Calcium-activated potassium channel
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
Calcium-activated potassium channels are divided into BK channels, IK channels, and SK channels based on their conductance (big, intermediate, and small conductance).
This family of ion channels is, for the most part, activated by intracellular Ca2+ and contains 8 members. It should be noted, however, that some of these channels (the KCa4 and KCa5 channels) are responsive instead to intracellular Na+ and Cl-. Furthermore, the KCa1 family is both Ca2+ and voltage activated, further complicating the description of this family. The KCa channel α subunits have six transmembrane segments similar to the KVs, except KCa1, in which the N-terminus makes a seventh pass across the membrane to end up outside the cell. The α subunits make homo- and hetero-tetrameric complexes.
Contents |
Homology classification
Below is a list of the 8 known calcium-activated potassium channel grouped according to sequence homology of transmembrane hydrophobic cores:[1]
BK channel
- Kca1.x : Kca1.1 (KCNMA1)
SK channel
- Kca2.x : Kca2.1 (KCNN1), Kca2.2 (KCNN2), Kca2.3 (KCNN3)
- Kca3.x: Kca3.1 (KCNN4)
- Kca4.x: Kca4.1 (KCNT1), Kca4.2 (KCNT2)
IK channel
- Kca5.x: Kca5.1 (KCNMC1)
See also
External links
References
Membrane transport protein: ion channels | |
|---|---|
| Ca2+: Calcium channel | Voltage-dependent calcium channel (L-type/Cav1.2, Cav2.1, N-type, P-type, Q-type, R-type, T-type) - Inositol triphosphate receptor - Ryanodine receptor - Cation channels of sperm - Two-pore channel |
| Na+: Sodium channel | Nav1.4 - Nav1.5 - Nav1.7- Nav1.9 - Epithelial sodium channel |
| K+: Potassium channel | Voltage-gated (Kv1.1, KvLQT1, KvLQT2, KvLQT3, HERG, Shaker gene, KCNE1) - Calcium-activated (BK channel, SK channel, SK3) - Inward-rectifier (ROMK, Kir2.1, KCNJ11) - Tandem pore domain |
| Cl-: Chloride channel | Cystic fibrosis transmembrane conductance regulator |
| Porin | Aquaporin (1, 2, 3, 4) - Voltage-dependent anion channel |
| Cations: TRP | TRPA - TRPC (TRPC6) - TRPM (TRPM6) - TRPML (Mucolipin-1) - TRPP - TRPV (TRPV1, TRPV6) |
| Other/general | Voltage-gated ion channel - Ligand-gated ion channel - Cyclic nucleotide-gated ion channel - Stretch-activated ion channel |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
