3beta-hydroxy-Delta5-steroid dehydrogenase

In enzymology, a 3beta-hydroxy-Delta5-steroid dehydrogenase is an enzyme that catalyzes the chemical reaction


 * a 3beta-hydroxy-Delta5-steroid + NAD+ $$\rightleftharpoons$$ a 3-oxo-Delta5-steroid + NADH + H+

Thus, the two substrates of this enzyme are 3beta-hydroxy-Delta5-steroid and NAD+, whereas its 3 products are 3-oxo-Delta5-steroid, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3beta-hydroxy-Delta5-steroid:NAD+ 3-oxidoreductase. Other names in common use include progesterone reductase, Delta5-3beta-hydroxysteroid dehydrogenase, 3beta-hydroxy-5-ene steroid dehydrogenase, 3beta-hydroxy steroid dehydrogenase/isomerase, 3beta-hydroxy-Delta5-C27-steroid dehydrogenase/isomerase, 3beta-hydroxy-Delta5-C27-steroid oxidoreductase, 3beta-hydroxy-5-ene-steroid oxidoreductase, steroid-Delta5-3beta-ol dehydrogenase, 3beta-HSDH, 5-ene-3-beta-hydroxysteroid dehydrogenase, and 3beta-hydroxy-5-ene-steroid dehydrogenase. This enzyme participates in c21-steroid hormone metabolism and androgen and estrogen metabolism.