Formate-dihydrofolate ligase

In enzymology, a formate-dihydrofolate ligase is an enzyme that catalyzes the chemical reaction


 * ATP + formate + dihydrofolate $$\rightleftharpoons$$ ADP + phosphate + 10-formyldihydrofolate

The 3 substrates of this enzyme are ATP, formate, and dihydrofolate, whereas its 3 products are ADP, phosphate, and 10-formyldihydrofolate.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is formate:dihydrofolate ligase (ADP-forming). Other names in common use include formyltransferase, dihydrofolate, dihydrofolate formyltransferase, and formyl dihydrofolate synthase.