Sepiapterin reductase

In enzymology, a sepiapterin reductase is an enzyme that catalyzes the chemical reaction


 * 7,8-dihydrobiopterin + NADP+ $$\rightleftharpoons$$ sepiapterin + NADPH + H+

Thus, the two substrates of this enzyme are 7,8-dihydrobiopterin and NADP+, whereas its 3 products are sepiapterin, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 7,8-dihydrobiopterin:NADP+ oxidoreductase. This enzyme participates in folate biosynthesis.

Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes, , , , and.