Amine N-methyltransferase

In enzymology, an amine N-methyltransferase is an enzyme that catalyzes the chemical reaction


 * S-adenosyl-L-methionine + an amine $$\rightleftharpoons$$ S-adenosyl-L-homocysteine + a methylated amine

Thus, the two substrates of this enzyme are S-adenosyl methionine and amine, whereas its two products are S-adenosylhomocysteine and methylated amine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:amine N-methyltransferase. Other names in common use include nicotine N-methyltransferase, tryptamine N-methyltransferase, arylamine N-methyltransferase, and tryptamine methyltransferase. This enzyme participates in tryptophan metabolism.

Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code.