HLA-A69

HLA-A69 (A69) is an HLA-A serotype. The serotype identifies the more common HLA-A*6901 gene product. A69 is a split antigen of the A28 broad antigen serotype. It is relatively rare outside of the middle east and mediterranean region. A*6901 is a derivative of the A*6801 allele that has undergone gene conversion with A*02. The recombination took place no more that 330,000 years ago.

Serotype
Serotyping of A69 is poor.

A69 distribution
Distribution of A69 places nodal center in the Levant, but high levels in West Africa. The model of human genetic origin places first migrations from Eastern Africa. However in many east African populations the frequency of A69 is zero. A more consistent model of A69 distribution is either a subsequent migration from West Africa, supported by A36 and HLA DR3-DQ2. The higher levels in the Gaza Palestinians supports this hypothesis.

Disease associations
A69 may be associated with sarcodiosis.