Adrenomedullin receptor

Adrenomedullin receptor is a receptor. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. adrenomedullin. It is encoded by the human gene ADMR.

Structure
The structure of the adrenomedullin receptor is a calcitonin receptor-like receptor (CL) linked to the second of three single transmembrane domain receptor activity-modifying proteins (RAMPs), i.e. RAMP2, which is essential for functional activity. It is worth noting that unlike the classical one ligand-one receptor notion of receptor signalling, the interaction of both CL and RAMP at the membrane, is required for AM to mediate its action.

Mechanism
The outcome of AM stimulatation of its receptor is activation of the G protein Gs, resulting in cellular production of both cyclic AMP (cAMP). The activated adrenomedullin receptor also produces nitric oxide production. Some may find the production of these inside the cell to be at odds, since often they have opposing effects, but as yet, the timing of these effects remains to be studied.