ERCC2 gene

ERCC2, or XPD can be regarded as a nucleotide excision repair protein.

The XPD (ERCC2) gene encodes for a 2.3-kb mRNA containing 22 exons and 21 introns. The XPD protein is a 760 amino acids polypeptide with a size of 87kDa.

Just like XPB, XPD is also a part of human transcriptional initiation factor TFIIH and has ATP-dependent helicase activity.

XPD is essential for the viability of cells. Deletion of XPD in mice is embryonic lethal.