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Brodmann area 46, or BA46, is part of the frontal cortex in the human brain. It is sandwiched between BA10 and BA45.
This area is known as middle frontal area 46. In the human it occupies approximately the middle third of the middle frontal gyrus and the most rostral portion of the inferior frontal gyrus. Brodmann area 46 roughly corresponds with the dorsolateral prefrontal cortex (DLPFC), though the borders of area 46 are based on cytoarchitecture rather than function. The DLPFC also encompasses part of granular frontal area 9, directly adjacent on the dorsal surface of the cortex.
Cytoarchitecturally, area 46 it is bounded dorsally by the granular frontal area 9, rostroventrally by the frontopolar area 10 and caudally by the triangular area 45 (Brodmann-1909). There is some discrepancy between the exetent of Brodman's area 8 (1905) and the same area as described by Walker (1940)[1]
Function
The DLPFC plays a role in sustaining attention and working memory. Lesions to the DLPFC impair short-term memory and cause difficulty inhibiting responses. Lesions may also eliminate much of the ability to make judgements about what's relevant and what's not.
References
- Petrides, M., Pandya, D.M., (1999) Dorsolateral prefrontal cortex: comparative cytoarchitectonic analysis in the human and the macaque brain and corticocortical connection patterns. European Journal of Neuroscience, Vol. 11, pp. 1011–1036
External links
See also
| Brain: telencephalon (cerebrum, cerebral cortex, cerebral hemispheres) |
|---|
| Frontal lobe | Precentral gyrus (Primary motor cortex, 4)
Superior frontal gyrus/Frontal eye fields (6, 8, 9), Middle frontal gyrus (46), Inferior frontal gyrus/Broca's area (44-Pars opercularis, 45-Pars triangularis)
Orbitofrontal cortex (10, 11, 12, 47)
Prefrontal cortex, Premotor cortex
Precentral sulcus - Superior frontal sulcus - Inferior frontal sulcus - Olfactory sulcus |
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| Parietal lobe | Somatosensory cortex (Primary (1, 2, 3, 43), Secondary (5)), Precuneus (7m) - Parietal operculum
Parietal lobules (Superior (7l), Inferior (40)), Angular gyrus (39)
Intraparietal sulcus, Marginal sulcus |
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| Occipital lobe | Primary visual cortex (17), (Cuneus, Lingual gyrus, Lateral occipital gyrus (18, 19))
Calcarine fissure |
|---|
| Temporal lobe | Primary auditory cortex (41, 42), Superior temporal gyrus (38, 22/Wernicke's area), Middle temporal gyrus (21), Inferior temporal gyrus (20)
Fusiform gyrus (37) Medial temporal lobe (Amygdala, Parahippocampal gyrus (27, 28, 34, 35, 36) |
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| Cingulate cortex/gyrus | Subgenual area (25), Anterior cingulate (24, 32, 33), Posterior cingulate (23, 31), Retrosplenial cortex (26, 29, 30)
Callosal sulcus |
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| Interlobar sulci/fissures | lateral: Central (frontal+parietal), Lateral (frontal+parietal+temporal), Parietoöccipital
medial: Medial longitudinal, Cingulate (frontal+cingulate), Collateral (temporal+occipital) |
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| White matter tracts | Commissural fibers - Association fibers
Internal capsule (Anterior limb, Genu, Posterior limb), Corona radiata, External capsule, Lamina terminalis, Extreme capsule, Semioval center
Olfactory tract, Terminal stria |
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| Other | Insular cortex
gray: Olfactory bulb, Anterior olfactory nucleus, Basal optic nucleus of Meynert, Substantia innominata, Anterior perforated substance
Corpus striatum - Limbic lobe |
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| Some categorizations are approximations, and some Brodmann areas span gyri. |
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