Toxic granulation

Toxic granulation refers to changes in granulocyte cells seen on examination of the peripheral blood film of patients with inflammatory conditions. They are commonly found in patients with sepsis. Toxic granulations are dark coarse granules found in granulocytes, particularly neutrophils. Along with Dohle bodies and cytosolic vacuolation, which are two other findings in the cytoplasm of granulocytes, toxic granulations are a peripheral blood film finding suggestive of an inflammatory process.