Naphthoate synthase

In enzymology, a naphthoate synthase is an enzyme that catalyzes the chemical reaction


 * o-succinylbenzoyl-CoA $$\rightleftharpoons$$ CoA + 1,4-dihydroxy-2-naphthoate

Hence, this enzyme has one substrate, o-succinylbenzoyl-CoA, and two products, CoA and 1,4-dihydroxy-2-naphthoate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing CoA-forming). Other names in common use include 1,4-dihydroxy-2-naphthoate synthase, dihydroxynaphthoate synthase, and o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing). This enzyme participates in ubiquinone biosynthesis.

Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes, , , , and.