Bone morphogenetic protein 6
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| It has been suggested that this article or section be merged with BMP6 (gene). (Discuss) |
| Bone morphogenetic protein 6 | |
|---|---|
| Other names: | vegetal related growth factor (TGFB-related) (VGR1) |
| Genetic data | |
| Locus: | Chr. 6 p24-p23 |
| Gene code: | HUGO code:BMP6 |
| Protein Structure/Function | |
| Functions: | cell signaling, cell differentiation,cartilage development, growth, ossification |
| Domains: | TGFβ |
| Other | |
| Taxa expressing: | many metazoan phyla |
| Cell types: | salivary gland, muscle, prostate, cartilage |
| Subcellular localization: | extracellular |
| Database Links | |
| Entrez: | 654 |
| OMIM: | 112266 |
| RefSeq: | NM_001718 |
| UniProt: | P22004 |
Bone morphogenetic protein 6 (BMP6) is a polypetide that is a member of the TGFβ superfamily of proteins. Bone morphogenetic proteins are known for their ability to induce the growth of bone and cartilage. BMP6 is able to induce all osteogenic markers in mesenchymal stem cells.
Cell signaling: TGF beta signaling pathway | |
|---|---|
| TGF beta superfamily of ligands | TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal) |
| TGF beta receptors | TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2 TGFBR3: betaglycan |
| Transducers/SMAD | R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4 |
| Ligand Inhibitors | Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1 |
| Coreceptors | BAMBI - Cripto |
| Other | SARA |
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