Cholesterol 25-hydroxylase

In enzymology, a cholesterol 25-hydroxylase is an enzyme that catalyzes the chemical reaction


 * cholesterol + AH2 + O2 $$\rightleftharpoons$$ 25-hydroxycholesterol + A + H2O

The 3 substrates of this enzyme are cholesterol, AH2, and O2, whereas its 3 products are 25-hydroxycholesterol, A, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating). This enzyme is also called cholesterol 25-monooxygenase.