Cancer procoagulant
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Cancer procoagulant is a hypothesised protein, most likely a cysteine protease enzyme (EC 3.4.22.26), that occurs only in fetal and malignant cells. Its activity appears to be the activation of factor X, one of the coagulation factors, and would account for the increased incidence of thrombosis in cancer patients. Tissue factor (TF) is also known to be present at increased levels around malignant cells.
References
- De Cicco M. The prothrombotic state in cancer: pathogenic mechanisms. Crit Rev Oncol Hematol 2004;50:187-96. PMID 15182825.
External links
Proteases: cysteine proteases (EC 3.4.22) | |
|---|---|
| Caspase | Caspase 1 - Caspase 2 - Caspase 3 - Caspase 4 - Caspase 5 - Caspase 8 - Caspase 9 - Caspase 10 - Caspase 12 - Caspase 13 |
| Fruit-derived | Papain - Ficain - Bromelain - Actinidain |
| Other | Clostripain - Cancer procoagulant - Separase - Calpain - Autophagin |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
