HLA-A31

HLA-A31 (A31) is an HLA-A serotype. The serotype identifies the more common HLA-A*31 gene products. A31 is a split antigen of the A19 broad antigen serotype group. It is similar to the antigens A29, 30, A32,A33, and A74. A31 is more common in Japan, Siberia and Indigenous Americans. It is also more frequent in NE Europe than SW Europe.

Serotype
There is substantive cross reaction of A30 with A*3101, otherwise serological identification is good.

A31-B Haplotypes
Examination of A31 haplotypes reveal a probably connection across northern Eurasia during the prehistoric period. Frequencies of the more 'tale-tell' haplotypes (A31-B60, B61, and B62) fall from NE to SW Europe. Other haplotypes appears to have spread from the middle east (A31-B51 and A31-B35).