Raloxifene drug interactions

List of drug interactions
Cholestyramine Warfarin Other Highly Protein-Bound Drugs Systemic estrogens Other concomitant medications

Cholestyramine
Concomitant administration of cholestyramine with Raloxifene is not recommended. The result is a major reduction in absorption and enterohepatic cycling of Raloxifene. Although not specifically studied, it is anticipated that other anion exchange resins would have a similar effect. Raloxifene should not be co-administered with other anion exchange resins. Return to top

Warfarin
If Raloxifene is given concomitantly with warfarin or other warfarin derivatives, prothrombin time should be monitored more closely when starting or stopping therapy with Raloxifene. Raloxifene may decrease anticoagulant effect. Return to top

Other Highly Protein-Bound Drugs
Raloxifene should be used with caution with certain other highly protein-bound drugs such as diazepam, diazoxide, and lidocaine. These may displace Raloxifene from protein-binding sites, increasing the effects of Raloxifene. Although not examined, Raloxifene might affect the protein binding of other drugs. Raloxifene is more than 95% bound to plasma proteins. Return to top

Systemic estrogens
The safety of concomitant use of Raloxifene with systemic estrogens has not been established and its use is not recommended. Return to top

Other concomitant medications
Raloxifene can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin. The concomitant use of Raloxifene and lipid-lowering agents or Cyclosporine has not been studied. Return to top

Moderate Interactions
Adgyn Estro, Aerodiol, Alora, Aquest, Bedol, Cenestin, chlorotrianisene, cholestyramine, Cholestyramine Light, Climara, Climaval, Climodien, Clinagen LA 40, Colestid, Colestid Flavored, colestipol, conjugated estrogens, conjugated estrogens synthetic A, conjugated estrogens synthetic B, Delestrogen, DELIDOSE, Dep Gynogen, Depo-Estradiol, Depogen, Dermestril, Dermestril - Septem, DERMESTRIL SEPTEM, diethylstilbestrol, Dioval 40, Dioval XX, Divigel 0.25 mg/packet, Divigel 0.5 mg/packet, Divigel 1 mg/packet, Dura-Estrin, Duragen, Elestrin, Elleste Solo, Eltroxin, Emcyt, Enjuvia, Esclim, esterified estrogens, Estinyl, Estra-C, Estra-V 40, Estrace, Estrace Vaginal Cream, Estraderm, Estraderm MX, Estraderm TTS, estradiol, estradiol acetate, estradiol benzoate, estradiol cypionate, ESTRADIOL G GAM, Estradiol Patch, estradiol topical, estradiol valerate, Estradot, Estradot 100, Estradot 37.5, Estradot 50, Estradot 75, Estragyn 5, Estragyn LA 5, estramustine, ESTRAPATCH, Estrasorb, ESTREVA, Estring, Estro-A, Estro-Cyp, Estro-L.A., Estro-Span 40, Estrofem, Estrogel, estrone, Estrone AQ, estropipate, ethinyl estradiol, Euthyrox, Eutroxsig, Evamist, Evorel, Evotrox, Fematrix, Fempatch, Femring, FEMSEPT, FemSeven, FemSeven Sequi Phase I, FemTab, Femtrace, Femtran, Gynodiol, Gynogen LA 20, Kestrone 5, L THYROXINE ROCHE, l-thyroxine, Levo-T, Levotabs, Levotec, Levothroid, LEVOTHYROX, levothyroxine, Levoxyl, Medidiol 10, Menaval-20, Menest, MENOREST, Menorest Patch, Menostar, mestranol, Nuvelle TS Phase I, Oesclim, Oestradiol, Oestradiol Implants, OESTRODOSE, OESTROGEL, Oestrogel Pump-Pack, Ogen 0.625, Ogen 1.25, Ogen 2.5, Organon Oestradiol, OROMONE, Oroxine, Ortho-Est, Premarin, Premarin Intravenous, Prevalite, Primogyn Depot, Progynova, Progynova TS, PROVAMES, Questran, Questran Light, quinestrol, Sandrena, Stilphostrol, Synthroid, SYSTEN, Tace, THAIS, THAISSEPT, Tirosint, Unithroid, Vagifem, Valergen, Vivelle, Vivelle-Dot, VIVELLEDOT, Zumenon

Minor Interactions
Anestacaine, anisindione, Coumadin, Diastat, Diastat AcuDial, Diastat Pediatric, diazepam, diazoxide, dicumarol, Dilocaine, Dizac, Hyperstat, Jantoven, L-Caine, lidocaine, Lidoject 1, Lidoject 2, Miradon, Nervocaine, Proglycem, Truxacaine, UAD Caine, Valium, Valrelease, warfarin, Xylocaine Dental Cartridges, Xylocaine Duo-Trach Kit, Xylocaine HCl, Xylocaine HCl For Spinal, Xylocaine-MPF, Zetran