Acylphosphatase

In enzymology, an acylphosphatase is an enzyme that catalyzes the chemical reaction


 * an acylphosphate + H2O $$\rightleftharpoons$$ a carboxylate + phosphate

Thus, the two substrates of this enzyme are acylphosphate and H2O, whereas its two products are carboxylate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is acylphosphate phosphohydrolase. Other names in common use include acetylphosphatase, 1,3-diphosphoglycerate phosphatase, acetic phosphatase, Ho 1-3, and GP 1-3. This enzyme participates in 3 metabolic pathways: glycolysis / gluconeogenesis, pyruvate metabolism, and benzoate degradation via coa ligation.

Structural studies
As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , , , , and.