Sphingosine N-acyltransferase

In enzymology, a sphingosine N-acyltransferase is an enzyme that catalyzes the chemical reaction


 * acyl-CoA + sphingosine $$\rightleftharpoons$$ CoA + N-acylsphingosine

Thus, the two substrates of this enzyme are acyl-CoA and sphingosine, whereas its two products are CoA and N-acylsphingosine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:sphingosine N-acyltransferase. Other names in common use include ceramide synthetase, and sphingosine acyltransferase. This enzyme participates in sphingolipid metabolism.