2,5-dihydroxypyridine 5,6-dioxygenase

In enzymology, a 2,5-dihydroxypyridine 5,6-dioxygenase is an enzyme that catalyzes the chemical reaction


 * 2,5-dihydroxypyridine + O2 + H2O $$\rightleftharpoons$$ maleamate + formate

The 3 substrates of this enzyme are 2,5-dihydroxypyridine, O2, and H2O, whereas its two products are maleamate and formate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is 2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase. Other names in common use include 2,5-dihydroxypyridine oxygenase, and pyridine-2,5-diol dioxygenase. This enzyme participates in nicotinate and nicotinamide metabolism. It employs one cofactor, iron.