(hydroxymethylglutaryl-CoA reductase (NADPH))-phosphatase

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In enzymology, a [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase (EC is an enzyme that catalyzes the chemical reaction

[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O [hydroxymethylglutaryl-CoA reductase (NADPH)] + phosphate

Thus, the two substrates of this enzyme are [[[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate]] and H2O, whereas its two products are [[[hydroxymethylglutaryl-CoA reductase (NADPH)]]] and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphate phosphohydrolase. This enzyme is also called reductase phosphatase.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Google Scholar references for
  • Gil G, Hegardt FG (1982). "Some properties of purified 3-hydroxy-3-methylglutaryl coenzyme A reductase phosphatases from rat liver". Arch. Biochem. Biophys. 214: 192&ndash, 8. PMID 6282220.
  • Gil G, Sitges M, Hegardt FG (1981). "Purification and properties of rat liver hydroxymethylglutaryl coenzyme A reductase phosphatases". Biochim. Biophys. Acta. 663: 211&ndash, 21. PMID 6260210.

External links

The CAS registry number for this enzyme class is 73507-97-8.

Gene Ontology (GO) codes