Mark A. Smith

Mark A. Smith (born August 15, 1965 in Leicester, England) is professor of pathology at Case Western Reserve University in Cleveland, Ohio. Smith is recognized in the field of Alzheimer's disease research particularly for his work on oxidative stress.

Biography
Smith received his B.Sc. in Molecular Biology & Biochemistry from Durham University, and his Ph.D. in Biochemistry from Hatfield College, Nottingham University in 1990. He was a postdoctoral biochemist in the Department of Immunodermatology at Sandoz Forschungsinstitut in Vienna, Austria. He performed the majority of his research at Case Western Reserve University. He is also distinguished as one of the top 20 Alzheimer’s disease researchers with over 600 publications, one of the top 100 most-cited scientists in Neuroscience & Behavior and one of the top 25 scientists in free radical research.

Research
The focus of Dr. Smith’s research involves investigating the pathological mechanism(s) underlying selective neuronal death in neurodegenerative diseases such as Alzheimer’s disease. Dr. Smith’s research involves a variety of techniques ranging from histological to molecular biology to cellular models and encompasses diagnostic, mechanistic, and therapeutic strategies. Current projects are directed towards 1) fundamental metabolic alterations; 2) homeostatic dysregulation of transition metals; 3) signal transduction alterations; and 4) inappropriate re-entry into the cell cycle.