Ethylphenidate

Ethylphenidate is a stimulant drug. It is formed inside the body when alcohol is consumed alongside the ADHD medication methylphenidate, by transesterification in the liver. Ethylphenidate formation appears to be more common when large quantities of methylphenidate and alcohol are consumed at the same time, such as in abuse or overdose scenarios. This process is also known to occur when cocaine and alcohol are consumed together, forming cocaethylene.

Ethylphenidate is a more selective dopamine reuptake inhibitor than methylphenidate, having around the same potency as a dopamine reuptake inhibitor compared to the parent compound, but significantly less activity as a noradrenaline reuptake inhibitor.