Fexofenadine drug interactions

List of drug interactions
Erythromycin and ketoconazole Antacids'''
 * Changes in plasma levels
 * Gastroinstestinal absorption

Erythromycin and ketoconazole
Fexofenadine has been shown to exhibit minimal (ca. 5%) metabolism. However, co-administration of Fexofenadine hydrochloride with either ketoconazole or erythromycin led to increased plasma concentrations of Fexofenadine. Fexofenadine had no effect on the pharmacokinetics of either erythromycin or ketoconazole. In 2 separate studies, Fexofenadine hydrochloride 120 mg twice daily (240 mg total daily dose) was co-administered with either erythromycin 500 mg every 8 hours or ketoconazole 400 mg once daily under steady-state conditions to healthy volunteers (n=24, each study). No differences in adverse events or QTc interval were observed when subjects were administered Fexofenadine hydrochloride alone or in combination with either erythromycin or ketoconazole. Return to top

Changes in plasma levels
The changes in plasma levels were within the range of plasma levels achieved in adequate and well-controlled clinical trials. Return to top

Gastroinstestinal absorption
The mechanism of these interactions has been evaluated in in vitro, in situ, and in vivo animal models. These studies indicate that ketoconazole or erythromycin co-administration enhances Fexofenadine gastrointestinal absorption. This observed increase in the bioavailability of Fexofenadine may be due to transport-related effects, such as p-glycoprotein. In vivo animal studies also suggest that in addition to enhancing absorption, ketoconazole decreases Fexofenadine gastrointestinal secretion, while erythromycin may also decrease biliary excretion. Return to top

Antacids
Administration of 120 mg of Fexofenadine hydrochloride (2 × 60 mg capsule) within 15 minutes of an aluminum and magnesium containing antacid (Maalox®) decreased Fexofenadine AUC by 41% and Cmax by 43%. Fexofenadine hydrochloride should not be taken closely in time with aluminum and magnesium containing antacids. Return to top

Moderate Interactions

 * Accupril
 * Aloh-Gel
 * Alternagel
 * Alu-Cap
 * Alu-Tab
 * aluminum carbonate
 * aluminum hydroxide
 * Amphojel
 * Aplisol
 * Aplitest
 * ARI Sodium Iodide (I123) 1-12 MBq
 * ARI Sodium Iodide (I123) 100-750 MBq
 * Basaljel
 * candida albicans extract
 * Candida Skin Test
 * Candin
 * coccidioidin skin test
 * Concentrated Phillips Milk of Magnesia
 * Dewees Carminative
 * Dialume
 * Ex-Lax Milk of Magnesia
 * histamine phosphate
 * Histatrol
 * Histolyn-Cyl
 * histoplasmin
 * Histoplasmin Diluted
 * Iodotope
 * Losospan
 * Lowsium
 * Mag-Carb
 * magaldrate
 * magnesium carbonate
 * magnesium hydroxide
 * Maoson
 * Mg hydroxide
 * Milk of Magnesia
 * Mono-Vacc Test (O.T.)
 * MSTA Mumps Skin Test Antigen
 * Multitest CMI
 * mumps skin test antigen
 * Phillips Milk of Magnesia
 * quinapril
 * Ri-Mag
 * Rifadin
 * Rifadin IV
 * rifampin
 * Rimactane
 * Riopan
 * Ron Acid
 * Sclavo Test-PPD
 * skin test antigens
 * multiple
 * sodium iodide I-123
 * sodium iodide-I-131
 * Spherulin
 * Trichophyton Allergenic Extracts
 * trichophyton skin test
 * tuberculin purified protein derivative
 * Tuberculin Tine Test
 * Tubersol

Minor Interactions

 * Amphadase
 * Biaxin
 * Biaxin XL
 * Biaxin XL-Pak
 * clarithromycin
 * clarithromycin extended release
 * clotrimazole
 * Diflucan
 * E-Mycin
 * E.E.S. Granules
 * E.E.S.-200
 * E.E.S.-400
 * E.E.S.-400 Filmtab
 * Ery-Tab
 * Eryc
 * EryPed
 * EryPed 200
 * EryPed 400
 * Erythrocin Lactobionate
 * Erythrocin Stearate Filmtab
 * Erythrocot
 * erythromycin
 * erythromycin base
 * erythromycin estolate
 * erythromycin ethylsuccinate
 * erythromycin lactobionate
 * erythromycin stearate
 * fluconazole
 * hyaluronidase
 * Hydase
 * Hylenex
 * hypericum perforatum
 * Ilosone
 * Ilotycin Gluceptate
 * itraconazole
 * ketoconazole
 * miconazole
 * Monistat I.V.
 * MY-E
 * Mycelex Troche
 * Nizoral
 * PCE Dispertab
 * Robimycin
 * Sporanox
 * St. John's wort
 * Tao
 * troleandomycin
 * VFEND
 * Vitrase
 * voriconazole
 * Wydase