Nitrofurantoin pharmacokinetics and molecular data

Pharmacokinetics
Absorption Distribution Metabolism Elimination Special populations

Absorption
Nitrofurantoin is well absorbed from the GI tract, macrocrystalline form is absorbed more slowly, and food increases bioavailability. Return to top

Distribution
Nitrofurantoin protein binding is approximately 60%. Return to top

Metabolism
Approximately 50% to 70% of nitrofurantoin is rapidly metabolized by body tissues. Return to top

Elimination
Nitrofurantoin is eliminated in urine (30% to 50% unchanged). The t ½ in healthy patients is 20 min, and the t ½ in anephric patients is 60 min. Return to top

Special populations
Renal Function Impairment
 * Nitrofurantoin accumulates in serum. Return to top