Phospholipid-hydroperoxide glutathione peroxidase

In enzymology, a phospholipid-hydroperoxide glutathione peroxidase is an enzyme that catalyzes the chemical reaction


 * 2 glutathione + a lipid hydroperoxide $$\rightleftharpoons$$ glutathione disulfide + lipid + 2 H2O

Thus, the two substrates of this enzyme are glutathione and lipid hydroperoxide, whereas its 3 products are glutathione disulfide, lipid, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a peroxide as acceptor (peroxidases). The systematic name of this enzyme class is glutathione:lipid-hydroperoxide oxidoreductase. Other names in common use include peroxidation-inhibiting protein, PHGPX, peroxidation-inhibiting protein: peroxidase, glutathione, (phospholipid hydroperoxide-reducing), phospholipid hydroperoxide glutathione peroxidase, and hydroperoxide glutathione peroxidase. This enzyme participates in glutathione metabolism.

Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and.