Carbamoyl phosphate synthase II

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carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Identifiers
Symbol	CAD
Entrez	790
HUGO	1424
OMIM	114010
RefSeq	NM_004341
UniProt	P27708
Other data
Locus	Chr. 2 p21

Carbamoyl phosphate synthase II is an enzyme which catalyzes the reactions which produce carbamoyl phosphate in the cytosol (as opposed to type I, which functions in the mitochondria).

In pyrimidine biosynthesis, it catalyzes the following reaction: Gln + CO₂ + 2 ATP + H₂O → carbamoyl phosphate + Glu + 2 ADP + P_i

It is one of the three enzyme functions coded by the CAD gene. It is classified under EC 6.3.5.5.

External links

MeSH Carbamoyl-Phosphate+Synthase+(Glutamine-Hydrolyzing)

Template:Enzyme-stub

v • d • e Enzymes: ligases (EC 6)
6.1 - Carbon-Oxygen	Aminoacyl tRNA synthetase
6.2 - Carbon-Sulfur	Succinyl coenzyme A synthetase - Acetyl Co-A synthetase - Long fatty acyl CoA synthetase
6.3 - Carbon-Nitrogen	Glutamine synthetase - Ubiquitin ligase (Von Hippel-Lindau tumor suppressor, UBE3A, Mdm2, Anaphase-promoting complex) - Glutathione synthetase - CTP synthase - Adenylosuccinate synthase - Argininosuccinate synthetase - Holocarboxylase synthetase - GMP synthase - Asparagine synthetase - Carbamoyl phosphate synthase (I , II )
6.4 - Carbon-Carbon	Carbon-carbon ligases
6.5 - Phosphoric Ester	DNA ligase

v • d • e

Metabolism: amino acid metabolism - nucleotide enzymes

Purine metabolism

Anabolism	R5P->IMP: Ribose-phosphate diphosphokinase - Amidophosphoribosyltransferase - Phosphoribosylglycinamide formyltransferase - AIR synthetase (FGAM cyclase) - Phosphoribosylaminoimidazole carboxylase - Phosphoribosylaminoimidazolesuccinocarboxamide synthase - IMP synthase IMP->AMP: Adenylosuccinate synthase - Adenylosuccinate lyase - reverse (AMP deaminase) IMP->GMP: IMP dehydrogenase - GMP synthase - reverse (GMP reductase)
Nucleotide salvage	Hypoxanthine-guanine phosphoribosyltransferase - Adenine phosphoribosyltransferase
Catabolism	Adenosine deaminase - Purine nucleoside phosphorylase - Guanine deaminase - Xanthine oxidase - Urate oxidase

Pyrimidine metabolism

Anabolism	CAD (Carbamoyl phosphate synthase II, Aspartate carbamoyltransferase, Dihydroorotase) Dihydroorotate dehydrogenase - Orotidine 5'-phosphate decarboxylase/Uridine monophosphate synthetase CTP synthase
Catabolism	Dihydropyrimidine dehydrogenase - Dihydropyrimidinase/DPYS - Beta-ureidopropionase/UPB1