Peptidyl-glutamyl peptide-hydrolyzing activity

Peptidyl-glutamyl peptide-hydrolyzing (PGPH) enzyme activity is a means of proteolysis that cleaves peptide bonds in proteins immediately after acidic or branched-chain amino acids. One of the three catalytic β subunits of the proteasome has PGPH activity and is strongly inhibited by the proteasome inhibitor epoxomicin.