Trypanothione synthase

In enzymology, a trypanothione synthase is an enzyme that catalyzes the chemical reaction


 * glutathione + glutathionylspermidine + ATP $$\rightleftharpoons$$ N1,N8-bis(glutathionyl)spermidine + ADP + phosphate

The 3 substrates of this enzyme are glutathione, glutathionylspermidine, and ATP, whereas its 3 products are N1,N8-bis(glutathionyl)spermidine, ADP, and phosphate.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). The systematic name of this enzyme class is glutathionylspermidine:glutathione ligase (ADP-forming).