6,7-dihydropteridine reductase

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In enzymology, a 6,7-dihydropteridine reductase (EC is an enzyme that catalyzes the chemical reaction

a 5,6,7,8-tetrahydropteridine + NAD(P)+ a 6,7-dihydropteridine + NAD(P)H + H+

The 3 substrates of this enzyme are 5,6,7,8-tetrahydropteridine, NAD+, and NADP+, whereas its 4 products are 6,7-dihydropteridine, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase. Other names in common use include 6,7-dihydropteridine:NAD(P)H oxidoreductase, DHPR, NAD(P)H:6,7-dihydropteridine oxidoreductase, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide), reductase, dihydropteridine reductase, dihydropteridine reductase (NADH), and 5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase. This enzyme participates in folate biosynthesis.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1YKI, 1YLR, and 1YLU.


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  • Harano T (1972). "New diaphorases from Bombyx silkworm eggs. NADH/NADPH cytochrome c reductase activity mediated with 6,7-dimethyltetrahydropterin". Insect Biochem. 2: 385&ndash, 399.
  • Hasegawa H (Tokyo). "Dihydropteridine reductase from bovine liver. Purification, crystallization, and isolation of a binary complex with NADH". J. Biochem.: 169&ndash, 77. PMID 191436. Check date values in: |date= (help)
  • Kaufman S (1962). "Phenylalanine hydroxylase". Methods Enzymol. 5: 809&ndash, 816.
  • Lind KE (1972). "Dihydropteridine reductase. Investigation of the specificity for quinoid dihydropteridine and the inhibition by 2,4-diaminopteridines". Eur. J. Biochem. 25: 560&ndash, 2. PMID 4402916.
  • Nakanishi N, Hasegawa H, Watabe S (Tokyo). "A new enzyme, NADPH-dihydropteridine reductase in bovine liver". J. Biochem.: 681&ndash, 5. PMID 16875. Check date values in: |date= (help)

External links

The CAS registry number for this enzyme class is 9074-11-7.

Gene Ontology (GO) codes