Gemfibrozil drug interactions

List of drug interactions
HMG-CoA reductase inhibitors Anticoagulants

HMG-CoA reductase inhibitors
The risk of myopathy and rhabdomyolysis is increased with combined gemfibrozil and HMG-CoA reductase inhibitor therapy. Myopathy or rhabdomyolysis with or without acute renal failure have been reported as early as three weeks after initiation of combined therapy or after several months (refs. 8, 9, 10, 11). There is no assurance that periodic monitoring of creatine kinase will prevent the occurrence of severe myopathy and kidney damage. Return to top

Anticoagulants
CAUTION SHOULD BE EXERCISED WHEN ANTI-COAGULANTS ARE GIVEN IN CONJUNCTION WITH LOPID. THE DOSAGE OF THE ANTICOAGULANT SHOULD BE REDUCED TO MAINTAIN THE PROTHROMBIN TIME AT THE DESIRED LEVEL TO PREVENT BLEEDING COMPLICATIONS. FREQUENT PROTHROMBIN DETERMINATIONS ARE ADVISABLE UNTIL IT HAS BEEN DEFINITELY DETERMINED THAT THE PROTHROMBIN LEVEL HAS STABILIZED. Return to top

Major Interactions
Altocor, Altoprev, anisindione, atorvastatin, Baycol, cerivastatin, Cholestin (obsolete), Coumadin, Crestor, dicumarol, fluvastatin, fluvastatin extended release, Jantoven, Lescol, Lescol XL, Lipitor, lovastatin, lovastatin extended release, Mevacor, Miradon, monascus, Prandin, Pravachol, pravastatin, red yeast rice, repaglinide, rosuvastatin, simvastatin, warfarin, Zocor

Moderate Interactions
Abraxane, acetoHEXAMIDE, Actos, Amaryl, Apidra, Apidra OptiClik Cartridge, Avandia, AZT, bexarotene, Celebrex, celecoxib, chlorproPAMIDE, colchicine, Colestid, Colestid Flavored, colestipol, Cubicin, cycloSPORINE, daptomycin, DiaBeta, Diabinese, Dymelor, etravirine, EXUBERA, EXUBERA Combination Pack 12, EXUBERA Combination Pack 15, EXUBERA Kit, ezetimibe, Gengraf, glimepiride, glipiZIDE, glipiZIDE extended release, GlipiZIDE XL, Glucotrol, Glucotrol XL, glyBURIDE, glyBURIDE micronized, Glynase PresTab, Humalog, Humalog Cartridge, Humalog KwikPen, Humalog Pen, Humulin L, Humulin N, Humulin N Pen, Humulin R, Humulin R (Concentrated), Humulin U, Iletin II Lente Pork, Iletin II NPH Pork, Iletin II Regular Pork, Iletin Lente, Iletin NPH, Iletin Regular, insulin, insulin analog, insulin aspart, insulin aspart protamine, insulin detemir, insulin glargine, insulin glulisine, insulin inhalation, rapid acting, insulin isophane, Insulin Lente Pork, insulin lispro, insulin lispro protamine, Insulin Purified NPH Pork, Insulin Purified Regular Pork, insulin regular, insulin zinc, insulin zinc extended, insulin, lente, insulin, NPH, insulin, ultralente, Intelence, Lantus, Lantus OptiClik Cartridge, Lantus Solostar Pen, Lente insulin, Levemir, Levemir FlexPen, Levemir InnoLet, Levemir PenFill, Levitra, Micronase, nateglinide, Neoral, Novolin L, Novolin N, Novolin N Innolet, Novolin N PenFill, Novolin R, Novolin R Innolet, Novolin R PenFill, NovoLog, NovoLog FlexPen, NovoLog PenFill, NPH insulin, Onxol, Orinase, paclitaxel, paclitaxel protein-bound, pioglitazone, protamine zinc insulin, ramelteon, Rapamune, regular insulin, ReliOn/Novolin N, ReliOn/Novolin R, Retrovir, rosiglitazone, Rozerem, Sandimmune, sirolimus, Starlix, Targretin, Taxol, telbivudine, temsirolimus, Tol-Tab, TOLAZamide, TOLBUTamide, Tolinase, Torisel, Tyzeka, Ultralente insulin, vardenafil, Velosulin BR, Zetia, zidovudine