Nitrofurantoin drug interactions

List of drug interactions
Antacids Uricosuric drugs Magnesium salts Anticholinergic drugs and food

Antacids
Antacids containing magnesium trisilicate, when administered concomitantly with Nitrofurantoin, reduce both the rate and extent of absorption. The mechanism for this interaction probably is adsorption of Nitrofurantoin onto the surface of magnesium trisilicate. Return to top

Uricosuric drugs
Uricosuric drugs, such as probenecid and sulfinpyrazone, can inhibit renal tubular secretion of Nitrofurantoin. The resulting increase in Nitrofurantoin serum levels may increase toxicity, and the decreased urinary levels could lessen its efficacy as a urinary tract antibacterial. Return to top

Magnesium salts
May reduce anti-infective action by decreasing absorption. Return to top

Anticholinergic drugs and food
Increased absorption of Nitrofurantoin. Return to top