Mastocytosis staging

WHO criteria
WHO Diagnostic Criteria; to make the diagnosis have 1 Major and 1 Minor criteria or at least 3 minor ones. Major Criteria; Mutlifocal dense infiltrates of mast cells in the bone marrow or other extracutaneous organ(s) (>15 mast cells in aggregate). Minor Criteria; 1) Mast cells in the bone marrow or other extracutaneous organ(s) show an abnormal morphology (>25% of cells). 2) C-kit mutation at codon 816 is found. 3) Mast cells in the bone marrow express CD2 and/or CD25. 4) Serum total tryptase >20 ng/ml.