ER retention

ER retention refers to proteins that are retained in the endoplasmic reticulum, or ER, after folding; these are known as ER resident proteins.

Their localization to the ER often depends on certain sequences of amino acids located at the N-terminal or C-terminal. The classical ER retention signal is the C-terminal KDEL sequence. These signals allow for retrieval from the Golgi apparatus, effectively maintaining the protein in the ER. Other mechanisms for ER retention are being studied but are not as well characterized as signal retention.