Anti-p62 antibodies
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| Autoantibody(s) | |
|---|---|
| Anti-p62 | |
| Autoantigen Isoform | Nucleoporin 62kDA |
| Autoantigen gene | NUP62 |
| Affected organ(s) | Bile Duct |
| AssociatedDisease(s) | Primary biliary cirrhosis |
| HLA associations | DR2 (weak) |
Anti-p62 antibodies (AP62A) are found in a primary biliary cirrhosis.[1] p62 is also more frequent in Stage IV primary biliary cirrhosis and is prognostic for severe disease.[2][3] The autoantigen is the nucleoporin 62kDA protein.
References
- ↑ Wesierska-Gadek J, Hohenuer H, Hitchman E, Penner E (1996). "Autoantibodies against nucleoporin p62 constitute a novel marker of primary biliary cirrhosis". Gastroenterology 110 (3): 840-7. PMID 8608894.
- ↑ Miyachi K, Hankins RW, Matsushima H, et al (2003). "Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: a multicenter study". J. Autoimmun. 20 (3): 247-54. PMID 12753810.
- ↑ Invernizzi P, Selmi C, Ranftler C, Podda M, Wesierska-Gadek J (2005). "Antinuclear antibodies in primary biliary cirrhosis". Semin. Liver Dis. 25 (3): 298-310. doi:10.1055/s-2005-916321. PMID 16143945.
