Steroid 11-beta-hydroxylase
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(Redirected from 11β-hydroxylase)
| cytochrome P450, family 11, subfamily B, polypeptide 1
| |
| Identifiers | |
| Symbol | CYP11B1 |
| Alt. Symbols | CYP11B |
| Entrez | 1584 |
| HUGO | 2591 |
| OMIM | 610613 |
| RefSeq | NM_001026213 |
| UniProt | P15538 |
| Other data | |
| EC number | 1.14.15.4 |
Steroid 11β-hydroxylase is a steroid hydroxylase found in the zona fasciculata.
Contents |
Function
It generates cortisol from 11-deoxycortisol and corticosterone from 11-deoxycorticosterone. Note the extra "–OH" added at the 11 position (near the center, on ring "C"):
Deoxycorticosterone.svg
|
Corticosterone-2D-skeletal.png
|
Location in pathway
Clinical significance
A mutation is associated with congenital adrenal hyperplasia due to 11β-hydroxylase deficiency.
Additional images
 Corticosteroid biosynthetic pathway in rat |
Steroid-nomenclature.png
Steroid numbering |
External links
Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14) | |
|---|---|
| 1.14.11 - 2-oxoglutarate | Prolyl hydroxylase - Lysyl hydroxylase |
| 1.14.13 - NADH or NADPH | Flavin-containing monooxygenase - Nitric oxide synthase - Cholesterol 7 alpha-hydroxylase - Methane monooxygenase - 3A4 -51A1 |
| 1.14.14 - reduced flavin or flavoprotein | 19A1 - 2D6 - 2E1 |
| 1.14.15 - reduced iron-sulfur protein | 11B1 - 11B2 - 11A1 |
| 1.14.16 - reduced pteridine | Phenylalanine hydroxylase - Tyrosine hydroxylase - Tryptophan hydroxylase |
| 1.14.17 - reduced ascorbate | Dopamine beta hydroxylase |
| 1.14.18-19 - other | Tyrosinase - Stearoyl-CoA desaturase-1 |
| 1.14.99 - miscellaneous | Cyclooxygenase - Heme oxygenase (HMOX1) - Squalene monooxygenase - 17A1 - 21A2 |
Cytochromes, oxygenases: cytochrome P450 (EC 1.14) | |
|---|---|
| CYP1 | A1, A2, B1 |
| CYP2 | A6, A7, A13, B6, C8, C9, C18, C19, D6, E1, F1, J2, R1, S1, U1, W1 |
| CYP3 | A4, A5, A7, A43 |
| CYP4 | A11, A22, B1, F2, F3, F8, F11, F12, F22, V2, X1, Z1 |
| CYP5-20 | CYP5 (A1) - CYP7 (A1, B1) - CYP8 (A1, B1) - CYP11 (A1, B1, B2) - CYP17 (A1) - CYP19 (A1) - CYP20 (A1) |
| CYP21-51 | CYP21 (A2) - CYP24 (A1) - CYP26 (A1, B1, C1) - CYP27 (A1, B1, C1) - CYP39 (A1) - CYP46 (A1) - CYP51 (A1) |
