Malate dehydrogenase (decarboxylating)

In enzymology, a malate dehydrogenase (decarboxylating) is an enzyme that catalyzes the chemical reaction


 * (S)-malate + NAD+ $$\rightleftharpoons$$ pyruvate + CO2 + NADH

Thus, the two substrates of this enzyme are (S)-malate and NAD+, whereas its 3 products are pyruvate, CO2, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-malate:NAD+ oxidoreductase (decarboxylating). Other names in common use include 'malic' enzyme, pyruvic-malic carboxylase, NAD+-specific malic enzyme, and NAD+-malic enzyme. This enzyme participates in pyruvate metabolism and carbon fixation.

Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , and.