Shikimate dehydrogenase

In enzymology, a shikimate dehydrogenase is an enzyme that catalyzes the chemical reaction


 * shikimate + NADP+ $$\rightleftharpoons$$ 3-dehydroshikimate + NADPH + H+

Thus, the two substrates of this enzyme are shikimate and NADP+, whereas its 3 products are 3-dehydroshikimate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is shikimate:NADP+ 3-oxidoreductase. Other names in common use include dehydroshikimic reductase, shikimate oxidoreductase, shikimate:NADP+ oxidoreductase, 5-dehydroshikimate reductase, shikimate 5-dehydrogenase, 5-dehydroshikimic reductase, DHS reductase, shikimate:NADP+ 5-oxidoreductase, and AroE. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis.

Structural studies
As of late 2007, 16 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , , , , , , , and.