CDGSH iron sulfur domain
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
| Image:2QH7.png | |
| Crystallographic structure (PDB 2QH7) of the CDGSH-type domain 1 dimer (green and cyan cartoon) complexed with iron (brown) and sulfur (yellow) Fe-S clusters. | |
| CDGSH iron sulfur domain 1
| |
| Identifiers | |
| Symbol | CISD1 |
| Alt. Symbols | C10orf70, ZCD1 |
| Entrez | 55847 |
| HUGO | 30880 |
| PDB | 2QH7 |
| RefSeq | NM_018464 |
| UniProt | Q9NZ45 |
| Other data | |
| Locus | Chr. 10 q21.3 |
| CDGSH iron sulfur domain 1B
| |
| Identifiers | |
| Symbol | CISD1B |
| Alt. Symbols | ZCD1B |
| Entrez | 130500 |
| HUGO | 29611 |
| RefSeq | XM_065750 |
| Other data | |
| Locus | Chr. 2 p24.1 |
| CDGSH iron sulfur domain 2
| |
| Identifiers | |
| Symbol | CISD2 |
| Alt. Symbols | ZCD2 |
| Entrez | 493856 |
| HUGO | 24212 |
| RefSeq | NM_001008388 |
| UniProt | Q7Z3D5 |
| Other data | |
| Locus | Chr. 4 q24 |
| CDGSH iron sulfur domain 3
| |
| Identifiers | |
| Symbol | CISD3 |
| Entrez | 284106 |
| HUGO | 27578 |
| Other data | |
| Locus | Chr. 17 q12 |
The CDGSH iron sulfur domain are a group of iron-sulfur (Fe-S) clusters and a unique 39 amino acid CDGSH domain [C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H].
The CDGSH iron sulfur domain 1 protein (also referred to as mitoNEET) is an integral membrane protein located in the outer mitochondrial membrane and whose function may be to transport iron into the mitochondria.[1] Iron in turn is essential for the function of several mitochondrial enzymes.
The antidiabetic drug pioglitazone, in addition to binding to the nuclear receptor PPAR, also has been shown to bind mitoNEET with approximately equal affinity.[1]
References
External links
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
