SUMO network



SUMO network consists of enzymes and substrates involved in the dynamic posttranslational modification process of sumoylation (i.e. transfer of SUMO protein to substrates).

Network members
The SUMO network members (gene name and aliases) as published in the last 100 newest PubMed entries (see below) are depicted hierarchically by Cytoscape in the figure on the right and are listed below as annotated by Gene Ontology.
 * sumo1 = pic1, smt3c, gmp1, sumo1, sumo-1, smt3, ubl1, smt3h3
 * senp1 = senp1
 * nf-kappab = nf-kappa b, nfkb, nf-kappab, nfkappa b, nfkappab
 * atm = ata, atm, atc, atdc, ate
 * ikbkg = nemo, fip-3, ip2, ikbkg, ikk-gamma, fip3, fip3p
 * rasa1 = cmavm, gap, rasa1, rasgap, p120gap, pkws, rasa
 * rgs17 = rgsz2, rgs17, hrgs17
 * rgs20 = rgs20, rgsz1, zgap1
 * efna2 = eplg6, lerk6, elf-1, efna2, hek7-l
 * elf4 = mef, elf4, elfr
 * myog = myf4, myogenin, myog
 * cdkn1a = cdkn1a, sdi1, mda-6, waf1, cip1, cdkn1, cap20, p21
 * skil = snoa, snon, sno, skil
 * rev1l = rev1l, rev1
 * rev3l = polz, rev3, rev3l
 * fus = tls, fus1, fus
 * rad1 = rad1, hrad1
 * rad51 = hsrad51, hrad51, hst16930, reca, rad51, rad51a
 * tp53 = p53, trp53, tp53
 * sumo2 = smt3b, sumo2, hsmt3, sumo-2, smt3h2
 * rad52 = rad52
 * hipk2 = hipk2, pro0593
 * krt6b = k6b, krtl1, ck6b, krt6b, pc2
 * pml = myl, pml, rnf71, trim19
 * fgfr1 = c-fgr, cek, h5, h4, h3, bfgfr, n-sam, fgfr1, flt2, h2
 * znf198 = mym, fim, scll, znf198
 * tdg = tdg
 * crebbp = rts, rsts, crebbp, cbp
 * ep300 = p300, ep300
 * creb1 = creb, mgc9284, creb1
 * setdb1 = kg1t, kiaa0067, setdb1, eset
 * mbd1 = cxxc3, mbd1, rft
 * pias3 = pias3, pias-3, flj14651
 * soat1 = soat1, stat, acact
 * pias1 = ddxbp1, pias1, gu/rh-ii
 * myb = c-myb, myb
 * mapk8 = jnk, sapk1, jnk1, mapk8, jnk1a2, jnk21b1/2, prkm8
 * cdkn3 = cdi1, kap, cip2, kap1, cdkn3
 * znf350 = zfqr, znf350, zbrk1
 * ube2i = c358b7.1, ubc9, ube2i
 * pcna = pcna, mgc8367
 * nbs1 = nbs, at-v2, nibrin, at-v1, nbs1, atv
 * daxx = dap6, bing2, daxx
 * sim2 = sim2, sim
 * sox2 = anop3, mgc2413, sox2
 * fgf4 = hst, hst-1, fgf4, kfgf, hbgf-4, k-fgf, hstf1
 * pou5f1 = oct4, otf4, oct3, otf3, pou5f1, mgc22487
 * src = src, c-src, src-1, src1, asv, p60-src
 * ptpn1 = ptp1b, ptpn1
 * stat1 = stat91, stat1, isgf-3
 * sumo3 = smt3a, sumo3, smt3h1, sumo-3
 * zbtb17 = miz-1, phz-67, miz1, zbtb17, znf151
 * uba2 = uba2, sae2, hrihfb2115
 * sae1 = aos1, hspc140, sae1, sua1
 * cdc2 = cdc2, cdk1
 * klf5 = iklf, bteb2, klf5
 * nr2c1 = tr2-11, tr2, nr2c1
 * pcaf = p/caf, pcaf, gcn5l, caf
 * nrip1 = rip140, nrip1
 * pparg = nr1c3, humpparg, pparg, ppargamma, pparg1, pparg2, ppar-gamma
 * abcc6 = mlp1, moate, ara, mrp6, est349056, abc34, abcc6
 * senp2 = kiaa1331, axam2, senp2, smt3ip2
 * kcna5 = pcn1, kcna5, kv1.5, hpcn1, hck1
 * taf12 = taf12, taf2j, tafii20
 * atf7 = atfa, atf7
 * tbp = tfiid, tbp, gtf2d1, gtf2d, sca17
 * fos = fos
 * jun = jun, ap1
 * hic1 = hic1, zbtb29
 * dynamin = dynamin-1, dynamin, dynamin1
 * pcap = hpc2, prostate cancer susceptibility 2, pcap, prca2
 * ctbp2 = ctbp2
 * ctbp1 = ctbp1
 * senp5 = mgc27076, senp5
 * hmga1 = mgc12816, mgc4854, hmga1, hmgiy, hmg-r, mgc4242
 * pias4 = piasg, mgc35296, flj12419, piasy, pias4
 * yy1 = ucrbp, nf-e1, yin-yang-1, yy1
 * cpa1 = cpa, cpa1
 * klk3 = psa, klk2a1, klk3
 * mdm2 = hdm2, mdm2, mgc71221
 * trps1 = gc79, trps1
 * ube2v1 = uev-1, ube2v, ube2v1, uev1, c-roc1, croc1, croc-1, cir1, uev1a
 * cul2 = cul2
 * dnmt3a = dnmt3a, m.hsaiiia, dnmt3a2
 * cbx4 = cbx4
 * col11a2 = col11a2, dfna13, stl3, hke5
 * sox9 = cmd1, sox9

SUMO antibodies
Comprehensive panel of antibodies to characterize the SUMO network is available by Abgent: SUMO1 Monoclonal Ab(AM1200a), UBC9 Ab(AM1261a),	SUMO3 C-term Ab(AP1225a),	NEDD8 N-term Ab(AP1226a),	SENP1 N-term Ab(AP1230a),	SENP2 N-term Ab(AP1232a),	SENP3 N-term Ab(AP1234a),	SENP5 N-term Ab(AP1236a),	SENP6 N-term Ab(AP1238a),	SENP7 N-term Ab(AP1240a),	PIAS1 C-term Ab(AP1243a),	PIAS3 N-term Ab(AP1244a),	PIASx1 N-term Ab(AP1248a),	PIASy1 N-term Ab(AP1249a),	SENP8 N-term Ab(AP1259a),	AOS1 Ab(AP1262a),	SUMO2 C-term Ab(AP1282a),	Pan SUMO Ab(AP1290a).