Tramadol overdose

Overdosage topics
General Treatment

General
A single or multiple overdose with Tramadol may be a potentially lethal polydrug overdose, and consultation with a regional poison control center is recommended. Return to top

Treatment
In treating an overdose of Tramadol, primary attention should be given to maintaining adequate ventilation along with general supportive treatment. While naloxone will reverse some, but not all, symptoms caused by overdosage with tramadol, the risk of seizures is also increased with naloxone administration. In animals, convulsions following the administration of toxic doses of tramadol could be suppressed with barbiturates or benzodiazepines but were increased with naloxone. Naloxone administration did not change the lethality of an overdose in mice. Based on experience with tramadol, hemodialysis is not expected to be helpful in an overdose because it removes less than 7% of the administered dose in a 4-hour dialysis period. Return to top