Beraprost

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Beraprost
Systematic (IUPAC) name
2,3,3a,8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4- methyl-1-octen-6-ynyl)-1H-cyclopenta(b)benzofuran- 5-butanoic acid
Identifiers
CAS number	88430-50-6 88475-69-8 (sodium salt)
ATC code	B01AC19
PubChem	5282428
Chemical data
Formula	C24H30O5
Mol. mass	398.492 g/mol
Pharmacokinetic data
Bioavailability	50–70%
Metabolism	Unknown
Half life	35–40 minutes
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	?
Routes	Oral

WikiDoc Resources for Beraprost
Articles
Most recent articles on Beraprost Most cited articles on Beraprost Review articles on Beraprost Articles on Beraprost in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Beraprost Images of Beraprost Photos of Beraprost Podcasts & MP3s on Beraprost Videos on Beraprost
Evidence Based Medicine
Cochrane Collaboration on Beraprost Bandolier on Beraprost TRIP on Beraprost
Clinical Trials
Ongoing Trials on Beraprost at Clinical Trials.gov Trial results on Beraprost Clinical Trials on Beraprost at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Beraprost NICE Guidance on Beraprost NHS PRODIGY Guidance FDA on Beraprost CDC on Beraprost
Books
Books on Beraprost
News
Beraprost in the news Be alerted to news on Beraprost News trends on Beraprost
Commentary
Blogs on Beraprost
Definitions
Definitions of Beraprost
Patient Resources / Community
Patient resources on Beraprost Discussion groups on Beraprost Patient Handouts on Beraprost Directions to Hospitals Treating Beraprost Risk calculators and risk factors for Beraprost
Healthcare Provider Resources
Symptoms of Beraprost Causes & Risk Factors for Beraprost Diagnostic studies for Beraprost Treatment of Beraprost
Continuing Medical Education (CME)
CME Programs on Beraprost
International
Beraprost en Espanol Beraprost en Francais
Businness
Beraprost in the Marketplace Patents on Beraprost
Experimental / Informatics
List of terms related to Beraprost

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Overview

Beraprost is a synthetic analogue of prostacyclin, under clinical trials for the treatment of pulmonary hypertension. It is also being studied for use in avoiding reperfusion injury.

Clinical pharmacology

As an analogue of prostacyclin PGI₂, beraprost effects vasodilation, which in turn lowers the blood pressure. Beraprost also inhibits platelet aggregation, though the role this phenomenon may play in relation to pulmonary hypertension has yet to be determined.

Dosage and administration

Beraprost is administered orally as a pill.

v • d • e Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)
Vitamin K antagonists	Acenocoumarol • Clorindione • Coumatetralyl • Dicumarol (Dicoumarol) • Diphenadione • Ethyl biscoumacetate • Phenprocoumon • Phenindione • Tioclomarol • Warfarin
Heparin group	Antithrombin III • Danaparoid • Heparin • Sulodexide • low molecular weight heparin (Bemiparin, Dalteparin, Enoxaparin, Nadroparin, Parnaparin, Reviparin, Tinzaparin)
Glycoprotein IIb/IIIa inhibitors	Abciximab • Eptifibatide • Tirofiban
Other platelet aggregation inhibitors	Acetylsalicylic acid/Aspirin • Aloxiprin • Ditazole • Carbasalate calcium • Cloricromen • Dipyridamole • Indobufen • Picotamide • Triflusal • ADP receptor inhibitors (Clopidogrel, Ticlopidine, Prasugrel) • prostaglandin analogue (Beraprost, Prostacyclin, Iloprost, Treprostinil)
Enzymes	plasminogen activators (Alteplase/Reteplase/Tenecteplase, Streptokinase, Urokinase/Saruplase, Anistreplase) • other serine endopeptidases (Ancrod, Drotrecogin alfa/Protein C, Fibrinolysin) • Brinase
Direct thrombin inhibitors	Argatroban • Bivalirudin • Dabigatran • Desirudin • Hirudin • Lepirudin • Melagatran • Ximelagatran
Other antithrombotics	Apixaban • Defibrotide • Dermatan sulfate • Fondaparinux • Idraparinux • Otamixaban • Rivaroxaban
Non-medicinal	Citrate • EDTA • Oxalate

v • d • e Medications used in the management of pulmonary arterial hypertension (B01, C02)
Prostacyclin analogues	Beraprost, Epoprostenol, Iloprost, Treprostinil
Endothelin receptor antagonists	Ambrisentan, Bosentan, Sitaxsentan
PDE5 inhibitors	Sildenafil, Tadalafil
Adjunctive therapy	Calcium channel blockers, Diuretics, Digoxin, Oxygen therapy, Warfarin

v • d • e Eicosanoids: prostaglandins
Endogenous/series 2	D2 - E2 (Dinoprostone) - F2 (Dinoprost) - H2 - I2 (Prostacyclin)
Prostaglandin analogues	E: Alprostadil - Enprostil - Misoprostol F: Bimatoprost - Carboprost - Latanoprost - Travoprost I: Beraprost - Iloprost - Treprostinil

v • d • e WikiDoc Research Resources for Beraprost (Click show to right to view)
Articles on Beraprost	Most recent articles on Beraprost • Most cited articles on Beraprost • Review articles on Beraprost • Articles on Beraprost in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Beraprost	Powerpoint slides on Beraprost • Images of Beraprost • Photos of Beraprost • Podcasts & MP3s on Beraprost • Videos on Beraprost
Evidence Based Medicine Regarding Beraprost	Cochrane Collaboration on Beraprost • Bandolier on Beraprost • TRIP on Beraprost
Cost Effectiveness of Beraprost	Cost Effectiveness of Beraprost
Clinical Trials Involving Beraprost	Ongoing Trials on Beraprost at Clinical Trials.gov • Trial results on Beraprost • Clinical Trials on Beraprost at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Beraprost	US National Guidelines Clearinghouse on Beraprost • NICE Guidance on Beraprost • NHS PRODIGY Guidance • FDA on Beraprost • CDC on Beraprost
Textbook Information on Beraprost	Books and Textbook Information on Beraprost
Pharmacology Resources on Beraprost	Dosing of Beraprost • Drug interactions with Beraprost • Side effects of Beraprost • Allergic reactions to Beraprost • Overdose information on Beraprost • Carcinogenicity information on Beraprost • Beraprost in pregnancy • Pharmacokinetics of Beraprost •
Genetics, Pharmacogenomics, and Proteinomics of Beraprost	Genetics of Beraprost • Pharmacogenomics of Beraprost • Proteomics of Beraprost
Newstories on Beraprost	Beraprost in the news • Be alerted to news on Beraprost • News trends on Beraprost
Commentary on Beraprost	Blogs on Beraprost
Patient Resources on Beraprost	Patient resources on Beraprost • Discussion groups on Beraprost • Patient Handouts on Beraprost • Directions to Hospitals Treating Beraprost • Risk calculators and risk factors for Beraprost
Healthcare Provider Resources on Beraprost	Symptoms of Beraprost • Causes & Risk Factors for Beraprost • Diagnostic studies for Beraprost • Treatment of Beraprost
Continuing Medical Education (CME) Programs on Beraprost	CME Programs on Beraprost
International Resources on Beraprost	Beraprost en Espanol • Beraprost en Francais
Business Resources on Beraprost	Beraprost in the Marketplace • Patents on Beraprost
Informatics Resources on Beraprost	List of terms related to Beraprost

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .