Prostaglandin F receptor

Prostaglandin F receptor (FP) is a receptor for Prostaglandin F2α. It is encoded by the gene PTGFR.

It is a member of the G-protein coupled receptor family.

Two transcript variants encoding different isoforms have been found for this gene.

Functions
Main effects of prostaglandin binding to the receptor are:
 * uterine contraction
 * bronchoconstriction

Via activation of this receptor, PGF2-alpha mediates luteolysis, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus and gastrointestinal tract sphincters.

Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor in ovarian luteal cells initiates luteolysis and thus induces parturition.