Proventil HFA drug interactions

List of drug interactions
Beta Blockers Diuretics Albuterol-Digoxin Monoamine Oxidase Inhibitors or Tricyclic Antidepressants

Beta Blockers
Beta-adrenergic-receptor blocking agents not only block the pulmonary effect of beta agonists, such as Proventil HFA Inhalation Aerosol, but may produce severe bronchospasm in asthmatic patients. Therefore, patients with asthma should not normally be treated with beta blockers. However, under certain circumstances, eg, as prophylaxis after myocardial infarction, there may be no acceptable alternatives to the use of beta-adrenergic-blocking agents in patients with asthma. In this setting, cardioselective beta blockers should be considered, although they should be administered with caution. Return to top

Diuretics
The ECG changes and/or hypokalemia which may result from the administration of nonpotassium sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by beta agonists, especially when the recommended dose of the beta agonist is exceeded. Although the clinical significance of these effects is not known, caution is advised in the coadministration of beta agonists with nonpotassium sparing diuretics. Return to top

Albuterol-Digoxin
Mean decreases of 16% and 22% in serum digoxin levels were demonstrated after single-dose intravenous and oral administration of albuterol, respectively, to normal volunteers who had received digoxin for 10 days. The clinical significance of these findings for patients with obstructive airway disease who are receiving albuterol and digoxin on a chronic basis is unclear; nevertheless, it would be prudent to carefully evaluate the serum digoxin levels in patients who are currently receiving digoxin and albuteraol. Return to top

Monoamine Oxidase Inhibitors or Tricyclic Antidepressants
Proventil HFA Inhalation Aerosol should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants, or within 2 weeks of discontinuation of such agents, because the action of albuterol on the cardiovascular system may be potentiated. Return to top