4-Methylbenzylidene camphor
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| 4-MBC | |
|---|---|
| Chemical name | 4-Methylbenzylidene camphor (4-MBC) |
| Chemical formula | C18H22O |
| Molecular mass | 254.4 |
| Melting point | 66-70°C |
| Boiling point | |
| Density | |
| CAS number | 36861-47-9 |
| SMILES | |
4-Methylbenzylidene camphor, short 4-MBC, also 3-(4-Methylbenzylidene)bornan-2-one, or 3-(4-Methylbenzylidene)-dl-camphor is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation. As such it is used in sunscreen lotions and deodorants. Its tradename is Eusolex® 6300.
Endocrine disruptor
Studies have raised the issue that 4-MBC acts an endocrine disruptor. There is controversy about the estrogenic effects of 4-MBC and while one study showed only a relatively minor effect[1], a study in Switzerland showed significant uterine growth in immature rodents.[1] In addition, there is some evidence that 4-MBC may suppress the pituitary-thyroid axis leading to hypothyroidism.[1]
The agent can also lead to a photoallergic dermatitis.
Approval status
4-MBC is approved for use in Europe by the European Union's Scientific Committee for Cosmetic Products & Non-Food Products but is not approved for use in the USA by the Food and Drug Administration. It is also approved in Canada by Health Canada, in Australia and other countries. It's not permitted in Japan.
Alternative agents
Alternative agents that block UV by absorption include:
See also
References
External links
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
