Glomerulosclerosis (patient information)

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Editors-in-Chief: C. Michael Gibson, M.S., M.D. Associate Editor-In-Chief: Ujjwal Rastogi, MBBS [mailto:urastogi@perfuse.org]

Overview
Glomerulosclerosis or better known as Focal segmental glomerulosclerosis is scar tissue that forms in parts of the kidney called glomeruli. The glomeruli serve as filters, helping rid the body of unnecessary or harmful substances. Each kidney has thousands of glomeruli. One glomeruli is called a glomerulus.

"Focal" means that some of the glomeruli become scarred, while others remain normal. "Segmental" means that only part of an individual glomerulus is damaged.

What are the symptoms of Glomerulosclerosis?

 * Foamy urine (from excess protein in the urine)
 * Poor appetite
 * Swelling, called generalized edema, from fluids held in the body
 * Weight gain

What causes Glomerulosclerosis?
The cause of focal segmental glomerulosclerosis is usually unknown.

Known causes include:
 * Heroin use
 * HIV
 * Inherited genetic problems
 * Obesity
 * Reflux nephropathy (a condition in which urine flows backward from the bladder to the kidney)
 * Sickle cell disease

Who is at highest risk?
The condition affects both children and adults. Men and boys are affected slightly more often than women and girls, and it also occurs more often in African Americans. Focal segmental glomerulosclerosis causes about 20 - 25% of all cases of nephrotic syndrome.

When to seek urgent medical care?
You should call your doctor if you develop symptoms of this condition, especially if there is fever, pain with urination, or decreased urine output.

Diagnosis
The health care provider will perform a physical examination. This may detect tissue swelling and high blood pressure. Signs of kidney (renal) failure and excess fluid may develop as the condition gets worse.

Tests may include:
 * Kidney biopsy
 * Kidney function tests (blood and urine)
 * Urinalysis
 * Urine microscopy
 * Urine protein

Treatment options
Some patients will receive high doses of corticosteroids or a drug called cyclosporine to suppress their immune system.

The goal of treatment is to control the symptoms of nephrotic syndrome and prevent chronic kidney failure.

In general, treatments may include:
 * Antibiotics to control infections
 * Anti-inflammatory medicines to reduce the immune response
 * Dialysis
 * Fluid restriction
 * Kidney transplant
 * Low-fat diet
 * Low- or moderate-protein diet (1 gram of protein per kilogram of body weight per day)
 * Medicines to treat high blood pressure, high blood cholesterol, and high triglyceride levels
 * Salt-reduced diet
 * Vitamin D supplements

Where to find medical care for Glomerulosclerosis?
Directions to Hospitals Treating Glomerulosclerosis

What to expect (Outlook/Prognosis)?
More than half of those with focal or segmental glomerulosclerosis develop chronic kidney failure within 10 years.

Possible complications

 * Chronic kidney failure
 * End-stage kidney disease
 * Infection
 * Malnutrition
 * Nephrotic syndrome

Prevention
No prevention is known.