Leukotriene C4 synthase

Leukotriene C4 synthase (or glutathione S-transferase II) is an enzyme which converts leukotriene A4 and glutathione to create leukotriene C4.

A trimer of Leukotriene C4 synthase is localized on the outer nuclear membrane and endoplasmic reticulum where it forms a complex with 5-Lipoxygenase activating protein. This protein is remotely related to microsomal glutathione S-transferase.