ANTH domain

The ANTH domain is a membrane binding domain that shows weak specificity for PtdIns(4,5)P2. Its structure is a solenoid of 9 helices. The PtdIns(4,5)P2 binding residues are spread over several helices at the tip of the structure. The PtdIns(4,5)P2 binding sequence is Kx9Kx(K/R)(H/Y). The ANTH domain is found in AP180 and in CALM. An ANTH domain is also found in HIP1 and HIP1R and the PtdIns(4,5)P2 binding sequence is conserved. More information is found on endocytosis.org.