Glyoxylate reductase

In enzymology, a glyoxylate reductase is an enzyme that catalyzes the chemical reaction


 * glycolate + NAD+ $$\rightleftharpoons$$ glyoxylate + NADH + H+

Thus, the two substrates of this enzyme are glycolate and NAD+, whereas its 3 products are glyoxylate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glycolate:NAD+ oxidoreductase. Other names in common use include NADH-glyoxylate reductase, glyoxylic acid reductase, and NADH-dependent glyoxylate reductase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes, , and.