Levofloxacin drug interactions

List of drug interactions
Levofloxacin Tablets Levofloxacin Injection'''
 * Theophylline
 * Warfarin
 * Cyclosporine
 * Digoxin
 * Probenecid and Cimetidine
 * Non-steroidal anti-inflammatory drugs
 * Antidiabetic agents

Levofloxacin Tablets
While the chelation by divalent cations is less marked than with other quinolones, concurrent administration of Levofloxacin with antacids containing magnesium, or aluminum, as well as sucralfate, metal cations such as iron, and multivitamin preparations with zinc may interfere with the gastrointestinal absorption of levofloxacin, resulting in systemic levels considerably lower than desired. Tablets with antacids containing magnesium, aluminum, as well as sucralfate, metal cations such as iron, and multivitamins preparations with zinc or Videx (didanosine) may substantially interfere with the gastrointestinal absorption of levofloxacin, resulting in systemic levels considerably lower than desired. These agents should be taken at least two hours before or two hours after levofloxacin administration. Return to top

Levofloxacin Injection
There are no data concerning an interaction of intravenous quinolones with oral antacids, sucralfate, multivitamins, Videx (didanosine), or metal cations. However, no quinolone should be co-administered with any solution containing multivalent cations, e.g., magnesium, through the same intravenous line. Return to top

Theophylline
No significant effect of levofloxacin on the plasma concentrations, AUC, and other disposition parameters for theophylline was detected in a clinical study involving 14 healthy volunteers. Similarly, no apparent effect of theophylline on levofloxacin absorption and disposition was observed. However, concomitant administration of other quinolones with theophylline has resulted in prolonged elimination half-life, elevated serum theophylline levels, and a subsequent increase in the risk of theophylline-related adverse reactions in the patient population. Therefore, theophylline levels should be closely monitored and appropriate dosage adjustments made when levofloxacin is co-administered. Adverse reactions, including seizures, may occur with or without an elevation in serum theophylline levels. Return to top

Warfarin
No significant effect of levofloxacin on the peak plasma concentrations, AUC, and other disposition parameters for R- and S- warfarin was detected in a clinical study involving healthy volunteers. Similarly, no apparent effect of warfarin on levofloxacin absorption and disposition was observed. There have been reports during the post-marketing experience in patients that levofloxacin enhances the effects of warfarin. Elevations of the prothrombin time in the setting of concurrent warfarin and levofloxacin use have been associated with episodes of bleeding. Prothrombin time, International Normalized Ratio (INR), or other suitable anticoagulation tests should be closely monitored if levofloxacin is administered concomitantly with warfarin. Patients should also be monitored for evidence of bleeding. Return to top

Cyclosporine
No significant effect of levofloxacin on the peak plasma concentrations, AUC, and other disposition parameters for cyclosporine was detected in a clinical study involving healthy volunteers. However, elevated serum levels of cyclosporine have been reported in the patient population when co-administered with some other quinolones. Levofloxacin Cmax and ke were slightly lower while Tmax and t½ were slightly longer in the presence of cyclosporine than those observed in other studies without concomitant medication. The differences, however, are not considered to be clinically significant. Therefore, no dosage adjustment is required for levofloxacin or cyclosporine when administered concomitantly. Return to top

Digoxin
No significant effect of levofloxacin on the peak plasma concentrations, AUC, and other disposition parameters for digoxin was detected in a clinical study involving healthy volunteers. Levofloxacin absorption and disposition kinetics were similar in the presence or absence of digoxin. Therefore, no dosage adjustment for levofloxacin or digoxin is required when administered concomitantly. Return to top

Probenecid and Cimetidine
No significant effect of probenecid or cimetidine on the rate and extent of levofloxacin absorption was observed in a clinical study involving healthy volunteers. The AUC and t½ of levofloxacin were 27-38% and 30% higher, respectively, while CL/F and CLR were 21-35% lower during concomitant treatment with probenecid or cimetidine compared to levofloxacin alone. Although these differences were statistically significant, the changes were not high enough to warrant dosage adjustment for levofloxacin when probenecid or cimetidine is co-administered. Return to top

Non-steroidal anti-inflammatory drugs
The concomitant administration of a non-steroidal anti-inflammatory drug with a quinolone, including levofloxacin, may increase the risk of CNS stimulation and convulsive seizures. Return to top

Antidiabetic agents
Disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported in patients treated concomitantly with quinolones and an antidiabetic agent. Therefore, careful monitoring of blood glucose is recommended when these agents are co-administered. Return to top

Major Interactions
amiodarone, anisindione, Anzemet, arsenic trioxide, BCG, bepridil, Betapace, Betapace AF, Betapace AF(obsolete), Budeprion SR, Budeprion XL, buPROPion, buPROPion 24 hour extended release, buPROPion extended release, Cardioquin, Chem Mart Tramadol, cisapride, Cordarone, Cordarone I.V., Corvert, Coumadin, dicumarol, Diskets, disopyramide, disopyramide extended release, dofetilide, dolasetron, Dolophine, Dromadol SR, Dromadol XL, droperidol, GenRx Tramadol, Geodon, Haldol, Haldol Decanoate, Halfan, halofantrine, haloperidol, haloperidol decanoate, ibutilide, Inapsine, iohexol, iopamidol, Iopamidol-370, Isovue-128, Isovue-200, Isovue-250, Isovue-300, Isovue-370, Isovue-M-200, Isovue-M-300, Jantoven, Larapam SR, levomethadyl acetate, Mellaril, Mellaril-S, mesoridazine, methadone, Methadose, metrizamide, Miradon, Myelo-Kit, nilotinib, Norpace, Norpace CR, Omnipaque 140, Omnipaque 180, Omnipaque 180 Redi-Unit, Omnipaque 210, Omnipaque 240, Omnipaque 240 Redi-Unit, Omnipaque 300, Omnipaque 350, Omnipaque Flexipak, Orap, Orlaam, Pacerone, pimozide, procainamide, procainamide 12 hour extended release, procainamide extended release, Procan SR, Procanbid, Pronestyl, Pronestyl-SR, Propulsid, Quin-G, Quin-Release, Quinaglute Dura-Tabs, Quinidex Extentabs, quinidine, quinidine extended release, Quinora, Ranexa, ranolazine, Serentil, sodium biphosphate, Sorine, sotalol, Sotalol Hydrochloride AF, Sotalol Hydrochloride AF(obsolete), sparfloxacin, Tasigna, Terry White Chemists Tramadol, TheraCys, thioridazine, Tice BCG Vaccine, Tikosyn, traMADOL, traMADOL extended release, Tramahexal, Tramahexal SR, Tramake, Tramake Insts, Tramal, Tramal SR, Tramedo, Trisenox, Ultram, Ultram ER, Vascor, warfarin, Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zagam, Zagam Respipac, Zamadol, Zamadol 24hr, Zamadol Melt, Zamadol SR, ziprasidone, Zyban, Zyban Advantage Pack, Zydol, Zydol SR, Zydol XL

Moderate Interactions
5-FU, 8-Mop, A-Hydrocort, A-Methapred, abarelix, ABC Plus Senior, ABC to Z, Abraxane, acarbose, Accuneb, Accupril, Acetocot, acetoHEXAMIDE, Acetylsalicylic Acid, Acid Relief, actinomycin D, Actos, Actron, Acuprin 81, Adapin, Adbeon, ADEKs, Adeno-jec, Adenocard, Adenoscan, adenosine, adenosine monophosphate, adenosine triphosphate, Adgan, Adlone-40, Adlone-80, Adrenocot, Adrenocot L.A., Adriamycin, Adriamycin RDF, Adrucil, Advil, Advil Childrens, Advil Junior Strength, Advil Liquigel, Advil Migraine, Advil Pediatric, Aflaxen, Airet, albuterol, albuterol extended release, aldesleukin, Aleve, Aleve Caplet, Aleve Easy Open Arthritis, Aleve Gelcap, alfuzosin, alfuzosin extended release, Alka-Mints, Alkeran, Alkeran I.V., Alkets, Alkums, Allbee-C 800 with Iron, Almora, Aloh-Gel, Aloxi, Alternagel, altretamine, Alu-Cap, Alu-Tab, aluminum carbonate, aluminum hydroxide, Alupent, Amaryl, Amersham Indium (111In) Oxine, Ami-Natal Plus One Improved, Amigesic, Amilac, Aminatal Plus, Aminatal Plus New Formula, Aminatal Plus One, Aminate, Aminate with 90 mg Iron, aminolevulinic acid topical, Amitone, amitriptyline, amoxapine, Amphojel, Anaflex, Anafranil, Anaprox, Anaprox-DS, Anemagen, Anemagen FA, Anemagen OB, Anergan 50, Ansaid, Antinaus 50, Antioxid Caplets, Antioxidant Formula, Antioxidant Ultra Formula, Apatate Forte, Apetimar with Iron, Apidra, Apidra OptiClik Cartridge, APO-Go, APO-Go Pen, Apokyn, apomorphine, AquADEKs, AquADEKs Pediatric, ara-C, Aralen Hydrochloride, Aralen Phosphate, arformoterol, Argesic-SA, Aristocort, Aristocort For Injection, Aristocort Forte, Aristopak, Aristospan Injection, Arthritis Pain, Arthropan, ASA, Ascriptin Enteric, Asendin, Aspergum Cherry, Aspergum Orginal, Aspir-Low, aspirin, aspirin extended release, Aspirin Lite Coat, Aspirin Litecoat, Aspirin Low Strength, Aspirtab, astemizole, Avail Calcium Intensive, Avandia, Aventyl HCl, azithromycin, Azithromycin 3 Day Dose Pack, Azithromycin 5 Day Dose Pack, azithromycin extended release, Azmacort, B-Plex Plus Minerals, Bacmin, balsalazide, Basaljel, Bayer Aspirin, Bayer Aspirin Regimen, Bayer Aspirin Sugar Free, Bayer Aspirin with Calcium, Bayer Childrens Aspirin, Bayer Low Strength, Bayer Plus, Bayer Select Backache Pain Formula, Becomax Rx, Bee-Zee, Beelith, Berocca Plus, Berplex Plus, Beta-Phos/AC, Betamed, betamethasone, betamethasone acet-betamethasone na phosphate, betamethasone sodium phosphate, Bextra, Biaxin, Biaxin XL, Biaxin XL-Pak, BiCNU, Biotin Forte with Zinc, bitolterol, Blenoxane, bleomycin, Brethaire, Brethine, Bricanyl, Bright Beginnings, bromfenac, Bronkometer, Brovana, Bubbli-Pred, Buffered Aspirin, Bufferin, Bufferin Arthritis Strength, Bufferin Extra Strength, Buffex, Bugs Bunny Complete, Bugs Bunny with Iron Chewable, busulfan, Busulfex, Cal Oys, Cal-Gest, Cal-Nate, Calafol Rx, Calcarb, Calcet Plus, Calci Mix, Calci-Chew, CalciFol, CalciFolic-D, Calcionate, Calciquid, Calcitab, calcium acetate, calcium carbonate, calcium citrate, Calcium Concentrate, calcium glubionate, calcium gluconate, calcium lactate, Calcium Liquid Softgel, Calcium Oyster, Calcium Oyster Shell, calcium phosphate, tribasic, Calphron, Caltrate, Caltrate 600 Plus, Caltrate Plus, Caltro, Camptosar, capecitabine, Carafate, carbonyl iron, carboplatin, Carboplatin Novaplus, CareNatal DHA, carmustine, Caromega, Cataflam, Ceenu, Celebrex, celecoxib, Celestone, Celestone Phosphate, Celestone Soluspan, Cell-U-Jec, CellCept, Cenogen Ultra, Centavite, Central, Central-Vite, Centrum, Centrum Cardio, Centrum Jr, Centrum Jr with Extra C, Centrum Jr with Extra Calcium, Centrum Kids Complete Dora the Explorer, Centrum Kids Complete SpongeBob SquarePants, Centrum Kids Complete Variety, Centrum Performance, Centrum Silver, Centrum Singles, Century, Century-Vite, Cerovite Advanced Formula, Cerovite Junior, Cerovite Liquid, Cerovite Senior, Certa-Vite, Certa-Vite Senior Plus Lutein, Certagen, Certagen Senior, Certagen Senior with Lutein, Certavite, CertaVite with Lutein, Cerubidine, Cezin-S, CF Vite, Chelated Magnesium, Chem Mart Tamoxifen, Chem-Sol, Childrens Ibuprofen Berry, chlorambucil, Chloromag, chloroquine, chloroquine hydrochloride, chloroquine phosphate, chlorproMAZINE, chlorproMAZINE extended release, chlorproPAMIDE, choline salicylate, Chooz, Chromagen, Chromagen (obsolete), Chromagen FA, Chromagen FA (obsolete), Chromagen Forte, Chromagen Forte (obsolete), Chromagen OB, Chromatinic, Circavite T, cisplatin, Cit Calcium (obsolete), Citra pH, Citracal, Citracal Liquitab, Citracal Plus with Magnesium, Citracal Prenatal + DHA, Citracal Prenatal 90+DHA, Citracal Prenatal Rx, CitraNatal 90 DHA, CitraNatal DHA, CitraNatal Rx, Citrate of Magnesia, Citrate-Phos-Dex, citric acid, Citroma Cherry, Citroma Lemon, clarithromycin, clarithromycin extended release, Clinacort, Clinalog, Clinoril, clofarabine, Clolar, clomiPRAMINE, Clusimar, Colazal, Colocort, Compazine, Compazine Spansule, Compete, Complete A-Z, Compro, Concentrated Phillips Milk of Magnesia, Conison, Contrin, Cort-K, Cortastat, Cortastat 10, Cortastat LA, Cortef, Cortenema, Cortifoam, cortisone, Cortone Acetate, Corvite, Corvite 150, Corvite Free, Cosmegen, Cotolone, cyclophosphamide, cyclophosphamide lyophilized, cytarabine, cytarabine arabinoside, Cytosar, Cytosar-U, Cytoxan, Cytoxan Lyophilized, dacarbazine, dactinomycin, Daily Combo, Daily Multi-Vitamins with Minerals, Daily-Vite Weight Control, Dalalone, Dalalone D.P., Dalalone L.A., dasatinib, DAUNOrubicin, DAUNOrubicin liposomal, Daunoxome, Dayalets Plus Iron, Daypro, ddI, De-Sone LA, Decadron, Decadron 5-12 Pak, Decadron Phosphate, Injectable, Decadron-LA, Decagen, Decaject, Decaject L.A., Definity, Deltasone, denileukin diftitox, Dep Medalone 80, Depmedalone, Depo-Medrol, Depo-Predate (obsolete), Depoject-80, Depopred, DermaVite, desipramine, Dewees Carminative, Dexacen-4, Dexacort Phosphate in Respihaler, Dexacort-LA, Dexacorten, dexamethasone, dexamethasone acetate, Dexamethasone Intensol, dexamethasone sodium phosphate, Dexasone, Dexasone LA, Dexone, Dexone LA, Dexpak Jr. Taperpak, Dexpak Taperpak, DiaBeta, Diabinese, Dialume, Dialyvite, Dialyvite 3000, Dialyvite 800 with Zinc, Dialyvite with Zinc Rx, Diatx Fe, Diatx Zn, Diavite Plus, Dicarbosil, diclofenac, diclofenac potassium, diclofenac sodium, diclofenac sodium extended release, didanosine, didanosine delayed release capsule, Diflucan, diflunisal, dihydroxyaluminum sodium carbonate, Disalcid, Disney Winnie the Pooh Complete, Disney Winnie the Pooh Gummies, Disney Winnie the Pooh with Extra C, Doans Pills, Doans Pills Extra Strength, docetaxel, Dolobid, Dolomite, doxepin, doxepin topical, Doxil, DOXOrubicin, DOXOrubicin liposomal, Droxia, DTIC-Dome, Dualvit OB, Duet, Duet Chewable, Duet DHA, Duet DHA EC, DurAct, Duralone, Dymelor, E-Mycin, E.E.S. Granules, E.E.S.-200, E.E.S.-400, E.E.S.-400 Filmtab, Easprin, EC-Naprosyn, Ecee Plus, Ecotrin, Ecotrin Adult Low Strength, Ecotrin Maximum Strength, Elavil, Eldercaps, Eldertonic, Elemental Iron, Elemental Iron-90, Ellence, Ellis Tonic Sherry, elon Matrix 5000 Complete, Emblon, Embrex 600, Empirin, Encora, Endep, Entaprin, Entercote, epirubicin, Equi-Natal Care, Equi-Natal M, Equi-Natal Plus, Equi-Natal Rx, Equi-Natal Z, Equi-Roca Plus, Equicyte Plus, Equilet, Equinatal 90, Ery-Tab, Eryc, EryPed, EryPed 200, EryPed 400, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, Erythrocot, erythromycin, erythromycin base, erythromycin estolate, erythromycin ethylsuccinate, erythromycin lactobionate, erythromycin stearate, Eskalith, Eskalith-CR, Estinyl, ethinyl estradiol, etodolac, etodolac extended release, Etopophos, etoposide, etoposide phosphate, Ex-Lax Milk of Magnesia, Extra Strength Bayer, Extra Strength Mylanta Calci Tabs, EXUBERA, EXUBERA Combination Pack 12, EXUBERA Combination Pack 15, EXUBERA Kit, Fasprin, Fe 50, FE C Tab Plus, Fe-Tinic 150, Fe-Tinic 150 Forte, Feldene, Fem-Natal, Femiron, Femiron Multi with Iron, Femnatal, Femtabs, fenoprofen, Feocyte, Feogen, Feosol, Feosol Caplet, Feosol Iron, Feostat, Fer-Gen-Sol, Fer-in-Sol, Feratab, Ferate, Ferbee, Fergon, Fero-Folic 500, Fero-Gradumet Filmtab, Ferocon, FeroSul, Ferotrinsic, Ferra T.D. Caps, Ferra-Cap, Ferra-TD, Ferragen, Ferralet, Ferralet 90, Ferrets, Ferretts IPS, Ferrex PC Forte, Ferrex-150, Ferrex-150 Forte, Ferrimin 150, Ferro-Bob, Ferro-Time, Ferrocite, Ferrogels Forte, Ferrospace, ferrous fumarate, ferrous gluconate, ferrous gluconate extended release, ferrous sulfate, ferrous sulfate extended release, Ferus Pic-150, Fetrin, FK506, flecainide, Flintstones Complete, Flintstones with Calcium, Flintstones with Iron Chewable, Flo-Pred, Florinef Acetate, floxuridine, fluconazole, Fludara, fludarabine, fludrocortisone, fluorouracil, Fluothane, fluphenazine, fluphenazine decanoate, fluphenazine enanthate, fluphenazine hydrochloride, flurbiprofen, Folbee Plus CZ, Folex PFS, Folgard OS, FoliTab 500, Folpace Rx, Foltabs, Foltrin, Foradil Aerolizer, formoterol, Formula B Plus, Formula Twenty-One, Fortamet, foscarnet, Foscavir, Fosfree, Fosrenol, Fruity Chews with Iron, FUDR, Fumasorb, Fumatinic, Galzin, Garfield Complete Vitamins, Garfield Vitamin with Iron, gemcitabine, gemtuzumab, Gemzar, Genacote, Generet-500 with Folic Acid, Generix-T, Gennin-FC, Genox, Genpril, Genprin, GenRx Tamoxifen, Geravim, Geri-Tabs, Geri-Tonic, Geritol, Geritol Complete, Geritol Extend, Gerivite Liquid, Gevrabon, Gevratonic, Gliadel, glimepiride, glipiZIDE, glipiZIDE extended release, GlipiZIDE XL, Glucophage, Glucophage XR, Glucotrol, Glucotrol XL, Glumetza, Glutofac-MX, Glutofac-ZX, glyBURIDE, glyBURIDE micronized, Glynase PresTab, Glyset, Gold Age Liquid Vitamins and Minerals, Gynovite, Hair Booster, Halfprin, halothane, Haltran, Hematinic Plus, Hematogen, Hematogen FA, Hematogen Forte, Hemax, heme iron polypeptide, Hemocyte, Hemocyte Plus, Hemocyte Plus (obsolete), Hemocyte-F Elixir, Hexadrol, Hexadrol Phosphate, Hexalen, Hi-Nate 90, High Potency, Hismanal, Humalog, Humalog Cartridge, Humalog KwikPen, Humalog Pen, Humulin L, Humulin N, Humulin N Pen, Humulin R, Humulin R (Concentrated), Humulin U, Hycamtin, Hydeltra-T.B.A., Hydeltrasol, Hydrea, hydrocortisone, hydrocortisone acetate, hydrocortisone cypionate, hydrocortisone hemisuccinate, hydrocortisone sodium phosphate, Hydrocortisone Sodium Succinate, Hydrocortone, Hydrocortone Phosphate, hydroxyurea, Hytinic, I-L-X, I-L-X and B12, I-Sense, I-Sense OccuShield, I-Vite, I-Vite Protect, IBC 500, Iberet, Iberet Liquid, Iberet-500, Iberet-Folic-500, Ibu, IBU-200, Ibu-4, Ibu-6, Ibu-8, Ibu-Tab, ibuprofen, Ibuprofen PMR, Icaps, ICaps AREDS, ICaps MV, ICaps Plus, Icaps TR, ICaps with Lutein and Zeaxan, Icar, Icar Prenatal, Icar Prenatal Chewable Calcium, Icar-C Plus, Icar-C Plus SR, Icare Prenatal Rx, Idamycin PFS, idarubicin, Iferex 150 Forte, Ifex, ifosfamide, Iletin II Lente Pork, Iletin II NPH Pork, Iletin II Regular Pork, Iletin Lente, Iletin NPH, Iletin Regular, Ilosone, Ilotycin Gluceptate, imipramine, imipramine pamoate, Inatal Advance, Inatal Ultra, indium oxyquinoline In-111, Indocin, Indocin SR, indomethacin, indomethacin extended release, insulin, insulin analog, insulin aspart, insulin aspart protamine, insulin detemir, insulin glargine, insulin glulisine, insulin inhalation, rapid acting, insulin isophane, Insulin Lente Pork, insulin lispro, insulin lispro protamine, Insulin Purified NPH Pork, Insulin Purified Regular Pork, insulin regular, insulin zinc, insulin zinc extended, insulin, lente, insulin, NPH, insulin, ultralente, Intrinsitinic, Invega, Ircon, irinotecan, Irofol, Iromin G, Iron Chews, iron polysaccharide, iron protein succinylate, isoetharine, isoproterenol, Isuprel HCl, Isuprel Mistometer, Ken-Jec 40, Kenaject-40, Kenalog-10, Kenalog-40, Ketek, Ketek Pak, ketoprofen, ketoprofen extended release, ketorolac, Key-Pred, Key-Pred SP, L-Tonic, Lactocal-F, lanthanum carbonate, Lantus, Lantus OptiClik Cartridge, Lantus Solostar Pen, lapatinib, Largon, Lariam, Leader Naproxen Sodium, Lente insulin, Leukeran, levalbuterol, Levemir, Levemir FlexPen, Levemir InnoLet, Levemir PenFill, Levitra, Levoprome, Levulan Kerastick, lindane topical, Liquid Pred, Litecoat Aspirin, lithium, lithium carbonate, lithium carbonate extended release, lithium citrate, Lithobid, Lithonate, Lithotabs, Livitrinsic-F, Lodine, Lodine XL, lomustine, Lorelco, Losospan, Low Dose ASA, Lowsium, Ludiomil, Lydia E. Pinkham, M-PREDNISolone, M-Vit, Maalox Antacid Barrier, Maalox Childrens', Maalox Quick Dissolve, Maalox Quick Dissolve Extra Strength, Maalox Quick Dissolve Maximum Strength, Maalox Regular Strength, Mag 64, Mag-200, Mag-Carb, Mag-Delay, Mag-G, Mag-Ox 400, Mag-SR, Mag-SR with Calcium, Mag-Tab SR, magaldrate, Magan, MagGel, Maginex, MagMin, Magna-C-7 Forte, MagneBind 400 Rx, Magnesiocard, magnesium amino acids chelate, magnesium aspartate, magnesium carbonate, magnesium chloride, magnesium chloride extended release, magnesium citrate, magnesium gluconate, magnesium hydroxide, magnesium lactate, magnesium oxide, magnesium salicylate, magnesium trisilicate, Magonate, Magonate Natal, Magonate Tablets, Magtrate, Maoson, maprotiline, Mar-Zinc, Marnatal-F Plus, Marthritic, Martinic, Materna, Maternal 90, Maternity, Maternity plus Beta Carotene, Maternity Vitamin Low Iron, Maternity-90, Matulane, Maxair, Maxair Autohaler, Maxaron Forte, Maxinate, mechlorethamine, meclofenamate, Meclomen, Med-Jec-40, Medicort, Medidex, Medidex LA, Medihaler-Iso, Mediplex Ultra, Medipred, Medralone, Medralone 40, Medralone 80, Medrol, Medrol Dosepak, mefenamic acid, mefloquine, meloxicam, melphalan, Menadol, Mens Pack, mercaptopurine, mestranol, Metaprel, metaproterenol, metformin, metformin extended release, Methacort 40, Methacort 80, methdilazine, methotrexate, Methotrexate Sodium, Preservative Free, methotrimeprazine, methoxsalen, Methylcotol, Methylcotolone, Methylpred DP, methylPREDNISolone, methylPREDNISolone acetate, MethylPREDNISolone Dose Pack, methylPREDNISolone sodium succinate, Meticorten, Mg chloride, Mg gluconate, Mg hydroxide, Mg lactate, Mg oxide, MG Plus Protein, Mi-C-T, Micro-Zn, Micronase, Midol Extended Relief, Midol IB, Midol Maximum Strength Cramp Formula, miglitol, Milk of Magnesia, Millipred, Minitabs, Mission Prenatal, Mission Prenatal FA, Mission Prenatal HP, Mission Prenatal Rx, Mithracin, mitomycin, mitoxantrone, Mobic, Mobidin, Mol-Iron, Mono-Gesic, Motrin, Motrin Childrens, Motrin IB, Motrin Infant Drops, Motrin Junior Strength, Motrin Migraine Pain, MST, Mult-Ferr Folic, Multi Vita Bets and Fluoride and Iron, Multi-betic, Multi-Day Plus Minerals, Multi-Day with Calcium and Extra Iron, Multi-Delyn with Iron, Multibret Folic 500, Multifol, Multifol Plus, Multilex, Multilex-T/M+Minerals, Multiret Folic 500, multivitamin with iron, multivitamin with iron and fluoride, multivitamin with minerals, multivitamin, prenatal, Mustargen, Mutamycin, My-A-Multi, MY-E, My-O-Den, Myadec, mycophenolate mofetil, mycophenolic acid, Myferon 150 Forte, Myfortic, MyKidz Iron, MyKidz Iron 10, MyKidz Iron FL, Mylanta Child, Myleran, Mylocel, Mylotarg, Mynatal, Mynatal FC, Mynatal Plus, Mynatal PN, Mynatal PN Forte, Mynatal Rx, Mynatal Ultracap, Mynatal Z, Mynate 90 Plus, Myvitalife, nabumetone, Nalfon, Naprelan '375', Naprelan '500', Naprosyn, naproxen, naproxen sodium, Naproxen Sodium DS, naproxen sodium extended release, Natacaps, Natachew, Natafolic-OB, Natafolic-PN, Natafort, NatalCare, NatalCare Advanced, NatalCare Advanced-RF, NatalCare CFE 60, Natalcare Pic, Natalcare Pic Forte, Natalcare Plus, Natalcare Rx, NatalCare Three, Natalcare(obsolete), Natalfirst, Natalins, Natalins Rx, Natarex, Natatab CFe, Natatab FA, Natatab Rx, nateglinide, Natelle, Natelle C, Natelle Plus with DHA, Natelle Prefer, Natelle-ez, Navelbine, Nebupent, Neevo, Neo-Calglucon, Neo-Forte, NeoProfen, Neosar, Nephro Calci, Nephro-Fer, Nephro-Vite with Fe, Nephron-FA, Nestabs, Nestabs CBF, Nestabs FA, Nestabs Rx, Neut, New Advanced Formula Prenatal Z, NIC 750, Nicomide, Niferex, Niferex Elixir, Niferex Gold, Niferex PN Forte, Niferex(obsolete), Niferex-150 (obsolete), Niferex-150 Forte, Niferex-150 Forte (obsolete), Niferex-150(obsolete), Niferex-PN, Nipent, Nolvadex, Nolvadex D, Norlac RX, Norpramin, nortriptyline, Norwich Aspirin, Novanatal, Novantrone, NovaStart, Novastart (obsolete), Novolin L, Novolin N, Novolin N Innolet, Novolin N PenFill, Novolin R, Novolin R Innolet, Novolin R PenFill, NovoLog, NovoLog FlexPen, NovoLog PenFill, Noxafil, NPH insulin, Nu-Iron, Nu-Iron 150, Nu-Iron Plus, Nu-Iron V, Nuprin, Nuprin Backache Caplet, NutriNate, Nutrispire, O-CAL F.A., O-Cal Prenatal, O-Cal-FA, OB Complete, OB Complete with DHA, Ob-20, Obegyn, Obnate 90, Obtrex, Occuplex, Ocuvite, Ocuvite Extra, Ocuvite Lutein, Ocuvite PreserVision, Oncovin, ondansetron, One Daily with Minerals, One Tab Daily with Iron, One Tab Daily with Minerals, One-A-Day Max, One-A-Day Men 50 Plus, One-A-Day WeightSmart, One-A-Day Women, One-A-Day Women 50 Plus, Ontak, Onxol, Opti-Gen, Optilets-M-500, Optimum Magnesium Gluconate, OptiNate, Optison, Optivite P.M.T., Orapred, Orapred ODT, Orasone, Orazinc, Orazinc 110, Orazinc 110(obsolete), Orazinc 220, Orinase, Ormazine, Orudis, Orudis KT, Oruvail, Os-Cal, Os-Cal 500, Os-Cal Forte, Os-Cal Ultra, Ostiva, oxaprozin, Oxsoralen-Ultra, Oysco 500, Oyst Cal, Oyst Cal 500, Oyster, Oyster Cal, Oyster Cal 500, Oyster Calcium, Oyster Shell, oyster shell calcium, Oyster Shell Calcium 500, paclitaxel, paclitaxel protein-bound, paliperidone, palonosetron, Pamelor, Pan OB Forte, Par-F, Paraplatin, PCE Dispertab, Pediacare Fever, Pediapred, Pentam 300, pentamidine, Pentazine, pentostatin, Pepto Children's, perflutren, Perforomist, Permitil, perphenazine, Pharmorubicin PFS, Pharmorubicin RDF, Phenadoz, Phenazine 50, Phenergan, Phenergan Fortis, Phenoject-50, phenyl salicylate, phenylbutazone, Phillips Milk of Magnesia, Phillips' Cramp-free, PhosLo, PhosLo Gelcap, pioglitazone, pirbuterol, piroxicam, Pitressin, Platinol-AQ, Plenaxis, plicamycin, PMS Balance, Poly Iron, Poly Iron Forte, Poly Vitamin with Fluoride with Iron, Poly-Vi-Flor with Iron, Poly-Vi-Sol with Iron, Poly-Vi-Sol with Iron Drops, Polysaccharide Iron, Ponstel, posaconazole, Posture, potassium citrate, Pramilet FA, Prandin, Pre-H-Cal, Precare, Precare Conceive, Precare Premier, Precose, Pred-Ject-50, Predacort 50, Predacorten, Predaject-50, Predalone 50, Predate-50, Predcor, Predicort RP, Predicort-50, Prednicen-M, Prednicot, prednisoLONE, prednisoLONE acetate, prednisoLONE sodium phosphate, prednisoLONE tebutate, predniSONE, PreferaOB, Prelone, Premesis Rx, PrenaFirst, Prenatabs CBF, Prenatabs FA, Prenatabs OBN, Prenatabs Rx, Prenatal 1 Plus 1, Prenatal 1 Plus 1 (Low Iron), Prenatal 19, Prenatal AD, Prenatal Elite, Prenatal H, Prenatal Low Iron, Prenatal MR 90, Prenatal MR 90 Fe, Prenatal MTR with Selenium, prenatal multivitamin, Prenatal Multivitamins, Prenatal Plus, Prenatal Plus Iron, Prenatal Plus with 27 mg Iron, Prenatal Plus with Beta-Carotene, Prenatal Rx, Prenatal Rx 1, Prenatal S, Prenatal Z Advanced Formula, Prenatal-U, Prenate 90, Prenate Advance, Prenate Advanced Formula, Prenate DHA, Prenate Elite, Prenate GT, Prenate Ultra, Prenavite, Prenavite FC, Prenavite PC, Prenazyme 1+1, Preterna, Pri-Cortin 50, PrimaCare, PrimaCare Advantage, Primacare One, Primethasone, Pro-Med, ProAir HFA, probucol, procarbazine, prochlorperazine, prochlorperazine extended release, Procot, Procycle Multi Vitamin with Minerals, Proferrin-ES, Proferrin-Forte, Prograf, Proleukin, Prolixin, Prolixin Decanoate, Prolixin Enanthate, Promacot, Promar, promazine, promethazine, Promethegan, Pronemia, propafenone, propafenone extended release, propiomazine, Prorex, Prosight, protamine zinc insulin, Protegra Softgel, protriptyline, Proventil, Proventil HFA, Proventil Repetabs, Prudoxin, Purinethol, Q-Profen, QM-260, Qualaquin, quetiapine, quetiapine extended release, quinapril, quinine, Re Dualvit F, Re Dualvit Plus, RE Fac-X, regular insulin, Relafen, ReliOn/Novolin N, ReliOn/Novolin R, Renagel, RenaPlex, Renatabs with Iron, Renax, Renax 5.5, Renvela, Reocyte Plus, repaglinide, Repliva 21/7, Resource Optisource, Respirol, Rexolate, Rezulin, Rheumatrex Dose Pack, Ri-Mag, Ridactate, Riomet, Riopan, Risperdal, Risperdal Consta, Risperdal M-Tab, risperidone, ritodrine, Robimycin, rofecoxib, Rolaids Sodium Free, Rolaids Soft Chew, Ron Acid, rosiglitazone, Ru-Lets M 500, Rufen, Rythmol, Rythmol SR, Saleto-200, Saleto-400, Saleto-600, Saleto-800, Salflex, salmeterol, salsalate, Salsitab, Select-OB, Selestoject, Senetonic, Senilezol, Serevent, Serevent Diskus, Seroquel, Seroquel XR, Sesame St. Vitamins Complete, Sesame St. Vitamins Plus Iron, sevelamer, Siderol, Simron, Sinequan, Sloprin, Slow Fe, Slow Release Iron, Slow-Mag, sodium bicarbonate, sodium citrate, sodium salicylate, sodium thiosalicylate, Soltamox, Solu-Cortef, Solu-Medrol, Solurex, Solurex LA, SourceCF Chewables, SourceCF Multivitamins with A,B,D,E & K plus Zinc, SourceCF Pediatric Drops, SourceCF Softgels, Sparine, Sprycel, SSS, SSS Tonic, St. Joseph Aspirin, St. Joseph Aspirin Adult Chewable, St. Joseph Aspirin Adult EC, Stanback Analgesic, Starlix, Stelazine, Sterapred, Sterapred DS, streptozocin, Stress 600 with Zinc, Stress Formula with Iron, Stress Formula with Zinc, Stresstabs with Iron, StressTabs with Zinc, Strongstart, strontium gluconate, Strovite, Strovite Advance, Strovite Advance+D, Strovite Forte, Strovite Plus, Stuart Prenatal with Beta Carotene, Stuartnatal Plus, Stuartnatal Plus 3, sucralfate, sulindac, Sunkist Child Chewable with Iron, Super Calcium, Super High Vitamins and Minerals, Support, Support 500, Surbex-750 with Iron, Surbex-750 with Zinc, Surmontil, Surpass, Surpass Extra Strength, T-Gran plus Minerals, T-Lite, Tab-A-Vite Maximum, Tab-A-Vite WeightSlim, Tab-A-Vite with Iron, Tab-A-Vite Womens Formula, TAC 3, Tacaryl, tacrolimus, Tambocor, Tamofen, Tamofen(obsolete), Tamone, Tamosin, Tamoxen, tamoxifen, Tamoxifen Hexal, Tandem DHA, Tandem OB, Tandem Plus, Tarabine PFS, Taxol, Taxotere, telithromycin, Temaril, Temodar, temozolomide, teniposide, terbutaline, terfenadine, Ternamar, Terry White Chemists Tamoxifen, Thera Hematinic, Thera M, Thera-M, Thera-Vite M, Theragener-H, Theragener-M, Theragran Hematinic, Theragran-M, Therapeutic-M, Therapy Bayer, Theravim M, Therems H, Therems M, Therobec Plus, thiethylperazine, thioguanine, Thioplex, thiotepa, Thorazine, Titralac, tizanidine, Tofranil, Tofranil-PM, Tol-Tab, TOLAZamide, TOLBUTamide, Tolectin, Tolectin 600, Tolectin DS, Tolfrinic, Tolinase, tolmetin, Toposar, topotecan, Toradol, Toradol IM, Toradol IV/IM, Torecan, Tornalate, Tramacort-D, tretinoin, Trexall, Tri Vites with Fluoride and Iron, Tri-Buffered Aspirin, Tri-Vi-Flor with Iron, Tri-Vi-Sol with Iron, Triam-A, Triam-Forte, triamcinolone, triamcinolone acetonide, triamcinolone diacetate, triamcinolone hexacetonide, Triamcot, Triamonide 40, tricalcium phosphate, TriCare, Tricitrasol, Tricon, trifluoperazine, triflupromazine, TriHEMIC 600, Trilafon, Trilog, Trilone, trimeprazine, trimipramine, Trinate, Trinsicon, Tristoject, troglitazone, Tums, Tums 500, Tums E-X, Tums Extra Strength, Tums Ultra, Tusal, Twin-K, Tykerb, typhoid vaccine, live, U-Tri-Lone, Udamin, Udamin SP, Ultra Mylanta Calci Tabs, Ultra NatalCare, Ultra-Natal, Ultralente insulin, Uni Kar Plus C SR, Uni-Daily Plus Iron, Uni-Fac ZX, Uni-Thera M with Beta Carotene, Unicap M, Unicap Senior, Unicap T, Unicap with Iron, Unicomplex M, Uprima, uracil mustard, Uro-Mag, Urocit-K, Uroxatral, Uvadex, V-C Forte, V-Gan-25, V-Gan-50, valdecoxib, Vanatrip, vardenafil, vasopressin, Velban, Velosulin BR, Ventolin, Ventolin HFA, Ventolin Nebules, Ventolin Rotacaps, VePesid, Verazinc, Vernate, Vernate Advanced, Verotin-BY, Verotin-GR, verteporfin, Vesanoid, VFEND, Vi-Daylin ADC with Iron, Vi-Daylin with Iron, Vi-Daylin with Iron Chewable, Vi-Daylin with Iron Drops, Vi-Daylin/F ADC with Iron, Vi-Daylin/F Plus Iron, Vi-Stress with Iron, Vi-Zac, Viactiv Calcium Flavor Glides, Viactiv Multi-Vitamin, Viactiv Multi-Vitamin Flavor Glides, Viactiv Soft Calcium Chews, Vica-Forte, Vicap Forte, Vicon Forte, Vicon Plus, Vicon-C, Videx, Videx EC, Vigortol Liquid, Vimar with Iron, Vinatal 600, Vinatal Forte, Vinate 90, Vinate Advanced (New Formula), Vinate AZ, Vinate AZ Extra, Vinate Calcium, Vinate Good Start, Vinate GT, Vinate II (New Formula), Vinate M, Vinate Ultra, vinBLAStine, Vincasar PFS, vinCRIStine, vinorelbine, Viogen-C, Vioxx, Visudyne, Vita Drops with Iron, Vita S Forte, Vita Zx, Vita-Dec, Vita-Min Rx, Vita-PMS, Vita-PMS Plus, Vita-Zinc, Vitacon Forte, Vitafol, Vitafol PN, Vitafol-OB, Vitafol-OB+DHA, Vital-D, Vitalize Plus, Vitamax, Vitamed Prenatal Formula, Vitaphil, Vitaplex Plus, Vitelle Nestabs OTC, Vivactil, Vivotif Berna, Volmax, Voltaren, Voltaren-XR, voriconazole, vorinostat, VoSpire ER, Vumon, Vynatal 1 Plus 1, Vynatal F.A., Womens Pack, Xeloda, Xopenex, Xopenex Concentrate, Xopenex HFA, Yieronia, YSP Aspirin, Yutopar, Z-Bec, Z-Gen, Z-Pak, Zanaflex, Zanosar, ZE-Plus, Zenate, Zenate Advanced Formula, Zenate Prenatal, Zero-Order Release, Zinc 50 mg Pink, zinc acetate, Zinc CR, zinc gluconate, zinc sulfate, Zinc with Vitamin C, Zinc-220, Zinca-pak, Zincate, Zincvit, Zitamin, Zithromax, Zithromax IV, Zithromax TRI-PAK, Zithromax Z-Pak, Zmax, Zodeac-100, Zofran, Zofran ODT, Zolinza, Zonalon, Zorprin

Minor Interactions
Benemid, probenecid