Benzylthiouracil
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| Benzylthiouracil
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| Systematic (IUPAC) name | |
| 1-(1-cyclohexa-2,4-dienylmethyl)-7-thia- 3,5-diazabicyclo[4.1.0]hepta-3,5-dien-2-one | |
| Identifiers | |
| CAS number | |
| ATC code | H03 |
| PubChem | |
| Chemical data | |
| Formula | C11H10N2OS |
| Mol. mass | 218.276 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | Oral |
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Benzylthiouracil (BTU) is an antithyroid preparation. It is a thioamide, closely related to propylthiouracil.
Adverse effects
Benzylthiouracil has been associated with severe adverse effects, notably vasculitis and subsequent ANCA-positive glomerulonephritis, as well as isolated reports of lung damage.[1][1][1][1]
References
Thyroid therapy (H03) | |
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| Thyroid hormones | Levothyroxine sodium - Liothyronine sodium - Tiratricol - Thyroid gland preparations |
| Antithyroid preparations | Thiouracils (Methylthiouracil, Propylthiouracil, Benzylthiouracil) - Sulfur-containing imidazole derivatives (Carbimazole, Thiamazole) - Perchlorates (Potassium perchlorate) - Other (Diiodotyrosine, Dibromotyrosine) |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

