PHEX

PHEX is a gene associated with X-linked hypophosphatemia.

PHEX may regulate FGF23 expression as part of a potential hormonal axis between bone and kidney that controls systemic phosphate homeostasis and mineralization. PHEX is highly expressed in cartilage, bone, and teeth, where it is present in osteoblasts, osteocytes, and odontoblasts, especially at the transition between the maturation of pre-osteoblasts to mature osteoblasts when PHEX expression is normally up-regulated.

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