Roflumilast

Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor which, due to its selective inhibition of the PDE4 isoenzyme, has potential antiinflammatory and antimodulatory effects in the pulmonary system. Karish SB, Gagnon JM. Ann Pharmacother. 2006 May 30

Roflumilast(3-cyclopropylmethoxy-4 difluromethoxy-n-[3,5-dicloropyrid-4yl]-benzamide) is a selective pde4 inhibitor developed by altana pharma.Inhibition of pde4 theoretically leads to inhibition of proinflammatory mediators and the clinical effects of inhibition of bronchoconstriction,chemotaxis,and inflammation

Prashant R. Shirode Mumbai( INDIA )

Roflumilast