Adenosyl-fluoride synthase

In enzymology, an adenosyl-fluoride synthase is an enzyme that catalyzes the chemical reaction


 * S-adenosyl-L-methionine + fluoride $$\rightleftharpoons$$ 5'-deoxy-5'-fluoroadenosine + L-methionine

Thus, the two substrates of this enzyme are S-adenosyl-L-methionine and fluoride, whereas its two products are 5'-deoxy-5'-fluoroadenosine and L-methionine.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is S-adenosyl-L-methionine:fluoride adenosyltransferase. This enzyme is also called fluorinase.

Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , and.