Biotin carboxylase

In enzymology, a biotin carboxylase is an enzyme that catalyzes the chemical reaction


 * ATP + biotin-carboxyl-carrier protein + CO2 $$\rightleftharpoons$$ ADP + phosphate + carboxybiotin-carboxyl-carrier protein

The 3 substrates of this enzyme are ATP, biotin-carboxyl-carrier protein, and CO2, whereas its 3 products are ADP, phosphate, and carboxybiotin-carboxyl-carrier protein.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming). This enzyme is also called biotin carboxylase (component of acetyl CoA carboxylase). This enzyme participates in fatty acid biosynthesis.

Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes, , , , and.