1-aminocyclopropane-1-carboxylate deaminase

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In enzymology, a 1-aminocyclopropane-1-carboxylate deaminase (EC is an enzyme that catalyzes the chemical reaction

1-aminocyclopropane-1-carboxylate + H2O 2-oxobutanoate + NH3

Thus, the two substrates of this enzyme are 1-aminocyclopropane-1-carboxylate and H2O, whereas its two products are 2-oxobutanoate and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in compounds that have not been otherwise categorized within EC number 3.5. The systematic name of this enzyme class is 1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing). This enzyme is also called 1-aminocyclopropane-1-carboxylate endolyase (deaminating). This enzyme participates in propanoate metabolism. It employs one cofactor, pyridoxal phosphate.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1RQX, 1TYZ, 1TZ2, 1TZJ, 1TZK, and 1TZM.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Honma M and Shimomura T (1978). "Metabolism of 1-aminocyclopropane-1-carboxylic acid". Agric. Biol. Chem. 42: 1825&ndash, 1831.
  • Wakatsuki S, Yokoi D, Murakami T, Honma M and Tanaka I (2000). "Crystal structure of 1-aminocyclopropane-1-carboxylate deaminase from Hansenula saturnus". J. Biol. Chem. 275: 34557&ndash, 34565.

External links

The CAS registry number for this enzyme class is 69553-48-6.

Gene Ontology (GO) codes