ACVR1B
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| Activin receptor type 1B | |
|---|---|
| Other names: | ACTR-IB, Serine/threonine-protein kinase receptor R2, SKR2, Activin receptor-like kinase 4, ALK-4 |
| Genetic data | |
| Gene code: | HUGO code: ACVR1B |
| Protein Structure/Function | |
| Protein type: | Serine/Threonine receptor kinase |
| Domains: | GS domain, TS domain, S/T domain |
| Other | |
| Taxa expressing: | Homo sapiens; homologs: many metazoan phyla |
| Cell types: | ubiquitous |
| Subcellular localization: | Plasma membrane |
| Enzymatic Data | |
| Catalytic activity: | ATP + (receptor-protein) = ADP + (receptor-protein) phosphate |
| Cofactor(s): | Magnesium or manganese |
| Medical/Biotechnological data | |
| Diseases: | Pancreatic Carcinoma |
ACVR1B or ALK-4 acts as a transducer of Activin or activin like ligands (eg. Inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3.[1] ACVR1B also transduces signals of nodal, GDF-1, and Vg1; however, unlike activin, they require other coreceptor molecules such as the protein Cripto[1].
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| Identifiers | |
| Symbol | ACVR1B |
| Alt. Symbols | ACVRLK4 |
| Entrez | 91 |
| HUGO | 172 |
| OMIM | 601300 |
| RefSeq | NM_020328 |
| UniProt | P36896 |
| Other data | |
| EC number | 2.7.11.30 |
| Locus | Chr. 12 q13 |
References
Cell signaling: TGF beta signaling pathway | |
|---|---|
| TGF beta superfamily of ligands | TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal) |
| TGF beta receptors | TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2 TGFBR3: betaglycan |
| Transducers/SMAD | R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4 |
| Ligand Inhibitors | Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1 |
| Coreceptors | BAMBI - Cripto |
| Other | SARA |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
