Melanocortin receptor

Melanocortin receptors are members of the rhodopsin family of 7-transmembrane, G-protein coupled receptors.

There are five members of the melanocortin receptor system each with differing specificities for melanocortins:

These receptors are inhibited by endogenous antagonists agouti signaling protein and agouti-related protein and activated by endogenous agonist melanocyte-stimulating hormone.
 * . Mc1r is associated with pigmentation genetics.
 * . It is also known as the ACTH receptor or corticotropin receptor because it is specific for ACTH alone.
 * . Defects in MC4R are a cause of autosomal dominant obesity, accounting for 6% of all cases of early-onset obesity.
 * . Defects in MC4R are a cause of autosomal dominant obesity, accounting for 6% of all cases of early-onset obesity.