Sulfatase

Sulfatases are esterase enzymes which remove sulfate from a variety of substrates by hydrolyzing various sulphate esters.

The following sulphatases were shown to be structurally related based on their sequence homology, ,
 * cerebroside-sulfatase
 * steryl-sulfatase
 * arylsulphatase A (ASA), a lysosomal enzyme which hydrolyzes cerebroside sulphate;
 * arylsulphatase B (ASB) which hydrolyzes the sulphate ester group from N-acetylgalactosamine 4-sulphate residues of dermatan sulphate;
 * arylsulphatase C (ASD) and E (ASE); steryl-sulphatase (STS), a membrane bound enzyme which hydrolyzes 3-beta-hydroxy steroid sulphates;
 * iduronate 2-sulphatase (IDS), a lysosomal enzyme that hydrolyzes the 2-sulphate groups from iduronic acids in dermatan sulphate and heparan sulphate;
 * N-acetylgalactosamine-6-sulphatase, which hydrolyzes the 6-sulphate groups of the N-acetyl-D-galactosamine of chondroitin sulphate and D-galactose 6-sulphate units of keratan sulphate;
 * N-sulphoglucosamine sulphohydrolase, the lysosomal enzyme that hydrolyses N-sulpho-D-glucosamine into glucosamine and sulphate;
 * glucosamine-6-sulphatase (G6S), which hydrolyzes the N-acetyl-D-glucosamine 6-sulphate units of heparan sulphate and keratan sulphate;
 * N-sulphoglucosamine sulphohydrolase, the lysosomal enzyme that hydrolyses N-sulpho-D-glucosamine into glucosamine and sulphate;
 * sea urchin embryo arylsulphatase ;
 * green algae arylsulphatase, which plays a role in the mineralization of sulphates; and
 * arylsulphatase from Escherichia coli, Klebsiella aerogenes and Pseudomonas aeruginosa.

Human proteins containing this domain
ARSA;     ARSB;      ARSD;      ARSE;      ARSF;      ARSG;      ARSH;      ARSI; ARSJ;     ARSK;      GALNS;     GNS;       IDS;       PIGG;      SGSH;      STS; SULF1;    SULF2;