TRNA nucleotidyltransferase

In enzymology, a tRNA nucleotidyltransferase is an enzyme that catalyzes the chemical reaction


 * tRNAn+1 + phosphate $$\rightleftharpoons$$ tRNAn + a nucleoside diphosphate

Thus, the two substrates of this enzyme are tRNA(n+1) and phosphate, whereas its two products are tRNA(n) and nucleoside diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is tRNA:phosphate nucleotidyltransferase. Other names in common use include phosphate-dependent exonuclease, RNase PH, and ribonuclease PH.

Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , and.