Hippocalcin

Hippocalcin is a calcium-binding protein that belongs to neuronal calcium sensors (NCS) family of proteins. It expressed in mammalian brains especially in the hippocampus. It possesses a Ca2+/myristoyl switch.

It takes part in the following prosesses:


 * Activation of PLD and PLD2 expression


 * Inhibition of apoptosis


 * MAP kinase signalling


 * Involved in long term depression in hippocampal neuron


 * Required for normal spatial learning

It interacts with following proteins:


 * Neuronal apoptosis inhibitory protein (NAIP)


 * Mixed lineage kinase 2 (MLK2) MLK2 is myosin light chain kinase 2


 * The b2 adaptin of the AP2 complex


 * Calcium-dependent activator protein for secretion (CAPS)