Hypoprothrombinemia

Hypoprothrombinemia is a blood disorder in which a deficiency of prothrombin (Factor II) results in impaired blood clotting, leading to an increased physiological risk for bleeding, especially in the gastrointestinal system, cranial vault, and superficial integumentary system.

Causes
Hypoprothrombinemia can be the result of a genetic defect or it may be acquired as the result of another disease process, or an adverse effect of medication. For example, 5-10% of patients with Systemic lupus erythematosus exhibit acquired hypoprothrombinemia due to the presence of autoantibodies which bind to prothrombin and remove it from the bloodstream (lupus anticoagulant-hypoprothrombinaemia syndrome).

Treatment
Hypoprothrombinemia can be treated with periodic infusions of purified prothrombin complexes.