FOLFOX

Overview
FOLFOX is a chemotherapy regimen for treatment of colorectal cancer, made up of the drugs
 * FOL– Folinic acid (leucovorin)
 * F – Fluorouracil (5-FU)
 * OX – Oxaliplatin (Eloxatin)

FOLFOX4
Adjuvant treatment in patients with stage III colon cancer is recommended for 12 cycles, every 2 weeks. The recommended dose schedule given every two weeks is as follows:

Day 1: Eloxatin® 85 mg/m² IV infusion in 250-500 mL D5W and leucovorin 200 mg/m² IV infusion in D5W both given over 120 minutes at the same time in separate bags using a Y-line, followed by 5-FU 400 mg/m² IV bolus given over 2-4 minutes, followed by 5-FU 600 mg/m² IV infusion in 500 mL D5W (recommended) as a 22-hour continuous infusion.

Day 2: Leucovorin 200 mg/m² IV infusion over 120 minutes, followed by 5-FU 400 mg/m² IV bolus given over 2-4 minutes, followed by 5-FU 600 mg/m² IV infusion in 500 mL D5W (recommended) as a 22-hour continuous infusion.



Premedication with antiemetics, including 5-HT3 blockers with or without dexamethasone, is recommended.