Orotate reductase (NADH)

In enzymology, an orotate reductase (NADH) is an enzyme that catalyzes the chemical reaction


 * (S)-dihydroorotate + NAD+ $$\rightleftharpoons$$ orotate + NADH + H+

Thus, the two substrates of this enzyme are (S)-dihydroorotate and NAD+, whereas its 3 products are orotate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-dihydroorotate:NAD+ oxidoreductase. This enzyme is also called orotate reductase (NADH). This enzyme participates in pyrimidine metabolism. It has 2 cofactors: FAD, and FMN.