Tachykinin receptor 1

TACR1 is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene.

This protein is considered an attractive drug target, particularly with regards to potential analgesics and anti-depressants. It was identified as a candidate in the etiology of bipolar disorder by a 2008 study.

Neurokinin 1 antagonists may have a role as novel antiemetics.