CYP2C18
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
| Cytochrome P450, family 2, subfamily C, polypeptide 18
| ||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | CYP2C18; CYP2C; CPCI; CYP2C17; DKFZp686I24235; P450-6B/29C; P450IIC17 | |||||||||||||
| External IDs | OMIM: 601131 MGI: 1919332 Homologene: 88339 | |||||||||||||
| ||||||||||||||
| RNA expression pattern | ||||||||||||||
| Image:PBB GE CYP2C18 208126 s at tn.png | ||||||||||||||
| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 1562 | 72082 | ||||||||||||
| Ensembl | ENSG00000108242 | ENSMUSG00000025002 | ||||||||||||
| Uniprot | P33260 | na | ||||||||||||
| Refseq | NM_000772 (mRNA) NP_000763 (protein) | NM_028089 (mRNA) NP_082365 (protein) | ||||||||||||
| Location | Chr 10: 96.43 - 96.49 Mb | Chr 19: 39.07 - 39.11 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Cytochrome P450, family 2, subfamily C, polypeptide 18, also known as CYP2C18, is a human gene.[1]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP4217 is now considered an artefact based on a chimera of CYP4218 and CYP2C19.[1]
References
Further reading
- Goldstein JA, de Morais SM (1995). "Biochemistry and molecular biology of the human CYP2C subfamily.". Pharmacogenetics 4 (6): 285-99. PMID 7704034.
- Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily.". Xenobiotica 28 (12): 1129-65. PMID 9890157.
- Ged C, Beaune P (1993). "Partial sequence and polymerase chain reaction-mediated analysis of expression of the human CYP2C18 gene.". Pharmacogenetics 2 (3): 109-15. PMID 1306110.
- Furuya H, Meyer UA, Gelboin HV, Gonzalez FJ (1991). "Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA.". Mol. Pharmacol. 40 (3): 375-82. PMID 1896026.
- Romkes M, Faletto MB, Blaisdell JA, et al. (1991). "Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.". Biochemistry 30 (13): 3247-55. PMID 2009263.
- Romkes M, Faletto MB, Blaisdell JA, et al. (1993). "Cloning and expression of complementary DNAs for multiple members of the human cytochrome PH50IIC subfamily.". Biochemistry 32 (5): 1390. PMID 8095407.
- Goldstein JA, Faletto MB, Romkes-Sparks M, et al. (1994). "Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans.". Biochemistry 33 (7): 1743-52. PMID 8110777.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
- de Morais SM, Schweikl H, Blaisdell J, Goldstein JA (1993). "Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18.". Biochem. Biophys. Res. Commun. 194 (1): 194-201. PMID 8333835.
- Richardson TH, Griffin KJ, Jung F, et al. (1997). "Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C51.". Arch. Biochem. Biophys. 338 (2): 157-64. doi:10.1006/abbi.1996.9817. PMID 9028867.
- Zaphiropoulos PG (1997). "Exon skipping and circular RNA formation in transcripts of the human cytochrome P-450 2C18 gene in epidermis and of the rat androgen binding protein gene in testis.". Mol. Cell. Biol. 17 (6): 2985-93. PMID 9154796.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
- Macé K, Bowman ED, Vautravers P, et al. (1998). "Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues.". Eur. J. Cancer 34 (6): 914-20. PMID 9797707.
- Klose TS, Blaisdell JA, Goldstein JA (1999). "Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs.". J. Biochem. Mol. Toxicol. 13 (6): 289-95. PMID 10487415.
- Finta C, Zaphiropoulos PG (2000). "The human CYP2C locus: a prototype for intergenic and exon repetition splicing events.". Genomics 63 (3): 433-8. doi:10.1006/geno.1999.6063. PMID 10704292.
- Thum T, Borlak J (2000). "Gene expression in distinct regions of the heart.". Lancet 355 (9208): 979-83. PMID 10768437.
- Marill J, Cresteil T, Lanotte M, Chabot GG (2001). "Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.". Mol. Pharmacol. 58 (6): 1341-8. PMID 11093772.
- Zhu-Ge J, Yu YN, Qian YL, Li X (2003). "Establishment of a transgenic cell line stably expressing human cytochrome P450 2C18 and identification of a CYP2C18 clone with exon 5 missing.". World J. Gastroenterol. 8 (5): 888-92. PMID 12378636.
 | This protein-related article is a stub. You can help WikiDoc by expanding it. |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
