Biotin-(propionyl-CoA-carboxylase (ATP-hydrolysing)) ligase

In enzymology, a biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase is an enzyme that catalyzes the chemical reaction


 * ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] $$\rightleftharpoons$$ AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)]

The 3 substrates of this enzyme are ATP, biotin, and apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)], whereas its 3 products are AMP, diphosphate, and [propionyl-CoA:carbon-dioxide ligase (ADP-forming)].

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is biotin:apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming). Other names in common use include biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] synthetase, biotin-propionyl coenzyme A carboxylase synthetase, and propionyl coenzyme A holocarboxylase synthetase. This enzyme participates in biotin metabolism.