Pancreatic polypeptide

GS undefined

Pancreatic polypeptide is a polypeptide secreted by PP cells in the endocrine pancreas predominantly in the head of the pancreas. It consists of 36 amino acids and has molecular weight about 4200 Da.

The function of PP is unknown, but effects on hepatic glycogen levels and gastrointestinal secretions have been suggested. For instance, it it thought to be a a cholecystokinin antagonist, and thus suppress the pancreatic secretion and stimulate gastric secretion.

Its secretion in humans is increased after a protein meal, fasting, exercise, and acute hypoglycemia and is decreased by somatostatin and intravenous glucose.

Increased

 * Advanced Age
 * Gastrinoma
 * Insulinoma
 * PPoma
 * VIPoma