Neurological malignant syndrome

Neuroleptic malignant syndrome is a life-threatening, neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs. Symptoms include high fever, sweating, unstable blood pressure, stupor, muscular rigidity, and autonomic dysfunction. In most cases, the disorder develops within the first two weeks of treatment with the drug, although it may develop any time during the therapy period. The syndrome can also occur in people taking drugs against anti-Parkinsonism (known as dopaminergics) if those drugs are discontinued abruptly.