S-ribosylhomocysteine lyase

In enzymology, a S-ribosylhomocysteine lyase is an enzyme that catalyzes the chemical reaction


 * S-(5-deoxy-D-ribos-5-yl)-L-homocysteine $$\rightleftharpoons$$ L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione

Hence, this enzyme has one substrate, S-(5-deoxy-D-ribos-5-yl)-L-homocysteine, and two products, L-homocysteine and (4S)-4,5-dihydroxypentan-2,3-dione.

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is S-(5-deoxy-D-ribos-5-yl)-L-homocysteine L-homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming]. Other names in common use include S-ribosylhomocysteinase, and LuxS. This enzyme participates in methionine metabolism.

Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes, , and.