Dopamine receptor D1

Overview
Dopamine receptor D1, also known as DRD1, is a human gene.

This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.

Ligands

 * (+)-trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline, a chromano (oxygen) bioisostere of dihydrexidine, potent full agonist, selective over D2
 * A-86929, full agonist