CD98

CD98 is a glycoprotein which comprises the light subunit of the Large neutral Amino acid Transporter (LAT1). LAT1 is a heterodimeric membrane transport protein which preferentially transports neutral branched (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine) amino acids. LAT is highly expressed in brain capillaries (which form the blood brain barrier) relative to other tissues.

Functional LAT1 transporters are comprised of two proteins encoded by two distinct genes:
 * 4F2hc heavy subunit protein encoded by the gene
 * CD98 light subunit protein encoded by the gene