Glutamyl-tRNA reductase

In enzymology, a glutamyl-tRNA reductase is an enzyme that catalyzes the chemical reaction


 * L-glutamate 1-semialdehyde + NADP+ + tRNAGlu $$\rightleftharpoons$$ L-glutamyl-tRNAGlu + NADPH + H+

The 3 substrates of this enzyme are L-glutamate 1-semialdehyde, NADP+, and tRNA(Glu), whereas its 3 products are L-glutamyl-tRNA(Glu), NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming). This enzyme participates in porphyrin and chlorophyll metabolism.