Amsterdam criteria

The Amsterdam criteria identify families likely to have Hereditary nonpolyposis colorectal cancer (HNPCC).

At least 3 relatives with a HNPCC-associated cancer: colorectal cancer, or cancer of the endometrium, small intestine, ureter or renal pelvis.


 * One patient should be a first degree relative of the other two


 * At least two successive generations should be affected


 * At least one tumour should be diagnosed <50 years of age


 * Familial adenomatous polyposis should be excluded in the colorectal cancer case (if any)


 * Tumours should be verified by histopathologic examination