1-hydroxy-2-naphthoate 1,2-dioxygenase

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In enzymology, a 1-hydroxy-2-naphthoate 1,2-dioxygenase (EC is an enzyme that catalyzes the chemical reaction

1-hydroxy-2-naphthoate + O2 (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate

Thus, the two substrates of this enzyme are 1-hydroxy-2-naphthoate and O2, whereas its product is (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is 1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing). Other names in common use include 1-hydroxy-2-naphthoate dioxygenase, 1-hydroxy-2-naphthoate-degrading enzyme, and 1-hydroxy-2-naphthoic acid dioxygenase. This enzyme participates in naphthalene and anthracene degradation. It employs one cofactor, iron.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Barnsley EA (1983). "Phthalate pathway of phenanthrene metabolism: formation of 2'-carboxybenzalpyruvate". J. Bacteriol. 154: 113&ndash, 7. PMID 6833175.

External links

The CAS registry number for this enzyme class is 85941-64-6.

Gene Ontology (GO) codes