ADAM protein

Adam protein (A Disintegrin and Metalloproteinase Protein) is a family of peptidase proteins. ADAMs are also known as the Adamalysin family. ADAMs are classified as Sheddases because they cut off or shed extracellular portions of transmembrane proteins. For example, ADAM 10 can cut off part of the HER2 receptor, activating it and ADAM 17 can cut off part of the EGFR once it has bound its ligand, freeing the ligand to go and stimulate another cell. Therapeutic ADAM inhibitors can potentiate anti-cancer therapy.

It is categorized under.

Types include:
 * ADAMTS2
 * ADAMTS13
 * ADAMTS5
 * ADAM17