Naproxen instructions for administration

Instructions for administration
Geriatric Patients Patients with Moderate to Severe Renal Impairment Rheumatoid Arthritis, Osteoarthritis and Ankylosing Spondylitis Juvenile Arthritis Management of Pain, Primary Dysmenorrhea, and Acute Tendonitis and Bursitis Acute Gout

Geriatric Patients
Studies indicate that although total plasma concentration of Naproxen is unchanged, the unbound plasma fraction of Naproxen is increased in the elderly. Caution is advised when high doses are required and some adjustment of dosage may be required in elderly patients. As with other drugs used in the elderly, it is prudent to use the lowest effective dose. Return to top

Patients with Moderate to Severe Renal Impairment
Naproxen-containing products are not recommended for use in patients with moderate to severe and severe renal impairment (creatinine clearance < 30 mL/min). Return to top

Rheumatoid Arthritis, Osteoarthritis and Ankylosing Spondylitis
Return to top
 * 275 mg (Naproxen 250 mg with 25 mg sodium) twice daily
 * or 550 mg (Naproxen 500 mg with 50 mg sodium) twice daily

Juvenile Arthritis
For the relief of juvenile arthritis, the recommended dose is approximately 10 mg/kg given orally in 2 divided doses (i.e., 5 mg/kg given twice a day). Naproxen sodium tablets are not well suited to this dosage so use of Naproxen oral suspension is recommended for this indication. Return to top

Management of Pain, Primary Dysmenorrhea, and Acute Tendonitis and Bursitis
The recommended starting dose is 550 mg of Naproxen sodium followed by 550 mg every 12 hours or 275 mg every 6 to 8 hours as required. The initial total daily dose should not exceed 1375 mg of Naproxen sodium. Thereafter, the total daily dose should not exceed 1100 mg of Naproxen sodium. Because the sodium salt of Naproxen is more rapidly absorbed, Naproxen sodium tablets are recommended for the management of acute painful conditions when prompt onset of pain relief is desired. Return to top

Acute Gout
The recommended starting dose is 825 mg of Naproxen sodium tablets followed by 275 mg every 8 hours until the attack has subsided. Return to top