Necrolytic migratory erythema

Overview
Necrolytic migratory erythema (NME) is a classical symptom observed in patients with glucagonoma and is present in 80% of cases. Associated NME is characterized by the spread of erythematous blisters and swelling across areas subject to greater friction and pressure, including the lower abdomen, buttocks, perineum, and groin.

Symptoms
It consists of serpiginous (slow progressing) erythematous plaques. Where the migratory edge has an "eroded" appearance. It usually starts in the Perineum.

Associated symptoms
Weight loss, anemia, mild diabetes, diarrhea and glossitis are associated. Liver metastasis is often present.

Rumień nekrotyczny wędrujący