Calsequestrin
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| Image:Calsequestrin 1a8y.png | |
| Calsequestrin monomer showing the three repeating calsequestrin domains | |
| calsequestrin 1 (fast-twitch, skeletal muscle)
| |
| Identifiers | |
| Symbol | CASQ1 |
| Alt. Symbols | CASQ |
| Entrez | 844 |
| HUGO | 1512 |
| OMIM | 114250 |
| PDB | 1A8Y |
| RefSeq | NM_001231 |
| UniProt | P31415 |
| Other data | |
| Locus | Chr. 1 q21 |
| calsequestrin 2 (cardiac muscle)
| |
| Identifiers | |
| Symbol | CASQ2 |
| Entrez | 845 |
| HUGO | 1513 |
| OMIM | 114251 |
| RefSeq | NM_001232 |
| UniProt | O14958 |
| Other data | |
| Locus | Chr. 1 p13.3-p11 |
Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. The protein helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction, even though the concentration of calcium in the sarcoplasmic reticulum is much higher than in the cytosol.
External links
References
Wang S, Trumble WR, Liao H, Wesson CR, Dunker AK, Kang CH (1998). "Crystal structure of calsequestrin from rabbit skeletal muscle sarcoplasmic reticulum". Nat. Struct. Biol. 5 (6): 476-83. PMID 9628486.
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Cell signaling: calcium signaling | |
|---|---|
| Second messengers | IP3 - NAADP - cADPR |
| Intracellular calcium store gates | IP3 receptor - Ryanodine receptor - putative NAADP receptor |
| Calcium pumps and exchangers | SERCA - Na/Ca antiport - Ca/H antiport |
| calcium binding protein domains | EF hand domain - C2 domain |
| Calcium based molecular switches, and kinases | Troponin C - CaM - CaM kinases - PKC - NCS |
| Intracellular calcium chelators (calcium buffers) and calcium sensors | Calbindin - S100 - pervalbumin - Calretinin - Calsequestrin - Sarcalumenin - Phospholamban - Synaptotagmins |
| Calcium dependent proteases | Calpain |
| Calcium dependent cytoskeleton remodeling proteins | Gelsolin |
| Cell membrane calcium channels | VDCC - TRP - NMDA receptor - AMPA receptor - 5-HT3 receptor - P2X Receptor |
| Calcium regulated chaperones | calreticulin - calnexin |
| Calcium based adhesion molecules | Cadherin |
| Calcium homeostasis | Parathyroid hormone - Calcitonin - calcium receptor - vitamin D |
Carrier protein: calcium-binding proteins | |
|---|---|
| Intracellular calcium-sensing proteins | Calmodulin - Calnexin - Calreticulin - Gelsolin - neuronal (Hippocalcin, Neurocalcin, Recoverin) |
| Other | Annexin (A1, A2, A5) - Vitamin D-dependent calcium-binding protein/Calbindin - Calexcitin - Calsequestrin - Osteocalcin - Matrix gla protein - Osteonectin - S-100 - Synaptotagmin - Troponin C |
The principle calcium - binding protein found in the Sarcoplasmic Reticulum which also provides calcium storage
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
