Fetomaternal alloimmune thrombocytopenia

Overview
In fetomaternal alloimmune thrombocytopenia (also known as Neonatal Alloimmune Thrombocytopenia or NAIT) maternal IgG antibodies (specific for platelet antigens) pass through the placenta and attack platelets in the fetal circulation. This results in the fetus having low numbers of platelets and a tendency for the fetus or neonate to bruise and bleed. Medical treatment is problematic.