4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase

In enzymology, a 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase is an enzyme that catalyzes the chemical reaction


 * 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + NADP+ + H2O $$\rightleftharpoons$$ 4-carboxy-2-hydroxy-cis,cis-muconate + NADPH + 2 H+

The 3 substrates of this enzyme are 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde, NADP+, and H2O, whereas its 3 products are 4-carboxy-2-hydroxy-cis,cis-muconate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ 6-oxidoreductase. Other names in common use include 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+, oxidoreductase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde, and dehydrogenase. This enzyme participates in tyrosine metabolism and benzoate degradation via hydroxylation.