Leukoencephalopathy with vanishing white matter

Overview
Leukoencephalopathy with vanishing white matter (VWM disease) is an autosomal recessive neurological disease. The cause of the disease are mutations in any of the 5 genes encoding subunits of the translation initiation factor EIF2B: EIF2B1, EIF2B2, EIF2B3, EIF2B4, or EIF2B5.

Adult-onset VWM disease can present with psychosis and may be hard to differentiate from schizophrenia.

Synonyms

 * childhood ataxia with central nervous system hypomyelinization; CACH
 * vanishing white matter leukodystrophy
 * cree leukoencephalopathy; CLE
 * vanishing white matter leukodystrophy with ovarian failure, included
 * ovarioleukodystrophy, included