Indole 2,3-dioxygenase

In enzymology, an indole 2,3-dioxygenase is an enzyme that catalyzes the chemical reaction


 * indole + O2 $$\rightleftharpoons$$ 2-formylaminobenzaldehyde

Thus, the two substrates of this enzyme are indole and O2, whereas its product is 2-formylaminobenzaldehyde.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is indole:oxygen 2,3-oxidoreductase (decyclizing). Other names in common use include indole oxidase, indoleamine 2,3-dioxygenase (ambiguous), indole:O2 oxidoreductase, indole-oxygen 2,3-oxidoreductase (decyclizing), and IDO (ambiguous). This enzyme participates in tryptophan metabolism. It has 3 cofactors: copper, Flavin, and Flavoprotein.