Calcium carbimide
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| Image:Citrated calcium carbimide.png | |
| Calcium carbimide
| |
| Systematic (IUPAC) name | |
| calcium 2-hydroxypropane-1,2,3-tricarboxylate; methylcyanamide | |
| Identifiers | |
| CAS number | |
| ATC code | N07 |
| PubChem | |
| Chemical data | |
| Formula | C6H8O7.CH2N2.Ca |
| Mol. mass | 288.268 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
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Calcium carbimide, sold as the citrate salt under the trade name Temposil, is an alcohol sensitizing agent. Its effects are similar to the drug disulfiram (Antabuse) in that it interferes with the normal metabolism of alcohol by preventing the breakdown of the metabolic byproduct acetaldehyde. The result is that when alcohol is consumed by users of calcium carbimide, they experience severe reactions which include symptoms such as sweating, difficulty breathing, rapid heartbeat, rash, nausea and vomiting, and headache.
While calcium carbimide is a good adjunct to other treatments for alcoholism, it has been found that, as with Antabuse, it is an ineffective therapy on its own, and many alcoholics will voluntarily discontinue the drug in order to continue drinking.
Drugs used in addictive disorders (N07B) | |
|---|---|
| Nicotine dependence/ (Nicotinic agonist) | Nicotine - Bupropion - Dianicline - Varenicline - Lobeline - Mecamylamine - Clonidine - Surinabant |
| Alcohol dependence | Disulfiram - Calcium carbimide - Acamprosate - Naltrexone - Nalmefene - Topiramate - Clonidine - Buprenorphine - Morphine |
| Opioid dependence | Buprenorphine - Methadone - Levacetylmethadol - Fentanyl - Dihydrocodeine - Dihydroetorphine - Clonidine - Lofexidine - Naltrexone - Ibogaine - 18-Methoxycoronaridine - Extended Release Morphine - Extended Release Hydromorphone |
| Stimulant dependence | Dexamphetamine - Bupropion - Vanoxerine - Nocaine - Vigabatrin |
| Benzodiazepine dependence | Clonidine - Diazepam - Phenytoin - Phenobarbital |
| Cocaine dependence | Bupropion - Vanoxerine - Nocaine - Baclofen - Vigabatrin |
| Sedative-Hypnotic dependence | Phenobarbital - Diazepam - Lorazepam - Clonidine - Chloral Hydrate |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
