(S)-2-hydroxy-fatty-acid dehydrogenase

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In enzymology, a (S)-2-hydroxy-fatty-acid dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

(S)-2-hydroxystearate + NAD+ 2-oxostearate + NADH + H+

Thus, the two substrates of this enzyme are (S)-2-hydroxystearate and NAD+, whereas its 3 products are 2-oxostearate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-2-hydroxystearate:NAD+ oxidoreductase. Other names in common use include dehydrogenase, L-2-hydroxy fatty acid, L-2-hydroxy fatty acid dehydrogenase, and 2-hydroxy fatty acid oxidase.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Huang WY, Tang J (1970). "Carboxyl-terminal sequence of human gastricsin and pepsin". J. Biol. Chem. 245: 2189&ndash, 93. PMID 4909888.

External links

The CAS registry number for this enzyme class is 37250-33-2.

Gene Ontology (GO) codes