Dihydrolipoyllysine-residue acetyltransferase

In enzymology, a dihydrolipoyllysine-residue acetyltransferase is an enzyme that catalyzes the chemical reaction


 * acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine $$\rightleftharpoons$$ CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine

Thus, the two substrates of this enzyme are acetyl-CoA and enzyme N6-(dihydrolipoyl)lysine, whereas its two products are CoA and enzyme N6-(S-acetyldihydrolipoyl)lysine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase. Other names in common use include acetyl-CoA:dihydrolipoamide S-acetyltransferase, dihydrolipoamide S-acetyltransferase, dihydrolipoate acetyltransferase, dihydrolipoic transacetylase, dihydrolipoyl acetyltransferase, lipoate acetyltransferase, lipoate transacetylase, lipoic acetyltransferase, lipoic acid acetyltransferase, lipoic transacetylase, lipoylacetyltransferase, thioltransacetylase A, transacetylase X, enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase, and acetyl-CoA:enzyme 6-N-(dihydrolipoyl)lysine S-acetyltransferase. This enzyme participates in 3 metabolic pathways: glycolysis / gluconeogenesis, alanine and aspartate metabolism, and pyruvate metabolism.

Structural studies
As of late 2007, 31 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , and.