Marc Lacroix

Overview
Marc Lacroix is a biochemist (educated at University of Liège) and a researcher (born 1963 in Verviers, Wallonia, Belgium) who specializes in breast cancer biology, metastasis and therapy                           . He works at Institut Jules Bordet (Brussels, Belgium).

Recent work
The amount of data on breast cancer available for the scientific and medical community is growing rapidly. According to PubMed, a search engine offering access to the MEDLINE database of citations and abstracts of biomedical research articles, 7918 papers containing the expression «breast cancer» were published in 2006. Their number was 3592 in 1996, 1455 in 1986 and only 626 in 1976. In general, the older information is overlayed by more recent data and forgotten to some extent. In 2004, Lacroix and colleagues collected and assembled data from hundreds of articles related to the biology, pathology and genetics of in situ, invasive and metastatic breast cancers. These papers were covering a time period of about 25 years. Lacroix et al. concluded that despite undergoing increasing genetic alteration, most individual breast cancers rather surprisingly maintain their phenotype when they evolve from in situ to the metastatic state. This conclusion was in opposition to a progression model widely accepted at that time, which was suggesting that carcinoma in situ could evolve into invasive carcinoma and subsequently produce metastases through an accumulation of molecular abnormalities possibly allowing extensive phenotype changes and subsequent gain of aggressiveness.

Bibliography: invited chapters in thematic books

 * Leclercq G, Lacroix M, Seo HS, Larsimont D. "Mechanisms regulating oestrogen receptor alpha expression in breast cancer.", in "Molecular Mechanisms of Action of Steroid Hormone Receptors" 65-75 (2002). Editors: Marija Krstic-Demonacos & Constantinos Demonacos, Research Signpost Publishers, Trivandrum, India, ISBN 81-7736-129-5, http://www.ressign.com/


 * Lacroix M, Leclercq G. "An updated view on cell lines as in vitro models for breast tumors.", in "Focus on Breast Cancer Research" 131-182 (2004). Editor: Andrew P. Yao, Nova Science Publishers, Inc, 400 Oser Ave, Ste 1600, Hauppauge, NY 11788-3635 USA, ISBN 1-59033-961-4, https://www.novapublishers.com/catalog/product_info.php?products_id=593


 * Sotiriou C, Desmedt C, Durbecq V, Dal Lago L, Lacroix M, Cardoso F, Piccart M. "Genomic and molecular classification of breast cancer.", in "Molecular Oncology of Breast Cancer"  81-95 (2004). Editors: Jeffrey S. Ross and Gabriel N. Hortobagy, Jones and Bartlett Publishers, 40 Tall Pine Drive, Sudbury, MA 01776 USA, ISBN 0-76374-810-2, http://www.jbpub.com/catalog/0763748102/table_of_contents.htm


 * Lacroix M, Leclercq G. "Hereditary breast cancer: an update on genotype and phenotype.",in "New Breast Cancer Research" 27-51 (2006). Editor: Andrew P. Yao, Nova Science Publishers, Inc, 400 Oser Ave, Ste 1600, Hauppauge, NY 11788-3635 USA, ISBN 1-59454-932-X, https://www.novapublishers.com/catalog/product_info.php?products_id=4134


 * (in press) Lacroix M. "An update on tumor suppressor genes in breast cancer.", in "Tumor Suppressor Genes" (2007). Editor: Katherine R. Polinsky, Nova Science Publishers, Inc, 400 Oser Ave, Ste 1600, Hauppauge, NY 11788-3635 USA, ISBN 1-60021-693-5, http://www.novapublishers.com/catalog/product_info.php?products_id=5679

Resources

 * Free access to "Stable 'portrait' of breast tumors during progression: data from biology, pathology and genetics"
 * Free access to and breast cancer, an update"
 * Free access to "Significance, detection and markers of disseminated breast cancer cells"
 * Université libre de Bruxelles – Marc Lacroix