Bendamustine

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Image:Bendamustine.png
Bendamustine
Systematic (IUPAC) name
4-[5-[Bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid
Identifiers
CAS number	?
ATC code	?
PubChem	65628
Chemical data
Formula	C16H21Cl2N3O2
Mol. mass	358.262 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Licence data	US
Pregnancy cat.	D(US)
Legal status	℞-only(US)
Routes	Intravenous

WikiDoc Resources for Bendamustine
Articles
Most recent articles on Bendamustine Most cited articles on Bendamustine Review articles on Bendamustine Articles on Bendamustine in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Bendamustine Images of Bendamustine Photos of Bendamustine Podcasts & MP3s on Bendamustine Videos on Bendamustine
Evidence Based Medicine
Cochrane Collaboration on Bendamustine Bandolier on Bendamustine TRIP on Bendamustine
Clinical Trials
Ongoing Trials on Bendamustine at Clinical Trials.gov Trial results on Bendamustine Clinical Trials on Bendamustine at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Bendamustine NICE Guidance on Bendamustine NHS PRODIGY Guidance FDA on Bendamustine CDC on Bendamustine
Books
Books on Bendamustine
News
Bendamustine in the news Be alerted to news on Bendamustine News trends on Bendamustine
Commentary
Blogs on Bendamustine
Definitions
Definitions of Bendamustine
Patient Resources / Community
Patient resources on Bendamustine Discussion groups on Bendamustine Patient Handouts on Bendamustine Directions to Hospitals Treating Bendamustine Risk calculators and risk factors for Bendamustine
Healthcare Provider Resources
Symptoms of Bendamustine Causes & Risk Factors for Bendamustine Diagnostic studies for Bendamustine Treatment of Bendamustine
Continuing Medical Education (CME)
CME Programs on Bendamustine
International
Bendamustine en Espanol Bendamustine en Francais
Businness
Bendamustine in the Marketplace Patents on Bendamustine
Experimental / Informatics
List of terms related to Bendamustine

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Overview

Bendamustine (INN, tradenames Ribomustin and Treanda) is a substance in the treatment of cancer. It belongs to the family of drugs called alkylating agents. It is also called SDX-105.

History

Bendamustine received its first marketing approval in Germany, which is marketed under the tradename Ribomustin, by Astellas Pharma GmbH's licensee, Mundipharma International Corporation Limited, which it is indicated as a single-agent or in combination with other anti-cancer agents for indolent NHL, multiple myeloma, and CLL. SymBio Pharmaceuticals Ltd holds exclusive rights to develop and market bendamustine HCl in Japan and selected Asia Pacific Rim countries.

On March 20, 2008, Cephalon received approval from the United States Food and Drug Administration to market bendamustine in the US, where it is sold under the tradename Treanda.^[1] Bendamustine is the first drug approved for patients with CLL in the US since 2001.

References

v • d • e Chemotherapeutic agents/Antineoplastic agents (L01)
Alkylating and alkylating-like agents	Nitrogen mustards: (Chlorambucil, Chlormethine, Cyclophosphamide, Ifosfamide, Melphalan, Bendamustine, Uramustine) Nitrosoureas:(Carmustine, Fotemustine, Lomustine, Streptozocin) Platinum (alkylating-like): (Carboplatin, Cisplatin, Oxaliplatin, Triplatin tetranitrate, Satraplatin) Alkyl sulfonates:(Busulfan, Treosulfan) Hydrazines:(Procarbazine, Dacarbazine, Temozolomide) Aziridines:(ThioTEPA)
Antimetabolites	Folic acid: (Aminopterin, Methotrexate, Pemetrexed, Raltitrexed). Purine:(Cladribine, Clofarabine, Fludarabine, Mercaptopurine, Pentostatin, Thioguanine) Pyrimidine:(Capecitabine, Cytarabine, Decitabine, Fluorouracil, Floxuridine, Gemcitabine)
Spindle poison/mitotic inhibitor	Taxane: (Docetaxel, Larotaxel, Paclitaxel). Vinca: (Vinblastine, Vincristine, Vindesine, Vinorelbine).
Cytotoxic/antitumor antibiotics	Anthracycline family: (Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mitoxantrone, Pixantrone, Valrubicin) streptomyces (Actinomycin, Bleomycin, Mitomycin, Plicamycin) - Hydroxyurea
Topoisomerase inhibitors	Camptotheca: (Camptothecin, Topotecan, Irinotecan, Rubitecan), Podophyllum:(Etoposide, Teniposide)
CI monoclonal antibodies	Receptor tyrosine kinase (Cetuximab, Panitumumab, Trastuzumab) - CD20 (Rituximab, Tositumomab) - other (Alemtuzumab, Bevacizumab, Gemtuzumab)
Photosensitizers	Aminolevulinic acid, Methyl aminolevulinate, Porfimer sodium, Verteporfin
Tyrosine kinase inhibitors	Axitinib, Bosutinib, Cediranib, Dasatinib, Erlotinib, Gefitinib, Imatinib, Lapatinib, Lestaurtinib, Nilotinib, Semaxanib, Sorafenib, Sunitinib, Vandetanib
Cyclin-dependent kinase inhibitor	Seliciclib
Other	retinoids (Alitretinoin, Tretinoin), Fusion protein (Aflibercept) - Altretamine, Amsacrine, Anagrelide, Arsenic trioxide, Asparaginase (Pegaspargase), Bexarotene, Bortezomib, Celecoxib, Denileukin diftitox, Elesclomol, Estramustine, Irofulven, Ixabepilone, Masoprocol, Mitotane, Oblimersen, Testolactone, Tipifarnib, Trabectedin

v • d • e WikiDoc Research Resources for Bendamustine
Articles on Bendamustine	Most recent articles on Bendamustine • Most cited articles on Bendamustine • Review articles on Bendamustine • Articles on Bendamustine in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Bendamustine	Powerpoint slides on Bendamustine • Images of Bendamustine • Photos of Bendamustine • Podcasts & MP3s on Bendamustine • Videos on Bendamustine
Evidence Based Medicine Regarding Bendamustine	Cochrane Collaboration on Bendamustine • Bandolier on Bendamustine • TRIP on Bendamustine
Cost Effectiveness of Bendamustine	Cost Effectiveness of Bendamustine
Clinical Trials Involving Bendamustine	Ongoing Trials on Bendamustine at Clinical Trials.gov • Trial results on Bendamustine • Clinical Trials on Bendamustine at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Bendamustine	US National Guidelines Clearinghouse on Bendamustine • NICE Guidance on Bendamustine • NHS PRODIGY Guidance • FDA on Bendamustine • CDC on Bendamustine
Textbook Information on Bendamustine	Books and Textbook Information on Bendamustine
Pharmacology Resources on Bendamustine	Dosing of Bendamustine • Drug interactions with Bendamustine • Side effects of Bendamustine • Allergic reactions to Bendamustine • Overdose information on Bendamustine • Carcinogenicity information on Bendamustine • Bendamustine in pregnancy • Pharmacokinetics of Bendamustine •
Genetics, Pharmacogenomics, and Proteinomics of Bendamustine	Genetics of Bendamustine • Pharmacogenomics of Bendamustine • Proteomics of Bendamustine
Newstories on Bendamustine	Bendamustine in the news • Be alerted to news on Bendamustine • News trends on Bendamustine
Commentary on Bendamustine	Blogs on Bendamustine
Patient Resources on Bendamustine	Patient resources on Bendamustine • Discussion groups on Bendamustine • Patient Handouts on Bendamustine • Directions to Hospitals Treating Bendamustine • Risk calculators and risk factors for Bendamustine
Healthcare Provider Resources on Bendamustine	Symptoms of Bendamustine • Causes & Risk Factors for Bendamustine • Diagnostic studies for Bendamustine • Treatment of Bendamustine
Continuing Medical Education (CME) Programs on Bendamustine	CME Programs on Bendamustine
International Resources on Bendamustine	Bendamustine en Espanol • Bendamustine en Francais
Business Resources on Bendamustine	Bendamustine in the Marketplace • Patents on Bendamustine
Informatics Resources on Bendamustine	List of terms related to Bendamustine

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .