Axitinib

You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.

Image:Axitinib.png
Axitinib
Systematic (IUPAC) name
N-Methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
Identifiers
CAS number	319460-85-0
ATC code	?
PubChem	6450551
Chemical data
Formula	C22H18N4OS
Mol. mass	386.469 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

WikiDoc Resources for Axitinib
Articles
Most recent articles on Axitinib Most cited articles on Axitinib Review articles on Axitinib Articles on Axitinib in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Axitinib Images of Axitinib Photos of Axitinib Podcasts & MP3s on Axitinib Videos on Axitinib
Evidence Based Medicine
Cochrane Collaboration on Axitinib Bandolier on Axitinib TRIP on Axitinib
Clinical Trials
Ongoing Trials on Axitinib at Clinical Trials.gov Trial results on Axitinib Clinical Trials on Axitinib at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Axitinib NICE Guidance on Axitinib NHS PRODIGY Guidance FDA on Axitinib CDC on Axitinib
Books
Books on Axitinib
News
Axitinib in the news Be alerted to news on Axitinib News trends on Axitinib
Commentary
Blogs on Axitinib
Definitions
Definitions of Axitinib
Patient Resources / Community
Patient resources on Axitinib Discussion groups on Axitinib Patient Handouts on Axitinib Directions to Hospitals Treating Axitinib Risk calculators and risk factors for Axitinib
Healthcare Provider Resources
Symptoms of Axitinib Causes & Risk Factors for Axitinib Diagnostic studies for Axitinib Treatment of Axitinib
Continuing Medical Education (CME)
CME Programs on Axitinib
International
Axitinib en Espanol Axitinib en Francais
Businness
Axitinib in the Marketplace Patents on Axitinib
Experimental / Informatics
List of terms related to Axitinib

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Overview

Axitinib (also known as AG013736) is a small molecule tyrosine kinase inhibitor under development by Pfizer. It inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117). It has been shown to significantly inhibit growth of breast cancer in xenograft models ^[1] and has been successful in trials with renal cell carcinoma (RCC) ^[1] and several other tumor types ^[1].

Currently, it is in Phase III clinical trials for pancreatic cancer.

References

v • d • e Chemotherapeutic agents/Antineoplastic agents (L01)
Alkylating and alkylating-like agents	Nitrogen mustards: (Chlorambucil, Chlormethine, Cyclophosphamide, Ifosfamide, Melphalan, Bendamustine, Uramustine) Nitrosoureas:(Carmustine, Fotemustine, Lomustine, Streptozocin) Platinum (alkylating-like): (Carboplatin, Cisplatin, Oxaliplatin, Triplatin tetranitrate, Satraplatin) Alkyl sulfonates:(Busulfan, Treosulfan) Hydrazines:(Procarbazine, Dacarbazine, Temozolomide) Aziridines:(ThioTEPA)
Antimetabolites	Folic acid: (Aminopterin, Methotrexate, Pemetrexed, Raltitrexed). Purine:(Cladribine, Clofarabine, Fludarabine, Mercaptopurine, Pentostatin, Thioguanine) Pyrimidine:(Capecitabine, Cytarabine, Decitabine, Fluorouracil, Floxuridine, Gemcitabine)
Spindle poison/mitotic inhibitor	Taxane: (Docetaxel, Larotaxel, Paclitaxel). Vinca: (Vinblastine, Vincristine, Vindesine, Vinorelbine).
Cytotoxic/antitumor antibiotics	Anthracycline family: (Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mitoxantrone, Pixantrone, Valrubicin) streptomyces (Actinomycin, Bleomycin, Mitomycin, Plicamycin) - Hydroxyurea
Topoisomerase inhibitors	Camptotheca: (Camptothecin, Topotecan, Irinotecan, Rubitecan), Podophyllum:(Etoposide, Teniposide)
CI monoclonal antibodies	Receptor tyrosine kinase (Cetuximab, Panitumumab, Trastuzumab) - CD20 (Rituximab, Tositumomab) - other (Alemtuzumab, Bevacizumab, Gemtuzumab)
Photosensitizers	Aminolevulinic acid, Methyl aminolevulinate, Porfimer sodium, Verteporfin
Tyrosine kinase inhibitors	Axitinib, Bosutinib, Cediranib, Dasatinib, Erlotinib, Gefitinib, Imatinib, Lapatinib, Lestaurtinib, Nilotinib, Semaxanib, Sorafenib, Sunitinib, Vandetanib
Cyclin-dependent kinase inhibitor	Seliciclib
Other	retinoids (Alitretinoin, Tretinoin), Fusion protein (Aflibercept) - Altretamine, Amsacrine, Anagrelide, Arsenic trioxide, Asparaginase (Pegaspargase), Bexarotene, Bortezomib, Celecoxib, Denileukin diftitox, Elesclomol, Estramustine, Irofulven, Ixabepilone, Masoprocol, Mitotane, Oblimersen, Testolactone, Tipifarnib, Trabectedin

v • d • e WikiDoc Research Resources for Axitinib
Articles on Axitinib	Most recent articles on Axitinib • Most cited articles on Axitinib • Review articles on Axitinib • Articles on Axitinib in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Axitinib	Powerpoint slides on Axitinib • Images of Axitinib • Photos of Axitinib • Podcasts & MP3s on Axitinib • Videos on Axitinib
Evidence Based Medicine Regarding Axitinib	Cochrane Collaboration on Axitinib • Bandolier on Axitinib • TRIP on Axitinib
Cost Effectiveness of Axitinib	Cost Effectiveness of Axitinib
Clinical Trials Involving Axitinib	Ongoing Trials on Axitinib at Clinical Trials.gov • Trial results on Axitinib • Clinical Trials on Axitinib at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Axitinib	US National Guidelines Clearinghouse on Axitinib • NICE Guidance on Axitinib • NHS PRODIGY Guidance • FDA on Axitinib • CDC on Axitinib
Textbook Information on Axitinib	Books and Textbook Information on Axitinib
Pharmacology Resources on Axitinib	Dosing of Axitinib • Drug interactions with Axitinib • Side effects of Axitinib • Allergic reactions to Axitinib • Overdose information on Axitinib • Carcinogenicity information on Axitinib • Axitinib in pregnancy • Pharmacokinetics of Axitinib •
Genetics, Pharmacogenomics, and Proteinomics of Axitinib	Genetics of Axitinib • Pharmacogenomics of Axitinib • Proteomics of Axitinib
Newstories on Axitinib	Axitinib in the news • Be alerted to news on Axitinib • News trends on Axitinib
Commentary on Axitinib	Blogs on Axitinib
Patient Resources on Axitinib	Patient resources on Axitinib • Discussion groups on Axitinib • Patient Handouts on Axitinib • Directions to Hospitals Treating Axitinib • Risk calculators and risk factors for Axitinib
Healthcare Provider Resources on Axitinib	Symptoms of Axitinib • Causes & Risk Factors for Axitinib • Diagnostic studies for Axitinib • Treatment of Axitinib
Continuing Medical Education (CME) Programs on Axitinib	CME Programs on Axitinib
International Resources on Axitinib	Axitinib en Espanol • Axitinib en Francais
Business Resources on Axitinib	Axitinib in the Marketplace • Patents on Axitinib
Informatics Resources on Axitinib	List of terms related to Axitinib

WikiDoc Help Menu Quick Start.. Get Started Here! How to Login How to Search Pages How to Start a New Page How to Edit a Page Cheat Sheet Editing basics Learning Basic Formatting How to make Links in WikiDoc & to External Sites How to Make Lists How to Ignoring Formatting Adding References or Footnotes to Articles Tracking Changes You Have Made How to Put an Article Into a Category When Multiple Topics Should Go To The Same Page (MI, Acute MI, AMI) Using Redirection Advanced editing How to Make Tables How to Insert Images and Other Media How to Add Video Help:How to Make Columns Web Colors How To Make Templates How to Move Pages Inserting Dynamic Dates and Times Inserting WikiDoc Statistics Editing the Table of Contents Communicating your edits Let others know what you changed: The importance of Edit Summaries Minor Edits Edit Conflicts Help Videos You Can Watch Getting Started Video