The Living Guidelines: Treatment of Special Populations. Suggest Revisions to the CLASS IIa Guidelines

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Class IIa Guidelines
1. The addition of isosorbide dinitrate and hydralazine to a standard medical regimen for HF, including ACEIs and beta-blockers, is reasonable and can be effective in blacks with NYHA functional class III or IV HF. Others may benefit similarly, but this has not yet been tested. (Level of Evidence: A)