Benign lymphoepithelial lesion

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Overview

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List of terms related to Benign lymphoepithelial lesion

Benign lymphoepithelial lesion is a type of benign enlargement of the parotid and/or lacrimal glands. This pathologic state is sometimes, but not always, associated with Sjögren's syndrome.

Historically, bilateral parotid and lacrimal gland enlargement was characterized by the term Mikulicz's disease if the enlargement appeared apart from other diseases. If it was secondary to another disease, such as tuberculosis, sarcoidosis, lymphoma, and Sjögren's syndrome, the term used was Mikulicz's syndrome. Both names derive from Jan Mikulicz-Radecki, the Polish surgeon best known for describing these conditions. Today, the terms "Mikulicz's disease" and "Mikulicz's syndrome" are viewed as ambiguous and outdated.

Locations

Occurring in 80% of cases, the gland most likely to be affected is the parotid gland. Lacrimal glands are also affected.

Characteristic

Benign lymphoepithelial lesion is most likely to occur in adults around 50 years of age. There is a predilection for gender with 60% - 80% being female. The gland affected has a diffuse swelling. The swelling can be asymptomatic, but mild pain can also be associated.

Most cases of benign lymphoepithelial lesions appear in conjunction with Sjögren's syndrome. When Sjögren's syndrome is present, the swelling is usually bilateral. Otherwise, the affected glands are usually only on one side of the body.

In most cases, a biopsy is needed to distinguish benign lymphoepithelial lesions from sialadenosis (sialosis).

Histology

There is a marked lymphoplasmacytic infiltration. Lymphoid follicles surround solid epithelial nests, giving rise to the 'epimyoepithelial islands', that are mainly composed of ductal cells with occasional myoepithelial cells. Excess hyaline basement membrane material is deposited between cells, and there is also acinar atrophy and destruction.

Treatment

Treatment usually consists of surgical removal of the affected gland. Prognosis is usually good, however occasionally this condition may evolve into lymphoma, or represent occult lymphoma from the outset.

References

• Kahn, Michael A. Basic Oral and Maxillofacial Pathology. Volume 1. 2001.
• Regezi, Joseph A. Oral Pathology: Clinical Pathologic Correlations. 4th ed. 2002.

External links

• synd/2087 at Who Named It - "Mikulicz's disease"
• MeSH Mikulicz'+Disease
• K11.8 - ICD10
• Lee S, Tsirbas A, McCann J, Goldberg R (2006). "Mikulicz's disease: a new perspective and literature review.". Eur J Ophthalmol 16 (2): 199-203. PMID 16703534.
• Ihrler S, Harrison J (2005). "Mikulicz's disease and Mikulicz's syndrome: analysis of the original case report of 1892 in the light of current knowledge identifies a MALT lymphoma.". Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100 (3): 334-9. PMID 16122662.

v • d • e WikiDoc Research Resources for Benign lymphoepithelial lesion
Articles on Benign lymphoepithelial lesion	Most recent articles on Benign lymphoepithelial lesion • Most cited articles on Benign lymphoepithelial lesion • Review articles on Benign lymphoepithelial lesion • Articles on Benign lymphoepithelial lesion in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Benign lymphoepithelial lesion	Powerpoint slides on Benign lymphoepithelial lesion • Images of Benign lymphoepithelial lesion • Photos of Benign lymphoepithelial lesion • Podcasts & MP3s on Benign lymphoepithelial lesion • Videos on Benign lymphoepithelial lesion
Evidence Based Medicine Regarding Benign lymphoepithelial lesion	Cochrane Collaboration on Benign lymphoepithelial lesion • Bandolier on Benign lymphoepithelial lesion • TRIP on Benign lymphoepithelial lesion
Cost Effectiveness of Benign lymphoepithelial lesion	Cost Effectiveness of Benign lymphoepithelial lesion
Clinical Trials Involving Benign lymphoepithelial lesion	Ongoing Trials on Benign lymphoepithelial lesion at Clinical Trials.gov • Trial results on Benign lymphoepithelial lesion • Clinical Trials on Benign lymphoepithelial lesion at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Benign lymphoepithelial lesion	US National Guidelines Clearinghouse on Benign lymphoepithelial lesion • NICE Guidance on Benign lymphoepithelial lesion • NHS PRODIGY Guidance • FDA on Benign lymphoepithelial lesion • CDC on Benign lymphoepithelial lesion
Textbook Information on Benign lymphoepithelial lesion	Books and Textbook Information on Benign lymphoepithelial lesion
Pharmacology Resources on Benign lymphoepithelial lesion	Dosing of Benign lymphoepithelial lesion • Drug interactions with Benign lymphoepithelial lesion • Side effects of Benign lymphoepithelial lesion • Allergic reactions to Benign lymphoepithelial lesion • Overdose information on Benign lymphoepithelial lesion • Carcinogenicity information on Benign lymphoepithelial lesion • Benign lymphoepithelial lesion in pregnancy • Pharmacokinetics of Benign lymphoepithelial lesion •
Genetics, Pharmacogenomics, and Proteinomics of Benign lymphoepithelial lesion	Genetics of Benign lymphoepithelial lesion • Pharmacogenomics of Benign lymphoepithelial lesion • Proteomics of Benign lymphoepithelial lesion
Newstories on Benign lymphoepithelial lesion	Benign lymphoepithelial lesion in the news • Be alerted to news on Benign lymphoepithelial lesion • News trends on Benign lymphoepithelial lesion
Commentary on Benign lymphoepithelial lesion	Blogs on Benign lymphoepithelial lesion
Patient Resources on Benign lymphoepithelial lesion	Patient resources on Benign lymphoepithelial lesion • Discussion groups on Benign lymphoepithelial lesion • Patient Handouts on Benign lymphoepithelial lesion • Directions to Hospitals Treating Benign lymphoepithelial lesion • Risk calculators and risk factors for Benign lymphoepithelial lesion
Healthcare Provider Resources on Benign lymphoepithelial lesion	Symptoms of Benign lymphoepithelial lesion • Causes & Risk Factors for Benign lymphoepithelial lesion • Diagnostic studies for Benign lymphoepithelial lesion • Treatment of Benign lymphoepithelial lesion
Continuing Medical Education (CME) Programs on Benign lymphoepithelial lesion	CME Programs on Benign lymphoepithelial lesion
International Resources on Benign lymphoepithelial lesion	Benign lymphoepithelial lesion en Espanol • Benign lymphoepithelial lesion en Francais
Business Resources on Benign lymphoepithelial lesion	Benign lymphoepithelial lesion in the Marketplace • Patents on Benign lymphoepithelial lesion
Informatics Resources on Benign lymphoepithelial lesion	List of terms related to Benign lymphoepithelial lesion

v • d • e Oral Pathology: Stomatognathic disease (K00-K14, 520-529)
Teeth	Developmental Quantity Anodontia/Hypodontia - Hyperdontia Abnormalities of size and form Concrescence - Fusion - Gemination - Dens evaginatus/Talon cusp - Dens invaginatus - Enamel pearl - Macrodontia - Microdontia - Taurodontism Disturbances in formation Dilaceration - Regional odontodysplasia - Turner's hypoplasia Other hereditary disturbances in structure Amelogenesis imperfecta - Dentinogenesis imperfecta - Dentin dysplasia Other Attrition - Abrasion - Ankylosis - Dental caries - Denticles - Erosion - External resorption - Fluorosis - Impaction - Internal resorption - Pulpitis - Toothache - Dentigerous cyst
Other Hard, Soft and Periapical Tissues	Gingivitis - Periodontitis - Ulcer
Dentofacial Anomalies	Gnathitis - Micrognathism - Prognathism - Retrognathism Malocclusion - Temporomandibular joint disorder
Maxillomandibular anomalies	Ameloblastoma - Cherubism - Congenital epulis - Odontogenic keratocyst - Torus mandibularis - Torus palatinus
Salivary glands	Sialadenitis - Drooling/sialorrhea - Benign lymphoepithelial lesion - Necrotizing sialometaplasia - Ranula - Sialolithiasis - Xerostomia
Lip and Oral mucosa	Cheilitis (Angular cheilitis) - Erythroplakia - Leukoplakia (Hairy leukoplakia) - White sponge nevus
Tongue	Glossitis (Geographic tongue) - Fissured tongue - Glossodynia - Black hairy tongue
Other	Stomatitis (Aphthous ulcer) Velopharyngeal inadequacy
see also neoplasia

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