Dimethylargininase

In enzymology, a dimethylargininase is an enzyme that catalyzes the chemical reaction


 * Nomega,Nomega'-methyl-L-arginine + H2O $$\rightleftharpoons$$ dimethylamine + L-citrulline

Thus, the two substrates of this enzyme are Nomega,Nomega'-methyl-L-arginine and H2O, whereas its two products are dimethylamine and L-citrulline.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is Nomega,Nomega'-methyl-L-arginine dimethylamidohydrolase. Other names in common use include dimethylarginine dimethylaminohydrolase, NG,NG-dimethylarginine dimethylaminohydrolase, NG,NG-dimethyl-L-arginine dimethylamidohydrolase, and omega,omega'-di-N-methyl-L-arginine dimethylamidohydrolase.

Structural studies
As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , and.