Small Nucleolar RNA SNORD99

Small Nucleolar RNA SNORD99 (also known as HBII-420) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

SNORD99 belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [1]. SNORD99 is predicted to guide the 2'O-ribose methylation of 28S ribosomal RNA at residue A2774 [3]. In the human genome this snoRNA shares the same host gene with the three H/ACA box snoRNAs ACA16, ACA44 and ACA61[3].