Morphine 6-dehydrogenase

In enzymology, a morphine 6-dehydrogenase is an enzyme that catalyzes the chemical reaction


 * morphine + NAD(P)+ $$\rightleftharpoons$$ morphinone + NAD(P)H + H+

The 3 substrates of this enzyme are morphine, NAD+, and NADP+, whereas its 4 products are morphinone, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is morphine:NAD(P)+ 6-oxidoreductase. Other names in common use include naloxone reductase, and reductase, naloxone. This enzyme participates in alkaloid biosynthesis i. This enzyme has at least one effector, Mercaptoethanol.