Aminoglutethimide

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Aminoglutethimide
Systematic (IUPAC) name
3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione
Identifiers
CAS number	125-84-8
ATC code	L02BG01
PubChem	2145
DrugBank	APRD00592
Chemical data
Formula	C13H16N2O2
Mol. mass	232.278 g/mol
Pharmacokinetic data
Bioavailability	>95%
Metabolism	Hepatic
Half life	12.5 ± 1.6 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	D: (USA) D:(AUS)
Legal status
Routes	Oral

WikiDoc Resources for Aminoglutethimide
Articles
Most recent articles on Aminoglutethimide Most cited articles on Aminoglutethimide Review articles on Aminoglutethimide Articles on Aminoglutethimide in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Aminoglutethimide Images of Aminoglutethimide Photos of Aminoglutethimide Podcasts & MP3s on Aminoglutethimide Videos on Aminoglutethimide
Evidence Based Medicine
Cochrane Collaboration on Aminoglutethimide Bandolier on Aminoglutethimide TRIP on Aminoglutethimide
Clinical Trials
Ongoing Trials on Aminoglutethimide at Clinical Trials.gov Trial results on Aminoglutethimide Clinical Trials on Aminoglutethimide at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Aminoglutethimide NICE Guidance on Aminoglutethimide NHS PRODIGY Guidance FDA on Aminoglutethimide CDC on Aminoglutethimide
Books
Books on Aminoglutethimide
News
Aminoglutethimide in the news Be alerted to news on Aminoglutethimide News trends on Aminoglutethimide
Commentary
Blogs on Aminoglutethimide
Definitions
Definitions of Aminoglutethimide
Patient Resources / Community
Patient resources on Aminoglutethimide Discussion groups on Aminoglutethimide Patient Handouts on Aminoglutethimide Directions to Hospitals Treating Aminoglutethimide Risk calculators and risk factors for Aminoglutethimide
Healthcare Provider Resources
Symptoms of Aminoglutethimide Causes & Risk Factors for Aminoglutethimide Diagnostic studies for Aminoglutethimide Treatment of Aminoglutethimide
Continuing Medical Education (CME)
CME Programs on Aminoglutethimide
International
Aminoglutethimide en Espanol Aminoglutethimide en Francais
Businness
Aminoglutethimide in the Marketplace Patents on Aminoglutethimide
Experimental / Informatics
List of terms related to Aminoglutethimide

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Aminoglutethimide blocks the conversion of cholesterol to pregnenolone by inhibiting the enzyme desmolase, thus inhibits synthesis of all hormonally active steroids. It can be used in conjunction with other drugs for treatment of steroid-producing adrenocortical cancer.

Its major side effects are liver toxicity, inhibition of cortisol in the human body, and it may also cause hypothyroidism. Since cortisol helps break down muscle, aminoglutethimide is used by bodybuilders in a steroid cycle.

It is still used to suppress corticosteroid production in Cushing's Syndrome.

See also

• Glutethimide

External links

• Medline Plus

v • d • e Sex hormones and related agents (primarily G03, also L02, H01C) - human endogenous in CAPS
Progestogens: (receptor)	PROGESTERONE,Dienogest, Desogestrel, Drospirenone, Dydrogesterone, Ethisterone, Etonogestrel, Ethynodiol diacetate, Gestodene, Gestonorone, Levonorgestrel, Lynestrenol, Medroxyprogesterone, Megestrol, Norelgestromin, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Norgestrienone, Tibolone Selective progesterone receptor modulator: Asoprisnil, CDB-4124 Antiprogestogen: Mifepristone
Androgens: (receptor)	TESTOSTERONE, Androstanolone, Fluoxymesterone, Mesterolone, Methyltestosterone, (see also anabolic steroids) Antiandrogens: Bicalutamide, Cyproterone, Dienogest, Flutamide, Nilutamide, Spironolactone
Estrogens: (receptor)	ESTRADIOL, ESTRIOL, ESTRONE, Chlorotrianisene, Dienestrol, Diethylstilbestrol, Ethinylestradiol, Fosfestrol, Mestranol, Polyestradiol phosphate Selective estrogen receptor modulator: Afimoxifene, Arzoxifene, Bazedoxifene, Clomifene, Fulvestrant, Lasofoxifene, Raloxifene, Tamoxifen, Toremifene Aromatase inhibitor: Aminogluthetimide, Anastrozole, Atamestane, Exemestane, Formestane, Letrozole, Vorozole
Gonadotropins: (FSHR/LHCGR)	ovulation stim.: Clomifene, Urofollitropin Antigonadotropins: Danazol, Gestrinone
GnRH: (receptor)	agonist: Buserelin, Goserelin, Histrelin, Leuprorelin, Nafarelin, Triptorelin antagonist: Abarelix, Cetrorelix, Ganirelix

v • d • e WikiDoc Research Resources for Aminoglutethimide (Click show to right to view)
Articles on Aminoglutethimide	Most recent articles on Aminoglutethimide • Most cited articles on Aminoglutethimide • Review articles on Aminoglutethimide • Articles on Aminoglutethimide in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Aminoglutethimide	Powerpoint slides on Aminoglutethimide • Images of Aminoglutethimide • Photos of Aminoglutethimide • Podcasts & MP3s on Aminoglutethimide • Videos on Aminoglutethimide
Evidence Based Medicine Regarding Aminoglutethimide	Cochrane Collaboration on Aminoglutethimide • Bandolier on Aminoglutethimide • TRIP on Aminoglutethimide
Cost Effectiveness of Aminoglutethimide	Cost Effectiveness of Aminoglutethimide
Clinical Trials Involving Aminoglutethimide	Ongoing Trials on Aminoglutethimide at Clinical Trials.gov • Trial results on Aminoglutethimide • Clinical Trials on Aminoglutethimide at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Aminoglutethimide	US National Guidelines Clearinghouse on Aminoglutethimide • NICE Guidance on Aminoglutethimide • NHS PRODIGY Guidance • FDA on Aminoglutethimide • CDC on Aminoglutethimide
Textbook Information on Aminoglutethimide	Books and Textbook Information on Aminoglutethimide
Pharmacology Resources on Aminoglutethimide	Dosing of Aminoglutethimide • Drug interactions with Aminoglutethimide • Side effects of Aminoglutethimide • Allergic reactions to Aminoglutethimide • Overdose information on Aminoglutethimide • Carcinogenicity information on Aminoglutethimide • Aminoglutethimide in pregnancy • Pharmacokinetics of Aminoglutethimide •
Genetics, Pharmacogenomics, and Proteinomics of Aminoglutethimide	Genetics of Aminoglutethimide • Pharmacogenomics of Aminoglutethimide • Proteomics of Aminoglutethimide
Newstories on Aminoglutethimide	Aminoglutethimide in the news • Be alerted to news on Aminoglutethimide • News trends on Aminoglutethimide
Commentary on Aminoglutethimide	Blogs on Aminoglutethimide
Patient Resources on Aminoglutethimide	Patient resources on Aminoglutethimide • Discussion groups on Aminoglutethimide • Patient Handouts on Aminoglutethimide • Directions to Hospitals Treating Aminoglutethimide • Risk calculators and risk factors for Aminoglutethimide
Healthcare Provider Resources on Aminoglutethimide	Symptoms of Aminoglutethimide • Causes & Risk Factors for Aminoglutethimide • Diagnostic studies for Aminoglutethimide • Treatment of Aminoglutethimide
Continuing Medical Education (CME) Programs on Aminoglutethimide	CME Programs on Aminoglutethimide
International Resources on Aminoglutethimide	Aminoglutethimide en Espanol • Aminoglutethimide en Francais
Business Resources on Aminoglutethimide	Aminoglutethimide in the Marketplace • Patents on Aminoglutethimide
Informatics Resources on Aminoglutethimide	List of terms related to Aminoglutethimide

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .