TRPV

TRPV is a family of transient receptor potential ion channels.

TRPV subunits contain three to five N-terminal ankyrin repeats and can be activated through a variety of mechanisms. TRPV1 to TRPV4 can act as thermometers on a molecular level. TRPV1, specifically, is activated by noxious heat, acidic pH and capsaicin TRPV4, alternatively, can be activated by cell swelling caused by 5',6'-ep-oxyeicosatrienoic acid.

TRPV5 and TRPV6 are calcium entry channels responsible for calcium absorption in kidney and intestine. They were originally named ECaC and CAT1 and expression is regulated by the vitamin D endocrine system through the active metabolite calcitriol.