearance of valproate. Valproate dosage adjustment may be necessary when it is coadministered with rifampin. Return to top

Antacids
A study involving the co-administration of valproate 500 mg with commonly administered antacids (Maalox, Trisogel, and Titralac - 160 mEq doses) did not reveal any effect on the extent of absorption of valproate. Return to top

Chlorpromazine
A study involving the administration of 100 to 300 mg/day of chlorpromazine to schizophrenic patients already receiving valproate (200 mg BID) revealed a 15% increase in trough plasma levels of valproate. Return to top

Haloperidol
A study involving the administration of 6 to 10 mg/day of haloperidol to schizophrenic patients already receiving valproate (200 mg BID) revealed no significant changes in valproate trough plasma levels. Return to top

Cimetidine and Ranitidine
Cimetidine and ranitidine do not affect the clearance of valproate. Return to top

Amitriptyline/Nortriptyline
Administration of a single oral 50 mg dose of amitriptyline to 15 normal volunteers (10 males and 5 females) who received valproate (500 mg BID) resulted in a 21% decrease in plasma clearance of amitriptyline and a 34% decrease in the net clearance of nortriptyline. Rare postmarketing reports of concurrent use of valproate and amitriptyline resulting in an increased amitriptyline level have been received. Concurrent use of valproate and amitriptyline has rarely been associated with toxicity. Monitoring of amitriptyline levels should be considered for patients taking valproate concomitantly with amitriptyline. Consideration should be given to lowering the dose of amitriptyline/nortriptyline in the presence of valproate. Return to top

Carbamazepine/carbamazepine-10,11-Epoxide
Serum levels of carbamazepine (CBZ) decreased 17% while that of carbamazepine-10,11-epoxide (CBZ-E) increased by 45% upon co-administration of valproate and CBZ to epileptic patients. Return to top

Clonazepam
The concomitant use of valproic acid and clonazepam may induce absence status in patients with a history of absence type seizures. Return to top

Diazepam
Valproate displaces diazepam from its plasma albumin binding sites and inhibits its metabolism. Co-administration of valproate (1500 mg daily) increased the free fraction of diazepam (10 mg) by 90% in healthy volunteers (n=6). Plasma clearance and volume of distribution for free diazepam were reduced by 25% and 20%, respectively, in the presence of valproate. The elimination half-life of diazepam remained unchanged upon addition of valproate. Return to top

Ethosuximide
Valproate inhibits the metabolism of ethosuximide. Administration of a single ethosuximide dose of 500 mg with valproate (800 to 1600 mg/day) to healthy volunteers (n=6) was accompanied by a 25% increase in elimination half-life of ethosuximide and a 15% decrease in its total clearance as compared to ethosuximide alone. Patients receiving valproate and ethosuximide, especially along with other anticonvulsants, should be monitored for alterations in serum concentrations of both drugs. Return to top

Lamotrigine
In a steady-state study involving 10 healthy volunteers, the elimination half-life of lamotrigine increased from 26 to 70 hours with valproate co-administration (a 165% increase). The dose of lamotrigine should be reduced when co-administered with valproate. Serious skin reactions (such as Stevens-Johnson Syndrome and toxic epidermal necrolysis) have been reported with concomitant lamotrigine and valproate administration. Return to top

Phenobarbital
Valproate was found to inhibit the metabolism of phenobarbital. Co-administration of valproate (250 mg BID for 14 days) with phenobarbital to normal subjects (n=6) resulted in a 50% increase in half-life and a 30% decrease in plasma clearance of phenobarbital (60 mg single-dose). The fraction of phenobarbital dose excreted unchanged increased by 50% in presence of valproate. Return to top

Primidone
Primidone, which is metabolized to a barbiturate, may be involved in a similar interaction as phenobarbital with valproate. Return to top

Phenytoin
In patients with epilepsy, there have been reports of breakthrough seizures occurring with the combination of valproate and phenytoin. The dosage of phenytoin should be adjusted as required by the clinical situation. Return to top

Tolbutamide
From in vitro experiments, the unbound fraction of tolbutamide was increased from 20% to 50% when added to plasma samples taken from patients treated with valproate. The clinical relevance of this displacement is unknown. Return to top

Warfarin
In an in vitro study, valproate increased the unbound fraction of warfarin by up to 32.6%. The therapeutic relevance of this is unknown; however, coagulation tests should be monitored if valproic acid therapy is instituted in patients taking anticoagulants. Return to top

Zidovudine
In six patients who were seropositive for HIV, the clearance of zidovudine (100 mg q8h) was decreased by 38% after administration of valproate (250 or 500 mg q8h); the half-life of zidovudine was unaffected. Return to top

Drugs with no interaction found
Drugs for which either no interaction or a likely clinically unimportant interaction has been observed: Return to top
 * Acetaminophen : Valproate had no effect on any of the pharmacokinetic parameters of acetaminophen when it was concurrently administered to three epileptic patients.
 * Clozapine: In psychotic patients (n=11), no interaction was observed when valproate was co-administered with clozapine.
 * Lithium: Co-administration of valproate (500 mg BID) and lithium carbonate (300 mg TID) to normal male volunteers (n=16) had no effect on the steady-state kinetics of lithium.
 * Lorazepam: Concomitant administration of valproate (500 mg BID) and lorazepam (1 mg BID) in normal male volunteers (n=9) was accompanied by a 17% decrease in the plasma clearance of lorazepam.
 * Oral Contraceptive Steroids: Administration of a single-dose of ethinyloestradiol (50 mcg)/levonorgestrel (250 mcg) to 6 women on valproate (200 mg BID) therapy for 2 months did not reveal any pharmacokinetic interaction.

Major Interactions

 * Darvon
 * Darvon-N
 * GHB
 * Lamictal
 * Lamictal Blue
 * Lamictal CD
 * Lamictal Green
 * Lamictal Orange
 * lamotrigine
 * PP-Cap
 * propoxyphene
 * propoxyphene hydrochloride
 * propoxyphene napsylate
 * sodium oxybate
 * sodium phenylacetate
 * vorinostat
 * Xyrem
 * Zolinza

Return to top

Moderate Interactions

 * 40 Winks
 * Abilify
 * Abilify Discmelt
 * acetylcarbromal
 * Acetylsalicylic Acid
 * Actidose-Aqua
 * Actidose-Aqua Advance
 * Actiq
 * Activated Charcoal
 * Activated Charcoal with Sorbitol (obsolete)
 * Active Carbon
 * Acuprin 81
 * Adapin
 * Adgan
 * Adgyn Estro
 * Aerodiol
 * AHist
 * alcohol
 * alcohol ethyl
 * Aler-Dryl
 * Aler-Tab
 * Alfenta
 * alfentanil
 * All Day Allergy
 * Aller-Chlor
 * Allergia-C
 * Allerhist-1
 * Allermax
 * Alora
 * Alphagan
 * Alphagan P
 * alprazolam
 * alprazolam extended release
 * Altaryl
 * Ambien
 * Ambien CR
 * Amen
 * Amigesic
 * amitriptyline
 * amobarbital
 * amoxapine
 * Amrix
 * Amytal Sodium
 * Anaflex
 * Anafranil
 * Anergan 50
 * anisindione
 * Antiflex
 * Antinaus 50
 * APO-Go
 * APO-Go Pen
 * Apokyn
 * apomorphine
 * apraclonidine ophthalmic
 * Aptivus
 * Aquachloral Supprettes
 * Aquest
 * Arava
 * Argesic-SA
 * aripiprazole
 * Arthritis Pain
 * Arthropan
 * ASA
 * Ascriptin Enteric
 * Asendin
 * Aspergum Cherry
 * Aspergum Orginal
 * Aspir-Low
 * aspirin
 * aspirin extended release
 * Aspirin Lite Coat
 * Aspirin Litecoat
 * Aspirin Low Strength
 * Aspirtab
 * Astramorph PF
 * Atarax
 * Ativan
 * Aventyl HCl
 * Avinza
 * Avonex
 * Avonex Prefilled Syringe
 * Aygestin
 * azatadine
 * AZT
 * B-Vex
 * baclofen
 * Banaril
 * Banflex
 * Banophen
 * Bayer Aspirin
 * Bayer Aspirin Regimen
 * Bayer Aspirin Sugar Free
 * Bayer Aspirin with Calcium
 * Bayer Childrens Aspirin
 * Bayer Low Strength
 * Bayer Plus
 * Bayer Select Backache Pain Formula
 * Bedol
 * Beldin
 * Belix
 * Ben-Tann
 * Benadryl
 * Benadryl Allergy
 * Benadryl Child Dye Free
 * Benadryl Childrens Allergy Fastmelt
 * Benadryl DF
 * Benadryl Dye Free Allergy
 * Benadryl Ultratab
 * Benahist-10
 * Benahist-50
 * Benoject-50
 * Benzacot
 * benztropine
 * Betaseron
 * Biaxin
 * Biaxin XL
 * Biaxin XL-Pak
 * Bidhist
 * Bismarex
 * Bismatrol
 * Bismatrol Maximum Strength
 * bismuth subsalicylate
 * brimonidine ophthalmic
 * Bromaphen
 * bromocriptine
 * brompheniramine
 * brompheniramine extended release
 * BroveX
 * BroveX CT
 * Buffered Aspirin
 * Bufferin
 * Bufferin Arthritis Strength
 * Bufferin Extra Strength
 * Buffex
 * Buprenex
 * buprenorphine
 * Busodium
 * BuSpar
 * BuSpar Dividose
 * busPIRone
 * butabarbital
 * butalbital
 * Butisol Sodium
 * butorphanol
 * Bydramine
 * C.P.M.
 * Calm-Aid
 * Camila
 * Carbacot
 * carbamazepine
 * carbamazepine extended release
 * Carbatrol
 * carbetapentane
 * carbinoxamine
 * carbinoxamine extended release
 * Carbinoxamine PD
 * Carbomix
 * Carbosorb X
 * Carboxine
 * carisoprodol
 * Catapres
 * Catapres-TTS-1
 * Catapres-TTS-2
 * Catapres-TTS-3
 * Cenestin
 * Cerebyx
 * Cesamet
 * cetirizine
 * Char-Flo with Sorbitol (obsolete)
 * Charcoaid
 * Charcoaid 2000
 * Charcoaid-G
 * charcoal
 * Charcoal Plus DS
 * Charcocaps
 * Charcodote
 * Charcodote (obsolete)
 * Charcotabs
 * Charcotrace
 * Chem Mart Nasal Decongestant Capsule
 * Chem Mart Tramadol
 * Childrens Kaopectate
 * Chlo-Amine
 * Chlor-Al Rel
 * Chlor-Mal
 * Chlor-Phen
 * Chlor-Phenit
 * Chlor-Trimeton
 * Chlor-Trimeton Allergy SR
 * chloral hydrate
 * chlordiazepoxide
 * chlormezanone
 * chlorotrianisene
 * Chlorphen
 * chlorphenesin
 * chlorpheniramine
 * Chlorpheniramine (Allergy)
 * chlorpheniramine 24 hour extended release
 * chlorpheniramine extended release
 * chlorpromazine
 * chlorpromazine extended release
 * ChlorTan
 * chlorzoxazone
 * cholestyramine
 * Cholestyramine Light
 * choline salicylate
 * cisplatin
 * clarithromycin
 * clarithromycin extended release
 * clemastine
 * Climara
 * Climaval
 * Climodien
 * Clinagen LA 40
 * clofarabine
 * Clolar
 * Clomipramine
 * clonazepam
 * clonidine
 * clonidine topical
 * clorazepate
 * clorazepate extended release
 * codeine
 * codeine phosphate
 * codeine sulfate
 * Codimal A
 * Cogentin
 * Compazine
 * Compazine Spansule
 * Compoz Nighttime Sleep Aid
 * Compro
 * Comtan
 * conjugated estrogens
 * conjugated estrogens synthetic A
 * conjugated estrogens synthetic B
 * conjugated estrogens topical
 * Contac 12 Hour Allergy
 * Cophene B
 * Cordron NR
 * Coumadin
 * Crinone
 * Curretab
 * cyclizine
 * cyclobenzaprine
 * cyclobenzaprine extended release
 * Cyclogest
 * Cycrin
 * Cylert
 * Cymbalta
 * cyproheptadine
 * Dailyhist-1
 * Dalgan
 * Dalmane
 * Dantrium
 * Dantrium Intravenous
 * dantrolene
 * Dazidox
 * Dehydrated Alcohol
 * Delestrogen
 * Delidose
 * Delta-Lutin
 * Demerol HCl
 * Dep Gynogen
 * Depo-Estradiol
 * Depo-Provera
 * Depo-Provera Contraceptive
 * depo-subQ provera 104
 * DepoDur
 * Depogen
 * Dermestril
 * Dermestril - Septem
 * Dermestril Septem
 * desipramine
 * desogestrel
 * desvenlafaxine
 * Desyrel
 * Desyrel Dividose
 * dexbrompheniramine
 * dexmedetomidine
 * dezocine
 * Di-Phen
 * Diastat
 * Diastat AcuDial
 * Diastat Pediatric
 * diazepam
 * dicumarol
 * dienestrol topical
 * diethylstilbestrol
 * diflunisal
 * dihydrocodeine
 * Dilantin
 * Dilantin Infatabs
 * Dilantin Kapseals
 * Dilantin-125
 * Dilaudid
 * Dilaudid-5
 * Dilaudid-HP
 * Dimetane
 * Dimetane Extentab
 * Dimetapp Allergy
 * Dimetapp Allergy Liquigel
 * Dioval 40
 * Dioval XX
 * Diphedryl
 * Diphen
 * Diphen AF
 * Diphen Cough
 * Diphenadryl
 * Diphendryl
 * Diphenhist
 * diphenhydramine
 * diphenhydramine citrate
 * diphenhydramine tannate
 * Diphenmax
 * Diphenydramine Quick Melt
 * Diphenyl
 * Diphenylin
 * Diprivan
 * Disalcid
 * Diskets
 * Divigel 0.25 mg/packet
 * Divigel 0.5 mg/packet
 * Divigel 1 mg/packet
 * Dizac
 * Doans Pills
 * Doans Pills Extra Strength
 * Dolobid
 * Dolophine
 * Doloral
 * Doloral Sirop
 * Doral
 * Doribax
 * doripenem
 * doxepin
 * doxepin topical
 * doxylamine
 * DPH
 * Dromadol SR
 * Dromadol XL
 * dronabinol
 * droperidol
 * drospirenone
 * duloxetine
 * Dura-Estrin
 * Duraclon
 * Duragen
 * Duragesic
 * Duragesic-100
 * Duragesic-12
 * Duragesic-25
 * Duragesic-50
 * Duragesic-75
 * Duralutin
 * Duramorph PF
 * Dytan
 * Dytuss
 * E-Mycin
 * E.E.S. Granules
 * E.E.S.-200
 * E.E.S.-400
 * E.E.S.-400 Filmtab
 * Easprin
 * echinacea
 * Ecotrin
 * Ecotrin Adult Low Strength
 * Ecotrin Maximum Strength
 * Ed Chlor-Tan
 * Ed ChlorPed
 * Effexor
 * Effexor XR
 * Efidac-24 Chlorpheniramine
 * Elavil
 * Elestrin
 * Elleste Solo
 * Empirin
 * Endep
 * Endocodone
 * Endometrin
 * Enjuvia
 * entacapone
 * Entaprin
 * Entercote
 * Epitol
 * Equanil
 * Equetro
 * Errin
 * ertapenem
 * Ery-Tab
 * Eryc
 * EryPed
 * EryPed 200
 * EryPed 400
 * Erythrocin Lactobionate
 * Erythrocin Stearate Filmtab
 * Erythrocot
 * erythromycin
 * erythromycin base
 * erythromycin estolate
 * erythromycin ethylsuccinate
 * erythromycin lactobionate
 * erythromycin stearate
 * escitalopram
 * Esclim
 * Eskalith
 * Eskalith-CR
 * estazolam
 * esterified estrogens
 * Estinyl
 * Estra-C
 * Estra-V 40
 * Estrace
 * Estrace Vaginal Cream
 * Estraderm
 * Estraderm MX
 * Estraderm TTS
 * estradiol
 * estradiol acetate
 * estradiol benzoate
 * estradiol cypionate
 * Estradiol G Gam
 * Estradiol Patch
 * estradiol topical
 * estradiol valerate
 * Estradot
 * Estradot 100
 * Estradot 37.5
 * Estradot 50
 * Estradot 75
 * Estragyn 5
 * Estragyn LA 5
 * Estrapatch
 * Estrasorb
 * ESTREVA
 * Estring
 * Estro-A
 * Estro-Cyp
 * Estro-L.A.
 * Estro-Span 40
 * Estrofem
 * Estrogel
 * estrone
 * Estrone AQ
 * estropipate
 * estropipate topical
 * eszopiclone
 * ETH-Oxydose
 * ethanol
 * ethinyl estradiol
 * ethotoin
 * Ethyl Alcohol
 * ethynodiol
 * etonogestrel
 * etravirine
 * Eucarbon
 * Evamist
 * Evorel
 * Extra Strength Bayer
 * EZChar
 * Eze D.S.
 * Fasprin
 * felbamate
 * Felbatol
 * Fematrix
 * Fempatch
 * Femring
 * Femsept
 * FemSeven
 * FemSeven Sequi Phase I
 * FemTab
 * Femtrace
 * Femtran
 * fentanyl
 * fentanyl topical
 * Fentora
 * Fexmid
 * First Progesterone MC10
 * First Progesterone MC5
 * First-Progesterone VGS 100
 * First-Progesterone VGS 200
 * First-Progesterone VGS 25
 * First-Progesterone VGS 400
 * First-Progesterone VGS 50
 * flavoxate
 * Flexeril
 * Flexoject
 * Flexon
 * fluphenazine
 * fluphenazine decanoate
 * fluphenazine enanthate
 * fluphenazine hydrochloride
 * flurazepam
 * fluvoxamine
 * fluvoxamine extended release
 * Folex PFS
 * fosphenytoin
 * Fosrenol
 * Genacote
 * Genahist
 * Gennin-FC
 * Genprin
 * GenRx Tramadol
 * Geodon
 * Gestone
 * Gynodiol
 * Gynogen LA 20
 * halazepam
 * Halcion
 * Haldol
 * Haldol Decanoate
 * Halfprin
 * haloperidol
 * haloperidol decanoate
 * Healthstream Activated Charcoal
 * Histaject
 * Histex CT
 * Histex I/E
 * Histex PD
 * Histex Pd 12
 * Hydramine
 * Hydramine Compound
 * Hydramine Cough Syrup
 * hydrocodone
 * Hydromorph Contin
 * hydromorphone
 * hydromorphone extended release
 * Hydrostat IR
 * hydroxyprogesterone
 * hydroxyzine
 * hydroxyzine hydrochloride
 * hydroxyzine pamoate
 * Hylutin
 * hypericum perforatum
 * Hyprogesterone
 * Hyrexin
 * Hyzine
 * Ilosone
 * Ilotycin Gluceptate
 * imipenem
 * imipramine
 * imipramine pamoate
 * Implanon
 * Inapsine
 * Infumorph
 * INH
 * Insta-Char
 * Intelence
 * interferon beta-1a
 * interferon beta-1b
 * Invanz
 * Invega
 * Ionsys
 * Iopidine
 * isocarboxazid
 * isoniazid
 * J-Tan
 * J-Tan PD
 * J.L. Bragg's Medicinal Charcoal
 * Jantoven
 * Jolivette
 * K-Pek
 * Kadian
 * Kao-Tin Bismuth Subsalicylate Formula
 * Kaopectate
 * Kaopectate Anti-Diarrheal Upset Stomach Reliever
 * Kaopectate Extra Strength
 * Kapectolin (New Formula)
 * Karbons
 * Kestrone 5
 * Ketalar
 * ketamine
 * Klonopin
 * Klonopin Wafer
 * lanthanum carbonate
 * Larapam SR
 * Largon
 * Lariam
 * leflunomide
 * Levo-Dromoran
 * levocetirizine
 * levomethadyl acetate
 * levonorgestrel
 * levorphanol
 * LEVRIX
 * Lexapro
 * Librium
 * Lioresal
 * Lioresal Intrathecal
 * Liqui-Char
 * Liqui-Char with Sorbitol (obsolete)
 * Litecoat Aspirin
 * lithium
 * lithium carbonate
 * lithium carbonate extended release
 * lithium citrate
 * Lithobid
 * Lithonate
 * Lithotabs
 * Lodrane 12 Hour
 * Lodrane 24
 * Lodrane XR
 * lorazepam
 * Low Dose ASA
 * loxapine
 * Loxitane
 * Loxitane C
 * Loxitane IM
 * Ludiomil
 * Luminal
 * Lunesta
 * Luvox
 * Luvox CR
 * Lyrica
 * M-Eslon
 * M-Oxy
 * M. O. S.
 * Maalox Total Stomach Relief
 * Magan
 * magnesium salicylate
 * Maolate
 * maprotiline
 * Marezine
 * Marinol
 * Marplan
 * Marthritic
 * Maximum Strength Stress
 * MB-TAB
 * Medicoal
 * Medidiol 10
 * Medroxyprogesterone
 * mefloquine
 * Megace
 * Megace ES
 * megestrol
 * Mellaril
 * Mellaril-S
 * Menaval-20
 * Menest
 * Menopause Formula Progesterone
 * Menorest
 * Menorest Patch
 * Menostar
 * meperidine
 * mephenytoin
 * meprobamate
 * Meridia
 * meropenem
 * Merrem
 * Merrem Novaplus
 * Mesantoin
 * mesoridazine
 * mestranol
 * metaxalone
 * methadone
 * Methadose
 * methocarbamol
 * methotrexate
 * Methotrexate Sodium Preservative Free
 * metoclopramide
 * midazolam
 * Miltown
 * Minitabs
 * Mio-Rel
 * Miradon
 * Mirapex
 * Mirena
 * mirtazapine
 * Mitran
 * Moban
 * Mobidin
 * molindone
 * Mono-Gesic
 * morphine
 * morphine 24 hour extended release
 * morphine extended release
 * Morphine IR
 * morphine liposomal
 * Morphine LP Epidural
 * morphine preservative-free
 * Morphine Rapi-Ject
 * Morphitec
 * MS
 * MS Contin
 * MS/S
 * MSIR
 * MST
 * MY-E
 * Myolin
 * Mysoline
 * nabilone
 * nalbuphine
 * naltrexone
 * Nardil
 * Nasahist B
 * Navane
 * ND-Stat
 * nefazodone
 * Nembutal
 * Nembutal Sodium
 * Nervine
 * Neupro
 * Nightime Sleepaid
 * Niravam
 * Nor-QD
 * Nora-Be
 * norelgestromin
 * norethindrone
 * norethindrone acetate
 * norethindrone topical
 * Norflex
 * Norflex Injectable
 * norgestimate
 * norgestrel
 * Norit
 * Norplant System
 * Norpramin
 * nortriptyline
 * Norwich Aspirin
 * Nu-Med
 * Nubain
 * Numorphan HCl
 * Nuprin Backache Caplet
 * Nuvelle TS Phase I
 * Nydrazid
 * Nytol Caplet
 * Nytol Maximum Strength
 * Oesclim
 * Oestradiol
 * Oestradiol Implants
 * Oestrodose
 * Oestrogel
 * Oestrogel Pump-Pack
 * Ogen 0.625
 * Ogen 1.25
 * Ogen 2.5
 * Ogen Vaginal Cream
 * olanzapine
 * olopatadine nasal
 * OMS
 * Opana
 * Opana ER
 * opium
 * Opium Deodorized
 * Optimine
 * Optimum Charcoal
 * Oramorph SR
 * Orap
 * Orfro
 * Organon Oestradiol
 * Orion Progesterone
 * Orlaam
 * Ormazine
 * Oromone
 * orphenadrine
 * orphenadrine extended release
 * Orphenate
 * Ortho Dienestrol
 * Ortho Micronor
 * Ortho-Est
 * Ovrette
 * oxazepam
 * oxycodone
 * oxycodone extended release
 * OxyContin
 * Oxyfast
 * OxyIR
 * oxymorphone
 * oxymorphone extended release
 * P-Tann
 * P-Tex
 * Palgic
 * paliperidone
 * Palladone
 * Palladone SR
 * Pamelor
 * Paraflex
 * Parafon Forte DSC
 * Paral
 * paraldehyde
 * Pardryl
 * Paregoric
 * Parlodel
 * Parnate
 * paroxetine
 * paroxetine extended release
 * paroxetine mesylate
 * Patanase
 * Paxarel
 * Paxil
 * Paxil CR
 * PBZ
 * PBZ-SR
 * PCE Dispertab
 * PediaTan
 * Pediatex
 * Pediatex 12
 * Pediox
 * Pediox-S
 * Peganone
 * pemoline
 * Pentazine
 * pentazocine
 * pentobarbital
 * Peptic Relief
 * Pepto-Bismol
 * Pepto-Bismol Maximum Strength
 * Percolone
 * pergolide
 * Periactin
 * Permax
 * Permitil
 * perphenazine
 * Pexeva
 * Pharmacia Carbosorb
 * phenacemide
 * Phenadoz
 * Phenazine 50
 * phenelzine
 * Phenergan
 * Phenergan Fortis
 * phenobarbital
 * Phenoject-50
 * Phenurone
 * phenyl salicylate
 * Phenytek
 * phenytoin
 * phenytoin extended release
 * Phenytoin Sodium
 * Prompt
 * pimozide
 * Pink Bismuth
 * Plan B
 * Platinol-AQ
 * pramipexole
 * Precedex
 * pregabalin
 * Premarin
 * Premarin Intravenous
 * Premarin Vaginal
 * Prevalite
 * Prialt
 * primidone
 * Primogyn Depot
 * Pristiq
 * Pro-Med
 * Prochieve
 * prochlorperazine
 * prochlorperazine extended release
 * Procot
 * Prodrox
 * Progest
 * Progestasert System
 * progesterone
 * progesterone topical
 * Progynova
 * Progynova TS
 * Prolixin
 * Prolixin Decanoate
 * Prolixin Enanthate
 * Promacot
 * promazine
 * promethazine
 * Promethegan
 * Prometrium
 * Prop-A-Tane
 * propiomazine
 * propofol
 * Prorex
 * Prosom
 * protriptyline
 * Provames
 * Provera
 * Prudoxin
 * Q-Dryl
 * Q-Dryl A/F
 * Qdall AR
 * quazepam
 * Quenalin
 * Questran
 * Questran Light
 * quetiapine
 * quetiapine extended release
 * quinestrol
 * Rebif
 * Reglan
 * Relaxazone
 * Remeron
 * Remeron SolTab
 * remifentanil
 * Remular
 * Remular-S
 * Repreve
 * Requip
 * ReQuip Follow on Pack
 * Requip Starter Kit
 * ReQuip Starter Pack
 * Rescudose
 * Restoril
 * Retrovir
 * ReVia
 * Rexolate
 * Rezine
 * Rheumatrex Dose Pack
 * Ridramin
 * Rifadin
 * Rifadin IV
 * rifampin
 * Rimactane
 * Risperdal
 * Risperdal Consta
 * Risperdal M-Tab
 * risperidone
 * RMS
 * Robaxin
 * Robaxin-750
 * Robimycin
 * Rohist
 * ropinirole
 * rotigotine
 * Roxanol
 * Roxanol 100
 * Roxanol-T
 * Roxicodone
 * Roxicodone Intensol
 * Salflex
 * salicylamide
 * salsalate
 * Salsitab
 * Sandrena
 * Scot-Tussin Allergy Relief Formula
 * secobarbital
 * Seconal Sodium
 * Serax
 * Serentil
 * Seroquel
 * Seroquel XR
 * sertraline
 * Serzone
 * sibutramine
 * Siladryl
 * Siladryl DAS
 * Siladyl SA
 * Silphen Cough
 * Siltane
 * Simply Sleep
 * Sinequan
 * Skelaxin
 * Skelex
 * Sleep Tab II
 * Sleep Tabs
 * Sleep-ettes
 * Sleep-Eze-3
 * Sleepinal
 * Sloprin
 * sodium salicylate
 * sodium thiosalicylate
 * Solfoton
 * solotuss
 * Soma
 * Sominex
 * Sominex Maximum Strength Caplet
 * Somnicaps
 * Somnote
 * Sonata
 * Sparine
 * St. John's wort
 * St. Joseph Aspirin
 * St. Joseph Aspirin Adult Chewable
 * St. Joseph Aspirin Adult EC
 * Stadol
 * Stadol NS
 * Stanback Analgesic
 * Statex
 * Stelazine
 * Stilphostrol
 * Stress Maximum Strength
 * Strifon Fort
 * Sublimaze
 * Subutex
 * Sufenta
 * sufentanil
 * Surmontil
 * Systen
 * Tace
 * Talwin Lactate
 * Tanacof-XR
 * TanaHist-PD
 * Tao
 * Tasmar
 * Tavist
 * Tavist Allergy
 * Tavist-1
 * Tegretol
 * Tegretol XR
 * Temaril
 * temazepam
 * Terry White Chemists Tramadol
 * THAIS
 * Thaissept
 * thalidomide
 * Thalomid
 * Theraflu Thin Strips Multi Symptom
 * Therapy Bayer
 * thioguanine
 * thioridazine
 * thiothixene
 * Thorazine
 * Ticon
 * Tigan
 * tipranavir
 * tizanidine
 * Tofranil
 * Tofranil-PM
 * tolcapone
 * Topamax
 * Topamax Sprinkle
 * topiramate
 * Total Allergy
 * tramadol
 * tramadol extended release
 * Tramahexal
 * Tramahexal SR
 * Tramake
 * Tramake Insts
 * Tramal
 * Tramal SR
 * Tramedo
 * Trancopal
 * Tranxene SD
 * Tranxene T-Tab
 * tranylcypromine
 * Trazodone
 * Trexall
 * Tri-Buffered Aspirin
 * Triaminic Allergy
 * Triaminic Thin Strips Cough & Runny Nose
 * triazolam
 * trifluoperazine
 * triflupromazine
 * Trilafon
 * trimeprazine
 * trimethobenzamide
 * trimipramine
 * tripelennamine
 * Tripohist
 * triprolidine
 * triprolidine extended release
 * troleandomycin
 * Trux-adryl
 * Tusal
 * Tusstat
 * Twilite
 * Ultiva
 * Ultram
 * Ultram ER
 * Uni-Tann
 * Unisom
 * Unisom Sleepgels Maximum Strength
 * Uprima
 * Urispas
 * V-Gan-25
 * V-Gan-50
 * Vagifem
 * Valergen
 * Valium
 * Valrelease
 * Valu-Dryl
 * Vanadom
 * Vanatrip
 * VaZol
 * venlafaxine
 * venlafaxine extended release
 * Versed
 * Vistacon
 * Vistacot
 * Vistaject-50
 * Vistaril
 * Vistaril IM
 * Vistazine
 * Vistazine 50
 * Vivactil
 * Vivelle
 * Vivelle-Dot
 * Vivelledot
 * Vivitrol
 * Wal-finate
 * warfarin
 * Xanax
 * Xanax XR
 * Xyzal
 * Xyzall
 * YSP Aspirin
 * zaleplon
 * Zamadol
 * Zamadol 24hr
 * Zamadol Melt
 * Zamadol SR
 * Zanaflex
 * Zero-Order Release
 * Zetran
 * ziconotide
 * zidovudine
 * ziprasidone
 * Zoloft
 * zolpidem
 * zolpidem extended release
 * Zonalon
 * Zorprin
 * Zumenon
 * Zydol
 * Zydol SR
 * Zydol XL
 * Zymine
 * Zymine XR
 * Zyprexa
 * Zyprexa Zydis
 * Zyrtec
 * Zyrtec Hives

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Minor Interactions

 * Acid Relief
 * Alka-Mints
 * Alkets
 * Alkums
 * Aloh-Gel
 * Alternagel
 * Alu-Cap
 * Alu-Tab
 * aluminum carbonate
 * aluminum hydroxide
 * Amilac
 * Amitone
 * Amphojel
 * Basaljel
 * bortezomib
 * Cal Oys
 * Cal-Gest
 * Calcarb
 * Calci Mix
 * Calci-Chew
 * Calcitab
 * calcium carbonate
 * Calcium Concentrate
 * Calcium Liquid Softgel
 * Calcium Oyster
 * Calcium Oyster Shell
 * Caltrate
 * Caltro
 * Chooz
 * cimetidine
 * Citra pH
 * Citrate-Phos-Dex
 * Clopine
 * clozapine
 * Clozapine Synthon
 * Clozaril
 * Concentrated Phillips Milk of Magnesia
 * Denzapine
 * Dewees Carminative
 * Dialume
 * Dicarbosil
 * dihydroxyaluminum sodium carbonate
 * Equilet
 * esomeprazole
 * ethosuximide
 * evening primrose
 * Evening Primrose Oil
 * Ex-Lax Milk of Magnesia
 * Extra Strength Mylanta Calci Tabs
 * FazaClo
 * fluoxetine
 * fluoxetine extended release
 * Gabitril
 * gingko
 * gingko biloba
 * Icar Prenatal Chewable Calcium
 * Losospan
 * Lowsium
 * Maalox Antacid Barrier
 * Maalox Childrens'
 * Maalox Quick Dissolve
 * Maalox Quick Dissolve Extra Strength
 * Maalox Quick Dissolve Maximum Strength
 * Maalox Regular Strength
 * Mag-200
 * Mag-Carb
 * Mag-Ox 400
 * magaldrate
 * MagGel
 * magnesium carbonate
 * magnesium hydroxide
 * magnesium oxide
 * magnesium trisilicate
 * Maoson
 * Mg hydroxide
 * Mg oxide
 * Milk of Magnesia
 * Mylanta Child
 * Nephro Calci
 * Nexium
 * Nexium I.V.
 * nimodipine
 * Nimotop
 * Orinase
 * Os-Cal
 * Os-Cal 500
 * oxcarbazepine
 * Oysco 500
 * Oyst Cal
 * Oyst Cal 500
 * Oyster
 * Oyster Cal
 * Oyster Cal 500
 * Oyster Calcium
 * Oyster Shell
 * oyster shell calcium
 * Oyster Shell Calcium 500
 * Pepto Children's
 * Phillips Milk of Magnesia
 * Phillips' Cramp-free
 * Primrose Oil
 * Prozac
 * Prozac Weekly
 * Rapiflux
 * Ri-Mag
 * Riopan
 * Rolaids Sodium Free
 * Rolaids Soft Chew
 * Ron Acid
 * Sarafem
 * Selfemra
 * sodium citrate
 * Super Calcium
 * Surpass
 * Surpass Extra Strength
 * Tagamet
 * Tagamet HB
 * tiagabine
 * Titralac
 * Tol-Tab
 * Tolbutamide
 * Tricitrasol
 * Trileptal
 * Tums
 * Tums 500
 * Tums E-X
 * Tums Extra Strength
 * Tums Ultra
 * Ultra Mylanta Calci Tabs
 * Uro-Mag
 * Velcade
 * Zaponex
 * Zarontin

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