2,6-dioxo-6-phenylhexa-3-enoate hydrolase

In enzymology, a 2,6-dioxo-6-phenylhexa-3-enoate hydrolase is an enzyme that catalyzes the chemical reaction


 * 2,6-dioxo-6-phenylhexa-3-enoate + H2O $$\rightleftharpoons$$ benzoate + 2-oxopent-4-enoate

Thus, the two substrates of this enzyme are 2,6-dioxo-6-phenylhexa-3-enoate and H2O, whereas its two products are benzoate and 2-oxopent-4-enoate.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-carbon bonds in ketonic substances. The systematic name of this enzyme class is 2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase. This enzyme is also called HOHPDA hydrolase. This enzyme participates in biphenyl degradation and fluorene degradation.

Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes, , and.