Creatininase

In enzymology, a creatininase is an enzyme that catalyzes the chemical reaction


 * creatinine + H2O $$\rightleftharpoons$$ creatine

Thus, the two substrates of this enzyme are creatinine and H2O, whereas its product is creatine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is creatinine amidohydrolase. This enzyme is also called creatinine hydrolase. This enzyme participates in arginine and proline metabolism.

Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes, , , and.