Nuclear receptor coactivator 1

The nuclear receptor coactivator 1 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA1 is recruited to DNA promotion sites by ligand activated nuclear receptors. NCOA1 in turn acylates histones which makes downsteam DNA more accessible to transcription. Hence NCOA1 assists nuclear receptors in the upregulation of DNA expression.

NCOA1 is also frequently called steroid receptor coactivator-1 (SRC-1).