Biogenesis of lysosome-related organelles complex 1

BLOC-1 or biogenesis of lysosome-related organelles complex 1 is a ubiquitously expressed multisubunit protein complex. BLOC-1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The complex was first described in 2004.

The identified protein subunits of BLOC-1 include:


 * pallidin,
 * muted (protein),
 * dysbindin,
 * cappuccino (protein)
 * Snapin,
 * BLOS1,
 * BLOS2,
 * BLOS3