Isochorismatase

In enzymology, an isochorismatase is an enzyme that catalyzes the chemical reaction


 * isochorismate + H2O $$\rightleftharpoons$$ 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate

Thus, the two substrates of this enzyme are isochorismate and H2O, whereas its two products are 2,3-dihydroxy-2,3-dihydrobenzoate and pyruvate.

This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds (ether hydrolases). The systematic name of this enzyme class is isochorismate pyruvate-hydrolase. Other names in common use include 2,3-dihydro-2,3-dihydroxybenzoate synthase, 2,3-dihydroxy-2,3-dihydrobenzoate synthase, and 2,3-dihydroxy-2,3-dihydrobenzoic synthase. This enzyme participates in the biosynthesis of siderophore group (nonribosomal).

Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes, , and.