C4BP (protein)

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complement component 4 binding protein, alpha
Identifiers
Symbol	C4BPA
Alt. Symbols	C4BP
Entrez	722
HUGO	1325
OMIM	120830
RefSeq	NM_000715
UniProt	P04003
Other data
Locus	Chr. 1 q32

complement component 4 binding protein, beta
Identifiers
Symbol	C4BPB
Alt. Symbols	C4BP
Entrez	725
HUGO	1328
OMIM	120831
RefSeq	NM_000716
UniProt	P20851
Other data
Locus	Chr. 1 q32

C4BP is a protein involved in the complement system. C4BP has a hydra-like structure with a central stalk and seven branching alpha-chains.

Functions

It inhibits the action of C4. It splits C4 convertase and is a cofactor for factor I which cleaves C4b.

C4BP binds necrotic cells and DNA, to clean up after swelling.

It also binds CD40 on B cells which potentiaties proliferation and costimulation.

External links

• MeSH Complement+C4b-Binding+Protein

v • d • e Proteins: complement system (C, L, A)
Activators	CLA: C3-convertase - MAC (C6, C7, C8, C9) - L: Mannan-binding lectin - A: Factor P/Properdin
Enzymes	C: C1Q/C1R/C1S - C4 - C2 - CLA: C3 - C5 (C5a) - L: MASP1 - MASP2 - A: Factor B - Factor D
Inhibitors	CLA: C1-inhibitor - Decay accelerating factor - Factor I - CL: C4BP - A: Factor H
Complement receptors	CR1 - CR2 - CR3 - CR4 - CD11b/CD11c/CD18 - Anaphylatoxin (C3a, C5a)

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .