Isocitrate lyase

In enzymology, an isocitrate lyase is an enzyme that catalyzes the chemical reaction


 * isocitrate $$\rightleftharpoons$$ succinate + glyoxylate

Hence, this enzyme has one substrate, isocitrate, and two products, succinate and glyoxylate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is isocitrate glyoxylate-lyase (succinate-forming). Other names in common use include isocitrase, isocitritase, isocitratase, threo-Ds-isocitrate glyoxylate-lyase, and isocitrate glyoxylate-lyase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes, , , , and.