Amitriptyline contraindications

List of contraindications
Amitriptyline hypersensitivity Monoamine oxidase inhibitors Cisapride Myocardial infarction

Amitriptyline hypersensitivity
Amitriptyline hydrochloride is contraindicated in patients who have shown prior hypersensitivity to it. Return to top

Monoamine oxidase inhibitors
It should not be given concomitantly with monoamine oxidase inhibitors. Hyperpyretic crises, severe convulsions, and deaths have occurred in patients receiving tricyclic antidepressant and monoamine oxidase inhibiting drugs simultaneously. When it is desired to replace a monoamine oxidase inhibitor with Amitriptyline hydrochloride, a minimum of 14 days should be allowed to elapse after the former is discontinued. Amitriptyline hydrochloride should then be initiated cautiously with gradual increase in dosage until optimum response is achieved. Return to top

Cisapride
Amitriptyline hydrochloride should not be given with cisapride due to the potential for increased QT interval and increased risk for arrhythmia. Return to top

Myocardial infarction
This drug is not recommended for use during the acute recovery phase following myocardial infarction. Return to top