Anxiogenic

An anxiogenic substance is one that causes anxiety. Anxiogenic effects can be measured by, for example, the hole-board test in rats and mice. . A number of agents are used to provoke anxiety (anxiogenes) or panic (panicogenes) in experimental models. Some of the most common substances are: DMCM, sodium lactate, carbon dioxide (CO2), caffeine, yohimbine, serotoninergic agents, adrenergic agents and cholecystokinin (CCK)

Anxiolytic substances have the opposite effect: they reduce anxiety.