Pseudohypoparathyroidism

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Overview
Pseudohypoparathyroidism is a condition caused by resistance to the parathyroid hormone. Patients have a low serum calcium and high phosphate, but the parathyroid hormone level is appropriately high.
 * Type 1a pseudohypoparathyroidism has a characteristic phenotypic appearance (Albright's hereditary osteodystrophy), including short fourth and fifth metacarpals and a rounded facies.
 * Type 1b pseudohypoparathyroidism lacks the physical appearance of type 1a, but is biochemically similar.

The term pseudopseudohypoparathyroidism is used to describe a condition where the individual has the phenotypic appearance of pseudohypoparathyroidism type 1a, but is biochemically normal.

Physical Examination

 * Short stature
 * Obesity

Laboratory Findings

 * Hypocalcemia
 * Hyperphosphatemia
 * Elevated parathyroid hormone (hyperparathyroidism)

Types

 * - Type 1A (closely associated with Albright's hereditary osteodystrophy)
 * - Type 1B
 * - Type 2