MAMSA

mAMSA (4'-(9'-acridinylamino)methanesulfon-m-anisidide) is an experimental anti-cancer drug, initially developed as an antileukemic agent, that inhibits Type II Topoisomerase. It causes cleavage of both strands in DNA and subsequent covalent binding of both strands to Topoisomerase II, causing more DNA strand breaks and possible mutagenesis.