Diacylglycerol lipase

Diacylglycerol lipase, also known as DAG lipase, DAGL or DGL, is a key enzyme in the biosynthesis of the endocannabinoid 2-arachidonoylglycerol. It catalyzes the hydrolysis of diacylglycerol releasing a free fatty acid and monoacylglycerol.

Two separate genes encoding DGL enzymes have been cloned, termed DGLα and DGLβ, that share 33% sequence identity.

Inhibitors
The enzyme has been described to be inhibited selectively by two agents, RHC80267 and tetrahydrolipstatin.