Tetrahydroberberine oxidase

In enzymology, a tetrahydroberberine oxidase is an enzyme that catalyzes the chemical reaction


 * (S)-tetrahydroberberine + 2 O2 $$\rightleftharpoons$$ berberine + 2 H2O2

Thus, the two substrates of this enzyme are (S)-tetrahydroberberine and O2, whereas its two products are berberine and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is (S)-tetrahydroberberine:oxygen oxidoreductase. This enzyme is also called (S)-THB oxidase. This enzyme participates in alkaloid biosynthesis.