Tuber cinereum

Overview
The tuber cinereum is a hollow eminence of gray matter situated between the mammilary bodies, behind, and the optic chiasma, in front. The tuber cinereum is part of the hypothalamus.

Structure
Laterally it is continuous with the anterior perforated substances and anteriorly with a thin lamina, the lamina terminalis.

The infundibulum, a hollow conical process, projects from the tuber cinereum. The infundibulum extends forward and down where it is attached to the posterior lobe of the pituitary gland.

It houses the nuclei:
 * tuberal nucleus
 * tuberomamillary nucleus

Tuberomamillary nucleus
The tuberomammillary nucleus (TMN) is the sole source of histamine in the brain.

Circadian rhythm
By its release of histamine, the tuberomamillary nucleus of the tuber cinereum regulates the circadian cycle.