(tyrosine 3-monooxygenase) kinase

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In enzymology, a [tyrosine 3-monooxygenase] kinase (EC is an enzyme that catalyzes the chemical reaction

ATP + [tyrosine-3-monooxygenase] ADP + phospho-[tyrosine-3-monooxygenase]

Thus, the two substrates of this enzyme are ATP and [[[tyrosine-3-monooxygenase]]], whereas its two products are ADP and [[phospho-[tyrosine-3-monooxygenase]]].

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[tyrosine-3-monoxygenase] phosphotransferase. Other names in common use include pheochromocytoma tyrosine hydroxylase-associated kinase, STK4, and tyrosine 3-monooxygenase kinase (phosphorylating). This enzyme participates in mapk signaling pathway and non-small cell lung cancer.


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  • Pigeon D, Drissi-Daoudi R, Gros F, Thibault J (1986). "[Copurification of tyrosine hydroxylase from rat pheochromocytoma by protein kinase]". C. R. Acad. Sci. III. 302: 435&ndash, 8. PMID 2872947.
  • Pigeon D, Ferrara P, Gros F, Thibault J (1987). "Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase". J. Biol. Chem. 262: 6155&ndash, 8. PMID 2883182.

External links

The CAS registry number for this enzyme class is 103537-12-8.

Gene Ontology (GO) codes