Malyl-CoA lyase

In enzymology, a malyl-CoA lyase is an enzyme that catalyzes the chemical reaction


 * (3S)-3-carboxy-3-hydroxypropanoyl-CoA $$\rightleftharpoons$$ acetyl-CoA + glyoxylate

Hence, this enzyme has one substrate, (3S)-3-carboxy-3-hydroxypropanoyl-CoA, and two products, acetyl-CoA and glyoxylate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming). Other names in common use include malyl-coenzyme A lyase, and (3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase. This enzyme participates in glyoxylate and dicarboxylate metabolism.