Caspase-9
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| caspase 9, apoptosis-related cysteine peptidase
| |
| Identifiers | |
| Symbol | CASP9 |
| Entrez | 842 |
| HUGO | 1511 |
| OMIM | 602234 |
| RefSeq | NM_032996 |
| UniProt | P55211 |
| Other data | |
| Locus | Chr. 1 p36.3-1p36.1 |
Caspase-9 is an initiator caspase.[1]
The aspartic acid specific protease caspase-9 has been linked to the mitochondrial death pathway. It is activated during programed cell death (apoptosis). Induction of stress signalling pathways JNK/SAPK causes release of cytochrome c from mitochondria and activation of apaf-1 (apoptosome), which in turn cleaves the pro-enzyme of caspase-9 into the active form.
Once intiated caspase-9 goes on to cleave procaspase-3 & procaspase-7 and which cleave several cellular targets, including poly ADP ribose polymerase.
References
External links
- Lei K, Nimnual A, Zong W, Kennedy N, Flavell R, Thompson C, Bar-Sagi D, Davis R (2002). "The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase.". Mol Cell Biol 22 (13): 4929-42. PMID 12052897.
- Earnshaw W, Martins L, Kaufmann S. "Mammalian caspases: structure, activation, substrates, and functions during apoptosis.". Annu Rev Biochem 68: 383-424. PMID 10872455.
Proteases: cysteine proteases (EC 3.4.22) | |
|---|---|
| Caspase | Caspase 1 - Caspase 2 - Caspase 3 - Caspase 4 - Caspase 5 - Caspase 8 - Caspase 9 - Caspase 10 - Caspase 12 - Caspase 13 |
| Fruit-derived | Papain - Ficain - Bromelain - Actinidain |
| Other | Clostripain - Cancer procoagulant - Separase - Calpain - Autophagin |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
