Toxic multinodular goiter

Overview
Toxic multinodular goitre (also known as toxic nodular goitre, toxic nodular struma) is a form of hyperthyroidism - where there is excess production of thyroid hormones.

It is the second most common cause of hyperthyroidism after Graves disease.

Symptoms
Symptoms of toxic multinodular goitre are similar to that of hyperthyroidism, including:
 * heat intolerance
 * hyperkinesis
 * tremor
 * irritability
 * weight loss
 * increased appetite
 * goitre (swelling of the thyroid gland)
 * tachycardia (high heart rate - above 180 bpm at rest)

Related eponym
Plummer's disease is named after an American physician Henry Stanley Plummer but refers to a single toxic nodule (adenoma) which may present with the background of a suppressed multinodular goitre.

Acknowledgements
The content on this page was first contributed by: C. Michael Gibson, M.S., M.D.

Doença de Plummer