Artesunate suppositories
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
| This article is orphaned as few or no other articles link to it. Please help introduce links in articles on related topics. |
Artesunate suppositories are used for the treatment of malaria. Artesunate is an antimalarial water-soluble derivative of dihydroartemisinin. Artemisinins are sesquiterpene lactones isolated from Artemisia annua, a Chinese traditional medicine.
The risk of death from severe malaria is largely dependent on the time lag between the onset of symptoms and treatment. Rapid access to effective treatment is therefore essential. For many patients, readily available oral drugs cannot be taken because of their symptoms (e.g. vomiting, convulsions, coma), and hospitals providing alternative, non-oral treatment are often inaccessible. The drug artesunate, given in suppository form, provides a potential solution to this problem: it can be made available in remote areas and thus can be given at the onset of symptoms.
Artesunate is one of a number of artemisinin derivatives discovered and developed by Chinese scientists and registered in China in the 1980s. Since the 1990s, UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR) supported studies to assess the properties of the drug. There were already indications that artesunate, given rectally, was effective in severe malaria. Significant work with artemisinin suppositories in severe malaria was conducted in Viet Nam in the early 1990s, [1,2,3] and clinical trials of rectal artesunate followed by mefloquine treatment in moderately severe malaria were conducted in Thailand.[4,5]
1. Hien et al, Trans R Soc Trop Med Hyg, 1992, 86: 582-583 2. Vinh et al, Trans R Soc Trop Med Hyg, 1997, 91: 465-457 3. Ashton et al, Clin Pharmacol Ther, 1998, 63 (4): 482-493 4. Looareesuwan et al, Ann Trop Med Parasitol, 1995, 89 (5): 469-475 5. Looareesuwan, Am J Trop Med Hyg, 1997, 57(3): 348-353
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
