(acyl-carrier-protein) S-malonyltransferase

In enzymology, a [acyl-carrier-protein] S-malonyltransferase is an enzyme that catalyzes the chemical reaction


 * malonyl-CoA + [acyl-carrier-protein] $$\rightleftharpoons$$ CoA + malonyl-[acyl-carrier-protein]

Thus, the two substrates of this enzyme are malonyl-CoA and [acyl-carrier-protein], whereas its two products are CoA and malonyl-[acyl-carrier-protein].

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:[acyl-carrier-protein] S-malonyltransferase. Other names in common use include malonyl coenzyme A-acyl carrier protein transacylase, malonyl transacylase, malonyl transferase, malonyl-CoA-acyl carrier protein transacylase, [acyl carrier protein]malonyltransferase, MAT, FabD, malonyl-CoA:acyl carrier protein transacylase, malonyl-CoA:ACP transacylase, MCAT, and malonyl-CoA:AcpM transacylase. This enzyme participates in fatty acid biosynthesis.

Structural studies
As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , and.