Ewing's sarcoma natural history


 * Assistant Editor(s)-In-Chief: Michael Maddaleni, B.S.

Prognosis
Out of all primary musculoskeletal tumors, Ewing's Sarcoma has maintained the form with the most unfavorable long term prognosis. In fact, prior to multi-drug chemotherapy, the survival rate was less than 10%. Now that there have been many options developed, such as chemotherapy, surgery, and irradiation, long term survival has increased to greater than 50% in most clinical centers. Staging attempts to distinguish patients with localized from those with metastatic disease. Most commonly, metastases occur in the chest, bone and/or bone marrow. Less common sites include the central nervous system and lymph nodes.

Survival for localized disease is 65-70% when treated with chemotherapy. Long term survival for metastatic disease can be less than 10% but some sources state it is 25-30%.