Calcitonin pharmacokinetics and molecular data

Pharmacokinetics
General Bioavailability Absorption Accumulation

General
The pharmacokinetic properties of Calcitonin after multiple dose administration were shown to be similar to that of a commercially available calcitonin-salmon product in healthy volunteers. Return to top

Bioavailability
The data on bioavailability of calcitonin-salmon nasal spray obtained by various investigators using different methods show great variability. In normal volunteers approximately 3% (range 0.3%-30.6%) of a nasally administered dose is bioavailable compared to the same dose administered by intramuscular injection. Return to top

Absorption
Calcitonin is absorbed rapidly by the nasal mucosa. Absorption of nasally administered calcitonin has not been studied in postmenopausal women. Return to top

Accumulation
There is no accumulation of the drug on repeated nasal administration at 10 hour intervals for up to 15 days. Return to top