Jacob Augustus Lockhart Clarke

Jacob Augustus Lockhart Clarke (1817—January 25, 1880) was a British physiologist and neurologist who is primarily known for his studies of the brain and the spinal cord.

Clarke was the first to establish the location of the nucleus dorsalis, which he then called "posterior vesicular columns", and described the nucleus intermediolateralis. He also differentiated the medial cuneate nucleus from the lateral cuneate nucleus (also called "Monakow's nucleus" after neuropathologist Constantin von Monakow). Clarke is credited with introducing the histological technique of mounting cleared sections of tissue in balsam media. He published numerous essays regarding the the anatomy and physiology of the medulla oblongata and the spinal cord. He also had works published regarding his studies with tetanus, diabetes, paraplegia and muscular atrophy. Clarke's nucleus (also known as the Column of Clarke) and Clarke's body are anatomical structures named after him.