Phosphatidate cytidylyltransferase

In enzymology, a phosphatidate cytidylyltransferase is an enzyme that catalyzes the chemical reaction


 * CTP + phosphatidate $$\rightleftharpoons$$ diphosphate + CDP-diacylglycerol

Thus, the two substrates of this enzyme are CTP and phosphatidate, whereas its two products are diphosphate and CDP-diacylglycerol.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:phosphatidate cytidylyltransferase. Other names in common use include CDP diglyceride pyrophosphorylase, CDP-diacylglycerol synthase, CDP-diacylglyceride synthetase, cytidine diphosphoglyceride pyrophosphorylase, phosphatidate cytidyltransferase, phosphatidic acid cytidylyltransferase, CTP:1,2-diacylglycerophosphate-cytidyl transferase, CTP-diacylglycerol synthetase, DAG synthetase, and CDP-DG. This enzyme participates in glycerophospholipid metabolism and phosphatidylinositol signaling system.