Beta-3 adrenergic receptor

The beta-3 adrenergic receptor (β3 adrenoreceptor), also known as ADRB3, is an beta-adrenergic receptor, and also denotes the human gene encoding it.

Functions
Actions of the β3 receptor include:
 * Enhancement of lipolysis in adipose tissue.
 * Thermogenesis in skeletal muscle

It is located mainly in adipose tissue and is involved in the regulation of lipolysis and thermogenesis.

Mechanism
Beta adrenergic receptors are involved in the epinephrine and norepinephrine-induced activation of adenylate cyclase through the action of the G proteins of the type Gs.

Agonists

 * L-796568
 * CL 316,243
 * LY 368842
 * Ro 40-2148

Antagonists
(Beta blockers)