Formins

Formins (formin homology proteins) are a group of proteins that are involved in the polymerisation of actin and associate with the fast-growing end (barbed end) of actin filaments. The structure of formins is mainly conserved in the C-terminal Formin Homology (FH) domains namely FH1, FH2 and the more loosely defined FH3 domain . The actin nucleation-promoting activity of S. cerevisiae formins has been localized to the FH1-FH2 domains. Other commonly shared domains are a GTPase binding domain (GBD) that bind for example Cdc42 at the N-terminus, and a DAD or Dia-autoregulatory domain, toward the C-terminus.