Secretoneurin

Secretoneurin, also called Chromogranin B (CHGB), is a 33-amino acid neuropeptide derived from secretogranin II (chromogranin C, CHGC). Because of this secretogranin II is also called secretoneurin-included (SN, included).

Secretoneurin is involved in chemotaxis of monocytes and epsinophils (comparable in potency to IL8) and endothelial cells and in regulation of endothelial cell proliferation. Highest secretoneurin levels are found in anterior pituitary, followed by adrenal medulla and posterior pituitary hypothalamus (2- to 6-fold lower levels in other brain regions investigated). Secretoneurin has been shown to have potent angiogenic activity in vivo in mouse cornea model and in vitro in a 3-dimensional gel.

Singaling
PI3 kinase, phosphodiesterase and phospholipase D inhibition inhobits its pro-migration effects, but blocking PKC and tyrosine kinases has notbeen shown to have effect. Downstream to these ERK type MAP kinase and AKT are activated.