Diarylpyrimidines

Diarylpyrimidines and diaryltriazines are two closely related classes of molecules resembling the pyrimidine nucleotides found in DNA. They show great potency in inhibiting the activity of HIV reverse transcriptase. Several compounds in this class are currently underdevelopment as the next generation of non-nucleoside reverse transcriptase inhibitors, notably a compound called TMC278 expected to receive FDA approval in 2009.