Alendronate drug interactions

List of drug interactions
Intravenous ranitidine Oral Prednisone Calcium and other Multivalent Cations Estrogen/hormone replacement therapy (HRT) Calcium Supplements/Antacids Aspirin Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

Intravenous ranitidine
Intravenous ranitidine was shown to double the bioavailability of oral alendronate. The clinical significance of this increased bioavailability and whether similar increases will occur in patients given oral H2-antagonists is unknown. Return to top

Oral Prednisone
In healthy subjects, oral prednisone (20 mg three times daily for five days) did not produce a clinically meaningful change in the oral bioavailability of alendronate (a mean increase ranging from 20 to 44%). Return to top

Calcium and other Multivalent Cations
Products containing calcium and other multivalent cations are likely to interfere with absorption of alendronate. Return to top

Estrogen/hormone replacement therapy (HRT)
Concomitant use of HRT (estrogen ± progestin) and FOSAMAX was assessed in two clinical studies of one or two years' duration in postmenopausal osteoporotic women. In these studies, the safety and tolerability profile of the combination was consistent with those of the individual treatments; however, the degree of suppression of bone turnover (as assessed by mineralizing surface) was significantly greater with the combination than with either component alone. The long-term effects of combined FOSAMAX and HRT on fracture occurrence have not been studied (see CLINICAL PHARMACOLOGY, Clinical Studies, Concomitant use with estrogen/hormone replacement therapy (HRT) and ADVERSE REACTIONS, Clinical Studies, Concomitant use with estrogen/hormone replacement therapy). Return to top

Calcium Supplements/Antacids
It is likely that calcium supplements, antacids, and some oral medications will interfere with absorption of FOSAMAX. Therefore, patients must wait at least one-half hour after taking FOSAMAX before taking any other oral medications. Return to top

Aspirin
In clinical studies, the incidence of upper gastrointestinal adverse events was increased in patients receiving concomitant therapy with daily doses of FOSAMAX greater than 10 mg and aspirin-containing products. Return to top

Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
FOSAMAX may be administered to patients taking NSAIDs. In a 3-year, controlled, clinical study (n=2027) during which a majority of patients received concomitant NSAIDs, the incidence of upper gastrointestinal adverse events was similar in patients taking FOSAMAX 5 or 10 mg/day compared to those taking placebo. However, since NSAID use is associated with gastrointestinal irritation, caution should be used during concomitant use with FOSAMAX. Return to top

Moderate Interactions
ABC Plus Senior, ABC to Z, Accupril, Acid Relief, activated attapulgite, Actron, ADEKs, Advil, Advil Childrens, Advil Junior Strength, Advil Liquigel, Advil Migraine, Advil Pediatric, Aflaxen, Aleve, Aleve Caplet, Aleve Easy Open Arthritis, Aleve Gelcap, Alka-Mints, Alkets, Alkums, Allbee-C 800 with Iron, Almora, Aloh-Gel, Alternagel, Alu-Cap, Alu-Tab, aluminum carbonate, aluminum hydroxide, Ami-Natal Plus One Improved, amikacin, Amikin, Amikin Pediatric, Amilac, Aminatal Plus, Aminatal Plus New Formula, Aminatal Plus One, Aminate, Aminate with 90 mg Iron, Amitone, Amphojel, Anaprox, Anaprox-DS, Anemagen, Anemagen FA, Anemagen OB, anhydrous calcium iodide, Ansaid, Antioxid Caplets, Antioxidant Formula, Antioxidant Ultra Formula, Apatate Forte, Apetimar with Iron, AquADEKs, AquADEKs Pediatric, attapulgite, Avail Calcium Intensive, B-Plex Plus Minerals, Bacmin, Basaljel, Bayer Select Backache Pain Formula, Becomax Rx, Bee-Zee, Beelith, Berocca Plus, Berplex Plus, Betamed, Biotin Forte with Zinc, Bright Beginnings, bromfenac, Bugs Bunny Complete, Bugs Bunny with Iron Chewable, Cal Oys, Cal-Gest, Cal-Nate, Calafol Rx, Calcarb, Calcet Plus, Calci Mix, Calci-Chew, CalciFol, CalciFolic-D, Calcionate, Calciquid, Calcitab, calcium acetate, calcium carbonate, calcium citrate, Calcium Concentrate, calcium glubionate, calcium gluconate, calcium lactate, Calcium Liquid Softgel, Calcium Oyster, Calcium Oyster Shell, calcium phosphate, tribasic, Calphron, Caltrate, Caltrate 600 Plus, Caltrate Plus, Caltro, Carafate, carbonyl iron, CareNatal DHA, Caromega, Cataflam, Cenogen Ultra, Centavite, Central, Central-Vite, Centrum, Centrum Cardio, Centrum Jr, Centrum Jr with Extra C, Centrum Jr with Extra Calcium, Centrum Kids Complete Dora the Explorer, Centrum Kids Complete SpongeBob SquarePants, Centrum Kids Complete Variety, Centrum Performance, Centrum Silver, Centrum Singles, Century, Century-Vite, Cerovite Advanced Formula, Cerovite Junior, Cerovite Liquid, Cerovite Senior, Certa-Vite, Certa-Vite Senior Plus Lutein, Certagen, Certagen Senior, Certagen Senior with Lutein, Certavite, CertaVite with Lutein, Cezin-S, CF Vite, Chelated Magnesium, Chem-Sol, Childrens Ibuprofen Berry, Chooz, Chromagen, Chromagen (obsolete), Chromagen FA, Chromagen FA (obsolete), Chromagen Forte, Chromagen Forte (obsolete), Chromagen OB, Chromatinic, Cidomycin, Circavite T, Cit Calcium (obsolete), Citracal, Citracal Liquitab, Citracal Plus with Magnesium, Citracal Prenatal + DHA, Citracal Prenatal 90+DHA, Citracal Prenatal Rx, CitraNatal 90 DHA, CitraNatal DHA, CitraNatal Rx, Citrate of Magnesia, Citroma Cherry, Citroma Lemon, Clinoril, Clusimar, Compete, Complete A-Z, Concentrated Phillips Milk of Magnesia, Conison, Contrin, Copper, copper gluconate, Corvite, Corvite 150, Corvite Free, Daily Combo, Daily Multi-Vitamins with Minerals, Daily-Vite Weight Control, Dayalets Plus Iron, Daypro, ddI, Decagen, DermaVite, Dewees Carminative, Dialume, Dialyvite, Dialyvite 3000, Dialyvite 800 with Zinc, Dialyvite with Zinc Rx, Diatx Fe, Diatx Zn, Diavite Plus, Dicarbosil, diclofenac, diclofenac potassium, diclofenac sodium, diclofenac sodium extended release, didanosine, didanosine delayed release capsule, dihydroxyaluminum sodium carbonate, Disney Winnie the Pooh Complete, Disney Winnie the Pooh Gummies, Disney Winnie the Pooh with Extra C, Doans Pills, Doans Pills Extra Strength, Dolomite, Donnagel, Dualvit OB, Duet, Duet Chewable, Duet DHA, Duet DHA EC, DurAct, EC-Naprosyn, Ecee Plus, Eldercaps, Eldertonic, Elemental Iron, Elemental Iron-90, Ellis Tonic Sherry, elon Matrix 5000 Complete, Embrex 600, Encora, Equi-Natal Care, Equi-Natal M, Equi-Natal Plus, Equi-Natal Rx, Equi-Natal Z, Equi-Roca Plus, Equicyte Plus, Equilet, Equinatal 90, etodolac, etodolac extended release, Ex-Lax Milk of Magnesia, Extra Strength Mylanta Calci Tabs, Fe 50, FE C Tab Plus, Fe-Tinic 150, Fe-Tinic 150 Forte, Feldene, Fem-Natal, Femiron, Femiron Multi with Iron, Femnatal, Femtabs, fenoprofen, Feocyte, Feogen, Feosol, Feosol Caplet, Feosol Iron, Feostat, Fer-Gen-Sol, Fer-in-Sol, Feratab, Ferate, Ferbee, Fergon, Fero-Folic 500, Fero-Gradumet Filmtab, Ferocon, FeroSul, Ferotrinsic, Ferra T.D. Caps, Ferra-Cap, Ferra-TD, Ferragen, Ferralet, Ferralet 90, Ferrets, Ferretts IPS, Ferrex PC Forte, Ferrex-150, Ferrex-150 Forte, Ferrimin 150, Ferro-Bob, Ferro-Time, Ferrocite, Ferrogels Forte, Ferrospace, ferrous fumarate, ferrous gluconate, ferrous gluconate extended release, ferrous sulfate, ferrous sulfate extended release, Ferus Pic-150, Fetrin, Flintstones Complete, Flintstones with Calcium, Flintstones with Iron Chewable, flurbiprofen, Folbee Plus CZ, Folgard OS, FoliTab 500, Folpace Rx, Foltabs, Foltrin, Formula B Plus, Formula Twenty-One, Fosfree, Fosrenol, Fruity Chews with Iron, Fumasorb, Fumatinic, Galzin, Garamycin, Garfield Complete Vitamins, Garfield Vitamin with Iron, Generet-500 with Folic Acid, Generix-T, Genpril, gentamicin, Geravim, Geri-Tabs, Geri-Tonic, Geritol, Geritol Complete, Geritol Extend, Gerivite Liquid, Gevrabon, Gevratonic, Glutofac-MX, Glutofac-ZX, Gold Age Liquid Vitamins and Minerals, Gynovite, Hair Booster, Haltran, Hematinic Plus, Hematogen, Hematogen FA, Hematogen Forte, Hemax, heme iron polypeptide, Hemocyte, Hemocyte Plus, Hemocyte Plus (obsolete), Hemocyte-F Elixir, Hi-Nate 90, High Potency, Hytinic, I-L-X, I-L-X and B12, I-Sense, I-Sense OccuShield, I-Vite, I-Vite Protect, IBC 500, Iberet, Iberet Liquid, Iberet-500, Iberet-Folic-500, Ibu, IBU-200, Ibu-4, Ibu-6, Ibu-8, Ibu-Tab, ibuprofen, Ibuprofen PMR, Icaps, ICaps AREDS, ICaps MV, ICaps Plus, Icaps TR, ICaps with Lutein and Zeaxan, Icar, Icar Prenatal, Icar Prenatal Chewable Calcium, Icar-C Plus, Icar-C Plus SR, Icare Prenatal Rx, Iferex 150 Forte, Inatal Advance, Inatal Ultra, Indocin, Indocin SR, indomethacin, indomethacin extended release, Intrinsitinic, Ircon, Irofol, Iromin G, Iron Chews, iron polysaccharide, iron protein succinylate, K-Pec, Ka-Pec, kanamycin, Kantrex, Kao-Pulgite, Kao-Tin(obsolete), kaolin, Kaopectate Caplets, Kaopek, ketoprofen, ketoprofen extended release, ketorolac, L-Tonic, Lactocal-F, lanthanum carbonate, Leader Naproxen Sodium, Livitrinsic-F, Lodine, Lodine XL, Losospan, Lowsium, Lydia E. Pinkham, M-Vit, Maalox Antacid Barrier, Maalox Childrens', Maalox Quick Dissolve, Maalox Quick Dissolve Extra Strength, Maalox Quick Dissolve Maximum Strength, Maalox Regular Strength, Mag-200, Mag-Carb, Mag-G, Mag-Ox 400, Mag-SR with Calcium, Mag-Tab SR, magaldrate, Magan, MagGel, Maginex, MagMin, Magna-C-7 Forte, MagneBind 400 Rx, Magnesiocard, magnesium amino acids chelate, magnesium aspartate, magnesium carbonate, magnesium citrate, magnesium gluconate, magnesium hydroxide, magnesium lactate, magnesium oxide, magnesium salicylate, magnesium trisilicate, Magonate, Magonate Natal, Magonate Tablets, Magtrate, Maoson, Mar-Zinc, Marnatal-F Plus, Martinic, Materna, Maternal 90, Maternity, Maternity plus Beta Carotene, Maternity Vitamin Low Iron, Maternity-90, Maxaron Forte, Maxinate, meclofenamate, Meclomen, Mediplex Ultra, Menadol, Mens Pack, Mg gluconate, Mg hydroxide, Mg lactate, Mg oxide, MG Plus Protein, Mi-C-T, Micro-Zn, Midol Extended Relief, Midol IB, Midol Maximum Strength Cramp Formula, Milk of Magnesia, Mission Prenatal, Mission Prenatal FA, Mission Prenatal HP, Mission Prenatal Rx, Mobidin, Mol-Iron, Motrin, Motrin Childrens, Motrin IB, Motrin Infant Drops, Motrin Junior Strength, Motrin Migraine Pain, MST, Mult-Ferr Folic, Multi Vita Bets and Fluoride and Iron, Multi-betic, Multi-Day Plus Minerals, Multi-Day with Calcium and Extra Iron, Multi-Delyn with Iron, Multibret Folic 500, Multifol, Multifol Plus, Multilex, Multilex-T/M+Minerals, Multiret Folic 500, multivitamin with iron, multivitamin with iron and fluoride, multivitamin with minerals, multivitamin, prenatal, My-A-Multi, Myadec, Mycifradin, Myferon 150 Forte, MyKidz Iron, MyKidz Iron 10, MyKidz Iron FL, Mylanta Child, Mynatal, Mynatal FC, Mynatal Plus, Mynatal PN, Mynatal PN Forte, Mynatal Rx, Mynatal Ultracap, Mynatal Z, Mynate 90 Plus, Myvitalife, nabumetone, Nalfon, Naprelan '375', Naprelan '500', Naprosyn, naproxen, naproxen sodium, Naproxen Sodium DS, naproxen sodium extended release, Natacaps, Natachew, Natafolic-OB, Natafolic-PN, Natafort, NatalCare, NatalCare Advanced, NatalCare Advanced-RF, NatalCare CFE 60, Natalcare Pic, Natalcare Pic Forte, Natalcare Plus, Natalcare Rx, NatalCare Three, Natalcare(obsolete), Natalfirst, Natalins, Natalins Rx, Natarex, Natatab CFe, Natatab FA, Natatab Rx, Natelle, Natelle C, Natelle Plus with DHA, Natelle Prefer, Natelle-ez, Nebcin, Nebcin Pediatric, Neevo, Neo-Calglucon, Neo-Forte, Neo-Fradin, Neo-Tab, neomycin, NeoProfen, Nephro Calci, Nephro-Fer, Nephro-Vite with Fe, Nephron-FA, Nestabs, Nestabs CBF, Nestabs FA, Nestabs Rx, netilmicin, Netromycin, New Advanced Formula Prenatal Z, NIC 750, Nicomide, Niferex, Niferex Elixir, Niferex Gold, Niferex PN Forte, Niferex(obsolete), Niferex-150 (obsolete), Niferex-150 Forte, Niferex-150 Forte (obsolete), Niferex-150(obsolete), Niferex-PN, Norlac RX, Novanatal, NovaStart, Novastart (obsolete), Nu-Iron, Nu-Iron 150, Nu-Iron Plus, Nu-Iron V, Nuprin, Nuprin Backache Caplet, NutriNate, Nutrispire, O-CAL F.A., O-Cal Prenatal, O-Cal-FA, OB Complete, OB Complete with DHA, Ob-20, Obegyn, Obnate 90, Obtrex, Occuplex, Ocuvite, Ocuvite Extra, Ocuvite Lutein, Ocuvite PreserVision, One Daily with Minerals, One Tab Daily with Iron, One Tab Daily with Minerals, One-A-Day Max, One-A-Day Men 50 Plus, One-A-Day WeightSmart, One-A-Day Women, One-A-Day Women 50 Plus, Opti-Gen, Optilets-M-500, Optimum Magnesium Gluconate, OptiNate, Optivite P.M.T., Orazinc, Orazinc 110, Orazinc 110(obsolete), Orazinc 220, Orudis, Orudis KT, Oruvail, Os-Cal, Os-Cal 500, Os-Cal Forte, Os-Cal Ultra, Ostiva, oxaprozin, Oysco 500, Oyst Cal, Oyst Cal 500, Oyster, Oyster Cal, Oyster Cal 500, Oyster Calcium, Oyster Shell, oyster shell calcium, Oyster Shell Calcium 500, Pan OB Forte, Par-F, Parepectolin, Pediacare Fever, Pepto Children's, phenylbutazone, Phillips Milk of Magnesia, Phillips' Cramp-free, PhosLo, PhosLo Gelcap, piroxicam, PMS Balance, Poly Iron, Poly Iron Forte, Poly Vitamin with Fluoride with Iron, Poly-Vi-Flor with Iron, Poly-Vi-Sol with Iron, Poly-Vi-Sol with Iron Drops, Polysaccharide Iron, Posture, Pramilet FA, Pre-H-Cal, Precare, Precare Conceive, Precare Premier, PreferaOB, Premesis Rx, PrenaFirst, Prenatabs CBF, Prenatabs FA, Prenatabs OBN, Prenatabs Rx, Prenatal 1 Plus 1, Prenatal 1 Plus 1 (Low Iron), Prenatal 19, Prenatal AD, Prenatal Elite, Prenatal H, Prenatal Low Iron, Prenatal MR 90, Prenatal MR 90 Fe, Prenatal MTR with Selenium, prenatal multivitamin, Prenatal Multivitamins, Prenatal Plus, Prenatal Plus Iron, Prenatal Plus with 27 mg Iron, Prenatal Plus with Beta-Carotene, Prenatal Rx, Prenatal Rx 1, Prenatal S, Prenatal Z Advanced Formula, Prenatal-U, Prenate 90, Prenate Advance, Prenate Advanced Formula, Prenate DHA, Prenate Elite, Prenate GT, Prenate Ultra, Prenavite, Prenavite FC, Prenavite PC, Prenazyme 1+1, Preterna, PrimaCare, PrimaCare Advantage, Primacare One, Procycle Multi Vitamin with Minerals, Proferrin-ES, Proferrin-Forte, Promar, Pronemia, Prosight, Protegra Softgel, Q-Profen, quinapril, Re Dualvit F, Re Dualvit Plus, RE Fac-X, Relafen, RenaPlex, Renatabs with Iron, Renax, Renax 5.5, Reocyte Plus, Repliva 21/7, Resource Optisource, Rheaban Maximum Strength, Ri-Mag, Ridactate, Riopan, Rolaids Sodium Free, Rolaids Soft Chew, Ron Acid, Ru-Lets M 500, Rufen, Saleto-200, Saleto-400, Saleto-600, Saleto-800, Select-OB, Senetonic, Senilezol, Septopal, Sesame St. Vitamins Complete, Sesame St. Vitamins Plus Iron, Siderol, Simron, Slow Fe, Slow Release Iron, SourceCF Chewables, SourceCF Multivitamins with A,B,D,E & K plus Zinc, SourceCF Pediatric Drops, SourceCF Softgels, SSS, SSS Tonic, streptomycin, Stress 600 with Zinc, Stress Formula with Iron, Stress Formula with Zinc, Stresstabs with Iron, StressTabs with Zinc, Strongstart, Strovite, Strovite Advance, Strovite Advance+D, Strovite Forte, Strovite Plus, Stuart Prenatal with Beta Carotene, Stuartnatal Plus, Stuartnatal Plus 3, sucralfate, sulindac, Sunkist Child Chewable with Iron, Super Calcium, Super High Vitamins and Minerals, Support, Support 500, Surbex-750 with Iron, Surbex-750 with Zinc, Surpass, Surpass Extra Strength, T-Gran plus Minerals, T-Lite, Tab-A-Vite Maximum, Tab-A-Vite WeightSlim, Tab-A-Vite with Iron, Tab-A-Vite Womens Formula, Tandem DHA, Tandem OB, Tandem Plus, Ternamar, Thera Hematinic, Thera M, Thera-M, Thera-Vite M, Theragener-H, Theragener-M, Theragran Hematinic, Theragran-M, Therapeutic-M, Theravim M, Therems H, Therems M, Therobec Plus, Titralac, Tobi, tobramycin, Tolectin, Tolectin 600, Tolectin DS, Tolfrinic, tolmetin, Toradol, Toradol IM, Toradol IV/IM, Tri Vites with Fluoride and Iron, Tri-Vi-Flor with Iron, Tri-Vi-Sol with Iron, tricalcium phosphate, TriCare, Tricon, TriHEMIC 600, Trinate, Trinsicon, Tums, Tums 500, Tums E-X, Tums Extra Strength, Tums Ultra, Udamin, Udamin SP, Ultra Mylanta Calci Tabs, Ultra NatalCare, Ultra-Natal, Uni Kar Plus C SR, Uni-Daily Plus Iron, Uni-Fac ZX, Uni-Thera M with Beta Carotene, Unicap M, Unicap Senior, Unicap T, Unicap with Iron, Unicomplex M, Uro-Mag, V-C Forte, Verazinc, Vernate, Vernate Advanced, Verotin-BY, Verotin-GR, Vi-Daylin ADC with Iron, Vi-Daylin with Iron, Vi-Daylin with Iron Chewable, Vi-Daylin with Iron Drops, Vi-Daylin/F ADC with Iron, Vi-Daylin/F Plus Iron, Vi-Stress with Iron, Vi-Zac, Viactiv Calcium Flavor Glides, Viactiv Multi-Vitamin, Viactiv Multi-Vitamin Flavor Glides, Viactiv Soft Calcium Chews, Vica-Forte, Vicap Forte, Vicon Forte, Vicon Plus, Vicon-C, Videx, Videx EC, Vigortol Liquid, Vimar with Iron, Vinatal 600, Vinatal Forte, Vinate 90, Vinate Advanced (New Formula), Vinate AZ, Vinate AZ Extra, Vinate Calcium, Vinate Good Start, Vinate GT, Vinate II (New Formula), Vinate M, Vinate Ultra, Viogen-C, Vita Drops with Iron, Vita S Forte, Vita Zx, Vita-Dec, Vita-Min Rx, Vita-PMS, Vita-PMS Plus, Vita-Zinc, Vitacon Forte, Vitafol, Vitafol PN, Vitafol-OB, Vitafol-OB+DHA, Vital-D, Vitalize Plus, Vitamax, Vitamed Prenatal Formula, Vitaphil, Vitaplex Plus, Vitelle Nestabs OTC, Voltaren, Voltaren-XR, Vynatal 1 Plus 1, Vynatal F.A., Womens Pack, Yieronia, Z-Bec, Z-Gen, ZE-Plus, Zenate, Zenate Advanced Formula, Zenate Prenatal, Zinc 50 mg Pink, zinc acetate, Zinc CR, zinc gluconate, zinc sulfate, Zinc with Vitamin C, Zinc-220, Zinca-pak, Zincate, Zincvit, Zitamin, Zodeac-100

Minor Interactions
Axid, Axid AR, Axid Pulvules, cimetidine, famotidine, Heartburn Relief, Leader Acid Reducer, Mylanta AR, nizatidine, Pepcid, Pepcid AC, Pepcid AC Maximum Strength, Pepcid RPD, ranitidine, ranitidine bismuth citrate, Tagamet, Tagamet HB, Tritec, Zantac, Zantac 150, Zantac 300, Zantac 300 GELdose, Zantac 75, Zantac EFFERdose, Zantac GELdose