Chloromuconate cycloisomerase

In enzymology, a chloromuconate cycloisomerase is an enzyme that catalyzes the chemical reaction


 * 2-chloro-2,5-dihydro-5-oxofuran-2-acetate $$\rightleftharpoons$$ 3-chloro-cis,cis-muconate

Hence, this enzyme has one substrate, 2-chloro-2,5-dihydro-5-oxofuran-2-acetate, and one product, 3-chloro-cis,cis-muconate.

This enzyme belongs to the family of isomerases, specifically the class of intramolecular lyases. The systematic name of this enzyme class is 2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing). This enzyme is also called muconate cycloisomerase II. This enzyme participates in gamma-hexachlorocyclohexane degradation and 1,4-dichlorobenzene degradation. It employs one cofactor, manganese.

Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes, , and.