Fatty-acyl-CoA synthase

In enzymology, a fatty-acyl-CoA synthase is an enzyme that catalyzes the chemical reaction


 * acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ $$\rightleftharpoons$$ long-chain-acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+

The 5 substrates of this enzyme are acetyl-CoA, malonyl-CoA, NADH, NADPH, and H+, whereas its 5 products are long-chain-acyl-CoA, CoA, CO2, NAD+, and NADP+.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing). This enzyme is also called yeast fatty acid synthase. This enzyme participates in fatty acid biosynthesis.

Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and.