Tyrosine-tRNA ligase

In enzymology, a tyrosine-tRNA ligase is an enzyme that catalyzes the chemical reaction


 * ATP + L-tyrosine + tRNATyr $$\rightleftharpoons$$ AMP + diphosphate + L-tyrosyl-tRNATyr

The 3 substrates of this enzyme are ATP, L-tyrosine, and tRNA(Tyr), whereas its 3 products are AMP, diphosphate, and L-tyrosyl-tRNA(Tyr).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-tyrosine:tRNATyr ligase (AMP-forming). This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis and aminoacyl-trna biosynthesis.

Structural studies
As of late 2007, 34 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , and.