Tabes Dorsalis natural history, complications, and prognosis

Overview
Tabes dorsalis is a slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The degenerating nerves are in the dorsal columns of the spinal cord (the portion closest to the back of the body) and carry information that help maintain a person's sense of position. If left untreated, tabes dorsalis can lead to paralysis, dementia, and blindness. Existing nerve damage cannot be reversed.

What to expect (Outlook/Prognosis)?
Progressive disability is possible if the disorder is left untreated.

Possible complications

 * Complications of late-stage syphilis infection, which may include:
 * Inflammation of the aorta (aortitis) with aortic aneurysm
 * Disease of the heart valves
 * Damage to bones, skin, and other organs
 * Complications of neurosyphilis, including dementia, stroke, eye disease
 * Difficulty with walking and balance
 * Paralysis