TRNA (guanine-N1-)-methyltransferase

In enzymology, a tRNA (guanine-N1-)-methyltransferase is an enzyme that catalyzes the chemical reaction


 * S-adenosyl-L-methionine + tRNA $$\rightleftharpoons$$ S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine

Thus, the two substrates of this enzyme are S-adenosyl methionine and tRNA, whereas its two products are S-adenosylhomocysteine and tRNA containing N1-methylguanine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase. Other names in common use include transfer ribonucleate guanine 1-methyltransferase, tRNA guanine 1-methyltransferase, and S-adenosyl-L-methionine:tRNA (guanine-1-N-)-methyltransferase.

Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes, , , , , and.