GPR35

GPR35 is a G protein-coupled receptor discovered in 1998. Hightened expression of GPR35 is found in immune and gastrointestinal tissues, including the crypts of Lieberkühn.

Ligands
One study has shown that kynurenic acid acts as an endogenous ligand for this receptor. Zaprinast, a PDE5A inhibitor, was found to be an agonist for GPR35.

Role in pathology
Deletion of GPR35 gene may be responsible for brachydactyly mental retardation syndrome. In one study GPR35 has been recognised as a potential oncogene in the stomach cancer.