Anti-cardiolipin antibodies
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Overview
Anti-cardiolipin antibodies (ACA) are antibodies often directed against cardiolipin and found in several diseases including syphilis[1], antiphospholipid syndrome, livedoid vasculitis, vertebrobasilar insufficiency, Behçet's syndrome[1], idiopathic spontaneous abortion,[1] and systemic lupus erythematosus(SLE).[1] They are a form of anti-mitochondrial antibody. In SLE, The anti-DNA antibodies and anti-cardiolipin act independently.[1] In rheumatoid arthritis[1] w/systemic sclerosis (scleroderma)[1] these antibodies may tie two conditions together.
Anti-cardiolipin antibodies come can be classified in two ways.
- As IgM, IgG or IgA
- As β2-glycoprotein dependent or independent
- In autoimmune disease ACA are beta-2 glycoprotein dependent
- syphilis ACA[1] are beta-2 glycoprotein independent and can be assayed using the Venereal Disease Research Laboratory test
Apolipoprotein H involvement
β2-glycoprotein I has been identified as Apolipoprotein H and is required for the recognition of ACA in autoimmune disease.[1] Only a subset of autoimmune anti-cardiolipin antibodies bind Apo-H, these anti-apolipoprotein antibodies are associated with increased thrombosis.
References
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
