(R)-dehydropantoate dehydrogenase

Jump to: navigation, search

In enzymology, a (R)-dehydropantoate dehydrogenase (EC 1.2.1.33) is an enzyme that catalyzes the chemical reaction

(R)-4-dehydropantoate + NAD+ + H2O (R)-3,3-dimethylmalate + NADH + 2 H+

The 3 substrates of this enzyme are (R)-4-dehydropantoate, NAD+, and H2O, whereas its 3 products are (R)-3,3-dimethylmalate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-4-dehydropantoate:NAD+ 4-oxidoreductase. Other names in common use include D-aldopantoate dehydrogenase, D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine, and nucleotide (DPN+) oxidoreductase. This enzyme participates in pantothenate and coa biosynthesis.

References

  • IUBMB entry for 1.2.1.33
  • BRENDA references for 1.2.1.33 (Recommended.)
  • PubMed references for 1.2.1.33
  • PubMed Central references for 1.2.1.33
  • Google Scholar references for 1.2.1.33
  • Magee PT, Snell EE (1966). "The bacterial degradation of pantothenic acid. IV. Enzymatic conversion of aldopantoate to alpha-ketoisovalerate". Biochemistry. 5: 409&ndash, 16. PMID 4287371.

External links

The CAS registry number for this enzyme class is 37250-96-7.

Gene Ontology (GO) codes

Template:1.2-enzyme-stub


Linked-in.jpg