Adenosine diphosphate
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| Adenosine diphosphate | |
|---|---|
| |
| Identifiers | |
| CAS number | |
| PubChem | |
| SMILES | Nc1ncnc2[n](cnc12)[C@@H]3O[C@H] (COP([O-])(=O)OP(O)([O-])=O)C(O)C3O |
| Properties | |
| Molecular formula | C10H15N5O10P2 |
| Molar mass | 427.201 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references | |
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Adenosine diphosphate, abbreviated ADP, is a nucleotide. It is an ester of pyrophosphoric acid with the nucleotide adenine. ADP consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase adenine.
ADP is the product of ATP dephosphorylation by ATPases. ADP is converted back to ATP by ATP synthases. ATP is an important energy transfer molecule in cells.
ADP is stored in dense bodies inside blood platelets and is released upon platelet activation. ADP interacts with a family of ADP receptors found on platelets (P2Y1, P2Y12 and P2X1), leading to further platelet activation.[1] ADP in the blood is converted to adenosine by the action of ecto-ADPases, inhibiting further platelet activation via adenosine receptors. The anti-platelet drug Plavix (clopidogrel) inhibits the P2Y12 receptor.
ADP is the end-product that results when ATP loses one of its phosphate groups located at the end of the molecule.[1] The conversion of these two molecules plays a critical role in supplying energy for many processes of life.[1] The deletion of one of ATP’s phosphorous bonds generates about the same amount of energy derived from human digestion of a single peanut, approximately 7.3 kilocalories per Mole of ATP.[1] ADP can be converted, or powered back to ATP through the process of releasing the chemical energy available in food; in humans this is constantly performed via aerobic respiration in the mitochondria.[1] Plants use photosynthetic pathways to convert and store the energy from sunlight, via conversion of ADP to ATP.[1] Animals use the energy released in the breakdown of glucose and other molecules to convert ADP to ATP, which can then be used to fuel necessary growth and cell maintenance.[1]
See also
References
de:Adenosindiphosphatid:Adenosin difosfat it:Adenosindifosfato he:ADP lt:ADP hu:Adenozin-difoszfát nl:Adenosinedifosfaat ja:アデノシン二リン酸simple:Adenosine diphosphate sr:Аденозин дифосфат sh:Adenozin difosfat fi:ADP sv:Adenosindifosfatuk:АДФ
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
