CYP4F2
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| Cytochrome P450, family 4, subfamily F, polypeptide 2
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| Identifiers | ||||||||||||||
| Symbol(s) | CYP4F2; CPF2 | |||||||||||||
| External IDs | OMIM: 604426 MGI: 2158641 Homologene: 88644 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
| Image:PBB GE CYP4F2 210452 x at tn.png | ||||||||||||||
| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 8529 | 170716 | ||||||||||||
| Ensembl | ENSG00000186115 | ENSMUSG00000024055 | ||||||||||||
| Uniprot | P78329 | na | ||||||||||||
| Refseq | NM_001082 (mRNA) NP_001073 (protein) | XM_993057 (mRNA) XP_998151 (protein) | ||||||||||||
| Location | Chr 19: 15.85 - 15.87 Mb | Chr 17: 32.66 - 32.69 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Cytochrome P450, family 4, subfamily F, polypeptide 2, also known as CYP4F2, is a human gene.[1]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away.[1]
References
Further reading
- Simpson AE (1997). "The cytochrome P450 4 (CYP4) family.". Gen. Pharmacol. 28 (3): 351-9. PMID 9068972.
- Kikuta Y, Kusunose E, Kondo T, et al. (1994). "Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver.". FEBS Lett. 348 (1): 70-4. PMID 8026587.
- Chen L, Hardwick JP (1993). "Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors.". Arch. Biochem. Biophys. 300 (1): 18-23. PMID 8424651.
- Powell PK, Wolf I, Jin R, Lasker JM (1998). "Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11.". J. Pharmacol. Exp. Ther. 285 (3): 1327-36. PMID 9618440.
- Kikuta Y, Miyauchi Y, Kusunose E, Kusunose M (1999). "Expression and molecular cloning of human liver leukotriene B4 omega-hydroxylase (CYP4F2) gene.". DNA Cell Biol. 18 (9): 723-30. doi:10.1089/104454999315006. PMID 10492403.
- Lasker JM, Chen WB, Wolf I, et al. (2000). "Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11.". J. Biol. Chem. 275 (6): 4118-26. PMID 10660572.
- Zhang X, Chen L, Hardwick JP (2000). "Promoter activity and regulation of the CYP4F2 leukotriene B(4) omega-hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells.". Arch. Biochem. Biophys. 378 (2): 364-76. doi:10.1006/abbi.2000.1836. PMID 10860554.
- Zhang X, Hardwick JP (2001). "Regulation of CYP4F2 leukotriene B4 omega-hydroxylase by retinoic acids in HepG2 cells.". Biochem. Biophys. Res. Commun. 279 (3): 864-71. doi:10.1006/bbrc.2000.4020. PMID 11162441.
- Peng X, Pan X, Kenga M (2002). "[Isolation and sequencing of a novel form of cytochrome p-450 4F family from human liver]". Zhonghua Yi Xue Za Zhi 79 (11): 860-2. PMID 11715494.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
- Nagata T, Takahashi Y, Ishii Y, et al. (2004). "Profiling of genes differentially expressed between fetal liver and postnatal liver using high-density oligonucleotide DNA array.". Int. J. Mol. Med. 11 (6): 713-21. PMID 12736711.
- Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
- Hsu MH, Savas U, Griffin KJ, Johnson EF (2007). "Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin.". J. Biol. Chem. 282 (8): 5225-36. doi:10.1074/jbc.M608176200. PMID 17142457.
- Sontag TJ, Parker RS (2007). "Influence of major structural features of tocopherols and tocotrienols on their omega-oxidation by tocopherol-omega-hydroxylase.". J. Lipid Res. 48 (5): 1090-8. doi:10.1194/jlr.M600514-JLR200. PMID 17284776.
- Stec DE, Roman RJ, Flasch A, Rieder MJ (2007). "Functional polymorphism in human CYP4F2 decreases 20-HETE production.". Physiol. Genomics 30 (1): 74-81. doi:10.1152/physiolgenomics.00003.2007. PMID 17341693.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
