Nitric oxide dioxygenase

In enzymology, a nitric oxide dioxygenase is an enzyme that catalyzes the chemical reaction


 * 2 nitric oxide + 2 O2 + NAD(P)H $$\rightleftharpoons$$ 2 nitrate + NAD(P)+ + H+

The 4 substrates of this enzyme are nitric oxide, O2, NADH, and NADPH, whereas its 4 products are nitrate, NAD+, NADP+, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of two atoms o oxygen into the other donor. The systematic name of this enzyme class is nitric oxide,NAD(P)H:oxygen oxidoreductase.