Bone morphogenetic protein 3
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| Bone morphogenetic protein 3 | |
|---|---|
| Other names: | Osteogenin |
| Genetic data | |
| Locus: | Chr. 4 p14-q21 |
| Gene code: | HUGO code:BMP3 |
| Protein Structure/Function | |
| Functions: | cell signaling, cell differentiation,cartilage development, ossification |
| Domains: | TGFβ |
| Other | |
| Taxa expressing: | many metazoan phyla |
| Cell types: | nervous system, bone |
| Subcellular localization: | extracellular |
| Database Links | |
| Entrez: | 651 |
| OMIM: | 112263 |
| RefSeq: | NM_001201 |
| UniProt: | P12645 |
Bone morphogenetic protein 3 (BMP3) is a polypeptide member of the Transforming growth factor beta superfamily of proteins. It, like other bone morphogenetic proteins (BMP's) is known for its ability to induce bone and cartilage development. It is a disulphide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors.
It is highly expressed in fractured tissues.
Cell signaling: TGF beta signaling pathway | |
|---|---|
| TGF beta superfamily of ligands | TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal) |
| TGF beta receptors | TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2 TGFBR3: betaglycan |
| Transducers/SMAD | R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4 |
| Ligand Inhibitors | Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1 |
| Coreceptors | BAMBI - Cripto |
| Other | SARA |
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