Cyclopropane-fatty-acyl-phospholipid synthase

In enzymology, a cyclopropane-fatty-acyl-phospholipid synthase is an enzyme that catalyzes the chemical reaction


 * S-adenosyl-L-methionine + phospholipid olefinic fatty acid $$\rightleftharpoons$$ S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid

Thus, the two substrates of this enzyme are S-adenosyl methionine and phospholipid olefinic fatty acid, whereas its two products are S-adenosylhomocysteine and phospholipid cyclopropane fatty acid.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing). Other names in common use include cyclopropane synthetase, unsaturated-phospholipid methyltransferase, cyclopropane synthase, cyclopropane fatty acid synthase, cyclopropane fatty acid synthetase, and CFA synthase.

Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes, , , , , and.