Oxalyl-CoA decarboxylase

In enzymology, an oxalyl-CoA decarboxylase is an enzyme that catalyzes the chemical reaction


 * oxalyl-CoA $$\rightleftharpoons$$ formyl-CoA + CO2

Hence, this enzyme has one substrate, oxalyl-CoA, and two products, formyl-CoA and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is oxalyl-CoA carboxy-lyase (formyl-CoA-forming). Other names in common use include oxalyl coenzyme A decarboxylase, and oxalyl-CoA carboxy-lyase. This enzyme participates in glyoxylate and dicarboxylate metabolism. It employs one cofactor, thiamin diphosphate.

Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes, , , , , and.