Glipizide (patient information)

IMPORTANT WARNING
Oral hypoglycemic drugs, including glipizide, have been associated with increased cardiovascular mortality. Talk to your doctor about the possible risks, benefits, and alternatives of using this drug for your condition.

Why this medication is prescribed
Glipizide is used to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood), particularly in people whose diabetes cannot be controlled by diet alone. Glipizide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently. The pancreas must be capable of producing insulin for this medication to work. Glipizide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood).

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How this medication should be used
Glipizide comes in tablets to take by mouth. It is usually taken once a day, 30 minutes before breakfast. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take glipizide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Continue to take glipizide even if you feel well. Do not stop taking glipizide without talking to your doctor.

Special precautions
Before taking glipizide:


 * tell your doctor and pharmacist if you are allergic to glipizide or any other drugs.
 * tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially antibiotics, anticoagulants ('blood thinners') such as warfarin (Coumadin), dexamethasone (Decadron), diuretics ('water pills'), estrogens, isoniazid (INH), MAO inhibitors [phenelzine (Nardil) and tranylcypromine (Parnate)], medications for high blood pressure or heart disease, niacin, oral contraceptives, phenytoin (Dilantin), prednisone, probenecid (Benemid), and vitamins.
 * tell your doctor if you have or have ever had kidney, liver, heart, or thyroid disease or a severe infection.
 * tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking glipizide, call your doctor.
 * if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking glipizide.
 * plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Glipizide may make your skin sensitive to sunlight.

Special dietary instructions
Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. It is important to eat a healthy diet.

Alcohol may cause a decrease in blood sugar. Ask your doctor about the safe use of alcoholic beverages while you are taking glipizide.

What to do if you forget a dose
Before you start taking glipizide, ask your doctor what to do if you forget to take a dose. Write these directions down so you can refer to them later.

As a general rule, take the missed dose as soon as you remember it unless it is almost time for the next dose. Do not take a double dose to make up for a missed one.

Minor side effects
This medication may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms.

You may experience hypoglycemia (low blood sugar) while you are taking this medication. Your doctor will tell you what you should do if you develop hypoglycemia. He or she may tell you to check your blood sugar, eat or drink a food or beverage that contains sugar, such as hard candy or fruit juice, or get medical care. Follow these directions carefully if you have any of the following symptoms of hypoglycemia:


 * shakiness
 * dizziness or lightheadedness
 * sweating
 * nervousness or irritability
 * sudden changes in behavior or mood
 * headache
 * numbness or tingling around the mouth
 * weakness
 * pale skin
 * hunger
 * clumsy or jerky movements

If hypoglycemia is not treated, severe symptoms may develop. Be sure that your family, friends, and other people who spend time with you know that if you have any of the following symptoms, they should get medical treatment for you immediately.


 * confusion
 * seizures
 * loss of consciousness

Call your doctor immediately if you have any of the following symptoms of hyperglycemia (high blood sugar):


 * extreme thirst
 * frequent urination
 * extreme hunger
 * weakness
 * blurred vision

If high blood sugar is not treated, a serious, life-threatening condition called diabetic ketoacidosis could develop. Call your doctor immediately if you have any of the these symptoms:


 * dry mouth
 * upset stomach and vomiting
 * shortness of breath
 * breath that smells fruity
 * decreased consciousness

Severe side effects
Glipizide may cause side effects. If you experience any of the following symptoms, call your doctor immediately:


 * skin rash
 * itching or redness
 * exaggerated sunburn
 * yellowing of the skin or eyes
 * light-colored stools
 * dark urine
 * unusual bleeding or bruising
 * fever
 * sore throat

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/report.htm] or by phone [1-800-332-1088].

Storage conditions needed for this medication
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Other information
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to glipizide. Your doctor will also tell you how to check your response to this medication by measuring your blood or urine sugar levels at home. Follow these instructions carefully.

You should always wear a diabetic identification bracelet to be sure you get proper treatment in an emergency.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

Brand names

 * Glucotrol®