3-dehydroquinate synthase

In enzymology, a 3-dehydroquinate synthase is an enzyme that catalyzes the chemical reaction


 * 3-deoxy-arabino-heptulonate 7-phosphate $$\rightleftharpoons$$ 3-dehydroquinate + phosphate

Hence, this enzyme has one substrate, 3-deoxy-arabino-heptulonate 7-phosphate, and two products, 3-dehydroquinate and phosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is 3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing 3-dehydroquinate-forming). Other names in common use include 5-dehydroquinate synthase, 5-dehydroquinic acid synthetase, dehydroquinate synthase, 3-dehydroquinate synthetase, 3-deoxy-arabino-heptulosonate-7-phosphate phosphate-lyase, (cyclizing), and 3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing). This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis. It employs one cofactor, cobalt.

Structural studies
As of late 2007, 15 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , , , , , , and.