MAP2K1IP1

Mitogen-activated protein kinase kinase 1 interacting protein 1, also known as MAP2K1IP1, is a human gene. . It was initially called MP1 (MEK1 binding Partner 1) when it was isolated in a yeast two hybrid screen using MEK1 as a bait. Subsequently Huber and colleagues found that a late endosomal/lysosome enriched protein of 14 kDa (p14) interacted with MP1 and this interaction is required for localizing this dimer to late endosome. Binding of MP1 to p14 is of high affinity (~12nM). The crystal structure of MP1/p14 dimer has been solved by two independent groups. MP1/p14 complex appears necessary for EGF mediated activation of ERK .Further, MP1 is required for efficient cell spreading on fibronectin. During acute cell spreading MP1 appears to downregulate Rho GTPase activity necessary for remodeling focal adhesions and membrane production at the leading edge.

Researchers who work on MP1
Hans J-Schaeffer Andrew D. Catling Ashok Pullikuth Tomas Vomastek M. Cygler D. Teis V.V. Lunin M.Sacher Lukas A Huber