NAD(P)+ transhydrogenase (B-specific)

In enzymology, a NAD(P)+ transhydrogenase (B-specific) is an enzyme that catalyzes the chemical reaction


 * NADPH + NAD+ $$\rightleftharpoons$$ NADP+ + NADH

Thus, the two substrates of this enzyme are NADPH and NAD+, whereas its two products are NADP+ and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is NADPH:NAD+ oxidoreductase (B-specific). Other names in common use include pyridine nucleotide transhydrogenase, transhydrogenase, NAD(P)+ transhydrogenase, nicotinamide adenine dinucleotide (phosphate) transhydrogenase, NAD+ transhydrogenase, NADH transhydrogenase, nicotinamide nucleotide transhydrogenase, NADPH-NAD+ transhydrogenase, pyridine nucleotide transferase, NADPH-NAD+ oxidoreductase, NADH-NADP+-transhydrogenase, NADPH:NAD+ transhydrogenase, H+-Thase, non-energy-linked transhydrogenase, and NAD(P)+ transhydrogenase (B-specific). This enzyme participates in nicotinate and nicotinamide metabolism. It employs one cofactor, FAD.

Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , and.