NAD(P)H oxidase

In enzymology, a NAD(P)H oxidase is an enzyme that catalyzes the chemical reaction


 * NAD(P)H + H+ + O2 $$\rightleftharpoons$$ NAD(P)+ + H2O2

The 4 substrates of this enzyme are NADH, NADPH, H+, and O2, whereas its 3 products are NAD+, NADP+, and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with oxygen as acceptor. The systematic name of this enzyme class is NAD(P)H:oxygen oxidoreductase. Other names in common use include THOX2, ThOX, dual oxidase, p138tox, thyroid NADPH oxidase, thyroid oxidase, thyroid oxidase 2, and NADPH oxidase.