Myelofibrosis laboratory tests

Laboratory Tests
Diagnosis is based upon:


 * Normochromic normocytic anaemia
 * Red cell poikilocytosis on blood film (tear-drop shaped RBCs)
 * JAK 2 mutation on Val 617 Phe locus in 50%
 * Raised levels of lactate dehydrogenase
 * Raised neutrophil alkaline phosphatase score

TB testing
The patient with the myelofibrosis should be tested for Tuberculosis even if the patient doesn't manifest the symptoms of TB. There is strong evidence of myelofibrois improvement with the antituberculous treatment.