Protein-histidine pros-kinase

In enzymology, a protein-histidine pros-kinase is an enzyme that catalyzes the chemical reaction


 * ATP + protein L-histidine $$\rightleftharpoons$$ ADP + protein Npi-phospho-L-histidine

Thus, the two substrates of this enzyme are ATP and protein L-histidine, whereas its two products are ADP and protein Npi-phospho-L-histidine.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain of histidine residues in proteins (protein-histidine kinases). The systematic name of this enzyme class is ATP:protein-L-histidine Npi-phosphotransferase. Other names in common use include ATP:protein-L-histidine N-pros-phosphotransferase, histidine kinase (ambiguous), histidine protein kinase (ambiguous), protein histidine kinase (ambiguous), protein kinase (histidine) (ambiguous), and HK2.