2-hydroxyglutarate dehydrogenase

In enzymology, a 2-hydroxyglutarate dehydrogenase is an enzyme that catalyzes the chemical reaction


 * (S)-2-hydroxyglutarate + acceptor $$\rightleftharpoons$$ 2-oxoglutarate + reduced acceptor

Thus, the two substrates of this enzyme are (S)-2-hydroxyglutarate and acceptor, whereas its two products are 2-oxoglutarate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (S)-2-hydroxyglutarate:acceptor 2-oxidoreductase. Other names in common use include alpha-ketoglutarate reductase, alpha-hydroxyglutarate dehydrogenase, L-alpha-hydroxyglutarate dehydrogenase, hydroxyglutaric dehydrogenase, alpha-hydroxyglutarate oxidoreductase, L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase, alpha-hydroxyglutarate dehydrogenase (NAD+ specific), and (S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase. This enzyme participates in butanoate metabolism.