Bone morphogenetic protein 2

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Bone morphogenetic protein 2
PDB rendering based on 3bmp.
Identifiers
Symbol(s)	BMP2; BMP2A
External IDs	OMIM: 112261 MGI: 88177 Homologene: 926
Gene ontology Molecular Function: • cytokine activity • growth factor activity Cellular Component: • extracellular region • extracellular space Biological Process: • osteoblast differentiation • ureteric bud branching • epithelial to mesenchymal transition • cell-cell signaling • negative regulation of cell proliferation • embryonic development • organ morphogenesis • bone mineralization • BMP signaling pathway • cardiac cell differentiation • growth • odontogenesis (sensu Vertebrata) • cell fate commitment • regulation of transcription • positive regulation of osteoblast differentiation • positive regulation of ossification • negative regulation of progression through cell cycle • positive regulation of astrocyte differentiation • cartilage development
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	650	12156
Ensembl	ENSG00000125845	ENSMUSG00000027358
Uniprot	P12643	Q3V1I4
Refseq	NM_001200 (mRNA) NP_001191 (protein)	NM_007553 (mRNA) NP_031579 (protein)
Location	Chr 20: 6.7 - 6.71 Mb	Chr 2: 133.24 - 133.25 Mb
Pubmed search	[2]	[3]

Bone morphogenetic protein 2 or BMP-2 is a protein that belongs to the TGF-β superfamily of proteins. It, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. It is involved in the Hedgehog pathway, TGF-beta signaling pathway, and the Cytokine-cytokine receptor interaction. It is involved also in cardiac cell differentiation and epithelial to mesenchymal transition.

BMP-2 and BMP-7 are osteogenic BMPs: they have been demonstrated to potently induce osteoblast differentiation in a variety of cell types.

Medical Uses

Bone morphogenetic protein 2 has been shown to stimulate the production of bone and recombinant human protein (rhBMP-2) and is currently available for orthopaedic usage in the United States. Implantation of BMP-2 in a collagen sponge induces new bone formation and can be used for the treatment of bony defects, delayed union, and non-union.

Further reading

External links

• Online Mendelian Inheritance in Man record: Online 'Mendelian Inheritance in Man' (OMIM) 112261

v • d • e Cell signaling: TGF beta signaling pathway
TGF beta superfamily of ligands	TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal)
TGF beta receptors	TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2 TGFBR3: betaglycan
Transducers/SMAD	R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4
Ligand Inhibitors	Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1
Coreceptors	BAMBI - Cripto
Other	SARA

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .