5-(carboxyamino)imidazole ribonucleotide synthase

In enzymology, a 5-(carboxyamino)imidazole ribonucleotide synthase is an enzyme that catalyzes the chemical reaction


 * ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- $$\rightleftharpoons$$ ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole

The 3 substrates of this enzyme are ATP, 5-amino-1-(5-phospho-D-ribosyl)imidazole, and HCO3-, whereas its 3 products are ADP, phosphate, and 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is 5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming). Other names in common use include N5-CAIR synthetase, N5-carboxyaminoimidazole ribonucleotide synthetase, and PurK.