Karyopherin

Karyopherins are a group of proteins involved in transporting molecules through the pores of the nuclear envelope (the membrane around a cell's nucleus).

Karyopherins, which may act as importins or exportins, are part of the Importin-β super-family which all share a similar three-dimensional structure.

They belong to 9.A.14 The Nuclear Pore Complex Family in TCDB.

Cycle
For example,
 * importin beta + adapter + cargo protein (cytoplasm)-->(karyoplasm)
 * importin beta + adapter + Ran-GTP (karyoplasm)-->(cytoplasm)
 * Ran-GTP --> Ran-GDP + P

Genes

 * KPNA1
 * KPNA2
 * KPNA3
 * KPNA4
 * KPNA5
 * KPNA6
 * KPNB1