2',3'-cyclic-nucleotide 3'-phosphodiesterase

In enzymology, a 2',3'-cyclic-nucleotide 3'-phosphodiesterase is an enzyme that catalyzes the chemical reaction


 * nucleoside 2',3'-cyclic phosphate + H2O $$\rightleftharpoons$$ nucleoside 2'-phosphate

Thus, the two substrates of this enzyme are nucleoside 2',3'-cyclic phosphate and H2O, whereas its product is nucleoside 2'-phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase. Other names in common use include cyclic-CMP phosphodiesterase, 2',3'-cyclic AMP phosphodiesterase, cyclic 2',3'-nucleotide 3'-phosphodiesterase, cyclic 2',3'-nucleotide phosphodiesterase, 2',3'-cyclic nucleoside monophosphate phosphodiesterase, 2',3'-cyclic nucleotide 3'-phosphohydrolase, CNPase, 2',3'-cyclic nucleotide phosphohydrolase, 2':3'-cyclic nucleotide 3'-phosphodiesterase, and 2':3'-CNMP-3'-ase.

Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes, , and.