Related to receptor tyrosine kinase

The related to receptor tyrosine kinases (RYKs) are a family of proteins that are a members of the receptor tyrosine kinase family of cell surface receptors.

History
The gene encoding mouse RYK was first identified in 1992. Subsequently cDNA encoding the RYK protein have been isolated from the following species.
 * rat
 * chicken
 * Human
 * Zebrafish
 * Drosophila and
 * C. elegans

Structure
In common with other receptor tyrosine kinase family members, RYK is composed of three domains, an N-terminal         extracellular  ligand binding domain, a transmembrane spanning domain and a C-terminal intracellular domain. However, in contrast to other receptor tyrosine kinases the C-terminal domain of RYK is devoid of detectable kinase activity.