BAPTA
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| BAPTA | |
|---|---|
| Image:Bapta.png | |
| IUPAC name | 1,2-bis(o-aminophenoxy)ethane- N,N,N',N'-tetraacetic acid |
| Identifiers | |
| CAS number | |
| PubChem | |
| Properties | |
| Molecular formula | C22H24N2O10 |
| Molar mass | 476.433 |
| Density | 1.494 g/cm3 |
| Melting point |
177-179 °C |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references | |
BAPTA (1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid) is a calcium-specific chelator. The presence of four carboxylic acid functional groups makes possible the binding of two calcium ions. The extensive flexibility of the carboxylate ligands is critical to the coordination of calcium, or other metal ions. Recent studies have demonstrated that the BAPTA moiety actually binds to zinc ions with a substantially higher affinity than calcium.[1] Interestingly, it appears that the assumption of the chelator's calcium preference may have contributed to evidence for the role of calcium ions as causal agents in ischemia (stroke), and brain trauma. Based on this evidence, pharmacological agents en masse have been designed and synthesized, yet have met with little success.
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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
