Arginine decarboxylase
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In enzymology, an arginine decarboxylase (EC 4.1.1.19) is an enzyme that catalyzes the chemical reaction
- L-arginine
agmatine + CO2
Hence, this enzyme has one substrate, L-arginine, and two products, agmatine and CO2.
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is L-arginine carboxy-lyase (agmatine-forming). Other names in common use include SpeA, and L-arginine carboxy-lyase. This enzyme participates in urea cycle and metabolism of amino groups and glutamate metabolism. It employs one cofactor, pyridoxal phosphate.
Contents |
Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1MT1, 1N13, 1N2M, 2NV9, and 2NVA.
References
- IUBMB entry for 4.1.1.19
- BRENDA references for 4.1.1.19 (Recommended.)
- PubMed references for 4.1.1.19
- PubMed Central references for 4.1.1.19
- Google Scholar references for 4.1.1.19
- Blethen SL, Boeker EA, Snell EE (1968). "Argenine decarboxylase from Escherichia coli. I. Purification and specificity for substrates and coenzyme". J. Biol. Chem. 243: 1671–7. PMID 4870599.
- Ramakrishna S, Adiga PR (1975). "Arginine decarboxylase from Lathyrus sativus seedlings. Purification and properites". Eur. J. Biochem. 59: 377–86. PMID 1252.
- Taylor ES and Gale EF (1945). "Studies on bacterial amino-acid decarboxylases. 6. Codecarboxylase content and action of inhibitors". Biochem. J. 39: 52–58.
External links
- The CAS registry number for this enzyme class is 9024-77-5.
Gene Ontology (GO) codes
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
