(R)-2-methylmalate dehydratase

Jump to: navigation, search

In enzymology, a (R)-2-methylmalate dehydratase (EC is an enzyme that catalyzes the chemical reaction

(R)-2-methylmalate 2-methylmaleate + H2O

Hence, this enzyme has one substrate, (R)-2-methylmalate, and two products, 2-methylmaleate and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (R)-2-methylmalate hydro-lyase (2-methylmaleate-forming). Other names in common use include citraconate hydratase, citraconase, citramalate hydro-lyase, (-)-citramalate hydro-lyase, and (R)-2-methylmalate hydro-lyase. This enzyme participates in valine, leucine and isoleucine biosynthesis and c5-branched dibasic acid metabolism. It employs one cofactor, iron.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Subramanian SS, Rao MR (1968). "Purification and properties of citraconase". J. Biol. Chem. 243: 2367&ndash, 72. PMID 4296839.

External links

The CAS registry number for this enzyme class is 9027-92-3.

Gene Ontology (GO) codes