Langerhans cell histiocytosis laboratory tests

Lab Tests
Diagnosis of LCH is confirmed histologically by tissue biopsy.

Haemotoxilin-eosin stain of biopsy slide will show features of Langerhans cell e.g. distinct cell margin, pink granular cytoplasm. Presence of Birbeck granules on electron microscopy and immuno-cytochemical features e. g. CD1 positivity are more specific.

Initially routine blood tests e.g. full blood count, liver function test, U&Es, bone profile are done to determine disease extent and rule out other causes.

Assessment of endocrine function and bonemarrow biopsy are also performed when indicated.