Protein:HSD11B1

Protein:HSD11B1 (also known as 11β-hydroxysteroid dehydrogenase type 1) is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system.

In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors.

It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers.