Paget's disease of the breast pathophysiology

Overview
Paget's disease of the breast, also known as Paget's disease of the nipple, is a condition that outwardly may have the appearance of eczema - with skin changes involving the nipple of the breast. Because of its seemingly innocuous and surface appearance, it often presents late, but it is a condition that may be fatal.

Extramammary Paget's disease (EMPD) has the same histologic features as Paget's disease of the breast but different locations.

Pathophysiology
Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology