Dihydrokaempferol 4-reductase

In enzymology, a dihydrokaempferol 4-reductase is an enzyme that catalyzes the chemical reaction


 * cis-3,4-leucopelargonidin + NADP+ $$\rightleftharpoons$$ (+)-dihydrokaempferol + NADPH + H+

Thus, the two substrates of this enzyme are cis-3,4-leucopelargonidin and NADP+, whereas its 3 products are (+)-dihydrokaempferol, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-3,4-leucopelargonidin:NADP+ 4-oxidoreductase. Other names in common use include dihydroflavanol 4-reductase, dihydromyricetin reductase, NADPH-dihydromyricetin reductase, and dihydroquercetin reductase. This enzyme participates in flavonoid biosynthesis.

Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and.