Steroidogenic factor 1

The steroidogenic factor 1 (SF1) protein is a member of the nuclear receptor family of intracellular transcription factors and is encoded by the gene (nuclear receptor subfamily 5, group A, member 1).

SF-1 is critical regulator of reproduction because its targets include genes at every level of the hypothalamic-pituitary-gonadal axis, as well as many genes involved in gonadal and adrenal steroidogenesis.