(S)-cheilanthifoline synthase

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In enzymology, a (S)-cheilanthifoline synthase (EC is an enzyme that catalyzes the chemical reaction

(S)-scoulerine + NADPH + H+ + O2 (S)-cheilanthifoline + NADP+ + 2 H2O

The 4 substrates of this enzyme are (S)-scoulerine, NADPH, H+, and O2, whereas its 3 products are (S)-cheilanthifoline, NADP+, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and the other dehydrogenated. The systematic name of this enzyme class is (S)-scoulerine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming). This enzyme is also called (S)-scoulerine oxidase (methylenedioxy-bridge-forming). This enzyme participates in alkaloid biosynthesis i.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Bauer W and Zenk MH (1991). "Two methylenedioxy bridge-forming cytochrome P-450 dependent enzymes are involved in (S)-stylopine biosynthesis". Phytochemistry. 30: 2953&ndash, 2961.

External links

The CAS registry number for this enzyme class is 138791-27-2.

Gene Ontology (GO) codes