Methyl-coenzyme M reductase

Methyl-coenzyme M reductase (MCR) is an enzyme that occurs in archaea and catalyzes the formation of methane by combining the hydrogen donor coenzyme B and the methyl donor coenzyme M. The enzyme has two active sites, each occupied by the nickel-containing F430 cofactor. This conversion is symbolically written as:
 * CH3-S-CoM + HS-CoB &rarr; CH4 + CoB-S-S-CoM