ICD-10 Chapter E: Endocrine, nutritional and metabolic diseases

(E00-E07) Thyroid gland / Thyroid hormone

 * Congenital iodine-deficiency syndrome


 * Iodine-deficiency-related thyroid disorders and allied conditions
 * Iodine-deficiency-related diffuse (endemic) goitre
 * Iodine-deficiency-related multinodular (endemic) goitre
 * Iodine-deficiency-related (endemic) goitre, unspecified
 * Other iodine-deficiency-related thyroid disorders and allied condition


 * Subclinical iodine-deficiency hypothyroidism
 * Other hypothyroidism
 * Congenital hypothyroidism with diffuse goitre
 * Congenital hypothyroidism without goitre
 * Hypothyroidism due to medicaments and other exogenous substances
 * Postinfectious hypothyroidism
 * Atrophy of thyroid (acquired)
 * Myxoedema coma
 * Other nontoxic goitre


 * Thyrotoxicosis (hyperthyroidism)
 * Thyrotoxicosis with diffuse goitre
 * Graves' disease
 * Thyrotoxicosis with toxic single thyroid nodule
 * Thyrotoxicosis with toxic multinodular goitre
 * Thyrotoxicosis from ectopic thyroid tissue
 * Thyrotoxicosis factitia
 * Thyroid crisis or storm
 * Other thyrotoxicosis
 * Thyrotoxicosis, unspecified


 * Thyroiditis
 * Acute thyroiditis
 * Subacute thyroiditis
 * De Quervain's thyroiditis
 * Chronic thyroiditis with transient thyrotoxicosis
 * Autoimmune thyroiditis
 * Hashimoto's thyroiditis
 * Drug-induced thyroiditis
 * Other chronic thyroiditis
 * Riedel's thyroiditis
 * Thyroiditis, unspecified


 * Other disorders of thyroid
 * Hypersecretion of calcitonin
 * Dyshormogenetic goitre
 * Other specified disorders of thyroid
 * Sick-euthyroid syndrome
 * Disorder of thyroid, unspecified

(E10-E14) Diabetes mellitus

 * Note: the following conditions are subtypes of each code from E10-14:
 * (E1x.0) Diabetic coma
 * (E1x.1) Diabetic ketoacidosis
 * (E1x.2) Diabetic nephropathy
 * (E1x.3) Diabetic retinopathy
 * (E1x.4) Diabetic neuropathy
 * (E1x.5) Diabetic angiopathy
 * (E1x.6) Diabetic arthropathy
 * Insulin-dependent diabetes mellitus
 * Non-insulin-dependent diabetes mellitus
 * Malnutrition-related diabetes mellitus
 * Other specified diabetes mellitus
 * Unspecified diabetes mellitus

(E15-E16) Other disorders of glucose regulation and pancreatic internal secretion

 * Nondiabetic hypoglycaemic coma
 * Drug-induced insulin coma in nondiabetic
 * Hyperinsulinism with hypoglycaemic coma
 * Hypoglycaemic coma NOS


 * Other disorders of pancreatic internal secretion
 * Drug-induced hypoglycaemia without coma
 * Other hypoglycaemia
 * Functional nonhyperinsulinaemic hypoglycaemia
 * Hyperinsulinism: NOS
 * Hyperinsulinism: functional
 * Hyperplasia of pancreatic islet beta cells NOS
 * Posthypoglycaemic coma encephalopathy
 * Hypoglycaemia, unspecified
 * Increased secretion of glucagon
 * Abnormal secretion of gastrin
 * Hypergastrinaemia
 * Zollinger-Ellison syndrome
 * Other specified disorders of pancreatic internal secretion
 * Disorder of pancreatic internal secretion, unspecified

(E20-E21) Parathyroid gland / PTH

 * Hypoparathyroidism
 * Idiopathic hypoparathyroidism
 * Pseudohypoparathyroidism


 * Hyperparathyroidism and other disorders of parathyroid gland
 * Primary hyperparathyroidism
 * Secondary hyperparathyroidism, not elsewhere classified

(E22-E23) Pituitary gland / ADH, oxytocin, GH, ACTH, TSH, LH, FSH, prolactin

 * Hyperfunction of pituitary gland
 * Acromegaly and pituitary gigantism
 * Hyperprolactinaemia
 * Syndrome of inappropriate secretion of antidiuretic hormone
 * Central precocious puberty


 * Hypofunction and other disorders of pituitary gland
 * Hypopituitarism
 * Fertile eunuch syndrome
 * Hypogonadotropic hypogonadism
 * Idiopathic growth hormone deficiency
 * Isolated deficiency of gonadotropin
 * Isolated deficiency of growth hormone
 * Isolated deficiency of pituitary hormone
 * Kallmann's syndrome
 * Lorain-Levi short stature
 * Necrosis of pituitary gland (postpartum)
 * Panhypopituitarism
 * Pituitary cachexia
 * Pituitary insufficiency NOS
 * Pituitary short stature
 * Sheehan's syndrome
 * Simmonds' disease
 * Drug-induced hypopituitarism
 * Diabetes insipidus
 * Hypothalamic dysfunction, not elsewhere classified
 * Other disorders of pituitary gland
 * Abscess of pituitary
 * Adiposogenital dystrophy
 * Disorder of pituitary gland, unspecified

(E24-E27) Adrenal gland / Aldosterone, cortisol, epinephrine, norepinephrine

 * Cushing's syndrome
 * Pituitary-dependent Cushing's disease
 * Nelson's syndrome
 * Ectopic ACTH syndrome
 * Alcohol-induced pseudo-Cushing's syndrome
 * Other Cushing's syndrome
 * Cushing's syndrome, unspecified


 * Adrenogenital disorders
 * Congenital adrenogenital disorders associated with enzyme deficiency
 * Congenital adrenal hyperplasia
 * Congenital adrenal hyperplasia due to 21-hydroxylase deficiency


 * Hyperaldosteronism
 * Primary hyperaldosteronism
 * Conn's syndrome
 * Primary aldosteronism due to adrenal hyperplasia (bilateral)
 * Secondary hyperaldosteronism
 * Other hyperaldosteronism
 * Bartter's syndrome
 * Hyperaldosteronism, unspecified


 * Other disorders of adrenal gland
 * Other adrenocortical overactivity
 * Primary adrenocortical insufficiency
 * Addison's disease
 * Addisonian crisis
 * Drug-induced adrenocortical insufficiency
 * Other and unspecified adrenocortical insufficiency
 * Hypoaldosteronism
 * Adrenocortical insufficiency NOS
 * Adrenomedullary hyperfunction

(E28-E30) Gonads / Estrogen, androgens, testosterone, etc.

 * Ovarian dysfunction
 * Estrogen excess
 * Androgen excess
 * Polycystic ovarian syndrome
 * Primary ovarian failure
 * Premature menopause NOS


 * Testicular dysfunction
 * Testicular hyperfunction
 * Testicular hypofunction
 * 5-Alpha-reductase deficiency (with male pseudohermaphroditism)
 * Testicular hypogonadism NOS


 * Disorders of puberty, not elsewhere classified
 * Delayed puberty
 * Precocious puberty
 * Other disorders of puberty
 * Premature thelarche

(E31-E35) Other

 * Polyglandular dysfunction
 * Autoimmune polyglandular failure
 * Schmidt's syndrome
 * Polyglandular hyperfunction


 * Diseases of thymus
 * Persistent hyperplasia of thymus
 * Abscess of thymus


 * Other endocrine disorders
 * Carcinoid syndrome
 * Other hypersecretion of intestinal hormones
 * Ectopic hormone secretion, not elsewhere classified
 * Short stature, not elsewhere classified
 * NOS
 * constitutional
 * Laron-type
 * psychosocial
 * Constitutional tall stature
 * Constitutional gigantism
 * Androgen resistance syndrome
 * Reifenstein's syndrome
 * Other specified endocrine disorders
 * Progeria


 * Disorders of endocrine glands in diseases classified elsewhere
 * Disorders of thyroid gland in diseases classified elsewhere
 * Disorders of adrenal glands in diseases classified elsewhere
 * Disorders of other endocrine glands in diseases classified elsewhere

(E40-E46) Malnutrition

 * Kwashiorkor
 * Nutritional marasmus
 * Marasmic kwashiorkor
 * Unspecified severe protein-energy malnutrition
 * Protein-energy malnutrition of moderate and mild degree
 * Retarded development following protein-energy malnutrition
 * Unspecified protein-energy malnutrition

(E50-E64) Other nutritional deficiencies

 * Vitamin A deficiency
 * Vitamin A deficiency with conjunctival xerosis
 * Vitamin A deficiency with Bitot's spot and conjunctival xerosis
 * Vitamin A deficiency with corneal xerosis
 * Vitamin A deficiency with corneal ulceration and xerosis
 * Vitamin A deficiency with keratomalacia
 * Vitamin A deficiency with night blindness
 * Vitamin A deficiency with xerophthalmic scars of cornea
 * Other ocular manifestations of vitamin A deficiency
 * Xerophthalmia NOS
 * Thiamine deficiency
 * Beriberi
 * Wernicke's encephalopathy
 * Niacin deficiency (pellagra)
 * Deficiency of other B group vitamins
 * Riboflavin deficiency
 * Ariboflavinosis
 * Pyridoxine deficiency
 * Deficiency of other specified B group vitamins
 * Ascorbic acid deficiency
 * Scurvy
 * Vitamin D deficiency
 * Rickets, active
 * Other vitamin deficiencies
 * Deficiency of vitamin E
 * Deficiency of vitamin K
 * Dietary calcium deficiency
 * Dietary selenium deficiency
 * Dietary zinc deficiency
 * Deficiency of other nutrient elements
 * Iron deficiency
 * Magnesium deficiency
 * Manganese deficiency
 * Chromium deficiency
 * Molybdenum deficiency
 * Vanadium deficiency
 * Other nutritional deficiencies
 * Essential fatty acid (EFA) deficiency
 * Sequelae of malnutrition and other nutritional deficiencies

(E65-E68) Obesity and other hyperalimentation

 * Localized adiposity
 * Fat pad


 * Obesity
 * Obesity due to excess calories
 * Drug-induced obesity
 * Extreme obesity with alveolar hypoventilation
 * Pickwickian syndrome
 * Other obesity
 * Morbid obesity
 * Obesity, unspecified


 * Other hyperalimentation
 * Hypervitaminosis A
 * Hypercarotenaemia
 * Megavitamin-B 6 syndrome
 * Hypervitaminosis D


 * Sequelae of hyperalimentation

(E70-E72) Amino-acids

 * Disorders of aromatic amino-acid metabolism
 * Classical phenylketonuria
 * Other hyperphenylalaninaemias
 * Disorders of tyrosine metabolism
 * Alkaptonuria (ILDS E70.210)
 * Ochronosis (ILDS E70.230)
 * Tyrosinaemia
 * Albinism
 * Chediak-Higashi syndrome
 * Cross syndrome
 * Hermansky-Pudlak syndrome
 * Other disorders of aromatic amino-acid metabolism
 * Disorders of histidine metabolism
 * Disorders of tryptophan metabolism
 * Disorder of aromatic amino-acid metabolism, unspecified


 * Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
 * Maple-syrup-urine disease
 * Other disorders of branched-chain amino-acid metabolism
 * Propionic acidemia
 * Methylmalonic acidemia
 * Isovaleric acidemia
 * Disorder of branched-chain amino-acid metabolism, unspecified
 * Disorders of fatty-acid metabolism
 * Adrenoleukodystrophy (Addison-Schilder)
 * Muscle carnitine palmityltransferase deficiency


 * Other disorders of amino-acid metabolism
 * Disorders of amino-acid transport
 * Cystinuria
 * Cystinosis
 * Hartnup disease
 * Lowe's syndrome
 * Disorders of sulfur-bearing amino-acid metabolism
 * Cystathioninuria
 * Homocystinuria
 * Methioninaemia
 * Sulfite oxidase deficiency
 * Disorders of urea cycle metabolism
 * Argininaemia
 * Argininosuccinic aciduria
 * Citrullinaemia
 * Hyperammonaemia
 * Disorders of lysine and hydroxylysine metabolism
 * Glutaric aciduria
 * Hydroxylysinaemia
 * Hyperlysinaemia
 * Lysinuric protein intolerance
 * Disorders of ornithine metabolism
 * Ornithinaemia (types I, II)
 * Disorders of glycine metabolism
 * Hyperhydroxyprolinaemia
 * Hyperprolinaemia (types I, II)
 * Non-ketotic hyperglycinaemia
 * Sarcosinaemia

(E73-E74) Carbohydrates

 * Lactose intolerance


 * Other disorders of carbohydrate metabolism
 * Glycogen storage disease
 * Glycogen storage disease type I (von Gierke's disease)
 * Glycogen storage disease type II (Pompe's disease)
 * Glycogen storage disease type III
 * Glycogen storage disease type IV
 * Glycogen storage disease type V (McArdle's disease)
 * Disorders of fructose metabolism
 * Essential fructosuria
 * Fructose-1,6-diphosphatase deficiency
 * Hereditary fructose intolerance
 * Disorders of galactose metabolism
 * Galactosaemia
 * Galactokinase deficiency
 * Other disorders of intestinal carbohydrate absorption
 * Glucose-galactose malabsorption
 * Sucrase deficiency
 * Disorders of pyruvate metabolism and gluconeogenesis
 * Deficiency of phosphoenolpyruvate carboxykinase
 * Deficiency of pyruvate carboxylase
 * Deficiency of pyruvate dehydrogenase
 * Other specified disorders of carbohydrate metabolism
 * Essential pentosuria
 * Oxalosis
 * Oxaluria
 * Renal glycosuria
 * Disorder of carbohydrate metabolism, unspecified

(E75) Lipids

 * Disorders of sphingolipid metabolism and other lipid storage disorders
 * GM 2 gangliosidosis
 * Sandhoff disease
 * Tay-Sachs disease
 * Other gangliosidosis
 * GM 1
 * GM 3
 * Mucolipidosis IV
 * Other sphingolipidosis
 * Gaucher's disease (ILDS E75.220)
 * Niemann-Pick disease (ILDS E75.230)
 * Farber's disease (ILDS E75.240)
 * Fabry's disease (ILDS E75.250)
 * Sphingolipidosis, unspecified
 * Neuronal ceroid lipofuscinosis
 * Batten disease (Type 3)
 * Bielschowsky-Jansky disease (Type 2)
 * Kufs disease (Type 4)
 * Spielmeyer-Vogt disease (Type 3)
 * Other lipid storage disorders
 * Cerebrotendinous cholesterosis (van Bogaert-Scherer-Epstein)
 * Wolman's disease
 * Lipid storage disorder, unspecified

(E76-E78) Combinations

 * Disorders of glycosaminoglycan metabolism
 * Mucopolysaccharidosis, type I
 * Hurler syndrome
 * Mucopolysaccharidosis, type II
 * Hunter syndrome
 * Other mucopolysaccharidoses
 * Sanfilippo syndrome
 * Morquio syndrome


 * Disorders of glycoprotein metabolism
 * Defects in post-translational modification of lysosomal enzymes
 * Mucolipidosis II (I-cell disease)
 * Mucolipidosis III (pseudo-Hurler polydystrophy)
 * Defects in glycoprotein degradation
 * Aspartylglucosaminuria
 * Fucosidosis
 * Mannosidosis
 * Sialidosis (mucolipidosis I)


 * Disorders of lipoprotein metabolism and other lipidaemias
 * Pure hypercholesterolaemia
 * Familial hypercholesterolaemia
 * Fredrickson's hyperlipoproteinaemia, type IIa
 * Hyperbetalipoproteinaemia
 * Hyperlipidaemia, group A
 * Low-density-lipoprotein-type (LDL) hyperlipoproteinaemia
 * Pure hyperglyceridaemia
 * Endogenous hyperglyceridaemia
 * Fredrickson's hyperlipoproteinaemia, type IV
 * Hyperlipidaemia, group B
 * Hyperprebetalipoproteinaemia
 * Very-low-density-lipoprotein-type (VLDL) hyperlipoproteinaemia
 * Mixed hyperlipidaemia
 * Broad- or floating-betalipoproteinaemia
 * Fredrickson's hyperlipoproteinaemia, type IIb or III
 * Hyperbetalipoproteinaemia with prebetalipoproteinaemia
 * Hypercholesterolaemia with endogenous hyperglyceridaemia
 * Hyperlipidaemia, group C
 * Tubero-eruptive xanthoma
 * Xanthoma tuberosum
 * Hyperchylomicronaemia
 * Fredrickson's hyperlipoproteinaemia, type I or V
 * Hyperlipidaemia, group D
 * Mixed hyperglyceridaemia
 * Other hyperlipidaemia
 * Familial combined hyperlipidaemia
 * Hyperlipidaemia, unspecified
 * Lipoprotein deficiency
 * Abetalipoproteinaemia
 * High-density lipoprotein deficiency
 * Hypoalphalipoproteinaemia
 * Hypobetalipoproteinaemia (familial)
 * Lecithin cholesterol acyltransferase deficiency
 * Tangier disease

(E79-E90) Other metabolic disorders

 * Disorders of purine and pyrimidine metabolism
 * Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
 * Lesch-Nyhan syndrome
 * Other disorders of purine and pyrimidine metabolism
 * Hereditary xanthinuria


 * Disorders of porphyrin and bilirubin metabolism
 * Hereditary erythropoietic porphyria
 * Erythropoietic protoporphyria (ILDS E80.010)
 * Erythropoietic porphyria, congenital (ILDS E80.020)
 * Gunther's disease (ILDS (ILDS E80.020)
 * Erythropoietic porphyria (ILDS (ILDS E80.030)
 * Erythropoietic coproporphyria (ILDS E80.040)
 * Porphyria cutanea tarda
 * Sporadic porphyria cutanea tarda (ILDS E80.110)
 * Familial porphyria cutanea tarda (ILDS E80.120)
 * Other porphyria
 * Acute intermittent porphyria (ILDS E80.210)
 * Hereditary coproporphyria (ILDS E80.222)
 * Variegate porphyria (ILDS E80.230)
 * Chester porphyria (ILDS E80.232)
 * Porphyria, hepatic (ILDS E80.240)
 * Pseudoporphyria (ILDS E80.250)
 * Toxic porphyria (ILDS E80.260)
 * Hepatoerythropoietic porphyria (ILDS E80.282)
 * Porphyria, NOS (ILDS E80.290)
 * Defects of catalase and peroxidase
 * Acatalasia (Takahara)
 * Gilbert's syndrome
 * Crigler-Najjar syndrome
 * Other disorders of bilirubin metabolism
 * Dubin-Johnson syndrome
 * Rotor's syndrome
 * Disorder of bilirubin metabolism, unspecified


 * Disorders of mineral metabolism
 * Disorders of copper metabolism
 * Wilson's disease
 * Menkes disease
 * Disorders of iron metabolism
 * Aceruloplasminemia
 * Hemochromatosis
 * Disorders of zinc metabolism
 * Acrodermatitis enteropathica
 * Disorders of phosphorus metabolism
 * Acid phosphatase deficiency
 * Familial hypophosphataemia
 * Hypophosphatasia
 * Vitamin-D-resistant osteomalacia
 * Vitamin-D-resistant rickets
 * Disorders of magnesium metabolism
 * Hypermagnesemia
 * Hypomagnesemia
 * Disorders of calcium metabolism
 * Familial hypocalciuric hypercalcaemia
 * Idiopathic hypercalciuria


 * Cystic fibrosis


 * Amyloidosis
 * Non-neuropathic heredofamilial amyloidosis
 * Familial Mediterranean fever
 * Hereditary amyloid nephropathy
 * Neuropathic heredofamilial amyloidosis
 * Amyloid polyneuropathy (Portuguese)
 * Heredofamilial amyloidosis, unspecified
 * Secondary systemic amyloidosis
 * Haemodialysis-associated amyloidosis
 * Organ-limited amyloidosis
 * Localized amyloidosis
 * Other amyloidosis
 * Amyloidosis, unspecified


 * Volume depletion
 * Dehydration
 * Hypovolaemia


 * Other disorders of fluid, electrolyte and acid-base balance
 * Hyperosmolality and hypernatraemia
 * Hypo-osmolality and hyponatraemia
 * Acidosis
 * Respiratory acidosis
 * Metabolic acidosis
 * Lactic acidosis
 * Alkalosis
 * Mixed disorder of acid-base balance
 * Hyperkalaemia
 * Hypokalaemia
 * Fluid overload
 * Other disorders of electrolyte and fluid balance, not elsewhere classified
 * Electrolyte imbalance NOS
 * Hyperchloraemia
 * Hypochloraemia


 * Other metabolic disorders
 * Disorders of plasma-protein metabolism, not elsewhere classified
 * Alpha-1-antitrypsin deficiency
 * Lipodystrophy, not elsewhere classified
 * Lipomatosis, not elsewhere classified


 * Postprocedural endocrine and metabolic disorders, not elsewhere classified
 * Postprocedural hypothyroidism
 * Postprocedural hypoinsulinaemia
 * Postprocedural hypoparathyroidism
 * Postprocedural hypopituitarism
 * Postprocedural ovarian failure
 * Postprocedural testicular hypofunction
 * Postprocedural adrenocortical(-medullary) hypofunction


 * Nutritional and metabolic disorders in diseases classified elsewhere