The Living Guidelines: UA/NSTEMI Recommendations for Non steroidal Anti-Inflammatory Drugs Use Suggest Revisions to the CLASS IIb Guidelines

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Class IIb Guidelines

 * 1) Non steroidal anti inflammatory drugs with increasing degrees of relative COX-2 selectivity may be considered for pain relief only for situations in which intolerable discomfort persists despite attempts at stepped-care therapy with acetaminophen, small doses of narcotics, non acetylated salicylates, or non selective NSAIDs. In all cases, the lowest effective doses should be used for the shortest possible time. (Level of Evidence: C)