Danaparoid

Danaparoid sodium (Orgaran®) is an anticoagulant that works by inhibiting activated factor X (factor Xa).

Danaparoid is considered a "low molecular weight heparin" by some sources, but is chemically distinct from heparin and thus has little cross-reactivity in heparin-intolerant patients.

Uses
It is used to prevent deep venous clots, particularly in situations with a high risk of clot formation, such as after hip surgery.

It is also used as a heparinoid substitute in heparin-induced thrombocytopenia which may otherwise cause paradoxical thrombosis.

Discontinuation
On August 14, 2002, this drug was withdrawn by Organon International.

Administration
IV IV and SC

Side effects

 * Bleeding problems
 * Low platelets, due to a low level of structural similarity between danaparoid and heparin
 * Asthma exacerbations, due to allergies to sulphites contained within the medicine