Wise-Rein disease

Wise-Rein disease (Lichen ruber moniliformis) is a rare skin disease named for Fred Wise and Charles R. Rein.

It is one of several diseases also known as Kaposi's disease.

The disease causes numerous whitish punctiform papules and brownish macules arranged in a necklace-like pattern.

It is thought to be a rare variety of lichen planus.