Alpha/beta hydrolase fold

The alpha/beta hydrolase fold is common to a number of hydrolytic enzymes of widely differing phylogenetic origin and catalytic function. The core of each enzyme is a alpha/beta-sheet (rather than a barrel), containing 8 strands connected by helices. The enzymes are believed to have diverged from a common ancestor, preserving the arrangement of the catalytic residues. All have a catalytic triad, the elements of which are borne on loops, which are the best conserved structural features of the fold.

This catalytic domain is found in a very wide range of enzymes.

Subfamilies

 * 3-oxoadipate enol-lactonase

Human proteins containing this domain
ABHD10;   ABHD11;    ABHD12;    ABHD12B;   ABHD13;    ABHD2;     ABHD3;     ABHD4; ABHD5;    ABHD6;     ABHD7;     ABHD8;     ABHD9;     BAT5;      BPHL;      C20orf135; EPHX1;    EPHX2;     FAM108B1;  LIPA;      LIPF;      LIPJ;      LIPK;      LIPM; LIPN;     MEST;      MGLL;      PPME1;     SERHL;     SERHL2;    SPG21;