Deoxyhypusine monooxygenase

In enzymology, a deoxyhypusine monooxygenase is an enzyme that catalyzes the chemical reaction


 * protein N6-(4-aminobutyl)-L-lysine + AH2 + O2 $$\rightleftharpoons$$ protein N6-[(R)-4-amino-2-hydroxybutyl]-L-lysine + A + H2O

The 3 substrates of this enzyme are protein N6-(4-aminobutyl)-L-lysine, AH2, and O2, whereas its 3 products are protein N6-[(R)-4-amino-2-hydroxybutyl]-L-lysine, A, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating). Other names in common use include deoxyhypusine hydroxylase, and deoxyhypusine dioxygenase.