Aristolochic acid
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| Aristolochic acid | |
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| Image:Aristolochic acid.PNG | |
| Other names | Aristolochic acid I
Aristolochic acid II
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| Identifiers | |
| CAS number | |
| Properties | |
| Molecular formula | C17H11NO7 |
| Molar mass | 341.27684 g/mol |
| Density | ? g/cm3 |
| Melting point |
260 - 265 °C |
| Boiling point |
°C |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references | |
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Overview
Aristolochic acid is a rodent carcinogen found in the Aristolochia and Asarum species, both in the Aristolochiaceae family of plants. Aristolochic acid is composed of a ~1:1 mixture of two forms, aristolochic acid I and aristolochic acid II.
In addition to its carcinogenicity, aristolochic acid is also highly nephrotoxic and may be a causative agent in Balkan nephropathy. However, despite these well-documented dangers, aristolochic acid is still sometimes used as a herbal remedy for weight loss.
References
- FDA Warns Consumers to Discontinue Use of Botanical Products that Contain Aristolochic acid. April 11 2001. Website-http://www.cfsan.fda.gov/%20~dms/addsbot.html
- FDA Concerned About Botanical Products, Including Dietary Supplements, Containing Aristolochic Acid. April 2001. Website-http://www.cfsan.fda.gov/~dms/ds-bot.html
- Health Canada advising not to use products labelled to contain Aristolochia. August 2001. Website - http://www.hc-sc.gc.ca/ahc-asc/media/advisories-avis/2001/2001_91_e.html
de:Aristolochiasäuren nl:Aristolochiazuur
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
