Hemolytic disease of the newborn (anti-RhE)

Overview
Hemolytic disease of the newborn (anti-RhE) is caused by the anti-RhE antibody of the Rhesus blood group system. The anti-RhE antibody can be naturally occurring, or arise following immune sensitization after a blood transfusion or pregnancy.

The anti-RhE antibody is quite common especially in the Rhesus genotype CDe/CDe; it can occasionally cause mild jaundice in the neonate, but it never causes severe haemolytic disease of the newborn. It can occur with other antibodies, usually the anti-Rhc antibody, which can cause a severe hemolytic disease.