Catalytic receptor
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A Catalytic receptor is an integral membrane protein possessing both enzymatic catalytic and receptor functions.[1]
The following is a list of the five major families of catalytic receptors:
| Family | Member | Gene | Catalytic activity | Endogenous Ligands | Synthetic Ligands |
|---|---|---|---|---|---|
| Erb | tyrosine kinase EC 2.7.10.1 | ||||
| ErbB1 (epidermal growth factor receptor) | EGFR | " | Epidermal growth factor, amphiregulin, betacellulin, epigen, epiregulin, HB-EGF, TGFa | GW583340, gefitinib, erlotinib, tyrphostins AG879 and AG1478 | |
| ErbB2 | ERBB2 | " | |||
| ErbB3 | ERBB3 | " | NRG-1, NRG-2 | GW583340, gefitinib, erlotinib, tyrphostins AG879 and AG1478 | |
| ErbB4 | ERBB4 | " | Betacellulin, epiregulin, HB-EGF, NRG-1, NRG-2, NRG-3, NRG-4 | GW583340, gefitinib, erlotinib, tyrphostins AG879 and AG1478 | |
| GDNF (glial cell-derived neurotrophic factor) | " | ||||
| GFRa1 | GFRa1 | " | GDNF > neurturin > artemin | ||
| GFRa2 | GFRa2 | " | Neurturin > GDNF | ||
| GFRa3 | GFRa3 | " | Artemin | ||
| GFRa4 | GFRa4 | " | Persephin | ||
| NPR (natriuretic peptide receptor) | guanylyl cyclase EC 4.6.1.2 | ||||
| NPR1 | NPR1 | " | Atrial natriuretic peptide | ||
| NPR2 | NPR2 | " | C-type natriuretic peptide | ||
| NPR3 | NPR3 | " | Atrial natriuretic peptide | ||
| NPR4 | NPR4 | " | Uroguanylin | ||
| trk neurotrophin receptor | tyrosine kinase EC 2.7.10.1 | ||||
| TrkA | NTRK1 | " | Nerve growth factor > NT-3 | GW441756, tyrphostin AG879 | |
| TrkB | NTRK2 | " | Brain-derived neurotrophic factor, NT-4/NT-5 > NT-3 | ||
| TrkC | NTRK3 | " | NT-3 | ||
| p75 | NGFR | " | NGF, BDNF, NT3, NT4/5 | ||
| Toll-like | " | ||||
| TLR1 | TLR1 | " | |||
| TLR2 | TLR2 | " | Peptidoglycan | ||
| TLR3 | TLR3 | " | polyIC, polyinosine-polycytosine | ||
| TLR4 | TLR4 | " | LPS, lipopolysaccharide derived from Gram-negative bacteria | ||
| TLR5 | TLR5 | " | Flagellin | ||
| TLR6 | TLR6 | " | |||
| TLR7 | TLR7 | " | resiquimod, imiquimod | ||
| TLR8 | TLR8 | " | |||
| TLR9 | TLR9 | " | CpG, DNA enriched in cytosine:guanosine pairs | ||
| TLR10 | TLR10 | " |
External links
http://www.nature.com/bjp/journal/vgrac/ncurrent/index.html#Catalytic-Receptors
References
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
