Langerhans cell histiocytosis epidemiology and demographics

Epidemiology
LCH histiocytosis usually affects children of between 1 and 15 years old and peak incidence is between age 5 and 10. Among children under the age of 10, yearly incidence is thought to be 1 in 200,000 ; and in adults even more rare, in about 1 in 560,000. It has been reported in elderly but is vanishingly rare. commoner in white race and boys are effected twice as often as girls.

LCH is usually sporadic and non-hereditary condition but familial clustering has been noted in limited number of cases. Hashimoto-Pritzker disease, a variant of Hand-Schüller-Christian disease, is a congenital self-healing form.