The Living Guidelines: Antiplatelet Agents/Anticoagulants: Warfarin Suggest Revisions to the CLASS I Guidelines

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Class I Guidelines

 * 1) Managing warfarin to an INR equal to 2.0 to 3.0 for paroxysmal or chronic atrial fibrillation or flutter is recommended, and in post-MI patients when clinically indicated (e.g., atrial fibrillation, left ventricular thrombus). (Class I Level of Evidence: A)
 * 2) Use of warfarin in conjunction with aspirin and/or clopidogrel is associated with an increased risk of bleeding and should be monitored closely. (Class I Level of Evidence: B)
 * 3) In patients requiring warfarin, clopidogrel, and aspirin therapy after PCI, an INR of 2.0 to 2.5 is recommended with low dose aspirin (75 mg to 81 mg) and a 75-mg dose of clopidogrel. (Class I Level of Evidence: C)