PDK4

Pyruvate dehydrogenase kinase, isozyme 4, also known as PDK4, is a human gene. It codes for an isozyme of pyruvate dehydrogenase kinase.

This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin.