Polynucleotide adenylyltransferase

In enzymology, a polynucleotide adenylyltransferase is an enzyme that catalyzes the chemical reaction


 * ATP + RNAn $$\rightleftharpoons$$ diphosphate + RNAn+1

Thus, the two substrates of this enzyme are ATP and RNAn, whereas its two products are diphosphate and RNAn+1.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:polynucleotide adenylyltransferase. Other names in common use include NTP polymerase, RNA adenylating enzyme, AMP polynucleotidylexotransferase, ATP-polynucleotide adenylyltransferase, ATP:polynucleotidylexotransferase, poly(A) polymerase, poly(A) synthetase, polyadenylate nucleotidyltransferase, polyadenylate polymerase, polyadenylate synthetase, polyadenylic acid polymerase, polyadenylic polymerase, terminal riboadenylate transferase, poly(A) hydrolase, RNA formation factors, PF1, and adenosine triphosphate:ribonucleic acid adenylyltransferase.

Structural studies
As of late 2007, 27 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , , , , , , , , , , , , , , , , , , and.