Acid phosphatase
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Acid phosphatase is a phosphatase, a type of enzyme, used to free attached phosphate groups from other molecules during digestion.It is basically a phospho homo esterase . It is stored in lysosomes and functions when these fuse with endosomes, which are acidified while they function; therefore, it has an acid pH optimum.
Different forms of acid phosphatase are found in different organs, and their serum levels are used as a diagnostic for disease in the corresponding organs. For example, elevated prostatic acid phosphatase levels may indicate the presence of prostate cancer.
Acid phosphatase catalyzes the following reaction at an optimal pH below 7:
Orthophosphoric monoester + H2O → alcohol + H3PO4
Differential Diagnosis
In alphabetical order. [1] [1]
Increased Acid Phosphatase
- Benign prostatic hypertrophy
- Bone metastases
- Breast Cancer
- Chronic Renal Disease
- Disseminated Intravascular Coagulation (DIC)
- Gaucher's Disease
- Hemolysis
- Hyperparathyroidism
- Leukemia
- Liver disease
- Megaloblastic anemia
- Multiple Myeloma
- Osteogenesis imperfecta
- Osteosarcoma
- Paget's Disease
- Polycythemia
- Prostate Cancer
- Prostatic manipulation
- Prostatitis
- Thrombocytosis
See also
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
