Benzatropine

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Benzatropine
Systematic (IUPAC) name
3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane
Identifiers
CAS number	86-13-5
ATC code	N04AC01
PubChem	1201549
DrugBank	APRD00748
Chemical data
Formula	C21H25NO
Mol. mass	307.429 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	36 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	C(US)
Legal status
Routes	oral, IM, IV

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Benzatropine mesilate (INN, commonly known as benztropine; marketed as Cogentin) is an anticholinergic drug principally used for the treatment of:

• Drug-induced parkinsonism, akathisia and acute dystonia;
• Parkinson disease; and
• Idiopathic or secondary dystonia.

Indications

It is used in patients with schizophrenia to reduce the side effects of antipsychotic treatment, such as parkinsonism and akathisia.

Benztropine is also a second-line drug for the treatment of Parkinson's disease. It improves tremor but not rigidity or bradykinesia.

Benztropine is also sometimes used for the treatment of dystonia, a rare disorder that causes abnormal muscle contraction, resulting in twisting postures of limbs, trunk, or face.

Side effects

These are principally anticholinergic:

• Dry mouth
• Blurred vision
• Cognitive changes
• Constipation
• Urinary retention
• Tachycardia
• Anorexia
• Psychosis (usually in overdose)

Some studies suggest that use of anticholinergics increases the risk of tardive dyskinesia, a long-term side effect of antipsychotics.^[1][1]

Other studies have found no association between anticholinergic exposure and risk of developing tardive dyskinesia.^[1]

References

v • d • e Anti-parkinson drugs: anticholinergic agents (N04A)
Tertiary amines	Trihexyphenidyl - Biperiden - Metixene - Procyclidine - Profenamine - Dexetimide - Phenglutarimide - Mazaticol - Bornaprine - Tropatepine
Ethers chemically close to antihistamines	Etanautine - Orphenadrine
Ethers of tropine or tropine derivatives	Benzatropine - Etybenzatropine

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .