Phosphogluconate 2-dehydrogenase

In enzymology, a phosphogluconate 2-dehydrogenase is an enzyme that catalyzes the chemical reaction


 * 6-phospho-D-gluconate + NAD(P)+ $$\rightleftharpoons$$ 6-phospho-2-dehydro-D-gluconate + NAD(P)H + H+

The 3 substrates of this enzyme are 6-phospho-D-gluconic acid, NAD+, and NADP+, whereas its 4 products are 6-phospho-2-dehydro-D-gluconic acid, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase. Other names in common use include 6-phosphogluconic dehydrogenase, phosphogluconate dehydrogenase, gluconate 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase (NAD+), and 2-keto-6-phosphogluconate reductase. This enzyme participates in pentose phosphate pathway and glutathione metabolism.