C3-convertase

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There are two forms of C3-convertase (EC 3.4.21.43).

• The first is an enzyme composed of the C4b-C2b complex, which forms during the Classical pathway of the complement system. It is formed when C1s cleaves off C2a from a membrane-bound C4b-C2 complex.

• The second consists of the C3bBb complex, which forms during the alternative complement pathway. It is formed when membrane bound C3b binds to factor B which is in turn cleaved by factor D in Ba and Bb. Bb remains bound to C3b while Ba is released into the surrounding medium.

Once formed, both C3-convertases will catalyze the proteolytic cleavage of C3 into C3a and C3b (hence the name "C3-convertase"). C3b can then act as an opsonizer or itself become a C3-convertase.

A convertase (of either type) with an additional 3b (C4b2b3b or C3bBb3b) is known as "C5-convertase".

External links

• MeSH C3+convertase

v • d • e Proteins: complement system (C, L, A)
Activators	CLA: C3-convertase - MAC (C6, C7, C8, C9) - L: Mannan-binding lectin - A: Factor P/Properdin
Enzymes	C: C1Q/C1R/C1S - C4 - C2 - CLA: C3 - C5 (C5a) - L: MASP1 - MASP2 - A: Factor B - Factor D
Inhibitors	CLA: C1-inhibitor - Decay accelerating factor - Factor I - CL: C4BP - A: Factor H
Complement receptors	CR1 - CR2 - CR3 - CR4 - CD11b/CD11c/CD18 - Anaphylatoxin (C3a, C5a)

v • d • e Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)
Digestive system	Enteropeptidase - Trypsin - Chymotrypsin - Elastase (Neutrophil, Pancreatic)
Complement system	Factor B - Factor D - Factor I - MASP (MASP1, MASP2) - C3-convertase
Coagulation	factors: Thrombin - Factor VIIa - Factor IXa - Factor Xa - Factor XIa - Factor XIIa - Kallikrein (PSA) fibrinolysis: Plasmin - Tissue plasminogen activator - Urinary plasminogen activator
Immune system	Chymase - Granzyme - Tryptase - Proteinase 3/Myeloblastin
Venombin	Ancrod - Batroxobin
Other	Acrosin - Pronase - Proprotein convertases (1, 2) - Subtilisin/Furin - Streptokinase - Prolyl endopeptidase

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .