2-Aminoethoxydiphenyl borate

2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit both IP3 receptors and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at higher concentrations). In research it is used to manipulate intracellular release of calcium ions (Ca2+) and modify TRP channel activity, although there its lack of specific effects make it less than ideal under some circumstances. Additionally, there is evidence that 2-APB acts directly to inhibit gap junctions comprised of connexin26 or connexin32.

Also note that many manufacturers provide descriptions of known pharmacologic activity for their products (i.e. Tocris or Sigma-Aldrich)