Small nucleolar RNA SNORD113 SNORD114 clusters

The Small_nucleolar_RNA_SNORD113_SNORD114_clusters are two large clusters of small nucleolar RNAs (snoRNAs) in the human genome. The imprinted human domain at 14q32 contains two clusters of tandemly repeated small nucleolar RNAs named 14q(I) and 14q(II) snoRNAs. These two clusters conatain 9 and 31 highly related snoRNAs respectively. The these snoRNAs are SNORD113 and SNORD114 respectively in the HGNC approved gene symbol nomenclature. The snoRNAs found in both clusters are clearly related and are simply referred to with a 1-9 or 1-31 suffix. All the snoRNAs in these clusters are intron encoded and are processed from the tissue-specific non-coding human MEG8 RNA, which lies downstream of the imprinted genes DLK1 and GTL2. snoRNAs 14q(I) and 14q(II) differ from previously identified C/D box snoRNAs in their expression profiles and lack of complementarity to rRNA and snRNA. Homologues of these snoRNAs are found in the imprinted non-coding mouse transcript Rian, and in the rat non-coding Bsr (brain-specific repetitive) RNA.