Phosphatidylethanolamine N-methyltransferase

In enzymology, a phosphatidylethanolamine N-methyltransferase is an enzyme that catalyzes the chemical reaction


 * S-adenosyl-L-methionine + phosphatidylethanolamine $$\rightleftharpoons$$ S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine

Thus, the two substrates of this enzyme are S-adenosyl methionine and phosphatidylethanolamine, whereas its two products are S-adenosylhomocysteine and phosphatidyl-N-methylethanolamine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase. Other names in common use include PEMT, LMTase, lipid methyl transferase, phosphatidylethanolamine methyltransferase, phosphatidylethanolamine-N-methylase, and phosphatidylethanolamine-S-adenosylmethionine methyltransferase. This enzyme participates in glycine, serine and threonine metabolism and glycerophospholipid metabolism.