Photoreceptor cell-specific nuclear receptor

The photoreceptor cell-specific nuclear receptor (PNR), also known as NR2E3 (nuclear receptor subfamily 2, group E, member 3), is a member of the nuclear receptor super family of intracellular transcription factors.

PNR is exclusively expressed in the retina. The main target genes of PNR are rhodopsin and several opsins which are essential for sight. Mutations in the PNR gene have been linked to several inherited retinal diseases, including enhanced S-cone syndrome (ESCS), a form of retinitis pigmentosa, and  Goldmann-Favre syndrome.