Citrate (pro-3S)-lyase

In enzymology, a citrate (pro-3S)-lyase is an enzyme that catalyzes the chemical reaction


 * citrate $$\rightleftharpoons$$ acetate + oxaloacetate

Hence, this enzyme has one substrate, citrate, and two products, acetate and oxaloacetate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is citrate oxaloacetate-lyase (forming acetate from the pro-S carboxymethyl group of citrate). Other names in common use include citrase, citratase, citritase, citridesmolase, citrate aldolase, citric aldolase, citrate lyase, citrate oxaloacetate-lyase, and citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]. This enzyme participates in citrate cycle (tca cycle) and two-component system - general.

Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes, , , and.