AD-mix

AD-mix in organic chemistry is a commercially available mixture of reagents for performing amongst others the Sharpless asymmetric dihydroxylation of alkenes. The mix is available in two variations, "AD-mix α" and "AD-mix β" following ingredient lists published by Shapless. As such it is used in research laboratories.

The mixes contain:


 * Potassium osmate K2OsO2(OH)4 as the source of Osmium tetroxide
 * Potassium ferricyanide K3Fe(CN)6, which is the re-oxidant in the catalytic cycle
 * Potassium carbonate
 * Chiral ligands (see below)


 * [[Image:DHQ2PHAL.png|300px|center|DHQ2PHAL AD-mix]]


 * In AD-mix α (DHQ)2PHAL (top) is the phthalazine adduct with dihydroquinine.


 * [[image:DHQD2PHAL.png|300px|center|DHQD2PHAL AD-mix]]


 * In AD-mix β; (DHQD)2PHAL is the phthalazine adduct with dihydroquinidine.