Nateglinide

Nateglinide (INN, trade name Starlix) is a drug for the treatment of type 2 diabetes.

Nateglinide belongs to the meglitinide class of blood glucose-lowering drugs and is sold by Novartis.

Pharmacology
Nateglinide lowers blood glucose by stimulating the release of insulin from the pancreas. It achieves this by closing ATP-dependent potassium channels in the membrane of the ß cells. This depolarizes the ß cells and causes voltage-gated calcium channels to open. The resulting calcium influx induces fusion of insulin-containing vesicles with the cell membrane, and insulin secretion occurs.

Dosage
Nateglinide is delivered in 60mg & 120mg tablet form.