N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase

In enzymology, a N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase is an enzyme that catalyzes the chemical reaction


 * UDP-alpha-D-glucuronate + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl- proteoglycan $$\rightleftharpoons$$ UDP + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)- beta-D-glucuronosyl-proteoglycan

The 3 substrates of this enzyme are UDP-alpha-D-glucuronate, N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-, and proteoglycan, whereas its 3 products are UDP, beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)-, and beta-D-glucuronosyl-proteoglycan.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D- glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase. Other names in common use include N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase, and heparan glucuronyltransferase II. This enzyme participates in heparan sulfate biosynthesis and glycan structures - biosynthesis 1.