Fluconazole drug interactions

List of drug interactions
Oral hypoglycemics Coumarin-type anticoagulants Phenytoin Cyclosporine Rifampin Theophylline Terfenadine Cisapride Astemizole Rifabutin Tacrolimus Short-acting benzodiazepines Oral contraceptives Cimetidine Antacid Hydrochlorothiazide Warfarin Zidovudine Tolbutamide Glipizide Glyburide Midazolam Azithromycin Complete List of Drug Interactions

Oral hypoglycemics
Clinically significant hypoglycemia may be precipitated by the use of Fluconazole with oral hypoglycemic agents; one fatality has been reported from hypoglycemia in association with combined Fluconazole and glyburide use. Fluconazole reduces the metabolism of tolbutamide, glyburide, and glipizide and increases the plasma concentration of these agents. When Fluconazole is used concomitantly with these or other sulfonylurea oral hypoglycemic agents, blood glucose concentrations should be carefully monitored and the dose of the sulfonylurea should be adjusted as necessary. The effects of Fluconazole on the pharmacokinetics of the sulfonylurea oral hypoglycemic agents tolbutamide, glipizide, and glyburide were evaluated in three placebo-controlled studies in normal volunteers. All subjects received the sulfonylurea alone as a single dose and again as a single dose following the administration of Fluconazole 100 mg daily for 7 days. In these three studies 22/46 (47.8%) of Fluconazole treated patients and 9/22 (40.1%) of placebo treated patients experienced symptoms consistent with hypoglycemia.

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Coumarin-type anticoagulants
Prothrombin time may be increased in patients receiving concomitant Fluconazole and coumarin-type anticoagulants. In post-marketing experience, as with other azole antifungals, bleeding events (bruising, epistaxis, gastrointestinal bleeding, hematuria, and melena) have been reported in association with increases in prothrombin time in patients receiving Fluconazole concurrently with warfarin. Careful monitoring of prothrombin time in patients receiving Fluconazole and coumarin-type anticoagulants is recommended.

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Phenytoin
Fluconazole increases the plasma concentrations of phenytoin. Careful monitoring of phenytoin concentrations in patients receiving Fluconazole and phenytoin is recommended. Phenytoin AUC was determined after 4 days of phenytoin dosing (200 mg daily, orally for 3 days followed by 250 mg intravenously for one dose) both with and without the administration of Fluconazole (oral Fluconazole 200 mg daily for 16 days) in 10 normal male volunteers. There was a significant increase in phenytoin AUC. The mean ± SD increase in phenytoin AUC was 88%± 68% (range: 16 to 247%). The absolute magnitude of this interaction is unknown because of the intrinsically nonlinear disposition of phenytoin.

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Cyclosporine
Fluconazole may significantly increase cyclosporine levels in renal transplant patients with or without renal impairment. Careful monitoring of cyclosporine concentrations and serum creatinine is recommended in patients receiving Fluconazole and cyclosporine. <br Cyclosporine AUC and Cmax were determined before and after the administration of Fluconazole 200 mg daily for 14 days in eight renal transplant patients who had been on cyclosporine therapy for at least 6 months and on a stable cyclosporine dose for at least 6 weeks. There was a significant increase in cyclosporine AUC, Cmax, Cmin (24-hour concentration), and a significant reduction in apparent oral clearance following the administration of Fluconazole. The mean ± SD increase in AUC was 92%± 43% (range: 18 to 147%). The Cmax increased 60%± 48% (range: −5 to 133%). The Cmin increased 157%± 96% (range: 33 to 360%). The apparent oral clearance decreased 45%± 15% (range: −15 to −60%).

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Rifampin
Rifampin enhances the metabolism of concurrently administered Fluconazole. Depending on clinical circumstances, consideration should be given to increasing the dose of Fluconazole when it is administered with rifampin. Administration of a single oral 200 mg dose of Fluconazole after 15 days of rifampin administered as 600 mg daily in eight healthy male volunteers resulted in a significant decrease in Fluconazole AUC and a significant increase in apparent oral clearance of Fluconazole. There was a mean ± SD reduction in Fluconazole AUC of 23%± 9%(range: −13 to −42%). Apparent oral clearance of Fluconazole increased 32%± 17% (range: 16 to 72%). Fluconazole half-life decreased from 33.4 ± 4.4 hours to 26.8 ± 3.9 hours.

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Theophylline
Fluconazole increases the serum concentrations of theophylline. Careful monitoring of serum theophylline concentrations in patients receiving Fluconazole and theophylline is recommended. The pharmacokinetics of theophylline were determined from a single intravenous dose of aminophylline (6 mg/kg) before and after the oral administration of Fluconazole 200 mg daily for 14 days in 16 normal male volunteers. There were significant increases in theophylline AUC, Cmax, and half-life with a corresponding decrease in clearance. The mean ± SD theophylline AUC increased 21%± 16% (range: −5 to 48%). The Cmax increased 13%± 17% (range: −13 to 40%). Theophylline clearance decreased 16%± 11% (range: −32 to 5%). The half-life of theophylline increased from 6.6 ± 1.7 hours to 7.9 ± 1.5 hours.

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Terfenadine
Because of the occurrence of serious cardiac dysrhythmias secondary to prolongation of the QTc interval in patients receiving azole antifungals in conjunction with terfenadine, interaction studies have been performed. One study at a 200-mg daily dose of Fluconazole failed to demonstrate a prolongation in QTc interval. Another study at a 400-mg and 800-mg daily dose of Fluconazole demonstrated that Fluconazole taken in doses of 400 mg per day or greater significantly increases plasma levels of terfenadine when taken concomitantly. The combined use of Fluconazole at doses of 400 mg or greater with terfenadine is contraindicated. The coadministration of Fluconazole at doses lower than 400 mg/day with terfenadine should be carefully monitored. Six healthy volunteers received terfenadine 60 mg BID for 15 days. Fluconazole 200 mg was administered daily from days 9 through 15. Fluconazole did not affect terfenadine plasma concentrations. Terfenadine acid metabolite AUC increased 36%± 36% (range: 7 to 102%) from day 8 to day 15 with the concomitant administration of Fluconazole. There was no change in cardiac repolarization as measured by Holter QTc intervals. Another study at a 400-mg and 800-mg daily dose of Fluconazole demonstrated that Fluconazole taken in doses of 400 mg per day or greater significantly increases plasma levels of terfenadine when taken concomitantly.

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Cisapride
There have been reports of cardiac events, including torsade de pointes in patients to whom Fluconazole and cisapride were coadministered. A controlled study found that concomitant Fluconazole 200 mg once daily and cisapride 20 mg four times a day yielded a significant increase in cisapride plasma levels and prolongation of QTc interval. The combined use of Fluconazole with cisapride is contraindicated. A placebo-controlled, randomized, multiple-dose study examined the potential interaction of Fluconazole with cisapride. Two groups of 10 normal subjects were administered Fluconazole 200 mg daily or placebo. Cisapride 20 mg four times daily was started after 7 days of Fluconazole or placebo dosing. Following a single dose of Fluconazole, there was a 101% increase in the cisapride AUC and a 91% increase in the cisapride Cmax. Following multiple doses of Fluconazole, there was a 192% increase in the cisapride AUC and a 154% increase in the cisapride Cmax. Fluconazole significantly increased the QTc interval in subjects receiving cisapride 20 mg four times daily for 5 days.

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Astemizole
The use of Fluconazole in patients concurrently taking astemizole or other drugs metabolized by the cytochrome P450 system may be associated with elevations in serum levels of these drugs. In the absence of definitive information, caution should be used when coadministering Fluconazole. Patients should be carefully monitored.

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Rifabutin
There have been reports of uveitis in patients to whom Fluconazole and rifabutin were coadministered. Patients receiving rifabutin and Fluconazole concomitantly should be carefully monitored. There have been published reports that an interaction exists when Fluconazole is administered concomitantly with rifabutin, leading to increased serum levels of rifabutin.

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Tacrolimus
There have been reports of nephrotoxicity in patients to whom Fluconazole and tacrolimus were coadministered. Patients receiving tacrolimus and Fluconazole concomitantly should be carefully monitored. There have been published reports that an interaction exists when Fluconazole is administered concomitantly with tacrolimus, leading to increased serum levels of tacrolimus.

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Short-acting benzodiazepines
Following oral administration of midazolam, Fluconazole resulted in substantial increases in midazolam concentrations and psychomotor effects. This effect on midazolam appears to be more pronounced following oral administration of Fluconazole than with Fluconazole administered intravenously. If short-acting benzodiazepines, which are metabolized by the cytochrome P450 system, are concomitantly administered with Fluconazole, consideration should be given to decreasing the benzodiazepine dosage, and the patients should be appropriately monitored. Fluconazole tablets coadministered with ethinyl estradiol- and levonorgestrel-containing oral contraceptives produced an overall mean increase in ethinyl estradiol and levonorgestrel levels; however, in some patients there were decreases up to 47% and 33% of ethinyl estradiol and levonorgestrel levels. The data presently available indicate that the decreases in some individual ethinyl estradiol and levonorgestrel AUC values with Fluconazole treatment are likely the result of random variation. While there is evidence that Fluconazole can inhibit the metabolism of ethinyl estradiol and levonorgestrel, there is no evidence that Fluconazole is a net inducer of ethinyl estradiol or levonorgestrel metabolism. The clinical significance of these effects is presently unknown. Physicians should be aware that interaction studies with medications other than those listed here have not been conducted, but such interactions may occur.

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Oral contraceptives
Oral contraceptives were administered as a single dose both before and after the oral administration of Fluconazole 50 mg once daily for 10 days in 10 healthy women. There was no significant difference in ethinyl estradiol or levonorgestrel AUC after the administration of 50 mg of Fluconazole. The mean increase in ethinyl estradiol AUC was 6% (range: −47 to 108%) and levonorgestrel AUC increased 17% (range: −33 to 141%). In a second study, twenty-five normal females received daily doses of both 200 mg Fluconazole tablets or placebo for two, ten-day periods. The treatment cycles were one month apart with all subjects receiving Fluconazole during one cycle and placebo during the other. The order of study treatment was random. Single doses of an oral contraceptive tablet containing levonorgestrel and ethinyl estradiol were administered on the final treatment day (day 10) of both cycles. Following administration of 200 mg of Fluconazole, the mean percentage increase of AUC for levonorgestrel compared to placebo was 25% (range: -12 to 82%) and the mean percentage increase for ethinyl estradiol compared to placebo was 38% (range: -11 to 101%). Both of these increases were statistically significantly different from placebo. A third study evaluated the potential interaction of once weekly dosing of Fluconazole 300 mg to 21 normal females taking an oral contraceptive containing ethinyl estradiol and norethindrone. In this placebo-controlled, double-blind, randomized, two-way crossover study carried out over three cycles of oral contraceptive treatment, Fluconazole dosing resulted in small increases in the mean AUCs of ethinyl estradiol and norethindrone compared to similar placebo dosing. The mean AUCs of ethinyl estradiol and norethindrone increased by 24% (95% C.I. range 18–31%) and 13% (95% C.I. range 8–18%), respectively relative to placebo. Fluconazole treatment did not cause a decrease in the ethinyl estradiol AUC of any individual subject in this study compared to placebo dosing. The individual AUC values of norethindrone decreased very slightly (<5%) in 3 of the 21 subjects after Fluconazole treatment.

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Cimetidine
Fluconazole 100 mg was administered as a single oral dose alone and two hours after a single dose of cimetidine 400 mg to six healthy male volunteers. After the administration of cimetidine, there was a significant decrease in Fluconazole AUC and Cmax. There was a mean±SD decrease in Fluconazole AUC of 13%± 11%(range: −3.4 to −31%) and Cmax decreased 19%± 14% (range: −5 to −40%). However, the administration of cimetidine 600 mg to 900 mg intravenously over a four-hour period (from one hour before to 3 hours after a single oral dose of Fluconazole 200 mg) did not affect the bioavailability or pharmacokinetics of Fluconazole in 24 healthy male volunteers.

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Antacid
Fluconazole 100 mg was administered as a single oral dose alone and two hours after a single dose of cimetidine 400 mg to six healthy male volunteers. After the administration of cimetidine, there was a significant decrease in Fluconazole AUC and Cmax. There was a mean±SD decrease in Fluconazole AUC of 13%± 11%(range: −3.4 to −31%) and Cmax decreased 19%± 14% (range: −5 to −40%). However, the administration of cimetidine 600 mg to 900 mg intravenously over a four-hour period (from one hour before to 3 hours after a single oral dose of Fluconazole 200 mg) did not affect the bioavailability or pharmacokinetics of Fluconazole in 24 healthy male volunteers.

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Hydrochlorothiazide
Concomitant oral administration of 100 mg Fluconazole and 50 mg hydrochlorothiazide for 10 days in 13 normal volunteers resulted in a significant increase in Fluconazole AUC and Cmax compared to Fluconazole given alone. There was a mean ± SD increase in Fluconazole AUC and Cmax of 45%± 31% (range: 19 to 114%) and 43%± 31% (range: 19 to 122%), respectively. These changes are attributed to a mean ± SD reduction in renal clearance of 30%± 12% (range: −10 to −50%).

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Warfarin
There was a significant increase in prothrombin time response (area under the prothrombin time-time curve) following a single dose of warfarin (15 mg) administered to 13 normal male volunteers following oral Fluconazole 200 mg administered daily for 14 days as compared to the administration of warfarin alone. There was a mean ± SD increase in the prothrombin time response (area under the prothrombin time-time curve) of 7%± 4% (range: −2 to 13%). Mean is based on data from 12 subjects as one of 13 subjects experienced a 2-fold increase in his prothrombin time response.

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Zidovudine
Plasma zidovudine concentrations were determined on two occasions (before and following Fluconazole 200 mg daily for 15 days) in 13 volunteers with AIDS or ARC who were on a stable zidovudine dose for at least two weeks. There was a significant increase in zidovudine AUC following the administration of Fluconazole. The mean ± SD increase in AUC was 20%± 32% (range: −27 to 104%). The metabolite, GZDV, to parent drug ratio significantly decreased after the administration of Fluconazole, from 7.6 ± 3.6 to 5.7 ± 2.2.

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Tolbutamide
Plasma zidovudine concentrations were determined on two occasions (before and following Fluconazole 200 mg daily for 15 days) in 13 volunteers with AIDS or ARC who were on a stable zidovudine dose for at least two weeks. There was a significant increase in zidovudine AUC following the administration of Fluconazole. The mean ± SD increase in AUC was 20%± 32% (range: −27 to 104%). The metabolite, GZDV, to parent drug ratio significantly decreased after the administration of Fluconazole, from 7.6 ± 3.6 to 5.7 ± 2.2.

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Glipizide
The AUC and Cmax of glipizide (2.5 mg single dose) were significantly increased following the administration of Fluconazole in 13 normal male volunteers. There was a mean ± SD increase in AUC of 49%± 13% (range: 27 to 73%) and an increase in Cmax of 19%± 23% (range: −11 to 79%).

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Glyburide
The AUC and Cmax of glyburide (5 mg single dose) were significantly increased following the administration of Fluconazole in 20 normal male volunteers. There was a mean ± SD increase in AUC of 44%± 29% (range: –13 to 115%) and Cmax increased 19%± 19% (range: −23 to 62%). Five subjects required oral glucose following the ingestion of glyburide after 7 days of Fluconazole administration.

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Midazolam
The effect of Fluconazole on the pharmacokinetics and pharmacodynamics of midazolam was examined in a randomized, crossover study in 12 volunteers. In the study, subjects ingested placebo or 400 mg Fluconazole on Day 1 followed by 200 mg daily from Day 2 to Day 6. In addition, a 7.5 mg dose of midazolam was orally ingested on the first day, 0.05 mg/kg was administered intravenously on the fourth day, and 7.5 mg orally on the sixth day. Fluconazole reduced the clearance of IV midazolam by 51%. On the first day of dosing, Fluconazole increased the midazolam AUC and Cmax by 259% and 150%, respectively. On the sixth day of dosing, Fluconazole increased the midazolam AUC and Cmax by 259% and 74%, respectively. The psychomotor effects of midazolam were significantly increased after oral administration of midazolam but not significantly affected following intravenous midazolam. A second randomized, double-dummy, placebo-controlled, cross-over study in three phases was performed to determine the effect of route of administration of Fluconazole on the interaction between Fluconazole and midazolam. In each phase the subjects were given oral Fluconazole 400 mg and intravenous saline; oral placebo and intravenous Fluconazole 400 mg; and oral placebo and IV saline. An oral dose of 7.5 mg of midazolam was ingested after Fluconazole/placebo. The AUC and Cmax of midazolam were significantly higher after oral than IV administration of Fluconazole. Oral Fluconazole increased the midazolam AUC and Cmax by 272% and 129%, respectively. IV Fluconazole increased the midazolam AUC and Cmax by 244% and 79%, respectively. Both oral and IV Fluconazole increased the pharmacodynamic effects of midazolam.

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Azithromycin
An open-label, randomized, three-way crossover study in 18 healthy subjects assessed the effect of a single 800 mg oral dose of Fluconazole on the pharmacokinetics of a single 1200 mg oral dose of azithromycin as well as the effects of azithromycin on the pharmacokinetics of Fluconazole. There was no significant pharmacokinetic interaction between Fluconazole and azithromycin.

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Major Interactions

 * Actiq
 * Alfenta
 * alfentanil
 * alprazolam
 * alprazolam extended release
 * Altocor
 * Altoprev
 * amiodarone
 * anisindione
 * atorvastatin
 * Baycol
 * Cardioquin
 * cerivastatin
 * Cholestin (obsolete)
 * cisapride
 * Cordarone
 * Cordarone I.V.
 * Coumadin
 * D.H.E. 45
 * dicumarol
 * dihydroergotamine
 * dihydroergotamine nasal
 * Duragesic
 * Duragesic-100
 * Duragesic-12
 * Duragesic-25
 * Duragesic-50
 * Duragesic-75
 * Ergomar
 * ergonovine
 * ergotamine
 * Ergotrate Maleate
 * fentanyl
 * fentanyl topical
 * Fentora
 * FK506
 * Halcion
 * Halfan
 * halofantrine
 * Ionsys
 * Jantoven
 * levomethadyl acetate
 * Lipitor
 * lovastatin
 * lovastatin extended release
 * Methergine
 * methylergonovine
 * methysergide maleate
 * Mevacor
 * midazolam
 * Migranal
 * Miradon
 * monascus
 * Niravam
 * Orap
 * Orlaam
 * Pacerone
 * pimozide
 * Prograf
 * Propulsid
 * Quin-G
 * Quin-Release
 * Quinaglute Dura-Tabs
 * Quinidex Extentabs
 * quinidine
 * quinidine extended release
 * Quinora
 * Ranexa
 * ranolazine
 * Rapamune
 * red yeast rice
 * Sansert
 * simvastatin
 * sirolimus
 * Sublimaze
 * tacrolimus
 * terfenadine
 * triazolam
 * Versed
 * warfarin
 * Xanax
 * Xanax XR
 * Zocor

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Moderate Interactions

 * A-Hydrocort
 * A-Methapred
 * Abilify
 * Abilify Discmelt
 * Abraxane
 * Acetocot
 * Acetohexamide
 * Actos
 * Adalat
 * Adalat CC
 * Adbeon
 * Adgyn Estro
 * Adlone-40
 * Adlone-80
 * Adrenocot
 * Adrenocot L.A.
 * Adriamycin
 * Adriamycin RDF
 * Aerodiol
 * Aerolate III
 * Aerolate JR
 * Aerolate SR
 * Afeditab CR
 * alfuzosin
 * alfuzosin extended release
 * aliskiren
 * Alora
 * Amaryl
 * ambrisentan
 * Amen
 * amitriptyline
 * amlodipine
 * Anafranil
 * Andro LA 200
 * Andro-Cyp 100
 * Andro-Cyp 200
 * Androderm
 * AndroGel
 * AndroGel 2.5 g/packet
 * AndroGel 5 g/packet
 * AndroGel Pump 1.25 g/actuation
 * Anestacaine
 * aprepitant
 * Aptivus
 * Aquaphyllin
 * Aquest
 * Arava
 * aripiprazole
 * Aristocort
 * Aristocort For Injection
 * Aristocort Forte
 * Aristopak
 * Aristospan Injection
 * Asmalix
 * astemizole
 * atazanavir
 * Avandia
 * Aventyl HCl
 * Avodart
 * Avonex
 * Avonex Prefilled Syringe
 * Aygestin
 * Azmacort
 * AZT
 * Bedol
 * bepridil
 * Beta-Phos/AC
 * betamethasone
 * betamethasone acet-betamethasone na phosphate
 * betamethasone sodium phosphate
 * Betaseron
 * bexarotene
 * Bextra
 * bortezomib
 * bosentan
 * bromocriptine
 * Bronkodyl
 * Bubbli-Pred
 * budesonide
 * Buprenex
 * buprenorphine
 * BuSpar
 * BuSpar Dividose
 * busPIRone
 * Calan
 * Calan SR
 * Camila
 * carbamazepine
 * carbamazepine extended release
 * Carbatrol
 * Cardene
 * Cardene IV
 * Cardene SR
 * Cardizem
 * Cardizem CD
 * Cardizem LA
 * Cardizem Monovial
 * Cardizem SR
 * Cartia XT
 * Celebrex
 * celecoxib
 * Celestone
 * Celestone Phosphate
 * Celestone Soluspan
 * Celexa
 * Cell-U-Jec
 * Cenestin
 * Cerebyx
 * cevimeline
 * chlorotrianisene
 * Chlorpropamide
 * Cialis
 * cilostazol
 * citalopram
 * Climara
 * Climaval
 * Climodien
 * Clinacort
 * Clinagen LA 40
 * Clinalog
 * clofarabine
 * Clolar
 * Clomipramine
 * cocaine topical
 * Colocort
 * conjugated estrogens
 * conjugated estrogens synthetic A
 * conjugated estrogens synthetic B
 * conjugated estrogens topical
 * Cort-K
 * Cortastat
 * Cortastat 10
 * Cortastat LA
 * Cortef
 * Cortenema
 * Cortifoam
 * cortisone
 * Cortone Acetate
 * Cotolone
 * Covera-HS
 * Cozaar
 * Crinone
 * Curretab
 * Cyclogest
 * Cyclosporine
 * Cycrin
 * Dalalone
 * Dalalone D.P.
 * Dalalone L.A.
 * darifenacin
 * dasatinib
 * De-Sone LA
 * Decadron
 * Decadron 5-12 Pak
 * Decadron Phosphate Injectable
 * Decadron-LA
 * Decaject
 * Decaject L.A.
 * Delatest
 * Delatestryl
 * delavirdine
 * Delestrogen
 * Delidose
 * Delta-Lutin
 * Deltasone
 * Dep Gynogen
 * Dep Medalone 80
 * Depandro 100
 * Depmedalone
 * Depo-Estradiol
 * Depo-Medrol
 * Depo-Predate (obsolete)
 * Depo-Provera
 * Depo-Provera Contraceptive
 * depo-subQ provera 104
 * Depo-Testosterone
 * Depogen
 * Depoject-80
 * Depopred
 * Depotest
 * Dermestril
 * Dermestril - Septem
 * Dermestril Septem
 * desipramine
 * desogestrel
 * Detrol
 * Detrol LA
 * Dexacen-4
 * Dexacort Phosphate in Respihaler
 * Dexacort-LA
 * Dexacorten
 * dexamethasone
 * dexamethasone acetate
 * Dexamethasone Intensol
 * dexamethasone sodium phosphate
 * Dexasone
 * Dexasone LA
 * Dexone
 * Dexone LA
 * Dexpak Jr. Taperpak
 * Dexpak Taperpak
 * Di-Phen
 * DiaBeta
 * Diabinese
 * dienestrol topical
 * diethylstilbestrol
 * Dilacor XR
 * Dilantin
 * Dilantin Infatabs
 * Dilantin Kapseals
 * Dilantin-125
 * Dilocaine
 * Diltia XT
 * diltiazem
 * diltiazem 24 hour extended release
 * diltiazem extended release
 * Diltiazem Hydrochloride CD
 * Diltiazem Hydrochloride SR
 * Diltiazem Hydrochloride XR
 * Diltiazem Hydrochloride XT
 * Dioval 40
 * Dioval XX
 * Diskets
 * disopyramide
 * disopyramide extended release
 * Divigel 0.25 mg/packet
 * Divigel 0.5 mg/packet
 * Divigel 1 mg/packet
 * docetaxel
 * dofetilide
 * Dolophine
 * Doxil
 * doxorubicin
 * doxorubicin liposomal
 * drospirenone
 * Dura-Estrin
 * Duragen
 * Duralone
 * Duralutin
 * Duratest
 * Durathate 200
 * dutasteride
 * Dymelor
 * Dynacirc
 * Dynacirc CR
 * E-Mycin
 * E.E.S. Granules
 * E.E.S.-200
 * E.E.S.-400
 * E.E.S.-400 Filmtab
 * Echinacea
 * Elavil
 * Elestrin
 * Eletriptan
 * Elixophyllin
 * Elleste Solo
 * Emend
 * Emend 3-Day
 * Emend for Injection
 * Enablex
 * Endep
 * Endometrin
 * Enjuvia
 * Entocort
 * Entocort EC
 * Epitol
 * Eplerenone
 * Equetro
 * Errin
 * Ery-Tab
 * Eryc
 * EryPed
 * EryPed 200
 * EryPed 400
 * Erythrocin Lactobionate
 * Erythrocin Stearate Filmtab
 * Erythrocot
 * Erythromycin
 * erythromycin base
 * erythromycin estolate
 * erythromycin ethylsuccinate
 * erythromycin lactobionate
 * erythromycin stearate
 * Esclim
 * esterified estrogens
 * Estinyl
 * Estra-C
 * Estra-V 40
 * Estrace
 * Estrace Vaginal Cream
 * Estraderm
 * Estraderm MX
 * Estraderm TTS
 * Estradiol
 * estradiol acetate
 * estradiol benzoate
 * estradiol cypionate
 * Estradiol G Gam
 * Estradiol Patch
 * estradiol topical
 * estradiol valerate
 * Estradot
 * Estradot 100
 * Estradot 37.5
 * Estradot 50
 * Estradot 75
 * Estragyn 5
 * Estragyn LA 5
 * Estrapatch
 * Estrasorb
 * Estreva
 * Estring
 * Estro-A
 * Estro-Cyp
 * Estro-L.A.
 * Estro-Span 40
 * Estrofem
 * Estrogel
 * estrone
 * Estrone AQ
 * estropipate
 * estropipate topical
 * ethinyl estradiol
 * ethosuximide
 * ethotoin
 * ethynodiol
 * etonogestrel
 * Etopophos
 * etoposide
 * etoposide phosphate
 * etravirine
 * Evamist
 * Everone
 * Evorel
 * Evoxac
 * Fareston
 * felodipine
 * felodipine extended release
 * Fematrix
 * Fempatch
 * Femring
 * Femsept
 * FemSeven
 * FemSeven Sequi Phase I
 * FemTab
 * Femtrace
 * Femtran
 * finasteride
 * First Progesterone MC10
 * First Progesterone MC5
 * First Testosterone
 * First-Progesterone VGS 100
 * First-Progesterone VGS 200
 * First-Progesterone VGS 25
 * First-Progesterone VGS 400
 * First-Progesterone VGS 50
 * First-Testosterone
 * First-Testosterone MC
 * Flo-Pred
 * Florinef Acetate
 * fludrocortisone
 * fluvastatin
 * fluvastatin extended release
 * Folex PFS
 * Fosaprepitant
 * Fosphenytoin
 * Furadantin
 * Gabitril
 * galantamine
 * galantamine extended release
 * gefitinib
 * Gengraf
 * Gestone
 * Gleevec
 * glimepiride
 * glipizide
 * glipizide extended release
 * Glipizide XL
 * Glucotrol
 * Glucotrol XL
 * glyburide
 * glyburide micronized
 * Glynase PresTab
 * granisetron
 * Granisol
 * Gynodiol
 * Gynogen LA 20
 * Haldol
 * Haldol Decanoate
 * haloperidol
 * haloperidol decanoate
 * Hexadrol
 * Hexadrol Phosphate
 * Hismanal
 * Histerone
 * Hydeltra-T.B.A.
 * Hydeltrasol
 * hydrocortisone
 * hydrocortisone acetate
 * hydrocortisone cypionate
 * hydrocortisone hemisuccinate
 * hydrocortisone sodium phosphate
 * Hydrocortisone Sodium Succinate
 * Hydrocortone
 * Hydrocortone Phosphate
 * hydroxyprogesterone
 * Hylutin
 * Hyprogesterone
 * Ifex
 * ifosfamide
 * Ilosone
 * Ilotycin Gluceptate
 * imatinib
 * imipramine
 * imipramine pamoate
 * Implanon
 * Inspra
 * Intelence
 * interferon beta-1a
 * interferon beta-1b
 * Iressa
 * Isoptin
 * Isoptin I.V.
 * Isoptin SR
 * isradipine
 * isradipine extended release
 * ixabepilone
 * Ixempra
 * Jolivette
 * Ken-Jec 40
 * Kenaject-40
 * Kenalog-10
 * Kenalog-40
 * Kestrone 5
 * Key-Pred
 * Key-Pred SP
 * Kytril
 * L-Caine
 * lapatinib
 * leflunomide
 * Lescol
 * Lescol XL
 * Letairis
 * Levaquin
 * Levaquin Leva-Pak
 * Levitra
 * levofloxacin
 * levonorgestrel
 * lidocaine
 * Lidoject 1
 * Lidoject 2
 * Liquid Pred
 * losartan
 * M-Prednisolone
 * Macrobid
 * Macrodantin
 * maraviroc
 * Med-Jec-40
 * Medicort
 * Medidex
 * Medidex LA
 * Medidiol 10
 * Medipred
 * Meditest
 * Medralone
 * Medralone 40
 * Medralone 80
 * Medrol
 * Medrol Dosepak
 * Medroxyprogesterone
 * Menaval-20
 * Menest
 * Menopause Formula Progesterone
 * Menorest
 * Menorest Patch
 * Menostar
 * mephenytoin
 * Mesantoin
 * mestranol
 * Methacort 40
 * Methacort 80
 * methadone
 * Methadose
 * methotrexate
 * Methotrexate Sodium Preservative Free
 * Methylcotol
 * Methylcotolone
 * Methylpred DP
 * methylprednisolone
 * methylprednisolone acetate
 * methylprednisolone dose pack
 * methylprednisolone sodium succinate
 * Meticorten
 * Mibefradil
 * Miconazole
 * Micronase
 * Millipred
 * Mirena
 * Monistat I.V.
 * MY-E
 * Mycobutin
 * Naltrexone
 * Nateglinide
 * Navelbine
 * Nefazodone
 * Nelfinavir
 * Neoral
 * Nervocaine
 * Nevirapine
 * Nicardipine
 * nicardipine extended release
 * Nifediac CC
 * Nifedical XL
 * Nifedipine
 * nifedipine extended release
 * Nilotinib
 * Nimodipine
 * Nimotop
 * nisoldipine
 * Nitro Macro
 * nitrofurantoin
 * nitrofurantoin dual release
 * nitrofurantoin macrocrystals
 * nitrofurantoin regular release
 * Nor-QD
 * Nora-Be
 * Norelgestromin
 * Norethindrone
 * norethindrone acetate
 * norethindrone topical
 * Norgestimate
 * Norgestrel
 * Norpace
 * Norpace CR
 * Norplant System
 * Norpramin
 * nortriptyline
 * Norvasc
 * Nuvelle TS Phase I
 * Oesclim
 * Oestradiol
 * Oestradiol Implants
 * Oestrodose
 * Oestrogel
 * Oestrogel Pump-Pack
 * Ogen 0.625
 * Ogen 1.25
 * Ogen 2.5
 * Ogen Vaginal Cream
 * Oncovin
 * Onxol
 * Orapred
 * Orapred ODT
 * Orasone
 * Organon Oestradiol
 * Orinase
 * Orion Progesterone
 * Oromone
 * Ortho Dienestrol
 * Ortho Micronor
 * Ortho-Est
 * Ovrette
 * paclitaxel
 * paclitaxel protein-bound
 * Pamelor
 * Parlodel
 * PCE Dispertab
 * Pediapred
 * Peganone
 * Phenytek
 * phenytoin
 * phenytoin extended release
 * Phenytoin Sodium
 * Prompt
 * Pioglitazone
 * Plan B
 * Plendil
 * Pletal
 * Posicor
 * Prandin
 * Pred-Ject-50
 * Predacort 50
 * Predacorten
 * Predaject-50
 * Predalone 50
 * Predate-50
 * Predcor
 * Predicort RP
 * Predicort-50
 * Prednicen-M
 * Prednicot
 * prednisolone
 * prednisolone acetate
 * prednisolone sodium phosphate
 * prednisolone tebutate
 * prednisone
 * Prelone
 * Premarin
 * Premarin Intravenous
 * Premarin Vaginal
 * Pri-Cortin 50
 * Primethasone
 * Primogyn Depot
 * Procardia
 * Procardia XL
 * Prochieve
 * Prodrox
 * Progest
 * Progestasert System
 * progesterone
 * progesterone topical
 * Progynova
 * Progynova TS
 * Prometrium
 * Propecia
 * Proscar
 * Provames
 * Provera
 * Pulmicort Flexhaler
 * Pulmicort Nebuamp
 * Pulmicort Respules
 * Pulmicort Turbuhaler
 * QM-260
 * Qualaquin
 * quetiapine
 * quetiapine extended release
 * Quibron-T
 * Quibron-T/SR
 * quinestrol
 * quinine
 * ramelteon
 * Razadyne
 * Razadyne ER
 * Rebif
 * Relpax
 * Reminyl
 * repaglinide
 * Rescriptor
 * Respbid
 * Retrovir
 * Revatio
 * ReVia
 * Reyataz
 * Rezulin
 * Rheumatrex Dose Pack
 * rifabutin
 * Rifadin
 * Rifadin IV
 * rifampin
 * Rimactane
 * Robimycin
 * rosiglitazone
 * Rozerem
 * Sandimmune
 * Sandrena
 * Selestoject
 * Selzentry
 * Seroquel
 * Seroquel XR
 * Serzone
 * sildenafil
 * Slo-Bid Gyrocaps
 * Slo-Phyllin
 * Slo-Phyllin 125
 * Slo-Phyllin 80
 * solifenacin
 * Solu-Cortef
 * Solu-Medrol
 * Solurex
 * Solurex LA
 * Sprycel
 * Starlix
 * Sterapred
 * Sterapred DS
 * Stilphostrol
 * Striant
 * Subutex
 * Sufenta
 * Sufentanil
 * Sular
 * Surmontil
 * Systen
 * T-Phyl
 * TAC 3
 * Tace
 * tadalafil
 * Tao
 * Targretin
 * Tasigna
 * Taxol
 * Taxotere
 * Taztia XT
 * Tegretol
 * Tegretol XR
 * Tekturna
 * temsirolimus
 * Testamone-100
 * Testim
 * Testim 5 g/packet
 * Testoderm
 * Testolin
 * Testopel Pellets
 * testosterone
 * Testosterone Cypionate
 * Testosterone Enanthate
 * testosterone propionate
 * testosterone topical
 * Testro
 * Testro AQ
 * Testro-L.A.
 * Thais
 * Thaissept
 * Theo-24
 * Theo-Dur
 * Theo-Dur Sprinkles
 * Theo-Time
 * Theo-X
 * Theobid
 * TheoCap
 * Theochron
 * Theoclear L.A.-130
 * Theoclear L.A.-260
 * Theoclear-80
 * Theolair
 * Theolair-SR
 * theophylline
 * theophylline 24 hr extended release
 * theophylline extended release
 * Theovent
 * Thioguanine
 * Tiagabine
 * Tiazac
 * Tikosyn
 * tipranavir
 * Tofranil
 * Tofranil-PM
 * Tol-Tab
 * Tolazamide
 * Tolbutamide
 * Tolinase
 * Tolterodine
 * tolterodine extended release
 * Toposar
 * Toremifene
 * Torisel
 * Tracleer
 * Tramacort-D
 * Trexall
 * Triam-A
 * Triam-Forte
 * triamcinolone
 * triamcinolone acetonide
 * triamcinolone diacetate
 * triamcinolone hexacetonide
 * Triamcot
 * Triamonide 40
 * Trilog
 * Trilone
 * Trimipramine
 * Tristoject
 * Troglitazone
 * Troleandomycin
 * Truxacaine
 * Truxophyllin
 * Tykerb
 * U-Tri-Lone
 * UAD Caine
 * Uni-Dur
 * Uniphyl
 * Uroxatral
 * Vagifem
 * valdecoxib
 * Valergen
 * Vanatrip
 * vardenafil
 * Vascor
 * Velban
 * Velcade
 * VePesid
 * verapamil
 * verapamil 24 hour extended release
 * verapamil extended release
 * Verelan
 * Verelan PM
 * Vesicare
 * Viagra
 * Vinblastine
 * Vincasar PFS
 * Vincristine
 * vinorelbine
 * Viracept
 * Viramune
 * Virilon IM
 * Vivelle
 * Vivelle-Dot
 * Vivelledot
 * Vivitrol
 * Xylocaine Dental Cartridges
 * Xylocaine Duo-Trach Kit
 * Xylocaine HCl
 * Xylocaine HCl For Spinal
 * Xylocaine-MPF
 * Zarontin
 * zidovudine
 * Zonegran
 * zonisamide
 * Zumenon

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Minor Interactions

 * Abelcet
 * Agenerase
 * Alavert
 * Allegra
 * Allegra ODT
 * Altabax
 * Ambien
 * Ambien CR
 * AmBisome
 * Amphocin
 * Amphotec
 * amphotericin B
 * amphotericin B cholesteryl sulfate
 * amphotericin B lipid complex
 * amphotericin B liposomal
 * amprenavir
 * Aricept
 * Aricept ODT
 * armodafinil
 * Avapro
 * Basic Vitamins Brewers Yeast
 * Biaxin
 * Biaxin XL
 * Biaxin XL-Pak
 * brewer's yeast
 * clarithromycin
 * clarithromycin extended release
 * Claritin
 * Claritin 24 Hour Allergy
 * Claritin Hives Relief
 * Claritin Reditab
 * Clear-Atadine
 * Clear-Atadine Children's
 * Crestor
 * Crixivan
 * Dimetapp ND
 * donepezil
 * Elidel
 * fexofenadine
 * Fortovase
 * Fungizone
 * Fungizone For Tissue Culture
 * Geodon
 * indinavir
 * Invirase
 * irbesartan
 * lopinavir
 * loratadine
 * Loratadine Reditab
 * Major Brewers Yeast
 * Marlex Brewers Yeast
 * Mason Vitamins Brewers Yeast
 * meloxicam
 * Meridia
 * Mifeprex
 * mifepristone
 * Mobic
 * modafinil
 * montelukast
 * Naropin
 * Naropin Novaplus
 * Naropin Polyamp
 * Naropin SDV
 * Natures Bounty Brewers Yeast
 * Natures Naturals Brewers Yeast
 * NeuTrexin
 * Norvir
 * Norvir Soft Gelatin
 * Nuvigil
 * pimecrolimus topical
 * Provigil
 * retapamulin topical
 * ritonavir
 * ropivacaine
 * rosuvastatin
 * RU-486
 * saquinavir
 * saquinavir mesylate
 * sibutramine
 * Singulair
 * Tavist ND
 * trimetrexate
 * Wal-itin
 * ziprasidone
 * zolpidem
 * zolpidem extended release

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