Nuclear receptor co-repressor 2

The nuclear receptor co-repressor 2 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the down regulation of DNA expression.

NCOA2 is also sometimes referred to as silencing mediator for retinoid and thyroid-hormone receptors (SMRT) or T3 receptor-associating cofactor 1 (TRAC-1).