Bactericidal/permeability increasing protein
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| bactericidal/permeability-increasing protein
| |
| Identifiers | |
| Symbol | BPI |
| Entrez | 671 |
| HUGO | 1095 |
| OMIM | 109195 |
| RefSeq | NM_001725 |
| UniProt | P17213 |
| Other data | |
| Locus | Chr. 20 q11.23 |
Bactericidal/permeability increasing protein is a bactericidal protein in neutrophil granulocytes.
External links
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The bactericidal/permeability-increasing protein (BPI) is an endogenous antibiotic protein used by neutrophils to kill certain types of bacteria. It also binds to compounds called lipopolysaccharides that are produced by Gram-negative bacteria. Lipolysaccharides are potent activators of the innate immune system, however BPI at certain concentrations can prevent this activation.
BPI was discovered by Jerrold Weiss and Peter Elsbach at New York University Medical School.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
