Talk:BRCA1

Some text in this article was originally taken from http://ghr.nlm.nih.gov/gene=brca1 (public domain)

I altered this article by adding "faulty" into the sentence "Women and men who inherit a copy of this gene...". This is because it is not the gene which causes an increased risk of cancer, but the presence of a faulty copy of the gene. A faulty copy means the gene's tumour-suppressing abilities cannot be expressed.

It is good that at least a stub is present on the BRCA genes. However, it would be best if both of these were extensively modified. As a first pass, I'd like to see the following: 1. Differential between genetic/familial breast csncers in age of onset (BRCA mutations are far more common in early onset disease) 2. Discussion of associated risks including recurrence on the other side, risks to males carrying mutations, and risks to first degree relatives. 3. Discussion of other cancers at increased risk in BRCA mutaion carriers 4. discussion of differences in clinical presentation of BRCA1 vs BRCA2 carriers 5. Increased prevalence of mutations in Ashkenazi jews This is not my specific field, and it would be great for a specialist to edit these.

adding ProteinBoxBot content
Anyone have any thoughts on how/if we should merge the existing infobox with the one generated using the ProteinBoxBot (shown at right)?

AndrewGNF 22:47, 14 September 2007 (UTC)

Hispanics
JAMA - Hispanics in Northern California have a lot of BRCA1. JFW | T@lk  18:49, 2 January 2008 (UTC)