Amino-acid racemase

You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.

In enzymology, an amino-acid racemase (EC 5.1.1.10) is an enzyme that catalyzes the chemical reaction

an L-amino acid a D-amino acid

Hence, this enzyme has one substrate, L-amino acid, and one product, D-amino acid.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is amino-acid racemase. This enzyme is also called L-amino acid racemase. This enzyme participates in 4 metabolic pathways: glycine, serine and threonine metabolism, cysteine metabolism, D-glutamine and D-glutamate metabolism, and D-arginine and D-ornithine metabolism. It employs one cofactor, pyridoxal phosphate.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 2FKP, 2GGG, 2GGH, 2GGI, and 2GGJ.

References

• IUBMB entry for 5.1.1.10
• BRENDA references for 5.1.1.10 (Recommended.)
• PubMed references for 5.1.1.10
• PubMed Central references for 5.1.1.10
• Google Scholar references for 5.1.1.10
• Soda K, Osumi T (1969). "Crystalline amino acid racemase with low substrate specificity". Biochem. Biophys. Res. Commun. 35: 363–8. PMID 5788493.

External links

The CAS registry number for this enzyme class is 9068-61-5.

• IUBMB entry for 5.1.1.10

• KEGG entry for 5.1.1.10

• BRENDA entry for 5.1.1.10

• NiceZyme view of 5.1.1.10

• EC2PDB: PDB structures for 5.1.1.10

• PRIAM entry for 5.1.1.10

• PUMA2 entry for 5.1.1.10

• IntEnz: Integrated Enzyme entry for 5.1.1.10

• MetaCyc entry for 5.1.1.10

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0047661: amino-acid racemase

• AMIGO entry for GO code 0047661: amino-acid racemase

Template:Isomerase-stub