(S)-norcoclaurine synthase

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In enzymology, a (S)-norcoclaurine synthase (EC 4.2.1.78) is an enzyme that catalyzes the chemical reaction

4-hydroxyphenylacetaldehyde + 4-(2-aminoethyl)benzene-1,2-diol (S)-norcoclaurine + H2O

Thus, the two substrates of this enzyme are 4-hydroxyphenylacetaldehyde and 4-(2-aminoethyl)benzene-1,2-diol, whereas its two products are (S)-norcoclaurine and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine (S)-norcoclaurine-forming]. Other names in common use include (S)-norlaudanosoline synthase, and 4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine). This enzyme participates in alkaloid biosynthesis i.

References

  • IUBMB entry for 4.2.1.78
  • BRENDA references for 4.2.1.78 (Recommended.)
  • PubMed references for 4.2.1.78
  • PubMed Central references for 4.2.1.78
  • Google Scholar references for 4.2.1.78
  • Stadler R, Zenk MH (1990). "A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline reticuline". Liebigs Ann. Chem.: 555&ndash, 562.
  • Stadler R, Kutchan TM, Zenk MH (1989). "(S)-Norcoclaurine is the central intermediate in benzylisoquinoline alkaloid biosynthesis". Phytochemistry. 28: 1083&ndash, 1086.
  • Samanani N, Facchini PJ (2002). "Purification and characterization of norcoclaurine synthase. The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants". J. Biol. Chem. 277: 33878&ndash, 83. PMID 12107162.

External links

The CAS registry number for this enzyme class is 79122-01-3.

Gene Ontology (GO) codes

Template:4.2-enzyme-stub


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