Arginine vasopressin receptor 1B

You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.

Arginine vasopressin receptor 1B
Identifiers
Symbol(s)	AVPR1B; AVPR3
External IDs	OMIM: 600264 MGI: 1347010 Homologene: 22678
Gene ontology Molecular Function: • rhodopsin-like receptor activity • receptor activity • vasopressin receptor activity • protein kinase C binding Cellular Component: • endosome • plasma membrane • integral to plasma membrane Biological Process: • signal transduction • G-protein coupled receptor protein signaling pathway • phospholipase C activation • elevation of cytosolic calcium ion concentration
Orthologs
	Human	Mouse
Entrez	553	26361
Ensembl	ENSG00000198049	ENSMUSG00000026432
Uniprot	P47901	Q9JLP2
Refseq	NM_000707 (mRNA) NP_000698 (protein)	NM_011924 (mRNA) NP_036054 (protein)
Location	Chr 1: 204.39 - 204.4 Mb	Chr 1: 133.43 - 133.44 Mb
Pubmed search	[1]	[2]

Arginine vasopressin receptor 1B (AVPR1B, vasopressin 3 receptor) is a protein that acts as receptor for arginine vasopressin. AVPR1B belongs to the subfamily of G-protein coupled receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system.

Contents 1 Tissue distribution 2 Clinical significance 2.1 Behavioral 2.2 Metabolic 2.3 Oncology 3 Ligands 4 References 5 External links

Tissue distribution

AVPR1B was initially described as a novel vasopressin receptor located in the anterior pituitary, where it stimulates ACTH release.^[1] Subsequent studies have shown its presence in the brain as well.^[1][1]

Clinical significance

Behavioral

Inactivation of the Avpr1b in mice (knockout) produces mice with greatly reduced aggression and a reduced ability to recognize recently investigated mice.^[1] Interestingly, defensive behavior and predatory behaviors appear to normal in these knockout mice.^[1] There is evidence that social motivation or awareness is reduced in these mice.^[1] The AVPR1B antagonist, SSR149415, has been shown to have anti-aggressive actions in hamsters^[1] and anti-depressant- and anxiety (anxiolytic)-like behaviors in rats.^[1] A single nucleotide polymorphism (SNP) has been associated with susceptiblility to depression in man.^[1]

Metabolic

Various stress-induced elevations of ACTH are blunted in the Avpr1b knockout mouse.^[1]

Oncology

AVPR1B is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids^[1] responsible for the ectopic ACTH syndrome.^[1]

Ligands

SSR149415^[1] and D-[Leu⁴-Lys⁸]-vasopressin^[1] are a specific antagonist and agonist for the vasopressin 1b receptor, respectively.

References

External links

• IUPHAR GPCR database - Arginine vasopressin receptor V_1B
• MeSH Receptors,+Vasopressin

v • d • e Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - Neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)
Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened

v • d • e Neuropeptide receptors
Hypothalamic hormone receptors	CRH - FSH - LHRH - TRH - Somatostatin
Pituitary hormone receptors	Vasopressin (1A, 1B, 2) - Oxytocin - LHCG - Type I cytokine receptor (GH, Prolactin) - TSH
Other hormone receptors	Atrial natriuretic factor - Calcitonin - Cholecystokinin (A, B) - VIP
Opioid receptors	Delta - Kappa - Mu - Sigma (1, 2) - Nociceptin
Other neuropeptide receptors	Angiotensin - Bradykinin (B1, B2) / Tachykinin (TACR1) - Calcitonin gene-related peptide - Galanin - GPCR neuropeptide (B/W, FF, S, Y) - Neurotensin