Biotin synthase

In enzymology, a biotin synthase is an enzyme that catalyzes the chemical reaction


 * dethiobiotin + sulfur + 2 S-adenosyl-L-methionine $$\rightleftharpoons$$ biotin + 2 L-methionine + 2 5'-deoxyadenosine

The 3 substrates of this enzyme are dethiobiotin, sulfur, and S-adenosyl-L-methionine, whereas its 3 products are biotin, L-methionine, and 5'-deoxyadenosine.

This enzyme belongs to the family of transferases, specifically the sulfurtransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is dethiobiotin:sulfur sulfurtransferase. This enzyme participates in biotin metabolism. It employs one cofactor, iron-sulfur.

Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code.