Hydroxyacylglutathione hydrolase

In enzymology, a Hydroxyacylglutathione hydrolase is an enzyme that catalyzes the chemical reaction


 * (R)-S-lactoylglutathione + water $$\rightleftharpoons$$ glutathione + a 2-hydroxy carboxylate

Hence, this enzyme has two substrate, (R)-S-lactoylglutathione and water, and two products, glutathione and a 2-hydroxy carboxylate. With the common substrate methylglyoxal, the product is D-lactate.

This enzyme belongs to the family of hydrolases, specifically the class of thioester lyases. This enzyme is commonly known asglyoxylase II. This enzyme participates in pyruvate metabolism.