Pioglitazone drug interactions

List of drug interactions
Oral Contraceptives Glipizide Digoxin Warfarin Metformin Theophylline Atorvastatin Calcium Ketoconazole

Oral Contraceptives
Administration of another thiazolidinedione with an oral contraceptive containing ethinyl estradiol and norethindrone reduced the plasma concentrations of both hormones by approximately 30%, which could result in loss of contraception. The pharmacokinetics of coadministration of Pioglitazone and oral contraceptives have not been evaluated in patients receiving Pioglitazone and an oral contraceptive. Therefore, additional caution regarding contraception should be exercised in patients receiving Pioglitazone and an oral contraceptive. Return to top

Glipizide
In healthy volunteers, coadministration of Pioglitazone (45 mg once daily) and glipizide (5.0 mg once daily) for seven days did not alter the steady-state pharmacokinetics of glipizide. Return to top

Digoxin
In healthy volunteers, coadministration of Pioglitazone (45 mg once daily) with digoxin (0.25 mg once daily) for seven days did not alter the steady-state pharmacokinetics of digoxin. Return to top

Warfarin
In healthy volunteers, coadministration of Pioglitazone (45 mg once daily) for seven days with warfarin did not alter the steady-state pharmacokinetics of warfarin. In addition, Pioglitazone has no clinically significant effect on prothrombin time when administered to patients receiving chronic warfarin therapy. Return to top

Metformin
In healthy volunteers, coadministration of metformin (1000 mg) and Pioglitazone (45 mg) after seven days of Pioglitazone (45 mg once daily) did not alter the pharmacokinetics of the single dose of metformin. Return to top

Theophylline
Coadministration of Pioglitazone for 7 days with theophylline 400 mg administered twice daily resulted in no changes in the pharmacokinetics of either drug. Return to top

Atorvastatin Calcium
Coadministration of Pioglitazone for 7 days with atorvastatin 80 mg once daily resulted in no clinically relevant effect upon atorvastatin pharmacokinetics. Coadministration of atorvastatin with Pioglitazone had no clinically relevant effect on pioglitazone pharmacokinetics. Return to top

Ketoconazole
Coadministration of Pioglitazone for 7 days with ketoconazole 200 mg administered twice daily resulted in no clinically relevant effect on pioglitazone pharmacokinetics. Return to top