ACVR1

ACVR1 or ALK-2 transduces signals of BMPs. BMPs bind either ACVR2A/ACVR2B or a BMPR2 and then forms a complex with ACVR1. These go on to recruit the R-SMADs SMAD1, SMAD2, SMAD3 or SMAD6 It is associated with fibrodysplasia ossificans progressiva.