Coenzyme-B sulfoethylthiotransferase

In enzymology, a coenzyme-B sulfoethylthiotransferase is an enzyme that catalyzes the chemical reaction


 * 2-(methylthio)ethanesulfonate (methyl-CoM) + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate (coenzyme B) $$\rightleftharpoons$$ CoM-S-S-CoB + methane

Thus, the two substrates of this enzyme are 2-(methylthio)ethanesulfonate and N-(7-mercaptoheptanoyl)threonine 3-O-phosphate, whereas its two products are CoM-S-S-CoB and methane.

This enzyme belongs to the family of transferases, specifically those transferring alkylthio groups. The systematic name of this enzyme class is 2-(methylthio)ethanesulfonate:N-(7-thioheptanoyl)-3-O-phosphothreoni ne S-(2-sulfoethyl)thiotransferase. Other names in common use include methyl-CoM reductase, and methyl coenzyme M reductase. This enzyme participates in folate biosynthesis.