Adenine phosphoribosyltransferase

Adenine phosphoribosyltransferase (or APRTase) is an enzyme involved in the purine nucleotide salvage pathway. It functions as a catalyst in the reaction between adenine and phosphoribosyl pyrophosphate (PRPP) to form AMP. APRTase is labeled as.

APRT is functionally related to hypoxanthine-guanine phosphoribosyltransferase (HPRT).

Pathology
Deficiency of APRT in human beings may lead to kidney stones formed of adenine and salts.

2,8 dihydroxy-adenine urolithiasis is also known as "adenine phosphoribosyltransferase deficiency".