15-oxoprostaglandin 13-oxidase

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In enzymology, a 15-oxoprostaglandin 13-oxidase (EC 1.3.1.48) is an enzyme that catalyzes the chemical reaction

(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ (5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+

The 3 substrates of this enzyme are (5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate, NAD+, and NADP+, whereas its 4 products are (5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprosta-13-enoate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Delta13-oxidoreductase. Other names in common use include 15-oxo-Delta13-prostaglandin reductase, Delta13-15-ketoprostaglandin reductase, 15-ketoprostaglandin Delta13-reductase, prostaglandin Delta13-reductase, prostaglandin 13-reductase, and 15-ketoprostaglandin Delta13-reductase.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1V3T, 1V3U, 1V3V, and 2DM6.

References

  • IUBMB entry for 1.3.1.48
  • BRENDA references for 1.3.1.48 (Recommended.)
  • PubMed references for 1.3.1.48
  • PubMed Central references for 1.3.1.48
  • Google Scholar references for 1.3.1.48
  • Hansen HS (1982). "Purification and assay of 15-ketoprostaglandin delta 13-reductase from bovine lung". Methods. Enzymol. 86: 156&ndash, 63. PMID 6290839.
  • Jarabak J (1982). "Isolation and properties of a 15-ketoprostaglandin delta 13-reductase from human placenta". Methods. Enzymol. 86: 163&ndash, 7. PMID 7132753.

External links

The CAS registry number for this enzyme class is 57406-74-3.

Gene Ontology (GO) codes

Template:1.3-enzyme-stub


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