Acyl-CoA oxidase

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In enzymology, an acyl-CoA oxidase (EC is an enzyme that catalyzes the chemical reaction

acyl-CoA + O2 trans-2,3-dehydroacyl-CoA + H2O2

Thus, the two substrates of this enzyme are acyl-CoA and O2, whereas its two products are trans-2,3-dehydroacyl-CoA and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is acyl-CoA:oxygen 2-oxidoreductase. Other names in common use include fatty acyl-CoA oxidase, acyl coenzyme A oxidase, and fatty acyl-coenzyme A oxidase. This enzyme participates in 3 metabolic pathways: fatty acid metabolism, polyunsaturated fatty acid biosynthesis, and ppar signaling pathway. It employs one cofactor, FAD.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1IS2, 1W07, 2DDH, 2FON, 2IX5, and 2IX6.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Google Scholar references for
  • T, Kikuchi T, Ando M, Okuda S (Tokyo). "Stereochemistry of dehydrogenation catalyzed by Acyl-CoA oxidase". J. Biochem.: 1481&ndash, 6. PMID 7462191. Check date values in: |date= (help)
  • Osumi T, Hashimoto T, Ui N (Tokyo). "Purification and properties of acyl-CoA oxidase from rat liver". J. Biochem.: 1735&ndash, 46. PMID 7400120. Check date values in: |date= (help)

External links

The CAS registry number for this enzyme class is 61116-22-1.

Gene Ontology (GO) codes