Alpha 1-antitrypsin deficiency differential diagnosis


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Overview
Alpha 1-antitrypsin deficiency (A1AD) may present in a physical examination of the lungs as emphysema, liver dysfunction, and panniculitis in the skin.

Differential Diagnosis

 * Adult hepatitis or cirrhosis of unclear origin
 * Adult pulmonary emphysema
 * Cachexia
 * Hepatitis of unclear origin in children
 * Hereditary, autosomal recessive alpha-1 antitrypsin deficiency
 * Malnutrition
 * Nephrotic Syndrome
 * Nonphysiologic neonatal jaundice

Associated Conditions
α1-antitrypsin deficiency has been associated with a number of diseases:
 * COPD
 * Asthma
 * Wegener's granulomatosis
 * Pancreatitis
 * Gallstones
 * Bronchiectasis (possibly)
 * Prolapse
 * Primary sclerosing cholangitis
 * Autoimmune hepatitis
 * Emphysema
 * Cancer
 * Hepatocellular carcinoma (liver)
 * Bladder carcinoma
 * Gallbladder cancer
 * Lymphoma
 * Lung cancer