Adenosylhomocysteine nucleosidase

In enzymology, an adenosylhomocysteine nucleosidase is an enzyme that catalyzes the chemical reaction


 * S-adenosyl-L-homocysteine + H2O $$\rightleftharpoons$$ S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Thus, the two substrates of this enzyme are S-adenosyl-L-homocysteine and H2O, whereas its two products are S-(5-deoxy-D-ribos-5-yl)-L-homocysteine and adenine.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is S-adenosyl-L-homocysteine homocysteinylribohydrolase. Other names in common use include S-adenosylhomocysteine hydrolase (ambiguous), S-adenosylhomocysteine nucleosidase, 5'-methyladenosine nucleosidase, S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase, and AdoHcy/MTA nucleosidase. This enzyme participates in methionine metabolism.

Structural studies
As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , and.