Marburg multiple sclerosis

Marburg multiple sclerosis, also known as malignant, acute or fulminant multiple sclerosis, is considered one of the multiple sclerosis borderline diseases, which is a collection of diseases classified by some as MS variants and by others as different diseases. Other diseases in this group are Neuromyelitis optica (NMO), Balo concentric sclerosis and Schilder's disease.

It took its name from Otto Marburg. It can be diagnosed in vivo with an MRI.

It is usually lethal, but recently it has been found to be responsive to Mitoxantrone and Alemtuzumab, and it has also been responsive to autologous stem cells transplantation.