Nialamide

Nialamide was one of the first MAOI (monoamine oxidase inhibitor) antidepressants. It is chemically related to iproniazide, another MAOI derived from isonicotinic acid.

Approved
Nialamide is effective for depression characterized by anergic symptoms, endogenous depression, and reactive depression.

Unapproved/Off-Label/Investigational
Nialamide is sometimes used in the treatment of trigeminal neuralgia. It has also been studied for alcoholism, dermatomally distributed vitiligo, irregular menstrual cycle,, angina, cerebrovascular disorders, and the prevention of streptomycin-induced deafness.

Side effects
Side effects of nialamide include insomnia, vertigo, hyperhidrosis, weight gain, vomiting, tachycardia, constipation, dry mouth, upset stomach, orthostatic hypotension and decreased systolic pressure.

Tradenames
Nialamide is sold under Psicodisten&reg;, Niaquitil&reg;, Nialamid&reg;, Niamidal&reg;, Niamide&reg;, Novazid&reg;, Nuredal&reg;, Niamid&reg; (Italy, Belgium, Netherlands, England, United States), Niazin&reg;, Nyazin&reg;, Surgex&reg; (Italy), Mygal&reg;, Delmoneurina&reg;, Isalizina&reg; (Italy), Espril&reg; (Italy), and Nyezin&reg;.

References and End Notes

 * 1)   [No abstract] PMID 5321917 List of Print Collections
 * 2)   [Article in French] New York Academy of Medicine Library holding
 * 3)   List of Library Holdings
 * 4)   [Article in French] PMID 13841128 Harvard University Library Holding
 * 5)   [Article in French] PMID 5930244 List of Library Holdings
 * 6)   [Article in Russian] PMID 1647635 List of Library Holdings
 * 7)   List of Library Holdings
 * 8)   List of Library Holdings
 * 9)   [Article in Russian] No absract. PMID 1021625 List of Library Holdings
 * 10)   [Article in Russian] PMID 1218262 List of Library Holdings
 * 11)   No abstract. PMID 4467804 List of Library Holdings

Ниаламид