2-oxoaldehyde dehydrogenase (NAD+)

In enzymology, a 2-oxoaldehyde dehydrogenase (NAD+) is an enzyme that catalyzes the chemical reaction


 * a 2-oxoaldehyde + NAD+ + H2O $$\rightleftharpoons$$ a 2-oxo acid + NADH + H+

The 3 substrates of this enzyme are 2-oxoaldehyde, NAD+, and H2O, whereas its 3 products are 2-oxo acid, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoaldehyde:NAD+ 2-oxidoreductase. Other names in common use include alpha-ketoaldehyde dehydrogenase, methylglyoxal dehydrogenase, NAD+-linked alpha-ketoaldehyde dehydrogenase, 2-ketoaldehyde dehydrogenase, NAD+-dependent alpha-ketoaldehyde dehydrogenase, and 2-oxoaldehyde dehydrogenase (NAD+). This enzyme participates in pyruvate metabolism.