Neurofuran

Neurofurans are 22-carbon compounds formed nonenzymatically by free radical mediated peroxidation of docosahexaenoic acid (DHA), an &omega;-3 essential fatty acid. The neurofurans are similar to the isofurans and are formed under similar conditions of oxidative stress, containing a substituted tetrahydrofuran ring. Measurement of the neurofurans may ultimately prove useful in diagnosis, timing and selection of dose in the treatment and chemoprevention of neurodegenerative disease.